Dithiolthiones are phytochemicals in the class of Organosulfides, found abundantly in cruciferous vegetables, garden sorrel, horseradish, etc.
Sulforaphane, a naturally organosulfur
compound found in broccoli, showed to exert its neuroprotective effects
through significantly attenuated the scopolamine-induced memory
impairment and improved cholinergic system reactivity, as indicated by
an increased ACh level, decreased AChE activity, and increased choline
acetyltransferase (ChAT) expression in the hippocampus and frontal
cortex(1). in a variety of acute and chronic neurodegenerative diseases,
phytochemicals, isothiocyanate sulforaphane, derived from the hydrolysis of the glucosinolate glucoraphanin mainly present in Brassica vegetables, demonstrated its neuroprotective
effects in several in vitro and in vivo studies, may be mainly ascribed
to its peculiar ability to activate the Nrf2/ARE pathway(2). In
dopaminergic neurotoxicity in mice induced by 6-hydroxydopamine
(6-OHDA), the phytochemical showed the neuroprotective effect through
its ability to enhance glutathione levels and its dependent enzymes
(glutathione-S-transferase and glutathione reductase) and to modulate
neuronal survival pathways(3).
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References
(1) Sulforaphane alleviates scopolamine-induced memory impairment in mice by Lee S1, Kim J1, Seo SG2, Choi BR3, Han JS3, Lee KW4, Kim J5.(PubMed)
(2) Sulforaphane as a potential protective phytochemical against neurodegenerative diseases byTarozzi A1, Angeloni C, Malaguti M, Morroni F, Hrelia S, Hrelia P.(PubMed)
(3) Neuroprotective effect of sulforaphane in 6-hydroxydopamine-lesioned mouse model of Parkinson's disease byMorroni F1, Tarozzi A, Sita G, Bolondi C, Zolezzi Moraga JM, Cantelli-Forti G, Hrelia P.(PubMed)
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