The Holistic prevention, management and treatment of Polycystic Ovarian Syndrome: The Stress Response and Management herbal Ashwagandha

  By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Polycystic Ovarian Syndrome

Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovasular disease(8)(13), acne(10)(14), endometrial cance(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to  continuously increase risk of type II diabetes, with no increasing altered glucose tolerance(20), CVD and hypertension(21).

                     In Herbal Medicine Perspective

The prevention and management 

Polycystic ovary syndrome (PCOS) is unpreventable in Western medicine. Early diagnosis and treatment  may reduce risk of its complications, including infertility, metabolic syndrome, obesity, diabetes, cardiovascular diseases, stroke, etc.
        Reduce fat intake less than 30% of total calories with a low proportion of saturated fat and high in fiber from predominantly low-glycaemic-index-carbohydrate foods for patients with PCOs(827a). Calorie intake should be distributed between several meals per day with restricted intake of snacks and drinks(828).
 
The stress management herbs

Stress in a natural reaction of human fight or fight response induced by pressure due to environmental condition or a stimulus. Long term stress can cause deleterious and cumulative effects on human body(1104), including emotional or cognitive problems, such as an increased risk of attentional deficit/hyperactivity, anxiety, and language delay(1103), especially for people with chronic illness, including women with Polycystic Ovarian Syndrome (PCOs)(1105).


Ashwagandha (Withania somnifera)


Ashwagandha(Withania somnifera), also known as Indian Ginseng is a nightshade plant belongings to the family Solanaceae, native to India, northern Africa, and the Middle East, used in Ayurvedic medicine over 3000 years(1101) as antitumors(1107)(1108), anti ulcers(1111), anti-stress(1112)(1115)(1118), improved cognition dysfunction(1109)(1110)(1118), anti-inflammatory(1113)(1116), antioxidant(1114)(1117), promoted immunity(1120)(1121), anti-aging(1119), etc., herbal medicine.

Phytochemicals(1102)
1. Isopelletierine
2. Anaferine
3. Cuseohygrine
4. Anahygrine
5. Withanolides
6. Withaferins
7. Saponins
8. Sitoindosides
9. Acylsterylglucosides
10. Z-Guggulsterone(1106)

10. Etc. 

Epidemiologically strong evidences suggested that herbal ashwagandha processes anti stress related disorders( induced by oxidative stress(1122)(1123) and long term stress(1123) effects, probably through its antioxidant(1123)(1124)(1126)(1114)(1117), anti-stress(1112)(1115)(1118), anti-inflammatory(1113)(1116), immunomoduratory(1120)(1121) effects. In rat model, hydroalcoholic extract exerted its antioxidant effect against psychological symptoms(1132) induced by long term stress, such as reduced motor performance(1124), cognitive impairment(1125)(1126, anxiety(1127)(1128), sleep disorder(1129)(1130), depression(1131), etc. In stress induced by phyisological symptoms, the herb has showen to reduce fatigue(1133) risk of hypertension(1134), risk of stroke(1135). risk of diabetes(1136), improve energy(1132), etc.



Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months   

References
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O¹.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF¹, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndrome and healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R¹, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N¹, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB¹, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA¹, Arduc A², Tuna MM¹, Karakılıc E¹, Dagdelen I¹, Tutuncu Y¹, Berker D¹, Guler S¹.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO¹.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO¹, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J¹, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK¹, Katalenich B², Nagireddy P³, Chabbra P⁴, Kuhadiya N⁵, Fonseca V¹.(PubMed)
(14) Acne in hirsute women by Lumezi BG¹, Pupovci HL¹, Berisha VL¹, Goçi AU², Gerqari A³.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N¹, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H¹, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women With Polycystic Ovary Syndrome. by Whigham LD¹, Butz DE², Dashti H³, Tonelli M³, Johnson LK¹, Cook ME², Porter WP⁴, Eghbalnia HR⁵, Markley JL⁶, Lindheim SR⁷, Schoeller DA⁸, Abbott DH⁹, Assadi-Porter FM¹⁰.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA¹, Azizia MM¹, Hardiman PJ².(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M¹, Kjaer SK², Jensen A¹, Munk C¹, Mellemkjaer L³.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E¹.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E¹, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(827a) Diet and nutrition in polycystic ovary syndrome (PCOS): pointers for nutritional management by Farshchi H, Rane A, Love A, Kennedy RL(PubMed)
(828) The optimal diet for women with polycystic ovary syndrome? by Marsh K, Brand-Miller J.(PubMed)  (1106) Simultaneous Estimation of Withaferin A and Z-Guggulsterone in Marketed Formulation by RP-HPLC by Agrawal P¹, Vegda R², Laddha K².(PubMed)
(1101) Steroidal lactones from Withania somnifera, an ancient plant for novel medicine by Mirjalili MH, Moyano E, Bonfill M, Cusido RM, Palazón J.(PubMed)
(1102) An Overview on Ashwagandha: A Rasayana (Rejuvenator) of Ayurveda by Narendra Singh, Mohit Bhalla, Prashanti de Jager, and Marilena Gilca(PubMed)
(1103) Antenatal maternal stress and long-term effects on child neurodevelopment: how and why? by Talge NM¹, Neal C, Glover V; Early Stress, Translational Research and Prevention Science Network: Fetal and Neonatal Experience on Child and Adolescent Mental Health.(PubMed)
(1104) Immediate and long-term effects of meditation on acute stress reactivity, cognitive functions, and intelligence by Singh Y¹, Sharma R, Talwar A.(PubMed)
(1105) The potential implications of a PCOS diagnosis on a woman's long-term health using data linkage by Hart R¹, Doherty DA.(PubMed)
(1106) Simultaneous Estimation of Withaferin A and Z-Guggulsterone in Marketed Formulation by RP-HPLC by Agrawal P¹, Vegda R², Laddha K².(PubMed)

