Beta Sitosterol is
a phytochemincal in the class of Phytosterols, belonging to the
group of Lipids, found abundantly in avocados, rice bran, wheat
germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, buckwheat.
etc.
Health Benefits
1. Benign prostatic hyperplasia (BPH)
In
the investigation of the effects of stinging nettle (Urtica dioica L.)
(UD) on benign prostatic hyperplasia (BPH) induced by testosterone.
Two biochemical markers viz., β-sitosterol
and scopoletin, were isolated and characterised in the extracts
utilising High-performance thin layer chromatographic shown that UD can
be used as an effective drug for the management of BPH, according to "Ameliorative effects of stinging nettle (Urtica dioica) on testosterone-induced prostatic hyperplasia in rats" by Nahata A, Dixit VK.(1)
2. Prostate cancer
In the investigation of the effect of two dietary sterols on prostate cancer cells in vitro. beta-Sitosterol
(SIT), the most common plant sterol, and cholesterol, an animal
sterol, were compared for effect on LNCaP cell growth, differentiation,
apoptosis, and sphingomyelin cycle intermediates, found that the
decrease in cell number and increase in apoptosis associated with SIT
treatment are mediated by activating the sphingomyelin cycle, according
to "beta-Sitosterol activates the sphingomyelin cycle and induces apoptosis in LNCaP human prostate cancer cells" by von Holtz RL, Fink CS, Awad AB.(2)
3. Breast cancer
in the evaluation of examine the effect of the two most common dietary PS, beta-sitosterol
(SIT) and campesterol, as compared to cholesterol, the main sterol in
the Western diet, on growth, apoptosis and cytotoxicity of MDA-MB-231
human breast cancer cells in culture, found that SIT supplementation for
3 days at 16 microM resulted in a 6-fold increase in apoptosis in
cells when compared to cholesterol treated cells. SIT treatment was
found to have no effect on the level and content of tumor cell PP2A. It
is concluded that SIT, by a still unknown mechanism, may offer
protection from breast cancer by inhibiting growth and stimulating
apoptosis, according to "Inhibition of growth and stimulation of apoptosis by beta-sitosterol treatment of MDA-MB-231 human breast cancer cells in culture" by Awad AB, Downie AC, Fink CS.(3)
4. Stomach cancer
In
the examination of the proliferation, cytotoxicity, and apoptosis of
beta-sitosterol in SGC-7901 human stomach cancer cells by
3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT)
assay, clone formation, lactate dehydrogenase (LDH) leakage assay,
acridine orange (AO)/ethidium bromide (EB) double staining,
4',6-diamidine-2'-phenylindole dihydrochloride (DAPI) staining, comet
assay, and Western blotting, showed that beta-sitosterol
suppresses the proliferation and induces the cell cytotoxicity of
SGC-7901 stomach cancer cells in a time- and dose-dependent manner.
Cells treated with different concentrations of beta-sitosterol also showed changes typical of apoptosis: morphological changes, according to "Beta-sitosterol inhibits cell growth and induces apoptosis in SGC-7901 human stomach cancer cells" by Zhao Y, Chang SK, Qu G, Li T, Cui H.(4)
5. Leukemia
In the investigation of the mechanism of apoptosis induced by beta-sitosterol in human leukemic U937 cells. beta-Sitosterol
induced cytotoxicity and apoptosis in U937 cells in a concentration
dependent manner, found that caspase-3 activation is partially essential
for beta-sitosterol-induced apoptosis. Bcl-2 overexpression also significantly blocked caspase-3 activation and the decrease in PARP cleavage by beta-sitosterol, and effectively attenuated the apoptotic response to beta-sitosterol. These results show that beta-sitosterol potently induces apoptosis in U937 cells and that beta-sitosterol-induced apoptosis is related to the selective activation of caspase-3 and induction of Bax/Bcl-2 ratio, according to "Beta-sitosterol
induces anti-proliferation and apoptosis in human leukemic U937 cells
through activation of caspase-3 and induction of Bax/Bcl-2 ratio" by Park C, Moon DO, Rhu CH, Choi BT, Lee WH, Kim GY, Choi YH.(5)
6. Anti cancers
Phytochemical
analysis of Fijian populations of the green alga Tydemania
expeditionis led to the isolation of two unsaturated fatty acids,
3(zeta)-hydroxy-octadeca-4(E),6(Z),15(Z)-trienoic acid (1) and
3(zeta)-hydroxy-hexadeca-4(E),6(Z)-dienoic acid (2), along with the
known 3(zeta)-hydroxy-octadeca-4(E),6(Z)-dienoic acid (4).
Investigations of the red alga Hydrolithon reinboldii led to
identification of a glycolipid, lithonoside (3), and five known
compounds, 15-tricosenoic acid, hexacosa-5,9-dienoic methyl ester, beta-sitosterol,
10(S)-hydroxypheophytin A, and 10(R)-hydroxypheophytin A. Compounds 1,
2, and 4, containing conjugated double bonds, demonstrated moderate
inhibitory activity against a panel of tumor cell lines (including
breast, colon, lung, prostate
and ovarian cells) with IC(50) values ranging from 1.3 to 14.4 microM.
The similar cell selectivity patterns of these three compounds suggest
that they might act by a common, but unknown, mechanism of action,
according to "Antineoplastic unsaturated fatty acids from Fijian macroalgae" by Jiang RW, Hay ME, Fairchild CR, Prudhomme J, Roch KL, Aalbersberg W, Kubanek J.(6)
7. Etc.
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Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/21806658
(2) http://www.ncbi.nlm.nih.gov/pubmed/9824850
(3) http://www.ncbi.nlm.nih.gov/pubmed/10762659
(4) http://www.ncbi.nlm.nih.gov/pubmed/19456133
(5) http://www.ncbi.nlm.nih.gov/pubmed/17603173
(6) http://www.ncbi.nlm.nih.gov/pubmed/18757069
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