Hemicrania continua (HC) is a chronic and persistent unilateral headache and considered as one of primary
headache disorders, according to International Headache Society's
International Classification(1), affecting 4 to 5% of the general
population.
Treatments
1. Indomethacin
Many researchers believe that Hemicrania continua is one of the indomethacin-responsive headache syndromes, patients may require daily indomethacin for years. The risks of
long-term indomethacin include gastrointestinal and renal dysfunction, but according to the study from the team and Dr. JA Pareja found that Six (23%) patients showed adverse events, mostly gastrointestinal
and relieved with ranitidine. No major side-effects
were observed. These results indicate that prolonged indomethacin
treatment
of HC or CPH has a good safety and tolerability
profile with a reduction of up to 60% in the initial dose.
2. Melatonin
Other suggested that Melatonin is a pineal hormone with a chemical structure very similar to
indomethacin as melatonin was shown to be effective for primary
stabbing headache, another indomethacin-responsive syndrome.(12)
3. Other
studies point out possible alternatives: Gabapentin, topiramate,
cyclooxygenase-2 inhibitors, piroxicam, beta-cyclodextrin,
amitriptyline, melatonin. Other drugs were described in different
reports as efficient, but most of them were considered inefficient in
other HC cases.(13) and a report of two cases of HC
responsive to topiramate and review the available alternatives for the
patients of HC. The side effects of indomethacin in the
various headache disorders and other painful conditions, and may need for trial of other drugs for the patients of HC.(14)
4. Etc.
Side effects
Side effects of indomethacin are not limit to
1. Indomethacin HC is
a life long condition, and
2. Skipping of a single dose of indomethacin
usually leads to reappearance of headache.(14)
3. risk for serious stomach/intestinal bleeding.
4. Others not common side effects include chest pain, shortness of
breath, weakness on one side of the body, sudden vision changes, slurred
speech.
5. Gastrointestinal and renal dysfunction.(15)
6. Etc.
Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight
Back to General health http://kylejnorton.blogspot.ca/p/general-health.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(12) http://www.ncbi.nlm.nih.gov/pubmed/16866728
(13) http://www.ncbi.nlm.nih.gov/pubmed/22440373
(14) http://www.ncbi.nlm.nih.gov/pubmed/19041987
(15) http://www.ncbi.nlm.nih.gov/pubmed/16866728
No comments:
Post a Comment