Herbal Aloe vera and Prostate cancer

Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan. It has become very popular for commercial cultivation due to its health benefits. Aloe vera has been used in herbal medicine in treating many kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated of cholesterol, etc. It is also one of many popular herb studied in scientific ways with some conflicted results.

Prostate cancer is defined as a condition in which the cells of prostate has become cancerous, causing abnormal cell growth which spread to the distant parts of the body. Most prostate cancers are slow growing and enlarged prostate and prostate cancer may be detected during the Physical (rectum) exams.

 

The Ingredients
The ten main areas of chemical constituents of Aloe vera include: Aloe-Emodin, amino acids, anthraquinones, enzymes, minerals, vitamins, lignins, monosaccharide, polysaccharides, salicylic acid, saponins, and sterols.

The benefits
 Aloe-amodin, an anthraquinone in aloe latex from the aloe plant has been found to suppress Breast Cancer Cell Proliferation through ER α Inhibition. In prostate cancer study, it found to  inhibite both proliferation and anchorage-independent growth of PC3 cells by by targeting mTORC2 as mTORC2  plays an important role in PC3 androgen refractory prostate cell proliferation and anchorage-independent growth.

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References

(1) Aloe-emodin suppresses prostate cancer by targeting the mTOR complex 2 by Liu K, Park C, Li S, Lee KW, Liu H, He L, Soung NK, Ahn JS, Bode AM, Dong Z, Kim BY, Dong Z.(PubMed)

(2) Oral type II collagen in the treatment of rheumatoid arthritis. A six-month double blind placebo-controlled study(PubMed)

(3) Oral aloe vera-induced hepatitis(PubMed)