Comfrey is a perennial Plant in the genus of Symphytum, belonging to the family Boraginaceae, native to Europe. It has been used in herbal and traditional medicine to ease excessive bleeding or on open wounds, relief pain and swollen, treat circulation issues, reduce cholesterol, etc.
Health benefits 1. Distortions
In the comparison of the efficacy of comfrey extract to a commercial diclofenac (CAS 78213-16-8) preparation in the treatment of unilateral ankle sprains found that superiority of the plant based ointment over the diclofenac gel in the treatment of distortions, according to the study of "Comfrey extract ointment in comparison to diclofenac gel in the treatment of acute unilateral ankle sprains (distortions)" by D'Anchise R, Bulitta M, Giannetti B.(1)
2. Painful osteoarthritis
In the investigation of the effect of a daily application of 6g Kytta-Salbe f (3 x 2 g) over a 3 week period with patients suffering from painful osteoarthritis of the knee with the complaints relating to osteoarthritis of the knee had persisted for 6.5 years found that the comfrey root extract ointment is well suited for the treatment of osteoarthritis of the knee. Pain is reduced, mobility of the knee improved and quality of life increased, according to "Efficacy of a comfrey root (Symphyti offic. radix) extract ointment in the treatment of patients with painful osteoarthritis of the knee: results of a double-blind, randomised, bicenter, placebo-controlled trial" by Grube B, Grünwald J, Krug L, Staiger C.(2)
3. Organic parasite control
In the investigation of Plants used for treating endo- and ectoparasites of rabbits and poultry in British Columbia and their effect in included Arctium lappa (burdock), including Symphytum officinale (comfrey), according to "Organic parasite control for poultry and rabbits in British Columbia, Canada" by Lans C, Turner N.(3)
4. Bone density
In the investigation of the removal torque and radiographic bone density around titanium implants and the effects of the effect of Symphytum officinale in homeopathic potency (6cH) found that that S. officinale 6cH treatment enhanced bone formation around the micro-implants, mainly at 14 days. At 56 days, the radiographic bone density was higher in the treated group., according to"Homeopathic Symphytum officinale increases removal torque and radiographic bone density around titanium implants in rats" by Spin-Neto R, Belluci MM, Sakakura CE, Scaf G, Pepato MT, Marcantonio E Jr.(4)
5. Wound healing
In evaluation of Wound healing effects of a topically applied preparation (Traumaplant) containing a concentrate (10 % active ingredient) from the aerial parts of medicinal comfrey found that after 2-3 days of application of the study medication a highly significantly and clinically relevantly faster initial reduction of wound size of 49 + or - 19 % versus 29 + or - 13 % per day in favour of verum (p < 5x10(-21)) with no adverse side effects, according to the study of "[Wound healing effects of a Symphytum herb extract cream (Symphytum x uplandicum NYMAN: ): results of a randomized, controlled double-blind study].[Article in German]" by Barna M, Kucera A, Hladícova M, Kucera M.(5)
6. Myalgia
In the examination of The effectiveness and tolerability of the topical Symphytum product Traumaplant (Harras Pharma Curarina, München, Germany) and it effects in treating myalgia found that Global efficacy was significantly better (P=1 x 10 -8 ) and onset of effects was faster (P=4 x 10 -7 ) with the high-concentration product. Tolerability of the highly concentrated study product was good to excellent in all patients. Study results confirm the known anti-inflammatory and analgesic effects of topical (Symphytum) cream, according to "Topical symphytum herb concentrate cream against myalgia: a randomized controlled double-blind clinical study" by Kucera M, Barna M, Horàcek O, Kàlal J, Kucera A, Hladìkova M.(6)
7. Antifungal activity
In the research of extracts from the leaves of medicinal comfrey and cowparsnip and their effects against the germination of Erysiphe graminis conidia and uredospores of Puccinia graminis found that protective activity of comfrey and cowparsnip extracts is associated with their action on the pathogenic fungus and with the activation of natural defense reactions of the host plant, according to "[Antifungal activity of aqueous extracts from the leaf of cowparsnip and comfrey].[Article in Russian]" by Karavaev VA, Solntsev MK, Iurina TP, Iurina EV, Poliakova IB, Kuznetsov AM.(7)
8. Etc.
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Side effects
1. The herb may cause liver toxicity and cancers, according to the observation of the chemical compound and it effect in liver toxicity and induced cancer in rat found that the active metabolites of PA in comfrey interact with DNA in liver endothelial cells and hepatocytes, resulting in DNA damage, mutation induction, and cancer development(a).
2. Do not use the herb in children
3. Do not use the herb if you are pregnant or breast feeding with out permission of related field specialist.
4. Etc.
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/18193693
(2) http://www.ncbi.nlm.nih.gov/pubmed/17169543
(3) http://www.ncbi.nlm.nih.gov/pubmed/21756341
(4) http://www.ncbi.nlm.nih.gov/pubmed/20970094
(5) http://www.ncbi.nlm.nih.gov/pubmed/18157595
(6) http://www.ncbi.nlm.nih.gov/pubmed/16510384
(7) http://www.ncbi.nlm.nih.gov/pubmed/11525124
(a) http://www.ncbi.nlm.nih.gov/pubmed/21170807
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