The Holistic prevention, management and treatment of Polycystic Ovarian Syndrome: The Immunity Boosting Minerals

Weight Loss the Easy Ways
Andrea Albright Featured on Health and Fitness Jan. 2015
will Personally Coach You How to Get There The Easy Way

If You Are Looking For a SoulMate
Celebrity Patti Stanger Will Coach You To Get Him/Her
and Keep Him/Her for Good,The Simple Way

By Kyle J. Norton Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


                                         Polycystic Ovarian Syndrome

Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovasular disease(8)(13), acne(10)(14), endometrial cance(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to  continuously increase risk of type II diabetes, with no increasing altered glucose tolerance(20), CVD and hypertension(21).



                        The prevention and management 

Polycystic ovary syndrome (PCOS) is unpreventable in Western medicine. Early diagnosis and treatment  may reduce risk of its complications, including infertility, metabolic syndrome, obesity, diabetes, cardiovascular diseases, stroke, etc.

Although PCOS cannot be completely avoided, strengthening immunity has shown a significant reduction of chronic inflammatory diseases(266)(267)(268).


                                   The Immunity Boosting Minerals

Recent studies showed that deficiencies of zinc, iron, copper, and selenium lower resistance to disease either due to impaired immune response or faulty white blood cells' function(421)
1. Magnesium
The mineral, magnesium plays a key role in the immune response, by acting as a co-factor for immunoglobulin synthesis(422) that significantly increases for both IgA and IgG, the antibody molecules that protect our body against bacterial and viral infections(423) and the lining of the respiratory passages, gastrointestinal and genitourinary tract(423).
The mineral also found to increase neutrophil function and enzyme peroxidase activity and reduce the incidence of health disorders by boosting immunity(424), including chronic inflammatory disease(425)(426). Low serum magnesium (Mg) is often associated with  incidences of insulin resistance (IR), cardiovascular problems, diabetes mellitus, hypertension and other components of metabolic syndrome(428) in patients with polycystic ovary syndrome (PCOS)(427).

2. Selenium
Selenium, a trace mineral plays an important and indirect role as an antioxidant(429)(430) by fulfilling its function as a necessary constituent of glutathione peroxidase(431)(432) and in production of glutathione(432), that inhibits the damage caused by oxidation of free radical hydrogen peroxide(433).
Extensively epidemiological studies suggested that selenium also benefits to health aspects, including anti cancers(434)(435), lowering cholesterol(436)(438), hypertension(439)(440), treating heart disease(427)(438), boosting immunity(441)(442) against microbial invasion(443)(444) and anti chronic inflammatory disease(445)(446).

3. Zinc
Zinc besides is an important mineral in boosting immune system activity(447)(449). Its nano-structure zinc(II) coordination compounds, has been used in zinc therapy to treat candida overgrowth(449) by promoting metallothionein (MT)(found in high concentration in intestinal mucosa)synthesis(450) through its anti inflammatory activity(451), including chronic inflammation(453)(454) via immune modulatory effects(452)(453)(454).

4. Manganese

Manganese is an essential trace nutrient in all forms of life. It is well known for its role in helping the body to maintain healthy skin(455)(456) and bone structure(457)(458), but also acts as cofactors for a number of enzymes(459) in higher organisms, where they are essential in iexhibting its antioxidant effects against free radicals(450)(451). Recent studies suggested that manganese also benefits in controlling bood glucose(452)(453), alleviating neuro symptoms such as anxiety, and depression(454) and treatment of high cholesterol levels(456), hypertension(455), infertility(457), cardiomyopathy(458), reduced oxidative stress, amyloid deposition, and memory(459) and boosting immune system anti microbial infections and inflammation(460).
In larger amounts, manganese can be poisoning to neurological damage(451)(462).

5. Iron
A mineral plays a vital role for production of hemoglobin(463)(464)utilised by the body for oxygen transport and energy production(467), for maintaining healthy bones(465) and neurotransmission(466), synthesizing of some hormones and connective tissue(467)(468)(469) and maintaining heart health(470). Deficiency of iron causes low level of hemoglobin, nervous tension((473)(474)), cognitive dysfunction(471)(476), heart disorders(472)(475), heavy menstrual bleeding(479)(480), iron deficiency anemia, etc.,.. Recent studies suggested that trace mineral iron improves immunity(481)(482) fighting against  microbial infection(481) and inflammatory disease(483)(484), including certain types of chronic inflammatory diseases(486)(485) due to low levels of hemoglobin impaired cell-mediated immune response and bacterial activity of leukocytes(421).

