The Holistic prevention, management and treatment of Polycystic Ovarian Syndrome: The Top 5 Anti inflammatory Foods

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                                         Polycystic Ovarian Syndrome

Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovasular disease(8)(13), acne(10)(14), endometrial cance(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to  continuously increase risk of type II diabetes, with no increasing altered glucose tolerance(20), CVD and hypertension(21).



                               The prevention and management 

Polycystic ovary syndrome (PCOS) is unpreventable in Western medicine. Early diagnosis and treatment  may reduce risk of its complications, including infertility, metabolic syndrome, obesity, diabetes, cardiovascular diseases, stroke, etc.

Although PCOS cannot be completely avoided, strengthening immunity has shown a significant reduction of chronic inflammatory diseases(266)(267)(268).


                             The Top 5 Anti inflammatory Foods 

According to Medical University Innsbruck, the interactions between diet, immunity, and the microbiota, may be necessary for the develop food-based approaches to prevent or treat many diseases(285).
1. Garlic
Garlic (Allium sativum) is a species in the onion genus, belongings to family Amaryllidaceae, native to central Asia, used popularly in traditional and Chinese medicine to treat common cold and flu(306), digestive disorders(313), diabetes(322)(323)(324), therosclerosis,(325), cardiovascular diseases(326)(327), strengthen immunity(319) against irregular cell growth suach as tumors(314)(315)(316)(317)(318), bacterias(310)(311)(312), fungii(310)(311) and virus(320)(321), lower blood pressure(328)(329)(330) and cholesterol levels(310)(331), etc. Recent studies also showed that garlic exhibits its anti-inflammatory effects against chronic inflammatory disease(307)(308)(309) through phytochemical allicin(307) and other machenisms(308)(309).

2. Ginger
Ginger (Zingiber officinale) or ginger root is the genus Zingiber, belongings to the family Zingiberaceae, native to Tamil,  used in traditional and Chinese medicine to treat dyspepsia(332)(333), gastrointestinal disorder(334) such as nausea and vomiting(335), constipation(337), gastric ulcer(338),.... edema(339)(340), difficult urination(340), colic and diarrea(341), etc.... Strong evidences in Western studies also showed that ginger also induce some mechanisms for treatment of pschological symptoms, such as anxiety(342). depression(343),..., diabetes(344)(345), hypertension(346), irregular cell growth  such as tumors(347)(348)(349), and rheumatoid arthritis(352) and  osteoarthritis(336) through its anti inflammatory, antioxidant and immune-modulatory effects(346)(350)(351), speed up wounding healing(352)(353), etc.

3. Turmeric
Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia. The herb has been used in traditional medicine as anti-oxidant(354)(355), hypoglycemic(356)(357), colorant(358), antiseptic(359)(360), wound healing(361) agents, and to treat flatulence(362), bloating(363), and appetite loss(364), ulcers(365), eczema(366), inflammations(367), etc. Epidemiological studies also found that the efficacy of turmeric for treatment for diabetes(369)(370), microbial infection(359)(371)(372), gastrointestinal diseases(359)(373) and irregular cell growth such as cancer(374)(375)(376) through its anti inflammatory(367)(368), antioxidant(377)(378) and immunmodulatory(379)(380) activities. 

4. Green tea
Green tea contains more amount of antioxidants than any drinks or food with the same volume, and is the leaves of Camellia sinensis, undergone minimal oxidation during processing, originated from China. Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Because of their health benefits, green tea has been cultivated for commercial purposes all over the world. Epidemiological studies suggested that green tea consists many pharmateutical properties, including anti cancers(381)(382), anti diabetes(383)(384), induced weight loss(385)(386)anti aging and longevity(387)(388), anti allergy(389)(390), anti micro-organisms(391)(392), anti lipidemic(393)(394). anti stroke(385)(396) and cardiovascular diseases, through its antioxidant(397)(398), anti inflammatory(399)(400) and immune modulatory(401)(402) activities.

