The Holistic prevention, management and treatment of Polycystic Ovarian Syndrome: The Stress Response and Management herbal Schisandra

By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Polycystic Ovarian Syndrome

Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovasular disease(8)(13), acne(10)(14), endometrial cancer(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to  continuously increase risk of type II diabetes, with no increasing altered glucose tolerance(20), CVD and hypertension(21).

                     In Herbal Medicine Perspective

The prevention and management 

Polycystic ovary syndrome (PCOS) is unpreventable in Western medicine. Early diagnosis and treatment  may reduce risk of its complications, including infertility, metabolic syndrome, obesity, diabetes, cardiovascular diseases, stroke, etc.
        Reduce fat intake less than 30% of total calories with a low proportion of saturated fat and high in fiber from predominantly low-glycaemic-index-carbohydrate foods for patients with PCOs(827a). Calorie intake should be distributed between several meals per day with restricted intake of snacks and drinks(828).
 
The stress management herbs

Stress in a natural reaction of human fight or fight response induced by pressure due to such as an environmental condition or a stimulus. Long term stress can cause deleterious and cumulative effects on human body(1104), including emotional or cognitive problems, such as an increased risk of attentional deficit/hyperactivity, anxiety, and language delay(1103), especially for people with chronic illness, including women with Polycystic Ovarian Syndrome (PCOs)(1105).

Schisandra (Wu Wei Zi)

Schisandra also is known as Wu Wei Zi, a twining shrub living its life by climbing on other vegetation, belongings to the family Schisandraceae, native to Asia and North America, The warm, sweet, bitter, sour, acrid, salty herb has been used in tradional Chinese medicine as antioxidant(1218)(1219), anti stress(1220)(1221), anti microbial(1224)(1225)(1226) agent and to improve metabolism(1227)(1228), enhance central nervous system(1229)(1230)(1233), treat hypertension(1231)(1232) and hypotension during exhaustion of circulatory function(1217), coughing(1234)(12135), insomnia(1237), premenstrual syndrome (PMS)(1239), menopausal symptoms(1240), depression(1233), irritability(1233), erectile dysfunction (ED)(1238), lower cholesterol(1241) and regulate blood glucose(1233), improve  memory(1222)(1223), etc.
by promoting function of lung and kidney channels(1217).

Phytochemicals(1217)
1. Schizandrin
2. Deoxyschisandrin
3. Gamma-schisandrin
4. Schisandrol
5. Pseudo-gamma-schisandrin
6. Schizandrate B
7. Gomisin A, B, C, F, G
8. Angeloylgomisin H
9. Tigloylgomisin H
10. Benzoylgomisin H
11. Epigomisin O
12. Malic acid
13. Citric acid
14. Tartaric acid
15. Succinic acid
16. A-pinene
17. Camphene
18. B-pinene
19. Byrcene
20. A-terpinene
21. Limonene
22. G-terpinene
23. P-cymene
24. Etc.

In chronic psychological stress male rat model, schisandra protect against stress induced complications such as carbohydrate metabolism(1227) and neurosis, psychogenic depression, astheno-depressive states, schizophrenia and alcoholism disorders(1233) and improved mental performance(1233).through its reduction of the levels of corticosterone (CORT) and glucose and protect the structure of the adrenal cortex(1227).
In physiological stress, the herbal medicine also exerted its stress-protective effect against a broad spectrum of harmful factors including heat shock, skin burn, cooling, frostbite, immobilisation, swimming under load in an atmosphere with decreased air pressure, aseptic inflammation, irradiation, and heavy metal intoxication(1233).
In oxidative stress induced damage heart(1242) tissues in animal models, schisandrin B (Sch B), a dibenzocyclooctadiene derivative isolated from the fruit of Schisandra chinensis attenuated cardiotoxicity via antioxidant and anti-inflammatory effects(1242). In oxidative stress induced liver damage, oral administration of Schisandra Lignans Extract (SLE)(1243)(1244) or triterpenoid(1245) a chemical constituent from Schisandra chinensis significantly reduced liver damage(1243)(1244)(1245) in experimental animal model, through its effects of balance of oxidation and reduction in cells(1243) or upregulating cell cycle progression(1244) and anti tumor antigen(1244), or ameliorating oxidative stress(1245).