3. Copper
Copper is vital in maintaining the production of antibodies(487)(488), white blood cells(489)(490), antioxidant enzymes(491)(492), for increasing the immune function in fighting against infection(487)(488) and inflammation(493)(494), including certain chronic inflammatory diseases(495)(496). The mineral also acts as a modulator of neuronal transmission(497), regulates production of certain hormones(498). Deficiency of copper may cause metabolic liver disease(502), copper deficiency anemia(503),....Deficiency and excess of copper levels can induce infertile(499), low libido and sexual issues(500), low quality sperm production(499)(500), disrupted nervous function(501), etc.,...





Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months   
 
References
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O¹.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF¹, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndrome and healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R¹, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N¹, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB¹, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA¹, Arduc A², Tuna MM¹, Karakılıc E¹, Dagdelen I¹, Tutuncu Y¹, Berker D¹, Guler S¹.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO¹.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO¹, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J¹, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK¹, Katalenich B², Nagireddy P³, Chabbra P⁴, Kuhadiya N⁵, Fonseca V¹.(PubMed)
(14) Acne in hirsute women by Lumezi BG¹, Pupovci HL¹, Berisha VL¹, Goçi AU², Gerqari A³.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N¹, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H¹, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women With Polycystic Ovary Syndrome. by Whigham LD¹, Butz DE², Dashti H³, Tonelli M³, Johnson LK¹, Cook ME², Porter WP⁴, Eghbalnia HR⁵, Markley JL⁶, Lindheim SR⁷, Schoeller DA⁸, Abbott DH⁹, Assadi-Porter FM¹⁰.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA¹, Azizia MM¹, Hardiman PJ².(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M¹, Kjaer SK², Jensen A¹, Munk C¹, Mellemkjaer L³.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E¹.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E¹, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(266) [Immunopathological responses in women with chronic inflammatory diseases of the uterus and appendages and their therapeutic correction].[Article in Russian] by Medvedev BI¹, Kazachkova EA, Kazachkov EL.(PubMed)
(267) Cross Talk Between ER Stress, Oxidative Stress, and Inflammation in Health and Disease by Dandekar A¹, Mendez R, Zhang K.(PubMed)
(268) New dog and new tricks: evolving roles for IL-33 in type 2 immunity by Lott JM¹, Sumpter TL¹, Turnquist HR².(PubMed)
(421) Trace Minerals and ImmunologyRichard C. Bull, Professor of Animal Sciences, University of Idaho

(422) Study of possible correlation between BLOOD IMMUNOGLOBULIN G INCREASED and MAGNESIUM CITRATE(Meds fact)

