By Kyle J. Norton Health article writer and researcher; Over
10.000 articles and research papers have been written and published on
line, including world wide health, ezine articles, article base,
healthblogs, selfgrowth, best before it's news, the karate GB daily,
etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by
Disilgold.com Named 50 of the best health Tweeters Canada - Huffington
Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as
international journal Pharma and Bio science, ISSN 0975-6299.
Diseases of Central Nervous system
Dementia
About 5-8% of all people over the age of 65 have some form of dementia,
and this number doubles every five years above that age. Dementia is
the loss of mental ability, severe enough to interfere with people's
every life and Alzheimer's disease is the most common type of dementia
in aging people.
VI. Treatments
Depending to the causes of disease, most medication are to control the symptoms
A. Alzheimer's disease and Diminished quality of acetylcholine
A.1. Treatments of mild and moderate Alzheimer's disease and Diminished quality of acetylcholine
1. Cholinesterase inhibitors
a. Cholinesterase inhibitors
are the
primary treatment, including tacrine(409)(410)(Cognex),
donepezil(411)(412)(Aricept),
rivastigmine(407)(408)(Exelon), and galantamine (Reminyl) for reductions
in acetylcholine and acetyltransferase activity(406) induced cognitive
symptoms of Alzheimer disease
(AD).
According to Dr. Trinh NH and the research team at the Massachusetts General
Hospital, there was no difference in
efficacy among various cholinesterase inhibitors(413). Persistent drug treatment had a positive impact on AD progression
in advanced disease(414).
In the article, Cholinesterase Inhibitors, posted in the
Minister of health, the inhibitors, improved the effectiveness of
acetylcholine either by increasing the levels in the brain or strengthening the way nerve cells response in
communication between nerve cells, may temporarily promote or
stabilize the symptoms of Alzheimer's disease(415).
b. Side effects are not limit to(416)(417)
b.1. Nausea
b.2. Diarrhea
b.3. Vomiting
b.4. Indigestion.
b.5. Abdominal pain
b.6. Loss of appetite
b.7. Fatigue
b.8. Weight loss
b.9. Etc.
A.2. Treatment of moderate and Severe Alzheimer's disease and Diminished quality of acetylcholine
1.
Namenda®(418)(419)(memantine), an N-methyl D-aspartate (NMDA)
antagonist(420) are
the most common medication used to moderate and severe Alzheimer's
disease, through it's therapeutic action in uncompetitive
binding to the NMDAR for preservance of the
physiological function of the receptor(421). But, according to other in 2
out of 3 six month studies, memantine showed only a small
beneficial effect but not in patients with vascular dementia(422).
2. Side effects are not limit to(423)(424)
b.1. Confusion
b.2. Dizziness
b.3. Drowsiness
b.4. Headache
b.5. Insomnia,
b.6. Agitation
b.7. Vomiting
b.8. Anxiety
b.9. Etc.
3. Other medications
3.1. Anticonvulsants
a. Anticonvulsants are a diverse group of pharmaceuticals used in the treatment of seizures(425), chronic neuropathic pain(426), and the clinical syndrome of Alzheimer's disease(427) by suppressing
the rapid and excessive firing of neurons(428). Some
researchers suggested that seizure pathophysiology may relate to increased
amyloid beta-peptide
production(429), causing cytoskeletal
dysfunction, cerebrovascular changes, neurotransmitter dysfunction or
combinations(430). By modification of these pathophysiological
pathways, anti-epileptic drugs such as
sodium valproate and lacosamide may be useful in the treatment of Alzheimer's disease(431)
b. Side effects are not limit to(432)(433)
b.1. Dizziness
b.2. Drowsiness
b.3. Unsteadiness
b.4. Nausea
b.5. Vomiting
b.6. Skin rashes
b.7. Etc.
3.2. Sedatives
a.
A sedative or tranquilizer is a drug that calms patients(434),
reduced
irritability and excitement by modulating signals within the central
nervous system for neuroprotection(436). The medication are highly
addictive. Benzodiazepine, one of the sedative has shown to reduce Aβ
plaques through its activation on Aβ-related synaptic and behavioral
impairment in AD(437).
b. Side effects are not limit to(438)
b.1. Stomach upset
b.2. Blurred vision
b.3. Headache
b.4. Impaired coordination
b.5. Depression
b.6. Memory loss
b.7. Drowsiness
b.8. Risk of fractures and falls(435)
b.9 Etc.