5. Shiitake mushrooms
Shiitake mushroom is an edible mushroom, genus Lentinula, belonging to family Marasmiaceae, native to East Asia and widely cultivated for consumption for its health benefits and commercial purpose in many Asian countries. The herb has been used in traditional medicine as blood tonic agent and to strengthen immune system)403)(405), treat colds(407), measles(407), bronchial inflammations(407), etc. Recent studies showed that Shiitake mushrooms are also consisted properties of anti cancers(403)(404), anti microorganisms(407)(408) such as  HIV)410)(411)and hepatitis virus(407)(412), enhanced immune system(403)(405)(406) against inflammation(413)(414) causes of chronic inflammatory diseases(415) and the development of free radicals(414)(416), lowering cholesterol levels(407)(417)(418), treating heart disease(407)(419), diabetes(407)(420), etc....



Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months   
 
References
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(268) New dog and new tricks: evolving roles for IL-33 in type 2 immunity by Lott JM¹, Sumpter TL¹, Turnquist HR².(PubMed)
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(336) Influence of a specific ginger combination on gastropathy conditions in patients with osteoarthritis of the knee or hip by Drozdov VN¹, Kim VA, Tkachenko EV, Varvanina GG.(PubMed)
(337) Antiproliferative properties of Padma Lax and its components ginger and elecampane by Hofbauer S¹, Kainz V, Golser L, Klappacher M, Kiesslich T, Heidegger W, Krammer B, Hermann A, Weiger TM.(PubMed)
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(340) Effects of various fragrant ingredients on desmopressin-induced fluid retention in mice by Morimoto Y¹, Shibata Y.(PubMed)
(341) Pharmacological basis for the medicinal use of ginger in gastrointestinal disorders by Ghayur MN¹, Gilani AH.(PubMed)
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(343) Antidepressant-like synergism of extracts from magnolia bark and ginger rhizome alone and in combination in mice by Yi LT¹, Xu Q, Li YC, Yang L, Kong LD.(PubMed)
(344) Comparative effects of dietary ginger (Zingiber officinale) and garlic (Allium sativum) investigated in a type 2 diabetes model of rats by Islam MS¹, Choi H.(PubMed)
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(348) Effects of ginger (Zingiber officinale Roscoe) on DNA damage and development of urothelial tumors in a mouse bladder carcinogenesis model by Bidinotto LT¹, Spinardi-Barbisan AL, Rocha NS, Salvadori DM, Barbisan LF.(PubMed)
(349) Gelam honey and ginger potentiate the anti cancer effect of 5-FU against HCT 116 colorectal cancer cells by Hakim L¹, Alias E, Makpol S, Ngah WZ, Morad NA, Yusof YA.(PubMed)
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(351) 6-Shogaol inhibits chondrocytes' innate immune responses and cathepsin-K activity by Villalvilla A¹, da Silva JA, Largo R, Gualillo O, Vieira PC, Herrero-Beaumont G, Gómez R.(PubMed)
(352) Zingiber officinale: A Potential Plant against Rheumatoid Arthritis by Al-Nahain A¹, Jahan R², Rahmatullah M¹.(PubMed)
(353) Theoretical and experimental study on lipophilicity and wound healing activity of ginger compounds by Bakht MA¹, Alajmi MF², Alam P², Alam A³, Alam P³, Aljarba TM³.(PubMed)
