By Kyle J. Norton
The widespread of incidence of asthma over large 20 years in South East
Asian population, specially in children and aging group has caused some
concerns to the government and scientific community. It may be due to
over intake in artificial ingredients, polluted environment as well as
intake foods triggering the inflammatory allergens.
Vitamin K(K1, phylloquinone; K2, menaquinones), is a fat soluble
vitamin, found abundantly in leafy green vegetables, broccoli, and
Brussels sprouts, etc. It is best known for promotion of coagulation and
bone health.
Epidemiological studies focusing vitamin K in reduced risk and treatment of asthma have been inconclusive(a)(b)(c).
Menaquinone (vitamin K2), a variant of vitamin K, in a double blind study of 191 patients with bronchial asthma,
showed an effective rate of 90.9% in mild patients, 86.7% in moderate
patients, and 72.7% in severe patients(1). Other researchers suggested
that treatment of menaquinone for long periods in patients with
bronchial asthma indicated a significant
inhibition of the disease(2). The data base of PubMed showed limitation
in quantity of the research, we, therefore make no conclusion of the
effectiveness of the vitamin in reduced risk and treatment of asthma.
Overdoses can induce symptoms of Skin rash, Diarrhea, Nausea, Vomiting,
Anemia, etc. Please make sure you follow the guideline of the
Institute of Medicine of the National Academies.
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References
(a) Maternal intake of vitamins A, E and K in pregnancy and child
allergic disease: a longitudinal study from the Danish National Birth
Cohort by Maslova E, Hansen S, Strøm M, Halldorsson TI, Olsen SF.(PubMed)
(b) Fat-soluble vitamins and atopic disease: what is the evidence? by Litonjua AA.(PubMed)
(c) [Antioxidant and fat intake in patients with polinic asthma].[Article in Spanish] by de Luis DA1, Izaola O, Aller R, Armentia A, Cuéllar L.(PubMed)
(1) Menaquinone (vitamin K2) therapy for bronchial asthma. II. Clinical effect of menaquinone on bronchial asthma by Kimur I, Tanizaki Y, Sato S, Saito K, Takahashi K.(PubMed)
(2) Menaquinone (vitamin K2) therapy for bronchial asthma. I. Mechanism of action menaquinone on allergic reactions by Kimura I, Tanizaki Y, Sato S, Saito K, Takahashi K.(PubMed)
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