By Kyle J. Norton
Chickweed is a cool-season annual plant often eaten by chickens., genus S. media, belonging to the family Caryophyllaceae,
native to Europe. The herb has been used in herbal medicine to treat
skin conditions, indigestion, eczema, cough, rashes, etc. and as
astringent, carminative, demulcent, diuretic, expectorant, laxative,
refrigerant, vulnerary agent.
Chemical constituents(1)(2)
1. Igenin 6-C-beta-D-galactopyranosyl-8-C-alpha-L-arabinopyranoside
2. Apigenin 6-C-alpha-L-arabinopyranosyl-8-C-beta-D-galactopyranoside
3. Apigenin 6-C-beta-D-galactopyranosyl-8-C-beta-L-arabinopyranoside
4. Apigenin 6-C-beta-D-glucopyranosyl-8-C-beta-D-galactopyranoside
5. Apigenin 6, 8-di-C-alpha-L-arabinopyranoside
6. Alkaloidal glycoside
7. Glucodichotomine B
8. Neolignan glycosides
9. Dichotomosides A, B, C, and D
10. Phenylpropanoid glycoside
11. Dichotomoside E
12. Saponins
13. Mucilage
14. PABA
15. Coumarin,
16. Flavonoids (rutin)
17. Hydroxycoumarin
Chickweed (Stellaria media (Linn.)
Villars) has been used in traditional Chinese medicine over 200 years,
mainly for the treatment of dermatitis and other skin diseases. In the
study to evaluated the anti-hepatitis B virus (HBV), using the human
HBV-transfected liver cell line HepG2.2.15, researched at the Jiangsu
Provincial Academy of Chinese Medicine indicated that the herbal 30
μg/mL SM-3 effectively suppressed the secretion of HBsAg and HBeAg after
6 days of treatment, Consistent with the reduction in HBV antigens,
SM-3 also reduced the level of HBV DNA in a dose-dependent manner(3). In
support of the result, the 1Siberian
State Medical University, indicated a hepaprotective effect of the herb
water-soluble polysaccharide fraction at a dose of 100 mg/kg(4). In the
evaluation of anti-hepatoma activity on five human liver-cancer cell
lines, i.e. HepG2/C3A, SK-HEP-1, HA22T/VGH, Hep3B and PLC/PRF/5, with 15
most common herbs used in Canada folk medicine, chickweed may be
effective in portect the liver against the growth of all five cell
lines, depending to further study validation(5).
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References
(1) [Studies on chemical constituents from stellaria media. I].[Article in Chinese] by Dong Q1, Huang Y, Qiao SY.(PubMed)
(2) Bioactive constituents from Chinese natural medicines. XIV. New glycosides of beta-carboline-type alkaloid, neolignan, and phenylpropanoid from Stellaria dichotoma L. var. lanceolata and their antiallergic activities by Morikawa T1, Sun B, Matsuda H, Wu LJ, Harima S, Yoshikawa M.(PubMed
(3) Anti-hepatitis B virus activity of chickweed [Stellaria media (L.) Vill.] extracts in HepG2.2.15 cells by Ma L1, Song J, Shi Y, Wang C, Chen B, Xie D, Jia X.(PubMed)
(4) Evaluation of hepatoprotective activity of water-soluble polysaccharide fraction of Stellaria media L. by Gorina YV1, Saprykina EV, Gereng EA, Perevozchikova TV, Krasnov EA, Ivanova EV, Fait EA, Baranova OV.(PubMed)
(5) In vitro anti-hepatoma activity of fifteen natural medicines from Canada by Lin LT1, Liu LT, Chiang LC, Lin CC.(PubMed)
References
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