Kyle J. Norton
The incidence of endometrial cancer among white women are higher in
comparison of black. According to the statistic, the risk of
endometrial cancer among women is 1 in 7000. Every year, about 40,000
women in US are diagnosed with the disease. Women who carry certain
mutation genes, such as BRCA1 or the BRCA2 are associated to increased
risk of endometrial cancer..
Vitamin B2 also known as
Riboflavin, is a water-soluble, yellow-orange organic compound found
abundantly in milk, meat, eggs, nuts, enriched flour, green vegetables,
etc. The vitamin is essential for normal cellular growth and function
and best known for converting energy from protein, fat, and
carbohydrates metabolism and its antioxidant effects in
oxidation-reduction reactions.
Epidemiological studies. linking dietary vitamin B2 in reduced risk of
endometrial cancer have produced inconclusive results. The study of
Harvard School of Public Health showed a inverse association of vitamin
B2 related to the risk of endometrial cancer in a relatively small
size of study(5). the co administration of riboflavin (45 mg/kg
bw/day), niacin (100 mg/kg
bw/day) and ascorbic acid (200 mg/kg bw/day) along with tamoxifen (45
mg/kg bw/day), in experimental animals with endometrial cancer bearing
rats, exhibited a significant decrease in the activity of glycolytic
enzymes and a
significant increase in the deficient activities of gluconeogenic
enzymes to near
normal levels, but not individually(6). Unfortunately, the study of Fu
Dan University School of Public Health indicted "no significant
association was observed for dietary vitamin B1 or vitamin B2 and risk
of endometrial cancer", in a population-based case-control study of 1,204
newly diagnosed endometrial cancer cases and 1,212 age frequency-matched controls(7)(8). In the study of one-carbon metabolism correlated to the incidence of endometrial cancer
using 26 years of follow-up data from the Nurses' Health Study,
indicated a no association of endometrial cancer risk with dietary
levels of folate, choline, methionine, vitamin B2, vitamin B6 or vitamin B12(9).
Taking altogether, without going into reviews, composited
administration of vitamin B2 and other micro nutrients such as niacin
and ascorbic acid, but not vitamin B2 itself may be associated in
reduced risk and treatment of endometrial cancer. But large example and
multi-centers studies are necessary to identify their effectiveness.
Over doses for a prolong period may cause symptoms of skin
rashes, hypersensitivity, high blood pressure etc., please make sure you
follow the guideline of the Institute of Medicine of the National
Academies.
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References
(1) Conference on "Multidisciplinary approaches to nutritional problems". Symposium on "Nutrition and health". Cruciferous vegetable intake and the risk of human cancer: epidemiological evidence BY Kim MK, Park JH(PubMed)
(2) Epidemiological studies on brassica vegetables and cancer risk by Verhoeven DT, Goldbohm RA, van Poppel G, Verhagen H, van den Brandt PA(PubMed)
(3) Brassica vegetables and cancer prevention. Epidemiology and mechanisms by van Poppel G, Verhoeven DT, Verhagen H, Goldbohm RA.(PubMed)
(4) Fruits and vegetables and endometrial cancer risk: a systematic literature review and meta-analysis by Bandera EV, Kushi LH, Moore DF, Gifkins DM, McCullough ML(PubMed)(5) Diet in relation to endometrial cancer risk: a case-control study in Greece by Petridou E1, Kedikoglou S, Koukoulomatis P, Dessypris N, Trichopoulos D(PubMed)
(6) Therapeutic potential of riboflavin, niacin and ascorbic acid on carbohydrate metabolizing enzymes in secondary endometrial carcinoma bearing rats by Sundravel S1, Shanthi P, Sachdanandam P.(PubMed)
(7) Nutritional factors in relation to endometrial cancer: a report from a population-based case-control study in Shanghai, China by Xu WH1, Dai Q, Xiang YB, Zhao GM, Ruan ZX, Cheng JR, Zheng W, Shu XO.(PubMed)
(8) Dietary folate intake, MTHFR genetic polymorphisms, and the risk of endometrial cancer among Chinese women by Xu WH1, Shrubsole MJ, Xiang YB, Cai Q, Zhao GM, Ruan ZX, Cheng JR, Zheng W, Shu XO.(PubMed)
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