(354) A Newly Designed Curcumin Analog Y20 Mitigates Cardiac Injury via Anti-Inflammatory and Anti-Oxidant Actions in Obese Rats by Qian Y¹, Zhong P², Liang D¹, Xu Z¹, Skibba M¹, Zeng C³, Li X¹, Wei T³, Wu L⁴, Liang G¹.(PubMed)
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(357) Curcumin enhances recovery of pancreatic islets from cellular stress induced inflammation and apoptosis in diabetic rats by Rashid K¹, Sil PC².(PubMed)
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(365) The evaluation of anti-ulcerogenic effect of rhizome starch of two source plants of Tugaksheeree (Curcuma angustifolia Roxb. and Maranta arundinacea Linn.) on pyloric ligated rats by Rajashekhara N¹, Ashok BK², Sharma PP³, Ravishankar B⁴.(PubMed)
(366) Clinical evaluation of an Indian polyherbal topical formulation in the management of eczema by Rawal RC¹, Shah BJ, Jayaraaman AM, Jaiswal V.(PubMed)
(367) Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: A randomized controlled trial and an updated meta-analysis by Panahi Y¹, Hosseini MS², Khalili N², Naimi E², Majeed M³, Sahebkar A⁴.(PubMed)
(368) Anti-Inflammatory Effects of Novel Standardized Solid Lipid Curcumin Formulations by Nahar PP¹, Slitt AL, Seeram NP.(PubMed)
(369) Involvement of liver in diabetes mellitus: herbal remedies by Thent ZC¹, Das S¹.(PubMed)
(370) Beneficial effects of Chinese prescription Kangen-karyu on diabetes associated with hyperlipidemia, advanced glycation endproducts, and oxidative stress in streptozotocin-induced diabetic rats by Kim HY¹, Okamoto T, Yokozawa T.(PubMed)
(371) Bactericidal activity of curcumin I is associated with damaging of bacterial membrane by Tyagi P¹, Singh M¹, Kumari H¹, Kumari A¹, Mukhopadhyay K¹.(PubMed)
(372) Antimicrobial activity of turmeric extract and its potential use in food industry by Gul P¹, Bakht J².(PubMed)
(373) Efficacy of turmeric in the treatment of digestive disorders: a systematic review and meta-analysis protocol by Thavorn K¹, Mamdani MM, Straus SE.(PubMed)
(374) Curcumol Induces Apoptosis in SPC-A-1 Human Lung Adenocarcinoma Cells and Displays Anti-neoplastic Effects in Tumor Bearing Mice by Tang QL¹, Guo JQ, Wang QY, Lin HS, Yang ZP, Peng T, Pan XD, Liu B, Wang SJ, Zang LQ.(PubMed)
(375) Curcumol induces apoptosis via caspases-independent mitochondrial pathway in human lung adenocarcinoma ASTC-a-1 cells by Zhang W¹, Wang Z, Chen T.(PubMed)
(376) Anti-cancer properties of terpenoids isolated from Rhizoma Curcumae--a review by Lu JJ¹, Dang YY, Huang M, Xu WS, Chen XP, Wang YT.(PubMed)
(377) In vitro Antioxidant Potential in Sequential Extracts of Curcuma caesia Roxb. Rhizomes by Reenu J¹, Azeez S¹, Bhageerathy C¹.(PubMed)
(378) Polyphenolic composition and antioxidant activities of 6 new turmeric (Curcuma longa L) accessions by Chinedum E¹, Kate E, Sonia C, Ironkwe A, Andrew I.(PubMed)
(379) Curcuma as a functional food in the control of cancer and inflammation by Schaffer M¹, Schaffer PM, Zidan J, Bar Sela G.(PubMed)
(380) Curcumin induces apoptosis in breast cancer cell lines and delays the growth of mammary tumors in neu transgenic mice by Masuelli L¹, Benvenuto M, Fantini M, Marzocchella L, Sacchetti P, Di Stefano E, Tresoldi I, Izzi V, Bernardini R, Palumbo C, Mattei M, Lista F, Galvano F, Modesti A, Bei R.(PubMed)
(381) Induction of apoptosis and cell cycle arrest in cancer cells by in vivo metabolites of teas by Zhang G¹, Miura Y, Yagasaki K.(PubMed)
