Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Tuesday 15 October 2019

Cranberry Inhibits Lung Cancer Cells Initiation and Progression

By Kyle J. Norton

The lung formed part of the respiratory system is a vital organ located near the backbone on either side of the heart with functions of inhaling oxygen from the air then transporting them to the bloodstream and exhaling carbon dioxide from the bloodstream.

Lung diseases are a class of conditions associated with reduced function of the lung, including lung cancer.

Lung cancer is a medical condition associated with abnormal growth of the cells in the lung's tissue that begins in the cells on the surface of the inner lining tissues of the lung due to the alternation of cell DNA.

Most common form of primary lung cancer is derived from epithelial cells.

In the US, lung cancer is the leading cause of cancer deaths. According to the statistics from the American Cancer Society, in 2019, about 228,150 new cases of lung cancer, including 116,440 in men and 111,710 in women will be diagnosed in the US.

Sadly, lung cancer also causes the death of 142,670 American death, including 76,650 in men and 66,020 in women in the same year.

The lifetime risk of lung cancer in a man is 6.7% compared to 5.9% in a woman.

The exact causes of lung cancer are not known. However, epidemiologically, smoking tobacco, second-hand smoke, radon, asbestos, occupational exposure to certain chemicals, personal or family history of lung cancer and lung disease and exposure to radiation are some major factors found in patients with lung cancer.

Dr. Ozlü T, the lead scientist wrote, " Tobacco use has been reported to be the main cause of 90% of male and 79% of female lung cancers. 90% of deaths from lung cancer are estimated to be due to smoking".

And, "The risk of lung cancer development is 20-40 times higher in lifelong smokers compared to non-smokers. Environmental cigarette smoke exposure and different types of smoking have been shown to cause pulmonary carcinoma. DNA adducts, the metabolites of smoke carcinogens bound covalently with DNA, are regarded as an indicator of cancer risk in smokers".

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

On finding a potential compound for the protection of lung cell integrity, researchers examined the effect of the efficacy of proanthocyanidin-rich cranberry fraction (PAC) on lung cancer.

According to the tested analysis, NCI-H460 human lung cancer cells treated with 50 µg/mL PAC or vehicle for 6 hours, PAC exerted a significant activity in the regulation of apoptosis, regulation of programmed cell death, positive regulation of cell death, positive regulation of apoptosis, and apoptotic mitochondrial changes.

Moreover, also NCI-H460 human lung cancer cells treated with 50 µg/mL PAC showed a strong effect on cancer cell metabolism, protein modifications, and cell cycle by inhibiting the M phase of the mitotic cell cycle, mitosis, M phase, cell cycle checkpoint, and regulation of cell cycle process.

More precisely, PAC induced lung cancer cell apoptosis and anti-proliferative activity through cell cycle arrest.

Furthermore, PAC treatment also enhanced the levels of glutathione S-transferases associated

with blocking cancer cell metastasis.

PAC treatment also down-regulated DNA metabolism, cell cycle, meiosis, mitosis and interestingly oncogenesis signaling.

PAC treatment also inhibited the alternation of ErbB receptors and signaling pathways and mTOR signaling pathways mutated in lung tumors, involved in cancer development and progression

Taken altogether, cranberry used conjunction with other remedies may be considered a remedy for the prevention and treatment of lung cancer, pending to the confirmation of the larger sample size and multicenter human study.

Sources
(1) Cranberry proanthocyanidins mediate growth arrest of lung cancer cells through modulation of gene expression and rapid induction of apoptosis by Kresty LA1, Howell AB, Baird M. (PubMed)
(2) Smoking and lung cancer by Ozlü T1, Bülbül Y. (PubMed)

Turmeric Inhibits Hair Loss and Promotes Hair Growth in Men

By Kyle J. Norton

Every day the scalp loses about 100 hairs and they will grow back in 5-6 weeks. However, in older men, hair loss was associated with the increase of levels of by-product prolactin of testosterone-induced the conversion of testosterone to gihydro-testosterones DHT, a leading cause in the promotion of hair growing back thinner or not grown back at all.

The presence of gihydro-testosterones DHT shrinks the follicles causing hair thins and hair receding at the forehead, crown, and temple for men and thins over the entire scalp for women.

