The widespread of incidence of asthma over large 20 years in South East
Asian population, specially in children and aging group has caused some
concerns to the government and scientific community. It may be due to
over intake in artificial ingredients, polluted environment as well as
intake foods triggering the inflammatory allergens.
Vitamin B12, also known as cobalamin, a water-soluble vitamin,
found abundantly in a variety of foods, such as fish, shellfish, meat,
eggs, dairy products, etc. plays an important role in regulating the
functions of nervous system and formation of blood.
The conflict results
Epidemiological studies, linking vitamin B12 in reduced risk and
treatment of asthma have produced inconclusive results. Some researchers
through searching the data base of asthma studies suggested that
insufficient evidence exists to recommend supplementation with any
vitamin or nutrient acting as a methyl donor to prevent or treat asthma(1).
Other found the conflict results in the associated risk of the
disease(2). Other insisted no correlation between vitamin B12 intake and
risk of asthma or atopy(3). Intake of
vitamin B12 during pregnancy may effect the incidence of asthma and
asthmatic symptoms of offspring, but according to the Osaka Maternal and
Child Health study, there was no correlation between maternal
consumption of folate, vitamin B(12) , vitamin B(6) , and vitamin B(2)
during pregnancy and the risk of wheeze or eczema in the offspring(4).
Because of limitation of quantity of the studies in the data base to
determine the risk of dietary intake of vitamin B12' effect on
asthmatics. We recommend the use of vitamin B12 with care in pregnancy.
As always, over doses of the vitamin B12 may induce symptoms of
toxicity, including headache, giddiness and abnormal heart functioning,
etc., please make sure to follow the guideline of the Institute of
Medicine of the National Academies.
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References
(1) Diet and asthma: vitamins and methyl donors by Han YY1, Blatter J1, Brehm JM1, Forno E1, Litonjua AA2, Celedón JC3.(PubMed)
(2) Asthma, allergy, and responses to methyl donor supplements and nutrients by Sharma S1, Litonjua A2.(PubMed)
(3) Atopy, asthma, and lung function in relation to folate and vitamin B(12) in adults by Thuesen BH1, Husemoen LL, Ovesen L, Jørgensen T, Fenger M, Gilderson G, Linneberg A.(PubMed)
(4) Maternal B vitamin intake during pregnancy and wheeze and eczema in
Japanese infants aged 16-24 months: the Osaka Maternal and Child Health
Study by Miyake Y1, Sasaki S, Tanaka K, Hirota Y.(PubMed)
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