Triterpenoid is a various unsaturated hydrocarbons, found in essential
oils and oleoresins of plants, including Ilex hainanensis Merr.
Non-alcoholic Fatty Liver Disease
is defined as a condition of the fatty liver diseases as a result of
accumulated of fat in the liver, not caused by abusive alcohol
consumption.
Progression of nonalcoholic steatohepatitis (NASH) to Non alcoholic
liver disease is inevitable if left untreated. Ilex hainanensis Merr. is
the Chinese herb used to treat for hypertension, dyslipidemia and
inflammation in Traditional Chinese Medicine (TCMs) and may be a
potential medicine to treat Non alcoholic fatty disease. In the study to
test the effect of Triterpenoid-rich fraction (TP) from Ilex
hainanensis Merr. on NAFLD with Male Sprague-Dawley (SD) rats fed a normal diet (control) or high fat diet (NAFLD
model), after 4 weeks, the high fat diet group was orally administrated
TF (250 mg/kg) for another two weeks. TP not only improves the symptoms
of the subjects, but also decreases the levels of triglyceride , total
cholesterol, low-density lipoprotein cholesterol, abnormality of lipid
accumulation , levels of inflammation and infection and apoptosis
response in the liver. Of these results, TF is found to be effective in
protecting liver against NAFLD by regulating lipids metabolism and alleviating insulin resistance, inflammation and oxidative stress.
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Reference
(1) Pharmacokinetic study of major bioactive components in rats after oral administration of extract of Ilex hainanensis by high-performance liquid chromatography/electrospray ionization mass spectrometry by Jie Yanga, 1, Fang Lva, 1, Xiao-qing Chenb, Wei-xi Cuia, Li-hong Chenc, Xiao-dong Wena, Qiang Wanga(Science direct)
(2) Triterpenoid-rich fraction from Ilex hainanensis Merr. attenuates non-alcoholic fatty liver disease induced by high fat diet in rats by Cui WX, Yang J, Chen XQ, Mao Q, Wei XL, Wen XD, Wang Q.(PubMed)
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