There are many factors involved in the loss of hair. Aging, nutrient deficiency, genetic proposition, smoking, and unhealthy diet are some of the most common risk factors that cause hair loss in the Western world.

Conventionally, Minoxidil, a topical medicine approved by The U.S. Food and Drug Administration (FDA) was found to stop hairs from getting thinner and stimulate hair growth on the top of the scalp with a number of side effects.

Dr. Rossi A, the lead scientist at the University Sapienza of Rome in the evaluation of the effects of
oral Minoxidil wrote, " Minoxidil is a potassium channel opener, causing hyperpolarization of cell membranes and it is also a vasodilator, it is speculated that, by widening blood vessels and opening potassium channels, it allows more oxygen, blood, and nutrients to the follicle".

And, "The most common adverse reactions of the topical formulation are limited to irritant and allergic contact dermatitis on the scalp. There have been cases of allergic reactions to the nonactive ingredient propylene glycol, which is found in some topical solution especially if they are galenic".

Therefore, if you are using the aforementioned product for the treatment of hair loss, please make sure you know all the side effects for preventive measure.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

With an aim to find a potential ingredient for the treatment of hair loss, researchers evaluated the efficacy of 5% hexane extract of Curcuma aeruginosa (turmeric), a botanically derived inhibitor of 5α-reductase and 5% minoxidil in the treatment of androgenetic alopecia.

The study included 87 men with androgenetic alopecia (AGA) randomized to receive 5% Curcuma aeruginosa, 5% minoxidil, combination formulation (5% hexane extract of Curcuma aeruginosa + 5% minoxidil) or placebo, twice daily for 6 months.

According to the tested assay, the combined treatment group showed statistically significant improvements of hair regrowth, and hair shedding in a global photographic review of all subjects, compared to the single treatment of groups and placebo.

In other words, treatment with 5% minoxidil and 5% C. aeruginosa extract shoed some degrees of hair regrowth without affecting hair shedding.

No adverse \effects were found during the course of the experiment.

Based on the results, researchers wrote in the final report, "In men with hair loss in the vertex area of the scalp, the combination of 5% hexane extract of C. aeruginosa and 5% minoxidil slowed hair loss and increased hair growth".

Taken altogether, turmeric used alone or combined with minoxidil may be considered supplements for the prevention and treatment of alopecia areata, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcuma aeruginosa, a novel botanically derived 5α-reductase inhibitor in the treatment of male-pattern baldness: a multicenter, randomized, double-blind, placebo-controlled study by Pumthong G1, Asawanonda P, Varothai S, Jariyasethavong V, Triwongwaranat D, Suthipinittharm P, Ingkaninan K, Leelapornpisit P, Waranuch N. (PubMed)
(2) Germacrene Analogs are Anti-androgenic on Androgen-dependent Cells by Srivflai J, Khorana N, Waranuch N, Wisuitiprot W, Suphrom N, Suksamrarn A, Ingkaninan K. (PubMed)
(3) Minoxidil use in dermatology, side effects and recent patents by Rossi A1, Cantisani C, Melis L, Iorio A, Scali E, Calvieri S. (PubMed)

Monday 14 October 2019

Healthy Food Onion Protects the brain Neuron Against Anxiety and Depression Induced by Stress

By Kyle J. Norton

Neurological disorders are a class of diseases of the nervous system caused by structural, biochemical or electrical abnormalities in the brain, spinal cord or nerves.

Neurodegenerative disease is a type of neurological disorder associated with the progressive loss of neuron in the brain caused by several mechanisms, including toxicity and oxygen deficiency.

Anxiety is a natural response to the stress involved in the feeling of fear of the event and event outcome.

Depression is a common and serious psychological condition associated with the negative feeling, that affects the way of thinking and acting.

Besides neurodegenerative disease, the most common types of neurological disorder are

epilepsy, multiple sclerosis, and migraines.

According to statistics provided by the Psychological Guide, neurological disorders affect millions of people around the world, including 326 million who suffer migraines.

There is no single cause of the neurological disorder. Some researchers suggested that unhealthy lifestyle, genetic preposition, nutrient, infection, and physical injury are some of the most prevalent factors found in most patients.

If you have experienced symptoms of seizures, difficulty reading, and writing, poor cognitive abilities, unexplained pain, muscle weakness, and decreased alertness, mood swing, depression and delusions, you may have some form of neurological disorder. Please check with your doctor to rule out the possibility

The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.

