The Holistic prevention, management and treatment of Polycystic Ovarian Syndrome: The Stress Response and Management herbal Rhaponticum

By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Polycystic Ovarian Syndrome

Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovasular disease(8)(13), acne(10)(14), endometrial cance(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to  continuously increase risk of type II diabetes, with no increasing altered glucose tolerance(20), CVD and hypertension(21).

                     In Herbal Medicine Perspective

The prevention and management 

Polycystic ovary syndrome (PCOS) is unpreventable in Western medicine. Early diagnosis and treatment  may reduce risk of its complications, including infertility, metabolic syndrome, obesity, diabetes, cardiovascular diseases, stroke, etc.
        Reduce fat intake less than 30% of total calories with a low proportion of saturated fat and high in fiber from predominantly low-glycaemic-index-carbohydrate foods for patients with PCOs(827a). Calorie intake should be distributed between several meals per day with restricted intake of snacks and drinks(828).
 
The stress management herbs

Stress in a natural reaction of human fight or fight response induced by pressure due to such as an environmental condition or a stimulus. Long term stress can cause deleterious and cumulative effects on human body(1104), including emotional or cognitive problems, such as an increased risk of attentional deficit/hyperactivity, anxiety, and language delay(1103), especially for people with chronic illness, including women with Polycystic Ovarian Syndrome (PCOs)(1105).

Rhaponticum or Maral root 

Rhaponticum also known as Maral root, is an herbaceous perennial plant belongings  the family Asteraceae, used in traditional Siberian, Russian and Chinese medicine as anti-depressant(1191)(1192), anti anxiety(1192), anti menopausal complaints(1192)(1193), antioxidant(1194)(1195), immunomodulatory(1194)(1195), anticancerogenic(1194)(1196)(1197), antimicrobial(1194)(1195)(1198)(1199) and adaptogen agent(1194) and to treat impotence(1194), enhance mental and physical performance(1194)(1200), support the nervous(1194)(1201) and cardiovascular system(1194)(1202)(1203), improve work capacity(1194), etc.


Phytochemicals(1190)
1. Rosavin
2. Rosin
3. Rosarin
4. Salidroside
5. Ecdysteroids
6. Flavonoids
7. Phenolic acids
8. Polyacetylenes,
9. Sesquiterpene lactones
10. Triterpenoid glycosides
11. Terpenes
12. Etc.


According to Russian Academy of Medical Sciences, therbal medicne also processed anti metabolic syndrome such as serum lipid profile, corticosterone and cytokine concentrations, glucose tolerance, systolic blood pressure, triacylglycerol accumulation and its induction of inflammation, stress, and hepatic steatosis in rat model(1004).
In in Wistar rats model, N-feruloylserotonins, isolated from the seeds of Leuzea carthamoides (WILLD.) DC, showed effectively in selective stress-reducing effects against stress-sensitive, such as reduced anxiety in the high-pain(1005).
In AdMax formulas, containing  Leuzea carthamoides Iljin, Rhodiola rosea L., Eleutherococcus senticosus Maxim, and from dry berries of Schizandra chinensis Baill, improve response to stimulus and stress, physical endurance and counteract fatigue accordiung to Genext Research, Inc.(1006)



Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months   

References
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O¹.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF¹, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndrome and healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R¹, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N¹, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB¹, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA¹, Arduc A², Tuna MM¹, Karakılıc E¹, Dagdelen I¹, Tutuncu Y¹, Berker D¹, Guler S¹.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO¹.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO¹, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J¹, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK¹, Katalenich B², Nagireddy P³, Chabbra P⁴, Kuhadiya N⁵, Fonseca V¹.(PubMed)
(14) Acne in hirsute women by Lumezi BG¹, Pupovci HL¹, Berisha VL¹, Goçi AU², Gerqari A³.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N¹, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H¹, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women With Polycystic Ovary Syndrome. by Whigham LD¹, Butz DE², Dashti H³, Tonelli M³, Johnson LK¹, Cook ME², Porter WP⁴, Eghbalnia HR⁵, Markley JL⁶, Lindheim SR⁷, Schoeller DA⁸, Abbott DH⁹, Assadi-Porter FM¹⁰.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA¹, Azizia MM¹, Hardiman PJ².(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M¹, Kjaer SK², Jensen A¹, Munk C¹, Mellemkjaer L³.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E¹.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E¹, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(827a) Diet and nutrition in polycystic ovary syndrome (PCOS): pointers for nutritional management by Farshchi H, Rane A, Love A, Kennedy RL(PubMed)
(828) The optimal diet for women with polycystic ovary syndrome? by Marsh K, Brand-Miller J.(PubMed)  (1106) Simultaneous Estimation of Withaferin A and Z-Guggulsterone in Marketed Formulation by RP-HPLC by Agrawal P¹, Vegda R², Laddha K².(PubMed)
(1190) Review Chemistry and pharmacology of Rhaponticum carthamoides: A review Ladislav Kokoska a,*, Dagmar Janovska(Elsevier)
(1191) [The use of a decoction of the rhizome of Leuzea carthamoides for the treatment of alcoholics with depressive states].[Article in Russian] by Ibatov AN.(PubMed)
(1192) Long-term effects of the rhapontic rhubarb extract ERr 731® on estrogen-regulated targets in the uterus and on the bone in ovariectomized rats by Keiler AM¹, Papke A, Kretzschmar G, Zierau O, Vollmer G.(PubMed)
(1193) Treatment of menopausal symptoms by an extract from the roots of rhapontic rhubarb: the role of estrogen receptors by Vollmer G¹, Papke A, Zierau O.(PubMed)
(1194) Chemistry and pharmacology of Rhaponticum carthamoides: a review by Kokoska L¹, Janovska D.(PubMed)
(1195) A study on the effect of ethanol extract of Radix rhapontici on erythrocyte immune function in rats by Yan X¹, Zhao H, Guan Y, Song Y, Meng J.(PubMed)
(1196) Anticarcinogenic activity of alpha-difluoromethylornithine, ginseng, eleutherococcus, and leuzea on radiation-induced carcinogenesis in female rats by Bespalov VG¹, Alexandrov VA, Semenov AL, Kovan'Ko EG, Ivanov SD.(PubMed)
(1197) Subtype-specific activation of estrogen receptors by a special extract of Rheum rhaponticum (ERr 731), its aglycones and structurally related compounds in U2OS human osteosarcoma cells by Möller F¹, Zierau O, Jandausch A, Rettenberger R, Kaszkin-Bettag M, Vollmer G.(PubMed)
(1198) Antimycobacterial effect of extract and its components from Rheum rhaponticum by Smolarz HD¹, Swatko-Ossor M, Ginalska G, Medyńska E.(PubMed)
(1199) Investigation of the antimicrobial activity of Rhaponticum (Rhaponticum carthamoides D.C. Iljin) and shrubby cinquefoil (Potentilla fruticosa L.).[Article in English, Lithuanian] by Jurkštienė V¹, Pavilonis A, Garšvienė D, Juozulynas A, Samsonienė L, Daukšienė D, Jankauskienė K, Simonienė-Kazlauskienė G, Stankevičius E.(PubMed)
(1200) Evaluation of molecular chaperons Hsp72 and neuropeptide Y as characteristic markers of adaptogenic activity of plant extracts by Asea A¹, Kaur P, Panossian A, Wikman KG.(PubMed)
(1201) [Cerebroprotector activity of Rhaponticum carthamoides extract in rats with brain ischemia].[Article in Russian] by Plotnikov MB, Logvinov SV, Pugachenko NV, Maslov MIu, Aliev OI, Vasil'ev AS, Suslov NI, Potapov AV.(PubMed)
(1202) [Lipid peroxide, membrane fluidity of smooth muscle cells and atherosclerosis].[Article in Chinese] by Lu YC1(PubMed)
(1203) [Cardioprotective and antiarrhythmic properties of preparations from Leuzea carthamoides, Aralia mandshurica, and Eleutherococcus senticosus].[Article in Russian] by Maslov LN, Guzarova NV.(PubMed)

(1204) Effects of rhaponticum carthamoides versus glycyrrhiza glabra and punica granatum extracts on metabolic syndrome signs in rats by Dushkin M¹, Khrapova M, Kovshik G, Chasovskikh M, Menshchikova E, Trufakin V, Shurlygina A, Vereschagin E.(PubMed)
(1205) The selective effect of N-feruloylserotonins isolated from Leuzea carthamoides on nociception and anxiety in rats by Yamamotová A¹, Pometlová M, Harmatha J, Rasková H, Rokyta R.(PubMed)
(1206) Influence of the plant extract complex "AdMax" on global gene expression levels in cultured human fibroblast(PubMed)