(382) Antimutagenic and anticarcinogenic activity of tea polyphenols by Kuroda Y¹, Hara Y.(PubMed)
(383) High oolong tea consumption predicts future risk of diabetes among Japanese male workers: a prospective cohort study by Hayashino Y¹, Fukuhara S, Okamura T, Tanaka T, Ueshima H; HIPOP-OHP Research Group.(PubMed)
(384) Antihyperglycemic effect of oolong tea in type 2 diabetes by Hosoda K¹, Wang MF, Liao ML, Chuang CK, Iha M, Clevidence B, Yamamoto S.(PubMed)
(385) Beneficial effects of oolong tea consumption on diet-induced overweight and obese subjects by He RR¹, Chen L, Lin BH, Matsui Y, Yao XS, Kurihara H.(PubMed)
(386) Thermogenic ingredients and body weight regulation by Hursel R¹, Westerterp-Plantenga MS.(PubMed)
(387) Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity by Calabrese V¹, Cornelius C, Cuzzocrea S, Iavicoli I, Rizzarelli E, Calabrese EJ.(PubMed)
(388) The potential influence of plant polyphenols on the aging process by Cherniack EP¹.(PubMed)
(389) Antiallergic constituents from oolong tea stem by Ohmori Y¹, Ito M, Kishi M, Mizutani H, Katada T, Konishi H.(PubMed)
(390) [Effect of tea extracts, catechin and caffeine against type-I allergic reaction].[Article in Japanese] by Shiozaki T¹, Sugiyama K, Nakazato K, Takeo T.(PubMed)
(391) Antibacterial activity of Iranian green and black tea on streptococcus mutans: an in vitro study by Naderi NJ¹, Niakan M, Kharazi Fard MJ, Zardi S.(PubMed)
(392) Overview of antibacterial, antitoxin, antiviral, and antifungal activities of tea flavonoids and teas by Friedman M¹.(PubMed)
(393) Mechanisms of hypolipidemic and anti-obesity effects of tea and tea polyphenols by Lin JK¹, Lin-Shiau SY.(PubMed)
(394) Polyphenol-enriched oolong tea increases fecal lipid excretion by Hsu TF¹, Kusumoto A, Abe K, Hosoda K, Kiso Y, Wang MF, Yamamoto S.(PubMed)
(395) Green and black tea consumption and risk of stroke: a meta-analysis by Arab L¹, Liu W, Elashoff D.(PubMed)
(396) Does tea affect cardiovascular disease? A meta-analysis by Peters U¹, Poole C, Arab L.(PubMed)
(397) Determination of tea components with antioxidant activity by Cabrera C¹, Giménez R, López MC.(PubMed)
(398) Structural determination and DPPH radical-scavenging activity of two acylated flavonoid tetraglycosides in oolong tea (Camellia sinensis) by Lee VS¹, Chen CR, Liao YW, Tzen JT, Chang CI.(PubMed)
(399) Evaluation of anti-inflammatory effects of green tea and black tea: A comparative in vitro study by Chatterjee P¹, Chandra S, Dey P, Bhattacharya S.(PubMed)
(400) Anti-inflammatory and anti-oxidative effects of the green tea polyphenol epigallocatechin gallate in human corneal epithelial cells by Cavet ME¹, Harrington KL, Vollmer TR, Ward KW, Zhang JZ.(PubMed)
(401)  Immunomodulatory effects of EGCG fraction of green tea extract in innate and adaptive immunity via T regulatory cells in murine model by Kuo CL¹, Chen TS, Liou SY, Hsieh CC.(PubMed)
(402) Immunomodulating effects of epigallocatechin-3-gallate from green tea: mechanisms and applications by Pae M¹, Wu D.(PubMed)
(403) Structure and inducing tumor cell apoptosis activity of polysaccharides isolated from Lentinus edodes by Wang KP¹, Zhang QL, Liu Y, Wang J, Cheng Y, Zhang Y.(PubMed)