On finding a potential compound for the prevention of stress-induced psychological syndromes researchers examined the effects of onion (AC) on single immobilization stress-induced biochemical and behavioral changes.

The experiment included mice in the test group were treated with AC powder (200 mg/kg/day), dissolved in water, while the control group received drinking water for 14 days.

According to the results after 14 days of treament that control and AC treated mice were further divided into unstressed and stressed groups,

* Administration of AC showed significant activity in attenuating the immobilization stress-induced behavioral deficit.

* AC also improved the memory performance was observed in stressed mice in maze test (EPM).

* AC pretreatment group also demonstrated a strong reduction of brain lipid peroxidation, increased antioxidant enzymes (SOD, CAT, GPx) and reduced acetylcholinesterase (AChE) levels.

In other words, the injection of AC inhibited the brain oxidative stress in the tested mice by promoting the production of antioxidants enzymes in the host.

Based on the finding, researchers suggested, "a role of antioxidant enzymes in the attenuation of 2-h stress-induced anxiety and depression, and enhanced cognitive function as well by AC".

More precisely, AC protected the brain neurons integrity and viability against the parameters induced by stress.

Sources
(1) Administration of Allium cepa L. bulb attenuates stress-produced anxiety and depression and improves memory in male mice by Samad N1, Saleem A. (PubMed)

Herbal Ashwagandha Exerts Cytotoxicity Against Leukemia in Vitro

By Kyle J. Norton

Leukemia is a condition characterized by an abnormal increase of white blood cells produced by the bone marrow and/or the lymphatic system. Depending on the malignant granulocytes or lymphocytes, leukemia is classified into myelogenous or lymphoblastic leukemia.

Bone marrow, containing two main types of stem cell is soft tissue inside the hollow center of the major bone, including the spine, pelvis, underarm, leg. etc. with the main function of generating blood cells.

Believe it or not, the bone marrow produces 200 billion new red blood cells every day, to replace the blood cells that die off, along with white blood cells and platelets.

According to the statistics provided by the leukemia research, leukemia is diagnosed 10 times more often in adults than children. Approximately, each year the disease causes death 68,000 American.

Acute leukemia is a condition caused by a rapid increase in the numbers of extreme immature white blood cells which appear in the bloodstream into other parts of the body, including tissue and organs, including acute lymphoblastic leukemia (ALL), acute lymphocytic leukemia (ALL) and acute myeloid leukemia (AML).

In ALL, lymphocytes appear immature in the bloodstream. Acute lymphoblastic leukemia (ALL) is the most common children forms of leukemia with about 80% of all cases.

Chronic leukemia is a condition of the slow but still excessive build-up of relatively mature abnormal white blood cells. the condition has a tendency to spread slowly to other parts of the body through the bloodstream and/or lymphatic system, including chronic lymphocytic leukemia (CLL) and chronic myelogenous leukemia (CML).

Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

On finding a potent compound for the treatment of leukemias, researchers explored the antileukemic activity of the dimethyl sulfoxide extract obtained from the roots of W. somnifera (WE).

On a human T-lymphoblastoid cell line, WE exerted a significant cytostatic and cytotoxic activity against the tested cell line observed by the differentiation of the different flow cytometric assays.

Furthermore, WE cytotoxic and cytostatic potential was atrribited to the effect involving in immunogenic cell death (ICD) observed in dying cancer cells that release damage-associated molecular patterns.

Furthermore, WE also promoted the intracellular Ca(2+) accumulation that alters cancer initiation and the generation of reactive oxygen species to induce cancer cell apoptosis.

In other words, the tested extract processed genotoxic potential. against leukemia cells in vitro.

Based on the findings, researchers said, "Since the use of Withania is suggested in different contexts including anti-infertility and osteoarthritis care, its genotoxicity should be carefully considered for an accurate assessment of its risk-benefit profiles".

