(Preview) Most common diseases of 50 plus - Diseases of Central Nervous system - Free radical causes of dementia (Multiple Sclerosis, MS)

By Kyle J. Norton 
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

               Diseases of Central Nervous system

                                 Dementia

About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability, severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.
II. Causes of dementia
B. Free radical causes of dementia
B.3. Multiple Sclerosis
1. Free radicals and Multiple Sclerosis
 Free radical activity is a contributory factors in MS(60) due to proinflammatory cytokines in free radicals production in the peripheral immune system and the central nervous system (CNS)(60).

2. Antioxidants and Multiple sclerosis
Antioxidants protect the neural tissues from damage against inflammation caused by oxidative stress.
a. TNFalpha 
TNFalpha, an imflammatory cytokine showed to associate with MS inhibited by antioxidants(61)) of green tea(62), and curcumin(63).

b. Melatonin
Melatonin functions as an antioxidant has the ability to protect neurons(65)(66) from free radicals cause of lipid peroxidation(64).

c Selenium
Some studies found that the level of selenium in the blood of people with MS was lower than in that of people without MS(67)(68). In patients with MS, all abnormalities may be normalized by daily intake of selenium(69),

d. Niacin
Niacin acting as antioxidant is a key to the successful treatment of multiple sclerosis,
. It profoundly prevents the degeneration(70) of demyelinated axons and improves the behavioral deficits(71).

e. Vitamin D
Seurm of 25(OH)D level showed to regulate expression dynamics of a large gene-gene interaction system in immune modulatory processes of MS activity(72). According to the study published by the journal Neurology, group receiving vitamin D supplement demonstrated a remarkable 41 percent reduction in new MS events with no meaningful side effects(73).

f. Etc.

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References
(60) http://www.ncbi.nlm.nih.gov/pubmed/18505779
(61) http://www.ncbi.nlm.nih.gov/pubmed/18322311
(62) http://www.ncbi.nlm.nih.gov/pubmed/25123184
(63) http://www.ncbi.nlm.nih.gov/pubmed/20163327
(64) http://www.ncbi.nlm.nih.gov/pubmed/25427383
(65) http://www.ncbi.nlm.nih.gov/pubmed/23183236
(66) http://www.ncbi.nlm.nih.gov/pubmed/22010042
(67) http://www.ncbi.nlm.nih.gov/pubmed/1702664
(68) http://www.ncbi.nlm.nih.gov/pubmed/10609336
(69) http://www.ncbi.nlm.nih.gov/pubmed/2484516 
(70) http://www.ncbi.nlm.nih.gov/pubmed/25317166
(71) http://www.ncbi.nlm.nih.gov/pubmed/17414505
(72) http://www.ncbi.nlm.nih.gov/pubmed/25285313  
(73) A phase I/II dose-escalation trial of vitamin D3 and calcium in multiple sclerosis,  June 8, 2010 74:1852-1859; published ahead of print April 28, 2010 1526-632X