Weight loss and serum 25-hydroxyvitamin D

Even though large observational studies and surveys have shown that obesity is independently associated with lower serum 25-hydroxyvitamin D (25[OH]D) concentration but data collected, conducted by University of California (1) from 383 overweight or obese women who participated in a 2-year clinical trial of a weight loss program, in which 51% (N=195) lost at least 5% of baseline weight by 24 months: 18% (N=67) lost 5-10%, and 33% (N=128) lost >10%. Women who did not lose weight at 24 months had an increase in serum 25(OH)D of 1.9 (9.7) ng/mL (mean [s.d.]); 25(OH)D increased by 2.7 (9.1) ng/mL for those who lost 5-10% of baseline weight; and 25(OH)D increased by 5.0 (9.2) ng/mL for those who lost >10% of baseline weight (P = 0.014). At baseline, 51% (N=197) of participants met or exceeded the recommended serum concentration of 20 ng/mL. And suggest that weight loss, presumably associated with a reduction in body fat, is associated with increased serum 25(OH)D concentration in overweight or obese women.

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(1) "Weight loss is associated with increased serum 25-hydroxyvitamin D in overweight or obese women" by Rock CL, Emond JA, Flatt SW, Heath DD, Karanja N, Pakiz B, Sherwood NE, Thomson CA., posted in PubMed