Taken altogether, Ashwagandha may be considered a functional herb for the prevention and treatment of leukemia, pending to the result of larger sample size and multicenter study

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Withania somnifera Induces Cytotoxic and Cytostatic Effects on Human T Leukemia Cells by Turrini E1, Calcabrini C2, Sestili P3, Catanzaro E4, de Gianni E5, Diaz AR6, Hrelia P7, Tacchini M8, Guerrini A9, Canonico B10, Papa S11, Valdrè G12, Fimognari C. (PubMed)

Sunday 13 October 2019

The 47 Health Benefits of Onion and Counting, Researchers Say

By Kyle J. Norton

The onion is a plant in the genus Allium, belongings to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.

and Counting

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

The 54 Health Benefits of Tomato and Counting, According to Scientific Studies

By Kyle J. Norton

Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, tomato is grown worldwide for commercial purposes often in the greenhouse.
1. How to Maintain A Healthy Skin, Naturally and Permanently, PubMed Studies Find
2. Tomatoes EnhanceYour Immunity Naturally, US National Library of Medicine Studies Suggest
3. How to Have a Perfect Breath and Optimal Oral Health Naturally
4. Tomatoes, The Vegetables Which Normalize the Blood Pressure in Hypertensive Patients
5. The Easy Way to Prevent Osteoporosis That No One Wants to Tell --Eat Your Tomato, Scientists Say
6. Tomato Improves Sleep Quality by Enhancing Levels of Melatonin
7. Tomato, the Anti Hyperlipidemia Functional Food for Type 2 Diabetics
8. Whole Food Tomatoes, Protects the Aging Vision Against Age-related Macular Degeneration (AMD)
9. Whole Food Tomato Protects the Lung Against Pulmonary Oxidative Stress
10. Whole Food Tomato Protects Diabetics Against Complications Caused by Oxidative Stress
11. Cooked Tomatoes, Protect the Blood Vessels Against the Onset of stroke
12. Whole Food Tomato and Its Bioactive Compound Lycopene Protect the Obese Patients Against Complications
13. Tomatoes Normalize the Blood Glucose Against Hyperglycemia on Diabetes
14. Whole Food Tomatoes, the Natural Treatment of Hypercholesterolemia
15. Whole Food Tomatoes Protect Your Stomach Against Gastric Cancer in Human Studies
16. Whole Food Tomatoes, the Best to Prevent and Treat Metabolic Syndrome, According to Human Studies
17. Whole Food Tomato, The Potent Inhibitor Against Platelet Aggregation in Vitro and Vivo.
18. Whole Food Tomato Modulates Hormone Angiotensin Against the Onset of Heart Disease
19. Tomato the Potent Anti Digestive-Tract Cancer Functional Food, Human Studies Show
20. Whole Food Tomato Inhibits Gene and Factors Associated with Obesity Complications in Vivo
21. Tomatoes Protect the Liver Against Non-alcoholic Steatohepatitis in Vivo
22. Healthy Food Tomatoes' Lycopene Inhibits Primary Lung Cancer
23. Whole Food Tomato Promotes the Lung Function in Human Trials
24. Whole Food Tomato Protects Your Heart Against Cardiovascular Diseases
25. Whole Food Tomato Improves Glucose Tolerance in Diabetics in Vivo
26. Whole Food Tomato Suppresses the Onset of Pulmonary Diseases
27. Whole Food Tomato Normalizes Hepatic Markers Against Liver Damage and Injury
29. Healthy Food Tomato, A Potential, and Natural Prevention and Treatment of Cancer
30. Whole Food Tomato Protects the Tissues of Stomach Against Gastric Injury
31. Whole Food Tomato, the Best Anti-Inflammatory Remedy with No Side Effects
32. Tomato Inhibits the Onset of Non-alcoholic Steatohepatitis
33. Herbal Tomato Promotes Immunomodulatory Activity Against the Onset of Colitis In Vivo
34. Whole Food Tomato Promote the Ratio of Gut Microbiota For Optimal Health
35. Healthy Food Tomato Inhibits Hepatic Steatosis in Vivo
36. Whole Food Tomato Protects the Obese Against Obesity-Related Co-Morbidities
37. Whole Food Tomato Balances the Ratio of Intestinal Microbiomes in the Gut
38. Whole Food Tomatoes prostate (PC3) Protects The Cells of Prostate Gland Against Prostate Cancer, Studies Show
39. Healthy Food Tomato Protects The Integrity of Neurons Against Neurological Disorders in Vivo
40. Whole Food Tomato Modulates Immune Function to the Body Needs
41 Healthy Food Tomato Induces Cytotoxicity Against Cancer Cells
42. Whole Food Tomatoes, the Best Antioxidant Functional Food
43. Tomato Protects the Ovary Against Cell DNA Alternation
44. Broccoli and Tomato Inhibits Elevated Hormone Resistin Associated with Insulin Resistance
45. Whole Food Tomato, the Anti-Insulin Resistance Natural Remedy
46. Whole Food Tomato Apoptoses Liver Cancer Better Than of Doxorubicin and Camptothecin in Vitro
47. Cooked Tomato's Lycopene Protects Protein, Lipid and Cell Damage Against Oxidative Stress in Human Studies
48. Healthy Food Tomato, the Natural and Potential Anti-Inflammatory Remedy
49. Tomato's Phytochemical Carotenoids Block the Onset of Colorectal Cancer in Patients with DICER1 rs3742330 Genotypeancer
50. Tomatoes Kill Bacterial Staphylococcus Aureus Against the Onset of Pneumonia
51. Tomato/Lycopene the Anti Cancers Functional Food
52. Whole Food Tomato Inhibits Colorectal Cancer in Vitro and Vivo
53. Whole Food Tomatoes, Kill Breast Cancer in Vitro
54. Tomato Inhibits the Onset and Progression of Non-Alcoholic Fatty Liver Disease (NAFLD)
55. Healthy Food Tomatoes inhibits the Growth and Progression of Liver Cancer in Vivo