(423 )In vitro antiviral and antibacterial activity of commercial intravenous immunoglobulin preparations--a potential role for adjuvant intravenous immunoglobulin therapy in infectious diseases by  Krause I¹, Wu R, Sherer Y, Patanik M, Peter JB, Shoenfeld Y.(PubMed)
(424) Effect of an injectable trace mineral supplement containing selenium, copper, zinc, and manganese on immunity, health, and growth of dairy calves by Teixeira AG¹, Lima FS¹, Bicalho ML¹, Kussler A¹, Lima SF¹, Felippe MJ¹, Bicalho RC².(PubMed)
(425) Effects of magnesium depletion on inflammation in chronic disease by Nielsen FH¹.(PubMed)
(426) Magnesium, inflammation, and obesity in chronic disease by Nielsen FH¹.(PubMed)
(427) Serum magnesium concentrations in polycystic ovary syndrome and its association with insulin resistance by Sharifi F¹, Mazloomi S, Hajihosseini R, Mazloomzadeh S.(PubMed)
(428) Serum magnesium concentrations and metabolic variables in polycystic ovary syndrome by Kauffman RP¹, Tullar PE, Nipp RD, Castracane VD.(PubMed)
(429) Low zinc and selenium concentrations in sepsis are associated with oxidative damage and inflammation by Mertens K¹, Lowes DA¹, Webster NR¹, Talib J², Hall L², Davies MJ³, Beattie JH⁴, Galley HF⁵.(PubMed)
(430) Serum selenium concentration and antioxidant activity in cervical cancer patients before and after treatment by Subramanyam D¹, Subbaiah KV, Rajendra W, Lokanatha V.(PubMed)
(431) Selenium regulation of glutathione peroxidase in human hepatoma cell line Hep3B by Baker RD¹, Baker SS, LaRosa K, Whitney C, Newburger PE.(PubMed)
(432) Selenium: biochemical role as a component of glutathione peroxidase by Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG, Hoekstra WG.(PubMed)
(433) Selenium suppressed hydrogen peroxide-induced vascular smooth muscle cells calcification through inhibiting oxidative stress and ERK activation by Liu H¹, Lu Q, Huang K.(PubMed)
(434) Associations of obesity with prostate cancer risk differ between u.s. African-american and non-Hispanic white men: results from the selenium and vitamin e cancer prevention trial by Barrington WE, Schenk JM, Etzioni R, Arnold KB, Neuhouser ML, Thompson IM, Lucia MS, Kristal AR.(PubMed)
(435) Selenium for preventing cancer by Vinceti M¹, Dennert G, Crespi CM, Zwahlen M, Brinkman M, Zeegers MP, Horneber M, D'Amico R, Del Giovane C.(PubMed)
(436) The association between selenium and lipid levels: a longitudinal study in rural elderly Chinese by Chen C¹, Jin Y¹, Unverzagt FW², Cheng Y¹, Hake AM³, Liang C¹, Ma F¹, Su L¹, Liu J¹, Bian J⁴, Li P⁵, Gao S⁶.(PubMed)
(437) Associations of selenium status with cardiometabolic risk factors: an 8-year follow-up analysis of the Olivetti Heart study by Stranges S¹, Galletti F, Farinaro E, D'Elia L, Russo O, Iacone R, Capasso C, Carginale V, De Luca V, Della Valle E, Cappuccio FP, Strazzullo P.(PubMed)
(438) Selenium status and blood lipids: the cardiovascular risk in Young Finns study by Stranges S¹, Tabák AG, Guallar E, Rayman MP, Akbaraly TN, Laclaustra M, Alfthan G, Mussalo-Rauhamaa H, Viikari JS, Raitakari OT, Kivimäki M.(PubMed)
(439) Influence of serum selenium concentrations on hypertension: the Lipid Analytic Cologne cross-sectional study by Berthold HK¹, Michalke B, Krone W, Guallar E, Gouni-Berthold I(PubMed)