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months   

References
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O¹.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF¹, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndrome and healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R¹, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N¹, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB¹, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA¹, Arduc A², Tuna MM¹, Karakılıc E¹, Dagdelen I¹, Tutuncu Y¹, Berker D¹, Guler S¹.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO¹.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO¹, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J¹, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK¹, Katalenich B², Nagireddy P³, Chabbra P⁴, Kuhadiya N⁵, Fonseca V¹.(PubMed)
(14) Acne in hirsute women by Lumezi BG¹, Pupovci HL¹, Berisha VL¹, Goçi AU², Gerqari A³.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N¹, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H¹, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women With Polycystic Ovary Syndrome. by Whigham LD¹, Butz DE², Dashti H³, Tonelli M³, Johnson LK¹, Cook ME², Porter WP⁴, Eghbalnia HR⁵, Markley JL⁶, Lindheim SR⁷, Schoeller DA⁸, Abbott DH⁹, Assadi-Porter FM¹⁰.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA¹, Azizia MM¹, Hardiman PJ².(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M¹, Kjaer SK², Jensen A¹, Munk C¹, Mellemkjaer L³.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E¹.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E¹, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(827a) Diet and nutrition in polycystic ovary syndrome (PCOS): pointers for nutritional management by Farshchi H, Rane A, Love A, Kennedy RL(PubMed)
(828) The optimal diet for women with polycystic ovary syndrome? by Marsh K, Brand-Miller J.(PubMed)  (1106) Simultaneous Estimation of Withaferin A and Z-Guggulsterone in Marketed Formulation by RP-HPLC by Agrawal P¹, Vegda R², Laddha K².(PubMed)