3.3. Antidepressants
a. Antidepressant is a type of
psychiatric medication used to treat depression(443), including mood
disorder(439), dysthymia(440)(441) and anxiety disorders(442)(443). According to Purpan-Casselardit Hospital, 34.8% of patients with AD are prescribed antidepressant foe daily use in AD(444).
b. Side effects are not limit to(445)
b.1. Dry mouth,
b.2. Blurred vision
b.5. Drowsiness,
b.4. Dizziness
b.5. Tremors
b.6. Sexual problems
b.7. Etc.
The Memory Healer program
Discover the Secret of natural Sources Mimic of TC-5132 for
Stage 2 Alzheimer, Dementia and Memory Loss Reversal Through Scientific Evidences
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
For over 1000 healthy recipes, visit http://kylejnorton.blogspot.ca/p/recipes.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(406) http://www.ncbi.nlm.nih.gov/pubmed/23862185
(407) http://www.ncbi.nlm.nih.gov/pubmed/23728651
(408) http://www.ncbi.nlm.nih.gov/pubmed/19370562
(409) http://www.ncbi.nlm.nih.gov/pubmed/17636619
(410) http://www.ncbi.nlm.nih.gov/pubmed/10796507
(411) http://www.ncbi.nlm.nih.gov/pubmed/16856114
(412) http://www.ncbi.nlm.nih.gov/pubmed/16437430
(413) http://www.ncbi.nlm.nih.gov/pubmed/12517232
(414) http://www.ncbi.nlm.nih.gov/pubmed/19845950
(415) http://www.health.gov.bc.ca/pharmacare/adti/clinician/cholinesterase.html
(416) http://alzonline.phhp.ufl.edu/en/reading/mmi_cholinesterase.php
(417) http://en.wikipedia.org/wiki/Acetylcholinesterase_inhibitor
(418) http://www.ncbi.nlm.nih.gov/pubmed/25523430
(419) http://www.ncbi.nlm.nih.gov/pubmed/25523285
(420) http://www.ncbi.nlm.nih.gov/pubmed/10465680
(421) http://www.ncbi.nlm.nih.gov/pubmed/21875407
(422)
http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD003154.pub4/abstract;jsessionid=81B82BC5B10FAB9959A92CF39D439C21.d02t02
(423) http://www.medicinenet.com/memantine-oral/page2.htm
(424) http://en.wikipedia.org/wiki/Memantine
(425) http://www.ncbi.nlm.nih.gov/pubmed/23996793
(426) http://www.ncbi.nlm.nih.gov/pubmed/25479151
(427) http://www.ncbi.nlm.nih.gov/pubmed/20096151
(428) http://www.ncbi.nlm.nih.gov/pubmed/24565570
(429) http://www.ncbi.nlm.nih.gov/pubmed/23926248
(430) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3385944/
(431) http://www.ncbi.nlm.nih.gov/pubmed/19557550
(432) http://www.webmd.com/bipolar-disorder/anticonvulsant-medication
(433) http://en.wikipedia.org/wiki/Anticonvulsant
(434) http://www.ncbi.nlm.nih.gov/pubmed/24552479
(435) http://www.ncbi.nlm.nih.gov/pubmed/18690999
(436) http://www.ncbi.nlm.nih.gov/pubmed/18311185
(437) http://www.ncbi.nlm.nih.gov/pubmed/20980585
(438) http://en.wikipedia.org/wiki/Sedative
(439) http://www.ncbi.nlm.nih.gov/pubmed/19192442
(440) http://www.ncbi.nlm.nih.gov/pubmed/15738743
(441) http://www.ncbi.nlm.nih.gov/pubmed/25177490
(442) http://www.ncbi.nlm.nih.gov/pubmed/24497254
(443) http://www.ncbi.nlm.nih.gov/pubmed/23737423
(444) http://www.ncbi.nlm.nih.gov/pubmed/19735591
(445) http://www.webmd.com/depression/features/coping-with-side-effects-of-depression-treatment
No comments:
Post a Comment