Calendula is also known as pot marigold, a annual or perennial herbaceous
plants of about 12–20 species of genus Calendula, belonging to the
family Asteraceae, native to Southern Europe. It has been used in herbal
medicine as spasmolytic, spasmogenic, inflammatory effects and to treat
abdominal cramps, wound healing, skin diseases, colitis, constipation,
etc.
Ingredients
Beside major chemical constituents of triterpenoids, flavonoids,
coumarines, quinones, volatile oil,carotenoids and amino acids, the herb
also contains loliolide (calendin), calendulin and n-paraffins.
According to the Federal University of Goiás, the
ethanolic extract, the dichloromethane, and hexanic fractions from
Calendula showed a positive effect in speeding up the chorioallantoic
membrane and cutaneous wounds healing through its anti-inflammatory and
anti bacterial activities in rat models.(1).
The exertion of angiogenesis of this herb may be not directly related to
the expression of VEGF and probably associated to other pro-angiogenic
factors(2). "Oral and topical application of Calendula officinalis flower extract showed a significant increase was observed in the hydroxy proline and hexosamine
content in the extract-treated group compared with the untreated
animals" Dr. Preethi KC, and Dr. Kuttan R.said(3).
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References
(1) Wound Healing and Anti-Inflammatory Effect in Animal Models of Calendula officinalis L. Growing in Brazil by Parente LM1, Lino Júnior Rde S, Tresvenzol LM, Vinaud MC, de Paula JR, Paulo NM.(PubMed)
(2) Angiogenic activity of Calendula officinalis flowers L. in rats by Parente LM1, Andrade MA, Brito LA, Moura VM, Miguel MP, Lino-Júnior Rde S, Tresvenzol LF, Paula JR, Paulo NM.(PubMed)
(3) Wound healing activity of flower extract of Calendula officinalis by Preethi KC1, Kuttan R.(PubMed)
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