By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and
research papers have been written and published on line, including
world wide health, ezine articles, article base, healthblogs,
selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by
Disilgold.com Named 50 of the best health Tweeters Canada - Huffington
Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as
international journal Pharma and Bio science, ISSN 0975-6299.
Diseases of Central Nervous system
Dementia
About 5-8% of all people over the age of 65 have some form of dementia, and this
number doubles every five years above that age. Dementia is the loss of mental
ability, severe enough to interfere with people's every life and
Alzheimer's disease is the most common type of dementia in aging people.
II. Causes of dementia
E. Hormonal Causes of Dementia
1. Growth hormone
According to Universidad de Barcelona, Barcelona, physiological decline of the growth hormone (GH)/insulin-like growth
factor-I (IGF-I) axis due to ageing, may involve in the progression of
cognitive deficits(116), probably due to ability of both hormones in
stimulation of beta amyloid release from neurons and IGF-I involved on
brain amyloid clearance(117).
2. Estrogen
According
to Scientist at the Kings College London, the decreased production of
estrogen due to aging in menopausal women may be association to the risk
of dementia(118). Estrogen-replacement therapy has shown to reduce prevalence of Alzheimer's disease
in postmenopausal women, but weighing risks and benefits of estrogen-replacement therapy must be taken into account(119)
3. Testosterone
Lower androgen levels in aging are associated with increased plasma Abeta 40
in older men with memory loss or dementia, according to the comparison of levels of serum total testosterone
and sex hormone binding globulin (SHBG) and
plasma levels of amyloid beta peptide 40(120).
4. DHEA
According to studies, a decreased concentration of dehydroepiandrosterone sulfate (DHEA-S) and lower DHEA-S/DHEA ratio are associated to risk of Alzheimer's disease (AD)(121)(122).
5. Sex-hormone binding globulin
Gonadotropins
may be involved in processes and contribution to the
etiology/pathogenesis of AD due to its involvement on inflammation, cholesterol
homeostasis, and insulin status(123).
6. Etc.
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References
(116) http://www.ncbi.nlm.nih.gov/pubmed/18537700
(117) http://www.ncbi.nlm.nih.gov/pubmed/15094079
(118) http://www.ncbi.nlm.nih.gov/pubmed/20840280
(119) http://www.ncbi.nlm.nih.gov/pubmed/9566385
(120) http://www.ncbi.nlm.nih.gov/pubmed/14624021
(121) http://www.ncbi.nlm.nih.gov/pubmed/8732462
(122) http://www.ncbi.nlm.nih.gov/pubmed/19665809
(123) http://www.ncbi.nlm.nih.gov/pubmed/16785601
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