(404) Polysaccharides from Tricholoma matsutake and Lentinus edodes enhance 5-fluorouracil-mediated H22 cell growth inhibition by Ren M, Ye L, Hao X, Ren Z, Ren S, Xu K, Li J.(PubMed)
(405) Structure and immuno-stimulating activities of a new heteropolysaccharide from Lentinula edodes by Xu X¹, Yan H, Zhang X.(PubMed)
(406) Dietary supplementation with rice bran fermented with Lentinus edodes increases interferon-γ activity without causing adverse effects: a randomized, double-blind, placebo-controlled, parallel-group study by Choi JY, Paik DJ, Kwon DY, Park Y¹.(PubMed)
(407) Lentinus edodes: a macrofungus with pharmacological activities by Bisen PS¹, Baghel RK, Sanodiya BS, Thakur GS, Prasad GB.(PubMed)
(408) An examination of antibacterial and antifungal properties of constituents of Shiitake (Lentinula edodes) and oyster (Pleurotus ostreatus) mushrooms by Hearst R¹, Nelson D, McCollum G, Millar BC, Maeda Y, Goldsmith CE, Rooney PJ, Loughrey A, Rao JR, Moore JE.(PubMed)
(409) Antimicrobial properties of shiitake mushrooms (Lentinula edodes) by Rao JR, Smyth TJ, Millar BC, Moore JE.(PubMed)
(410) A placebo-controlled trial of the immune modulator, lentinan, in HIV-positive patients: a phase I/II trial by Gordon M¹, Bihari B, Goosby E, Gorter R, Greco M, Guralnik M, Mimura T, Rudinicki V, Wong R, Kaneko Y.(PubMed)
(411) A phase II controlled study of a combination of the immune modulator, lentinan, with didanosine (ddI) in HIV patients with CD4 cells of 200-500/mm3 by Gordon M¹, Guralnik M, Kaneko Y, Mimura T, Goodgame J, DeMarzo C, Pierce D, Baker M, Lang W.(PubMed)
(412) [Liver protective effect of Lentinula edodes mycelia(LEM)].[Article in Japanese] by Yagi K¹.(PubMed)
 (413) Anti-inflammatory effects of five commercially available mushroom species determined in lipopolysaccharide and interferon-γ activated murine macrophages by Gunawardena D¹, Bennett L, Shanmugam K, King K, Williams R, Zabaras D, Head R, Ooi L, Gyengesi E, Münch G.(PubMed)
(414) Effect of shiitake (Lentinus edodes) extract on antioxidant and inflammatory response to prolonged eccentric exercise by Zembron-Lacny A¹, Gajewski M, Naczk M, Siatkowski I.(PubMed)
(415) Both common and specialty mushrooms inhibit adhesion molecule expression and in vitro binding of monocytes to human aortic endothelial cells in a pro-inflammatory environment by Martin KR¹.(PubMed)
(416) Fumigation with essential oils improves sensory quality and enhanced antioxidant ability of shiitake mushroom (Lentinus edodes) by Jiang T¹, Luo Z², Ying T³.(PubMed)
(417) Antihyperlipidemic Effect of Dietary Lentinus edodes on Plasma, Feces and Hepatic Tissues in Hypercholesterolemic Rats by Yoon KN¹, Alam N, Lee JS, Cho HJ, Kim HY, Shim MJ, Lee MW, Lee TS.(PubMed)
(418) Cholesterol-lowering effects of maitake (Grifola frondosa) fiber, shiitake (Lentinus edodes) fiber, and enokitake (Flammulina velutipes) fiber in rats by Fukushima M¹, Ohashi T, Fujiwara Y, Sonoyama K, Nakano M.(PubMed)
(419) Effects of Lentinus edodes mycelia on dietary-induced atherosclerotic involvement in rabbit aorta by Yamada T¹, Oinuma T, Niihashi M, Mitsumata M, Fujioka T, Hasegawa K, Nagaoka H, Itakura H.(PubMed)
(420) Protective effects of fractional extracts from Panellus serotinus on non-alcoholic fatty liver disease in obese, diabetic db/db mice by Inafuku M¹, Nagao K, Nomura S, Shirouchi B, Inoue N, Nagamori N, Nakayama H, Toda T, Yanagita T.(PubMed)