(1217) Wu Wei Zi(Complementary and Alternative Healing University)
(1218) Antioxidant and hepatoprotective effects of Schisandra chinensis pollen extract on CCl4-induced acute liver damage in mice by Cheng N¹, Ren N, Gao H, Lei X, Zheng J, Cao W.(PubMed)
(1219) Schizandrin, an antioxidant lignan from Schisandra chinensis, ameliorates Aβ1-42-induced memory impairment in mice by Hu D¹, Cao Y, He R, Han N, Liu Z, Miao L, Yin J.(PubMed)
(1220) Schisantherin A recovers Aβ-induced neurodegeneration with cognitive decline in mice by Li X¹, Zhao X¹, Xu X¹, Mao X¹, Liu Z¹, Li H¹, Guo L¹, Bi K², Jia Y³.(PubMed)
(1221) Schisandrin B prevents doxorubicin induced cardiac dysfunction by modulation of DNA damage, oxidative stress and inflammation through inhibition of MAPK/p53 signaling by Thandavarayan RA¹, Giridharan VV², Arumugam S³, Suzuki K⁴, Ko KM⁵, Krishnamurthy P⁶, Watanabe K³, Konishi T⁷.(PubMed)
(1222) Schizandrin, an antioxidant lignan from Schisandra chinensis, ameliorates Aβ1-42-induced memory impairment in mice by Hu D¹, Cao Y, He R, Han N, Liu Z, Miao L, Yin J.(PubMed)
(1223) Deoxyschizandrin isolated from the fruits of Schisandra chinensis ameliorates Aβ₁₋₄₂-induced memory impairment in mice by Hu D¹, Li C, Han N, Miao L, Wang D, Liu Z, Wang H, Yin J.(PubMed)
(1224) A comparison of the anti-Staphylococcus aureus activity of extracts from commonly used medicinal plants by Snowden R¹, Harrington H, Morrill K, Jeane L, Garrity J, Orian M, Lopez E, Rezaie S, Hassberger K, Familoni D, Moore J, Virdee K, Albornoz-Sanchez L, Walker M, Cavins J, Russell T, Guse E, Reker M, Tschudy O, Wolf J, True T, Ukaegbu O, Ahaghotu E, Jones A, Polanco S, Rochon Y, Waters R, Langland J.(PubMed)
(1225) Anti-HIV-1 activity of lignans from the fruits of Schisandra rubriflora by Xiao WL¹, Wang RR, Zhao W, Tian RR, Shang SZ, Yang LM, Yang JH, Pu JX, Zheng YT, Sun HD.(PubMed)
(1226) Compositions and biological activities of essential oils of Kadsura longepedunculata and Schisandra sphenanthera by Song L¹, Ding JY, Tang C, Yin CH.(PubMed)
(1227) [Effects of schisandra on the function of the pituitary-adrenal cortex, gonadal axis and carbohydrate metabolism in rats undergoing experimental chronic psychological stress, navigation and strenuous exercise].[Article in Chinese] by Sun LJ¹, Wang GH, Wu B, Wang J, Wang Q, Hu LP, Shao JQ, Wang YT, Li J, Gu P, Lu B.(PubMed)
(1228) In vivo to in vitro effects of six bioactive lignans of Wuzhi tablet (Schisandra sphenanthera extract) on the CYP3A/P-glycoprotein-mediated absorption and metabolism of tacrolimus by Qin XL¹, Chen X, Wang Y, Xue XP, Wang Y, Li JL, Wang XD, Zhong GP, Wang CX, Yang H, Huang M, Bi HC.(PubMed)
(1229) The effects of lignan-riched extract of Shisandra chinensis on amyloid-β-induced cognitive impairment and neurotoxicity in the cortex and hippocampus of mouse by Jeong EJ¹, Lee HK, Lee KY, Jeon BJ, Kim DH, Park JH, Song JH, Huh J, Lee JH, Sung SH.(PubMed)
(1230) Schisandrin B exerts anti-neuroinflammatory activity by inhibiting the Toll-like receptor 4-dependent MyD88/IKK/NF-κB signaling pathway in lipopolysaccharide-induced microglia by Zeng KW¹, Zhang T, Fu H, Liu GX, Wang XM.(PubMed)
(1231) Preventive effect of gomisin J from Schisandra chinensis on angiotensin II-induced hypertension via an increased nitric oxide bioavailability by Ye BH¹, Lee SJ¹, Choi YW², Park SY¹, Kim CD¹.(PubMed)
(1232) Antihypertensive effect of gomisin A from Schisandra chinensis on angiotensin II-induced hypertension via preservation of nitric oxide bioavailability by Young Park J¹, Wook Yun J, Whan Choi Y, Ung Bae J, Won Seo K, Jin Lee S, Youn Park S, Whan Hong K, Kim CD.(PubMed)
(1233) Pharmacology of Schisandra chinensis Bail.: an overview of Russian research and uses in medicine by Panossian A¹, Wikman G.(PubMed)
(1234) Effects of Schisandra chinensis extracts on cough and pulmonary inflammation in a cough hypersensitivity guinea pig model induced by cigarette smoke exposure by Zhong S¹, Nie YC¹, Gan ZY¹, Liu XD¹, Fang ZF¹, Zhong BN¹, Tian J¹, Huang CQ¹, Lai KF², Zhong NS¹.(PubMed)
(1235) Effects of the Schisandra fructus water extract on cytokine release from a human mast cell line. by Kang OH¹, Chae HS, Choi JH, Choi HJ, Park PS, Cho SH, Lee GH, So HY, Choo YK, Kweon OH, Kwon DY.(PubMed)
(1236) [Effects of extracts from ziziphi spinosae semen and schisandrae chinensis fructus on amino acid neurotransmitter in rats with insomnia induced by PCPA].[Article in Chinese] by Gao JR, Ji WB, Jiang H, Chen JF.(PubMed)
(1237) Gomisin N isolated from Schisandra chinensis augments pentobarbital-induced sleep behaviors through the modification of the serotonergic and GABAergic system by Zhang C¹, Mao X¹, Zhao X¹, Liu Z¹, Liu B¹, Li H¹, Bi K², Jia Y³.(PubMed)
(1238) Panax ginseng, Rhodiola rosea and Schisandra chinensis by Chan SW1.(PubMed)
(1239) Herbal composition for promoting hormonal balance in women and methods of using same US 6242012 B1
(1240) The mechanism of vasorelaxation induced by Schisandra chinensis extract in rat thoracic aorta by Park JY1, Shin HK, Lee YJ, Choi YW, Bae SS, Kim CD.(PubMed)
(1241) Shengmai San reduces hepatic lipids and lipid peroxidation in rats fed on a high-cholesterol diet by Yao HT1, Chang YW, Chen CT, Chiang MT, Chang L, Yeh TK.(PubMed)
(1242) Schisandrin B prevents doxorubicin induced cardiac dysfunction by modulation of DNA damage, oxidative stress and inflammation through inhibition of MAPK/p53 signaling by Thandavarayan RA1, Giridharan VV2, Arumugam S3, Suzuki K4, Ko KM5, Krishnamurthy P6, Watanabe K3, Konishi T7.(PubMed)
(1243) Schisandra Lignans Was Related with Its Antioxidative Actions in Liver Cells by Pu HJ1, Cao YF, He RR, Zhao ZL, Song JH, Jiang B, Huang T, Tang SH, Lu JM, Kurihara H.(PubMed)
(1244) Therapeutic efficacy of Wuzhi tablet (Schisandra sphenanthera Extract) on acetaminophen-induced hepatotoxicity through a mechanism distinct from N-acetylcysteine by Fan X1, Chen P1, Jiang Y1, Wang Y1, Tan H1, Zeng H1, Wang Y1, Qu A1, Gonzalez FJ1, Huang M1, Bi H2.(PubMed)
(1245) Effects of triterpenoid from Schisandra chinensis on oxidative stress in alcohol-induced liver injury in rats by Li B1, Zhu L, Wu T, Zhang J, Jiao X, Liu X, Wang Y, Meng X.(PubMed)