Herbal Andrographis and Renoprotective effects

Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka. It has been used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia, swollen lymph nodes, leprosy, bronchitis, sore throats, tuberculosis, chicken pox, etc.
Renoprotective effect is defined of a protection against harmful of the kidney.

The Ingredients
Beside the main ingredient andrographolides, giving the plant a bitter taste, other ingredients includediterpene lactones, such as: neoandrographolide, andrographiside, 14-doexy-11, 12-didehydro andrographolide, etc., flavonoinds viz., oroxylin, wogonin, andrographidines A, B, C, D, E, F.

The Benefits
Renal failure is an increasingly common condition with limited treatment options in developing world. In the study to evaluate the antirenal failure activity of A. paniculata, aqueous extract of A. paniculata attenuated the gentamicin-induced increase in serum creatinine, serum urea, and blood urea nitrogen levels by 176.92%, 106.27%, and 202.90%, respectively by exhibiting a significant renoprotective effect in gentamicin-induced nephrotoxicity in rats. Other in the study of the effect of various herbal adaptogens, including on cadmium (Cd)-induced oxidative stress and its accumulation in broiler chicken, found that  the increase in TBARS and decrease in GSH concentrations of liver and kidney tissues in cadmium intoxicated birds were significantly reversed by the above-said herbs. The liver and kidney functional markers were also restored to normal levels.  Unfortunately, Andrographolide was found to cause acute kidney injury shortly after intravenous infusion of andrographolide, with symptoms including flank pain, decreased urine output, and nausea or vomiting.
 
The Side effects
1. Antifertility
Dry leaf powder of A. paniculata increases the risk accumulating of glycogen and cholesterol in the testis, and increased activities of lactate dehydrogenase in testis and alkaline phosphatase in testis and ventral prostate, thus reducing the risk of fertility.
 2. People with gallbladder disease may want to consult with their doctor before using because of the herb stimulating gallbladder contraction effect.


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References 
(1) Antifertility effect of Andrographis paniculata (Nees) in male albino rat" by Akbarsha MA, Manivannan B, Hamid KS, Vijayan B., posted in (PubMed)
(2) Renoprotective effects of Andrographis paniculata (Burm. f.) Nees in rats by Singh P, Srivastava MM, Khemani LD.(PubMed)
(3) Andrographolide induced acute kidney injury: Analysis of 26 cases reported in Chinese Literature by Zhang WX, Zhang ZM, Zhang ZQ, Wang Y, Zhou W.(PubMed)
(4) Prevention of cadmium bioaccumulation by herbal adaptogens by Bharavi K, Reddy AG, Rao GS, Kumar PR, Kumar DS, Prasadini PP.(PubMed)