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During the last stage of the menstrual cycle, normally a layer of endometriosis lining on the inside of the uterus is expelled, known as menstruation blood, instead some of the endometriosis tissues grow somewhere in the body to cause endometriosis. Endometriosis also react to hormone signals of the monthly menstrual cycle, by building and breaking up tissues and eliminating them through menstrual period.
Zinc is a chemical with the symbol Zn and with the atomic number of 30. It is found in over 200 of the body's enzymes and included in most single tablet over-the-counter daily vitamins and mineral supplements. It is said to have an antioxidant property that helps to protect premature aging of skin and muscles.
The affects of zinc in women with endometriosis
1. Immune system(1)(3)
Since Zn helps in protein and fatty acid metabolism resulting in strengthening the function of the liver and white blood cells in the body which help to protect against the accumulation of toxins as well as improving the ability of the immune system in fighting against all kinds of invasion such as virus, bacteria(2), endometrial implants, and adhesion(3).
2. Nervous system(1)
As we mentioned above, Zn plays an important role in protein and fatty acid metabolism which provide essential elements for our brain to function better resulting in reducing symptoms of endometriosis such as headache(4), irritation, and anxiety.
3. Hormone balancing
Since Zn helps in fatty acid metabolism, it balances the hormones of the protagslandins family which control the muscles in the uterus(6). Deficiency of zinc causes over-production of certain protagslandins hormones resulting in menstrual cramps(5).
4. Circulatory system
Besides protecting other systems in the body, Zn helps to reduce the levels of cholesterol and triglycerides(7) in the blood stream resulting in fatty acid metabolism. Deficiency of Zn increases the risk of heart disease and stroke as well as blood stagnation causing endometrial pains(5).
5. Relationship with vitamin A and E(8)
Deficiency of Zn interferes with the functioning of vitamin A and E metabolism, such as:
a) Decreasing the synthesis of retinol binding protein.
b) Decreasing the activity of liver in releasing of retinyl palmitate.
c) Causing Acne
6. Relationship with magnesium and calcium
Healthy levels of zinc, magnesium, and calcium helps to strengthen the bone density and hormone balancing which are necessary for women with endometriosis.
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References
(1) Zinc and the immune system by Rink L1, Gabriel P.(PubMed)
(2) Zinc status in human immunodeficiency virus infection by Baum MK1, Shor-Posner G, Campa A.(PubMed)
(3) Women with endometriosis improved their peripheral antioxidant markers after the application of a high antioxidant diet by Mier-Cabrera J1, Aburto-Soto T, Burrola-Méndez S, Jiménez-Zamudio L, Tolentino MC, Casanueva E, Hernández-Guerrero C.(PubMed)
(4) Association of headaches and the metals by Donma O1, Donma MM.(PubMed)
(5) Zinc alleviates pain through high-affinity binding to the NMDA receptor NR2A subunit by Nozaki C1, Vergnano AM, Filliol D, Ouagazzal AM, Le Goff A, Carvalho S, Reiss D, Gaveriaux-Ruff C, Neyton J, Paoletti P, Kieffer BL.(PubMed)
(6) Comparison of the Effect of Ginger and Zinc Sulfate on Primary Dysmenorrhea: A Placebo-Controlled Randomized Trial by Kashefi F1, Khajehei M2, Cher MT3, Alavinia M4, Asili J5.(PubMed)
(7) Effect of zinc supplementation on triglyceride, cholesterol, LDL, and HDL levels in zinc-deficient hemodialysis patients by Roozbeh J1, Hedayati P, Sagheb MM, Sharifian M, Hamidian Jahromi A, Shaabani S, Jalaeian H, Raeisjalali GA, Behzadi S.(PubMed)
(8) Zinc (Micronutrient Information Center)
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