(440) Serum selenium concentrations and hypertension in the US Population by Laclaustra M¹, Navas-Acien A, Stranges S, Ordovas JM, Guallar E.(PubMed)
(441) The role of selenium in inflammation and immunity: from molecular mechanisms to therapeutic opportunities by Huang Z¹, Rose AH, Hoffmann PR.(PubMed)
(442) The influence of selenium on immune responses by Hoffmann PR¹, Berry MJ.(PuMed)
(443) Selenium containing heterocycles: synthesis, anti-inflammatory, analgesic and anti-microbial activities of some new 4-cyanopyridazine-3(2H)selenone derivatives by Abdel-Hafez ShH¹.(PubMed)
(444) Antimicrobial selenium nanoparticle coatings on polymeric medical devices by Tran PA¹, Webster TJ.(PubMed)
(445) Selenium and selenoproteins in inflammatory bowel diseases and experimental colitis by Speckmann B¹, Steinbrenner H.(PubMed)
(446) Selenium, selenoproteins and human health: a review by Brown KM¹, Arthur JR.(PubMed)
(447) Zinc and the immune system by Rink L1, Gabriel P.(PubMed)
(448) The immune system and the impact of zinc during aging by Haase H1, Rink L.(PubMed)
(449) Some new nano-structure zinc(II) coordination compounds of an imidazolidine Schiff base: spectral, thermal, antimicrobial properties and DNA interaction. Montazerozohori M1, Musavi SA2, Naghiha A3, Zohour MM4.(PubMed)
(450) Candida article zinc and metallothionein(Cure zone)
(451) Metallothionein as an Anti-Inflammatory Mediator(Mediators of inflammation) 
(452) Zinc and its role in immunity and inflammation by Bonaventura P¹, Benedetti G¹, Albarède F², Miossec P³.(PubMed)
(453) Zinc: role in immunity, oxidative stress and chronic inflammation by Prasad AS1(PubMed)
(454) Zinc transporter SLC39A10/ZIP10 controls humoral immunity by modulating B-cell receptor signal strength by Hojyo S¹, Miyai T², Fujishiro H³, Kawamura M⁴, Yasuda T⁵, Hijikata A⁶, Bin BH⁷, Irié T⁸, Tanaka J⁸, Atsumi T⁹, Murakami M⁹, Nakayama M¹⁰, Ohara O¹¹, Himeno S³, Yoshida H⁵, Koseki H¹², Ikawa T¹³, Mishima K⁸, Fukada T14(PubMed)
(455) Frequency of autoallergy to manganese superoxide dismutase in atopic dermatitis patients: experience of three Italian dermatology centers by Guarneri F¹, Costa C, Foti C, Hansel K, Guarneri C, Guarneri B, Lisi P, Stingeni L.(PubMed)
(456) IgE-mediated and T cell-mediated autoimmunity against manganese superoxide dismutase in atopic dermatitis by Schmid-Grendelmeier P¹, Flückiger S, Disch R, Trautmann A, Wüthrich B, Blaser K, Scheynius A, Crameri R.(PubMed)
(457) Manganese accumulation in bone following chronic exposure in rats: steady-state concentration and half-life in bone by O'Neal SL¹, Hong L¹, Fu S¹, Jiang W¹, Jones A¹, Nie LH¹, Zheng W².(PubMed)
(458) A compact DD neutron generator-based NAA system to quantify manganese (Mn) in bone in vivo by Liu Y¹, Byrne P, Wang H, Koltick D, Zheng W, Nie LH.(PubMed)
(459) Role of metal cofactors in enzyme regulation. Differences in the regulatory properties of the Escherichia coli nicotinamide adenine dinucleotide phosphate specific malic enzyme, depending on whether magnesium ion or manganese ion serves as divalent cation by Brown DA, Cook RA.(PubMed)
(450) Antioxidants and NOS inhibitors selectively targets manganese-induced cell volume via Na-K-Cl cotransporter-1 in astrocytes by Alahmari KA¹, Harini P², Prabhakaran K³, Chandramoorthy HC⁴, Ramakrishnan R⁵.(PubMed)
(451) Antioxidant effect of manganese by Coassin M¹, Ursini F, Bindoli A.(PubMed)