(1107) Selective killing of cancer cells by leaf extract of Ashwagandha: components, activity and pathway analyses by Widodo N¹, Takagi Y, Shrestha BG, Ishii T, Kaul SC, Wadhwa R.(PubMed)
(1108) Selective killing of cancer cells by leaf extract of Ashwagandha: identification of a tumor-inhibitory factor and the first molecular insights to its effect by Widodo N¹, Kaur K, Shrestha BG, Takagi Y, Ishii T, Wadhwa R, Kaul SC.(PubMed)
(1109) Effect of standardized aqueous extract of Withania somnifera on tests of cognitive and psychomotor performance in healthy human participants by Pingali U¹, Pilli R¹, Fatima N¹.(PubMed)
(1110) Randomized placebo-controlled adjunctive study of an extract of withania somnifera for cognitive dysfunction in bipolar disorder by Chengappa KN¹, Bowie CR, Schlicht PJ, Fleet D, Brar JS, Jindal R.(PubMed)
(1111) Evaluation of the anti-ulcer activity of NR-ANX-C (a polyherbal formulation) in aspirin & pyloric ligature induced gastric ulcers in albino rats by Nair V¹, Arjuman A, Gopalakrishna HN, Dorababu P, Mirshad PV, Bhargavan D, Chatterji D.(PubMed)
(1112) Effect of Withania somnifera (Ashwagandha) root extract on amelioration of oxidative stress and autoantibodies production in collagen-induced arthritic rats by Khan MA, Subramaneyaan M, Arora VK, Banerjee BD, Ahmed RS.(PubMed)
(1113) Evaluation of anti-inflammatory effect of Withania somnifera root on collagen-induced arthritis in rats by Gupta A¹, Singh S.(PubMed)
(1114) Protective effect of Withania somnifera root powder in relation to lipid peroxidation, antioxidant status, glycoproteins and bone collagen on adjuvant-induced arthritis in rats by Rasool M¹, Varalakshmi P.(PubMed)
(1115) Withania somnifera Improves Semen Quality in Stress-Related Male Fertility by Mahdi AA¹, Shukla KK, Ahmad MK, Rajender S, Shankhwar SN, Singh V, Dalela D.(PubMed)
(1116) Withaferin A inhibits pro-inflammatory cytokine-induced damage to islets in culture and following transplantation by SoRelle JA¹, Itoh T, Peng H, Kanak MA, Sugimoto K, Matsumoto S, Levy MF, Lawrence MC, Naziruddin B.(PubMed)
(1117) Evaluation of antioxidant potential of Rasayana drugs in healthy human volunteers by Kuchewar VV¹, Borkar MA², Nisargandha MA³.(PubMed)
(1118) Withania somnifera (Ashwagandha) in neurobehavioural disorders induced by brain oxidative stress in rodents: a systematic review and meta-analysis by Durg S¹, Dhadde SB, Vandal R, Shivakumar BS, Charan CS.(PubMed)
(1119) In vitro protective effects of Withania somnifera (L.) dunal root extract against hydrogen peroxide and β-amyloid(1-42)-induced cytotoxicity in differentiated PC12 cells by Kumar S¹, Seal CJ, Howes MJ, Kite GC, Okello EJ.(PubMed)
(1120) Chemotypical variations in Withania somnifera lead to differentially modulated immune response in BALB/c mice by Kushwaha S¹, Roy S, Maity R, Mallick A, Soni VK, Singh PK, Chaurasiya ND, Sangwan RS, Misra-Bhattacharya S, Mandal C.(PubMed)
(1121) Molecular insight into the immune up-regulatory properties of the leaf extract of Ashwagandha and identification of Th1 immunostimulatory chemical entity by Khan S¹, Malik F, Suri KA, Singh J.(PubMed)
(1122) Evaluation of the anti-proliferative and anti-oxidative activities of leaf extract from in vivo and in vitro raised Ashwagandha by Kaur K¹, Rani G, Widodo N, Nagpal A, Taira K, Kaul SC, Wadhwa R.(PubMed)
(1123) Anti-oxidant effect of Withania somnifera glycowithanolides in chronic footshock stress-induced perturbations of oxidative free radical scavenging enzymes and lipid peroxidation in rat frontal cortex and striatum by Bhattacharya A¹, Ghosal S, Bhattacharya SK.(PubMed)
(1124) Evaluation of Withania somnifera in a middle cerebral artery occlusion model of stroke in rats by Chaudhary G¹, Sharma U, Jagannathan NR, Gupta YK.(PubMed)
(1125) Propoxur-induced acetylcholine esterase inhibition and impairment of cognitive function: attenuation by Withania somnifera by Yadav CS¹, Kumar V, Suke SG, Ahmed RS, Mediratta PK, Banerjee BD.(PubMed)
(1126) Attenuation of oxidative damage-associated cognitive decline by Withania somnifera in rat model of streptozotocin-induced cognitive impairment by Ahmed ME¹, Javed H, Khan MM, Vaibhav K, Ahmad A, Khan A, Tabassum R, Islam F, Safhi MM, Islam F.(PubMed)
(1127) An alternative treatment for anxiety: a systematic review of human trial results reported for the Ayurvedic herb ashwagandha (Withania somnifera) by Pratte MA¹, Nanavati KB, Young V, Morley CP.(PubMed)
(1128) Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence by Sarris J¹, McIntyre E, Camfield DA.(PubMed)
(1129) Effect of Withania somnifera on Sleep-Wake Cycle in Sleep-Disturbed Rats: Possible GABAergic Mechanism by Kumar A¹, Kalonia H.(PubMed)
(1130) Protective effect of Withania somnifera Dunal on the behavioral and biochemical alterations in sleep-disturbed mice (Grid over water suspended method) by Kumar A¹, Kalonia H.(PubMed)
(1131) Protective effect of Withania somnifera dunal root extract against protracted social isolation induced behavior in rats by Gupta GL¹, Rana AC.(PubMed)
(1132) An overview on ashwagandha: a Rasayana (rejuvenator) of Ayurveda by Singh N¹, Bhalla M, de Jager P, Gilca M.(PubMed)
(1133) Effect of Withania somnifera (Ashwagandha) on the development of chemotherapy-induced fatigue and quality of life in breast cancer patients by Biswal BM¹, Sulaiman SA, Ismail HC, Zakaria H, Musa KI.(PubMed)
(1134) Withania somnifera shows a protective effect in monocrotaline-induced pulmonary hypertension by Kaur G¹, Singh N, Samuel SS, Bora HK, Sharma S, Pachauri SD, Dwivedi AK, Siddiqui HH, Hanif K.(PubMed)
(1135) Withania somnifera Improves Ischemic Stroke Outcomes by Attenuating PARP1-AIF-Mediated Caspase-Independent Apoptosis by Raghavan A¹, Shah ZA.(PubMed)
(1136) The aqueous extract of Withania coagulans fruit partially reverses nicotinamide/streptozotocin-induced diabetes mellitus in rats by Shukla K¹, Dikshit P, Shukla R, Gambhir JK.(PubMed)