Cat's claw found in in the tropical jungles of South and Central
America, is a genus Uncaria, belonging to the family Rubiaceae. It has
been used in traditional medicine over two thousand years as a tonic,
contraceptive, anti-inflammatory and infectious agent, and to treat
diarrhea, rheumatic disorders, acne, diabetes, cancer and diseases of
the urinary tract, etc..
Ingredients
The chemical constustuents of Cat's claw include, ajmalicine,
akuammigine, campesterol, catechin, carboxyl alkyl esters, chlorogenic
acid, cinchonain, corynantheine, corynoxeine, daucosterol, epicatechin,
harman, hirsuteine, hirsutine, iso-pteropodine, etc.
Free radicals are atoms, molecules, or ions with unpaired electrons through chemical bonds with other atoms or molecules
during a chemical reaction. They may have positive, negative or zero
charge. The unpaired electrons cause radicals to be highly chemically
reactive in the human body, leading to aging and cancers.
Herbal Cat's claw has found to be efficacy for treatment of
osteoarthritis, probably through its anti inflammatory and antioxidant
mechanisms.
According to the, oral administration of Cat's claw protected against
indomethacin-induced gastritis, and prevented TNFalpha mRNA(proteins are
key regulators of T-cell activation, migration, and proliferation)
expression and apoptosis due to its antioxidant and anti-inflammatory
activities(1).
Pteropodine, a chemical compound isolated from Cat's claw, showed to exert its cytostatic, anti-inflammatory and antimutagenic properties in DPPH assay(2).
Aqueous and ethanolic extracts of the Uncaria
tomentosa bark, in the study at the Institute of Bioorganic Chemistry,
Polish Academy of Sciences, supported the antioxidant effect of the
extract with the most in total phenolic compounds of the alcoholic
preparations butmay cause undesirable gastric effects(3).
Other chemical compound, proanthocyanidins found in the decoctions prepared from the bark of Uncaria tomentosa (cat's claw)
also was found to exert its high capacity to reduce the free radical
diphenylpicrylhydrazyl, and by its reaction with superoxide anion,
peroxyl and hydroxyl radicals as well as with the oxidant species,
hydrogen peroxide and hypochlorous acid(4).
Side effects
1. It may cause allergic reaction, including itching, rash and allergic inflammation of the kidneys, etc. to certain people, according to the article of `Uncaria Tomentosa`by Wikipedia(a)
2. If you are taking blood pressure medicines, blood-thinning medications, hormones, or insulin do not take cat's claw
3. Do not take Cat's claw if you are pregnant or breast feeding with out approval of your related field specialist
4. Do not take cat’s claw if you have low blood pressure or an
autoimmune disease (such as lupus or multiple sclerosis) or have had an
organ or bone marrow transplant.
5. Etc.
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References
(1) Anti-inflammatory and antioxidant activities of cat's claw (Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid content by Sandoval M1, Okuhama NN, Zhang XJ, Condezo LA, Lao J, Angeles' FM, Musah RA, Bobrowski P, Miller MJ.(PubMed)
(2) Antigenotoxic, antioxidant and lymphocyte induction effects produced by pteropodine by Paniagua-Pérez R1, Madrigal-Bujaidar E, Molina-Jasso D, Reyes-Cadena S, Alvarez-González I, Sánchez-Chapul L, Pérez-Gallaga J.(PubMed)
(3) Antioxidant activity of ethanolic and aqueous extracts of Uncaria tomentosa (Willd.) DC by Pilarski R1, Zieliński H, Ciesiołka D, Gulewicz K.(PubMed)
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