(452) Manganese supplementation protects against diet-induced diabetes in wild type mice by enhancing insulin secretion by Lee SH¹, Jouihan HA, Cooksey RC, Jones D, Kim HJ, Winge DR, McClain DA.(PubMed)
(453) Manganese-Mediated MRI Signals Correlate With Functional β-Cell Mass During Diabetes Progression by Meyer A¹, Stolz K¹, Dreher W², Bergemann J¹, Holebasavanahalli Thimmashetty V², Lueschen N¹, Azizi Z¹, Khobragade V¹, Maedler K³, Kuestermann E².(PubMed)
(454) Essential elements in depression and anxiety. Part II by Młyniec K¹, Gaweł M², Doboszewska U³, Starowicz G⁴, Pytka K⁵, Davies CL⁶, Budziszewska B⁷.(PubMed)
(455) Effect of antioxidant mineral elements supplementation in the treatment of hypertension in albino rats by Muhammad SA¹, Bilbis LS, Saidu Y, Adamu Y.(PubMed)
(456) Manganese supplementation reduces the blood cholesterol levels in Ca-deficient ovariectomized rats by Bae YJ¹, Choi MK, Kim MH.(PubMed)
(457) BOVINE INFERTILITY--RESPONSE TO MANGANESE THERAPY by WILSON JG.(PubMed)
(458)Pharmaceutical effect of manganese porphyrins on manganese superoxide dismutase deficient mice by Hayakawa N¹, Asayama S, Noda Y, Shimizu T, Kawakami H.(PubMed)
(459) Reduction of oxidative stress, amyloid deposition, and memory deficit by manganese superoxide dismutase overexpression in a transgenic mouse model of Alzheimer's disease by Dumont M¹, Wille E, Stack C, Calingasan NY, Beal MF, Lin MT.(PubMed)
(460) Nutritional immunity beyond iron: a role for manganese and zinc by Kehl-Fie TE¹, Skaar EP.(PubMed)
(461) Genetic factors and manganese-induced neurotoxicity. by Chen P¹, Parmalee N¹, Aschner M¹.(PubMed)
(462) Manganese neurotoxicity: a focus on glutamate transporters by Karki P, Lee E, Aschner M¹.(PubMed)
(463) HEMOGLOBIN PRODUCTION IN ANEMIA LIMITED BY LOW PROTEIN INTAKE : INFLUENCE OF IRON INTAKE, PROTEIN SUPPLEMENTS AND FASTING by Hahn PF¹, Whipple GH.(PubMed)
(464) Effect of iron deficiency anemia on the levels of hemoglobin A1c in nondiabetic patients by Coban E¹, Ozdogan M, Timuragaoglu A.(PubMed)
(465) Low serum levels of zinc, copper, and iron as risk factors for osteoporosis: a meta-analysis by Zheng J¹, Mao X, Ling J, He Q, Quan J.(PubMed)
(466) Brain iron deficiency and excess; cognitive impairment and neurodegeneration with involvement of striatum and hippocampus by Youdim MB¹.(PubMed)
(467) Athletic induced iron deficiency: new insights into the role of inflammation, cytokines and hormones by Peeling P¹, Dawson B, Goodman C, Landers G, Trinder D.(PubMed)
(468) Aggett PJ. Iron. In: Erdman JW, Macdonald IA, Zeisel SH, eds. Present Knowledge in Nutrition. 10th ed. Washington, DC: Wiley-Blackwell; 2012:506-20.
(469) Murray-Kolbe LE, Beard J. Iron. In: Coates PM, Betz JM, Blackman MR, et al., eds. Encyclopedia of Dietary Supplements. 2nd ed. London and New York: Informa Healthcare; 2010:432-8.
(470) Cardiac ferroportin regulates cellular iron homeostasis and is important for cardiac function by Lakhal-Littleton S¹, Wolna M², Carr CA², Miller JJ², Christian HC², Ball V², Santos A³, Diaz R³, Biggs D³, Stillion R⁴, Holdship P⁵, Larner F⁵, Tyler DJ², Clarke K², Davies B³, Robbins PA².(PubMed)
(471) Effect of dietary iron loading on recognition memory in growing rats by Han M¹, Kim J¹.(PubMed)
(472) [Anaemia and iron deficiency in clinical practice:from cardiology to gastroenterology and beyond].

