Piperine is a phytochemical alkaloid in the class of organosulfur compound, found abundantly in white and black pepper, long pepper, etc.
Obesity is defined as a
medical condition of excess body fat has accumulated overtime, while
overweight is a condition of excess body weight relatively to the
height. According to the Body Mass Index(BMI), a BMI between 25 to
29.9 is considered over weight, while a BMI of over 30 is an
indication of obesity. According to the statistic, 68% of American
population are either overweight or obese.
The benefits
Study of combination of bioactive food ingredients, including piperine
in Forty-one patients and 45 patients in control group, showed a
significantly greater decrease in insulin resistance, with leptin,
ghrelin, C-reactive protein decreased and resting energy expenditure
increased significantly in the supplemented group compared to the
placebo. In mice fed with high fat diet-induced hepatic
steatosis, administration of piperine (50 mg/kg body weight) significant increased in plasma adiponectin levels, induced elevated plasma concentrations of insulin and glucose. Piperine
also reversed HFD-induced down-regulation of adiponecitn-AMP-activated
protein kinase (AMPK)( a metabolic enzyme in controls a number of
metabolic pathways) signalling molecules linking to lipogenesis, fatty
acid oxidation and insulin signalling in the livers of mice. Also in Male Wistar rats fed with high fat diet study, piperine
supplementation also improved the plasma levels of apo A-I, T3, T4,
testosterone, and I and significantly reduced apo B, TSH, and insulin to near normal levels.
Ovarian Cysts And PCOS Elimination
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References
(1) Improvement in insulin resistance and favourable changes in plasma
inflammatory adipokines after weight loss associated with two months'
consumption of a combination of bioactive food ingredients in overweight
subjects by Rondanelli M, Opizzi A, Perna S, Faliva M, Solerte SB,
Fioravanti M, Klersy C, Cava E, Paolini M, Scavone L, Ceccarelli P,
Castellaneta E, Savina C, Donini LM.(PubMed)
(2) Piperine reverses high fat diet-induced hepatic steatosis and insulin resistance in mice by Choi S, Choi Y, Choi Y, Kim S, Jang J, Park T.(PubMed)
(3) Piperine, an active principle from
Piper nigrum, modulates hormonal and apo lipoprotein profiles in
hyperlipidemic rats by Vijayakumar RS, Nalini N.(PubMed)
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