Kyle J. Norton
Cinnamon, a kitchen spice in many cultures, may be best known for its
effect in reduced levels of blood glucose in diabetics and lipid
peroxidation through its antioxidant activity(4) . Its underline
mechanisms in enhancing fertility in both sexes are
unknown.
Infertility is defined as the inability of a couple to conceive after 12
months of unprotected sexual intercourse or the cannot carry the
pregnancy full term. It affects over 5 million couples alone in the U.
S. and many times more in the world. Because of an unawareness of
treatments, only 10% seek help from professional specialists. In fact,
about 35% of infertility is caused by the male's inability to fertilize.
35% is caused by the female's inability to conceive, 10% attributes to
both, and 10 % is considered a failure with an unknown cause.
A 45 women randomized, 26 women completed 3 months of the study, and 17
women completed the entire 6 months of the study, with Polycystic Ovary
Syndrome, showed a positive effect in improvement of menstrual cyclicity
associated to Luteal phase progesterone levels and ovulatory menses
without altering insulin resistance or serum androgen levels(1).
Cinnamaldehyde, a major chemical compound of cinnamon, also showed to
enhance fertility through selectively induced progesterone production
and inhibited production of testosterone and dehydroepiandrosterone in
human adrenal cells(3).
Its extract in PCOs study not only showed to reduce insulin resistance
in vitro and in vivo by increasing phosphatidylinositol 3-kinase
activity in the insulin signaling pathway, but also improved menstrual
cyclicity through significant reductions in insulin resistance(8).
In infertile male rat study conducted by Fırat University, long-term cinnamon
bark oil(CPO) improved the effect on testicular oxidant-antioxidant
balance and sperm quality with significantly decreasing the abnormal
sperm rate and apoptotic germ cell count(2).
The study in male rat reproductive system induced by carbon tetrachloride
(CCl4 ), the cinnamon bark oil(CPO), also showed a significant
improvements in absolute weights of testis and epididymis, all sperm
quality parameters, LPO level, apoptotic index and testicular(6)
Taken altogether, Cinnamon may be effective in promoting fertility in
both sexes through enhancing the menstrual cycle in women and improving
sperm performance in men. Unfortunately, according to DR. Georgakopoulou
EA(6), Oral intake of Cinnamon may cause Stomatitis, and burning
sensation in mouth with large amount. The traditional Chinese medicine
also insisted that Overdoses of cinnamon can be toxic and damaged to
liver(5).
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References
(1) Preliminary Evidence that Cinnamon Improves Menstrual Cyclicity in Women with Polycystic Ovarian Syndrome: a Randomized Controlled Trial by Kort DH1, Lobo RA.(PubMed)
(2) Effects of cinnamon (Cinnamomum zeylanicum) bark oil on testicular antioxidant values, apoptotic germ cell and sperm quality by Yüce A1, Türk G, Çeribaşi S, Sönmez M, Çiftçi M, Güvenç M.(PubMed)
(3) Selective stimulation by cinnamaldehyde of progesterone secretion in human adrenal cells by Iwaoka Y1, Hashimoto R, Koizumi H, Yu J, Okabe T.(PubMed)
(4) Preventive effect of cinnamon essential oil on lipid oxidation of vegetable oil by Keshvari M1, Asgary S, Jafarian-Dehkordi A, Najafi S, Ghoreyshi-Yazdi SM(PubMed)
(5) Popular #Herbs - #Dang Qui (Angelica sinensis)
(6) Chromium and polyphenols from cinnamon improve insulin sensitivity by Anderson RA.(PubMed)
(7) Effectiveness of cinnamon (Cinnamomum zeylanicum) bark oil in the prevention of carbon tetrachloride-induced damages on the male reproductive system by Yüce A1, Türk G, Çeribaşı S, Güvenç M, Çiftçi M, Sönmez M, Özer Kaya Ş, Çay M, Aksakal M.(PubMed)
(8) The effect of cinnamon extract on insulin resistance parameters in polycystic ovary syndrome: a pilot study by Wang JG1, Anderson RA, Graham GM 3rd, Chu MC, Sauer MV, Guarnaccia MM, Lobo RA.(PubMed)
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