[Article in Czech] by Češka R.(PubMed)

(473) Iron and mechanisms of emotional behavior by Kim J¹, Wessling-Resnick M².(PubMed)
(474) Essential elements in depression and anxiety. Part I by Młyniec K¹, Davies CL², de Agüero Sánchez IG³, Pytka K⁴, Budziszewska B⁵, Nowak G⁶.(PubMed)
(475) Iron deficiency: an emerging therapeutic target in heart failure by Cohen-Solal A¹, Leclercq C², Deray G³, Lasocki S⁴, Zambrowski JJ⁵, Mebazaa A⁶, de Groote P⁷, Damy T⁸, Galinier M⁹.(PubMed)
(476) Effect of iron-deficiency anemia on cognitive skills and neuromaturation in infancy and childhood by Walter T¹.(PubMed)
 (479) Effects of anemia and iron deficiency on quality of life in women with heavy menstrual bleeding by Peuranpää P¹, Heliövaara-Peippo S, Fraser I, Paavonen J, Hurskainen R.(PubMed)
(480) Iron deficiency and fatigue in adolescent females with heavy menstrual bleeding by Wang W¹, Bourgeois T, Klima J, Berlan ED, Fischer AN, O'Brien SH.(PubMed)
(481) Iron at the interface of immunity and infection by Nairz M¹, Haschka D¹, Demetz E¹, Weiss G¹.(PubMed)
(482) Impact of iron deficiency anemia on cell-mediated and humoral immunity in children: A case control study by Das I¹, Saha K¹, Mukhopadhyay D², Roy S¹, Raychaudhuri G³, Chatterjee M², Mitra PK¹.(PubMed)
(483) Iron Supplementation Attenuates the Inflammatory Status of Anemic Piglets by Regulating Hepcidin by Pu Y¹, Guo B, Liu D, Xiong H, Wang Y, Du H.(PubMed)
(484) A novel inflammatory pathway mediating rapid hepcidin-independent hypoferremia by Guida C¹, Altamura S², Klein FA³, Galy B³, Boutros M⁴, Ulmer AJ⁵, Hentze MW⁶, Muckenthaler MU².(PubMed)
(485) Prediction of iron deficiency in chronic inflammatory rheumatic disease anaemia by Baumann Kurer S¹, Seifert B, Michel B, Ruegg R, Fehr J.(PubMed)
(486) Changes in Echocardiographic Parameters in Iron Deficiency Patients with Heart Failure and Chronic Kidney Disease Treated with Intravenous Iron by Toblli JE¹, Di Gennaro F², Rivas C².(PubMed)
(487) Antimicrobial copper's potential.[No authors listed](PubMed)
(488) Effects of in-feed copper and tylosin supplementations on copper and antimicrobial resistance in fecal enterococci of feedlot cattle by Amachawadi RG¹, Scott HM, Aperce C, Vinasco J, Drouillard JS, Nagaraja TG.(PubMed)
(489) Copper and immunity by Percival SS¹.(PubMed)
(490) The immune system as a physiological indicator of marginal copper status? by Bonham M¹, O'Connor JM, Hannigan BM, Strain JJ.(PubMed)
(491) Molecular basis for antioxidant enzymes in mediating copper detoxification in the nematode Caenorhabditis elegans by Song S¹, Zhang X¹, Wu H¹, Han Y², Zhang J¹, Ma E¹, Guo Y².(PubMed)
(492) The effects of coadministration of dietary copper and zinc supplements on atherosclerosis, antioxidant enzymes and indices of lipid peroxidation in the cholesterol-fed rabbit by Alissa EM¹, Bahijri SM, Lamb DJ, Ferns GA.(PubMed)
(493) Is copper pro- or anti-inflammatory? A reconciling view and a novel approach for the use of copper in the control of inflammation by Berthon G1(PubMed)
(494) Effect of a topical copper indomethacin gel on inflammatory parameters in a rat model of osteoarthritis by Yassin NZ¹, El-Shenawy SM¹, Abdel-Rahman RF¹, Yakoot M², Hassan M³, Helmy S⁴.(PubMed)
(495) Enhanced analgesic properties and reduced ulcerogenic effect of a mononuclear copper(II) complex with fenoprofen in comparison to the parent drug: promising insights in the treatment of chronic inflammatory diseases by Agotegaray M¹, Gumilar F², Boeris M³, Toso R³, Minetti A².(PubMed)
(496) Nutraceuticals of anti-inflammatory activity as complementary therapy for rheumatoid arthritis by Al-Okbi SY¹.(PubMed)
(497) Copper homeostasis in the CNS: a novel link between the NMDA receptor and copper homeostasis in the hippocampus by Schlief ML¹, Gitlin JD.(PubMed)
(498) Effect of sex hormones on copper, zinc, iron nutritional status and hepatic lipid peroxidation in rats by Wachnik A¹, Biró G, Biró L, Korom M, Gergely A, Antal M.(PubMed)
(499) Copper-zinc superoxide dismutase deficiency impairs sperm motility and in vivo fertility by Garratt M¹, Bathgate R, de Graaf SP, Brooks RC.(PubMed)
(500)  Iron and copper in male reproduction: a double-edged sword by Tvrda E1, Peer R, Sikka SC, Agarwal A.(PubMed)
(501) Interactions of peptide amidation and copper: novel biomarkers and mechanisms of neural dysfunction by Bousquet-Moore D1, Prohaska JR, Nillni EA, Czyzyk T, Wetsel WC, Mains RE, Eipper BA.(PubMed)
(502) Deficient copper concentrations in dried-defatted hepatic tissue from ob/ob mice: A potential model for study of defective copper regulation in metabolic liver disease by Church SJ1, Begley P1, Kureishy N1, McHarg S1, Bishop PN1, Bechtold DA2, Unwin RD3, Cooper GJ4.(PubMed)
(503) Update on anemia and neutropenia in copper deficiency by Lazarchick J1.(PubMed)