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Friday, 1 November 2013

Chinese Herbs – Xi Yang Shen (Radix Panacis Quinque Folii)

Xi Yang Shen is also known as American Ginseng Root. The sweet, bitter and cool herb has been used in TCM

Ingredients
1. Octanol
2. Hexanoic acid
3. Undecane
4. Pinocarveol
5. Octanoic acid
6. Dodecane
7. 3-phenylhexane
8.  1-phenylhexane
9.  1, 3, 5- triisopropylphene
10. Beta-gurjunene
11. Piperitene
12. Beta-farnesene
13. 2, 6-diterbutyl-4-methylphenol
14. 3-phenyldecane
15. 6-phenylundecane
16. Etc.

Health Benefits
1. Colorectal cancer
In the investigation of American ginseng (Panax quinquefolius L., Araliaceae) and its anti-cancer potentialfound that three genes were up-regulated (AKAPA8L, PMPCB and PDE5A) and three were down-regulated (PITPNA, DUS2L and RIC8A). Although further studies are needed to elucidate the mechanisms of action, our findings should expand the understanding of the molecular framework of American ginseng as an anti-cancer agent, according to “Characterization of gene expression regulated by American ginseng and ginsenoside Rg3 in human colorectal cancer cells” by Luo X, Wang CZ, Chen J, Song WX, Luo J, Tang N, He BC, Kang Q, Wang Y, Du W, He TC, Yuan CS.(1)
2. Cardiovascular disease
In the demonstration of emerging evidence suggests ginseng has therapeutic potential in cardiovascular disease found that ginseng treatment significantly decreased infarct size and myocardial apoptosis following I/R in WT mice, but not in either eNOS(-/-) mice or WT mice treated with LY294002. We conclude that ginseng treatment protects the heart from I/R injury via upregulation of eNOS expression. Our study suggests that ginseng may serve as a potential therapeutic agent to limit myocardial I/R injury, according to “North American ginseng protects the heart from ischemia and reperfusion injury via upregulation of endothelial nitric oxide synthase” by Wu Y, Lu X, Xiang FL, Lui EM, Feng Q.(2)
3. Pediatric upper respiratory tract infection
In the evaluation of Panax quinquefolius (American ginseng root extract) standardized to contain 80% poly-furanosyl-pyranosyl-saccharides and theirs effect on upper respiratory tract infections in childdren found that standard doses of ginseng were well tolerated and merit additional evaluation with regard to treatment of pediatric upper respiratory tract infection, according to “Safety and tolerability of North American ginseng extract in the treatment of pediatric upper respiratory tract infection: a phase II randomized, controlled trial of 2 dosing schedules” by Vohra S, Johnston BC, Laycock KL, Midodzi WK, Dhunnoo I, Harris E, Baydala L.(3)
4. Glycemia and insulinemia
In the assessment the evidence indicates that the glycemia-lowering effect of American ginseng root may be batch dependent. found that American ginseng decreased postprandial glycemia and insulinemia; however, 40% of the batches did not reduce glycemia with the anticipated magnitude, irrespective of their saponin composition, according to “Five batches representative of Ontario-grown American ginseng root produce comparable reductions of postprandial glycemia in healthy individuals” by
Dascalu A, Sievenpiper JL, Jenkins AL, Stavro MP, Leiter LA, Arnason JT, Vuksan V.(4)
5. Etc.

Side Effects
1. The herb can cause tremors, nervousness, headache, vomiting, insomnia, nose bleeding, etc.
2. Please do not use Xi Yang Shen, if you have heart disease or taken heart problem medicine
3. Xi Yang Shen may interact with other medication, including aspirin, Warfarin/Coumadin, etc.
4. Do not use the herb if you are pregnant
5. Etc.

Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/18425323
(2) http://www.ncbi.nlm.nih.gov/pubmed/21621617
(3) http://www.ncbi.nlm.nih.gov/pubmed/18676527
(4) http://www.ncbi.nlm.nih.gov/pubmed/18066131

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