and Counting

Turmeric Protects the Heart Muscles Against Cardiotoxicity in Vivo

By Kyle J. Norton

Cardiac toxicity is a condition in which the heart has been damage to some extent caused by harmful chemicals, including toxins induced by the treatment of chemotherapy.

Cardiac toxicity reduced heart muscle function to pump blood and is a leading cause of heart failure.

Long term intake of certain medication and people who are under treatment of chemotherapy have been found in most cases of cardiotoxicity.

Dr. Danúbia Silva dos Santo and colleagues in the examination of doxorubicin (DOX) in the risk of cardiotoxicity wrote, "Doxorubicin (DOX) is among the most effective anticancer agents ever developed. DOX has been used mainly for the treatment of breast cancer, solid tumors in children, soft tissue sarcomas, and aggressive lymphomas".

However, researchers continued, "the use of DOX may have dose-dependent cardiotoxic effects that generate changes in myocardial structure, which can develop into severe and irreversible cardiomyopathy".

Additionally, human immunodeficiency virus (HIV) infection, genetic preposition, a malignant disease associated with the amyloid deposited on the heart or other organs, high blood pressure, untreated hyperthyroidism, and vitamin b2 deficiency are some of the most prevalent factors found in patients with cardiotoxicity.

Depending on the cells of the areas of the heart that have been damaged, cardiac toxicity includes cardiomyopathy, myocarditis, pericarditis, acute coronary syndromes, and congestive heart failure.

Most common symptoms of cardiotoxicity are associated with not enough blood circulation in the body such as tiredness and fatigue, a long-term (chronic) cough, shortness of breath, floating due to the enlarged heart muscle, abnormal heart or lung sounds and swelling in your hands, feet, or unusual weight gain.

Conventionally, treatment of cardiotoxicity is totally depending on the types of the disease including
Beta-blockers, ACE inhibitors induce (widen) the arterial dilation and improvement of the blood flow and diuretics.

Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On findings a potential compound for the treatment of heart disease associated with chemical toxicity, researchers examined the effect of nanomicelle curcumin on BPA-induced subchronic cardiotoxicity in rats.

The selected rat was randomly divided into 6 groups including control, nanomicelle curcumin (50 mg/kg, gavage), BPA (50 mg/kg, gavage), nanomicelle curcumin (10, 25, and 50 mg/kg) plus BPA for 4 weeks.

Based on the results of assays, BPA significantly induced cardiac injuries including focal lymphatic inflammation, nuclear degenerative changes, and cytoplasmic vacuolation associated with inflammation.

Compared to the control, BPA caused the increased body weight, systolic and diastolic blood pressures, and cardiac stress observed by the increased levels of malondialdehyde and myocardial cell wall injury observed by the creatine phosphokinase-MB level.

Furthermore, levels of antioxidant enzymes in the rat also such as glutathione content was also decreased by the BPA injection.

The cardiac injury in BPA also observed by the electrocardiographic graph, RR, QT, and PQ intervals.

BPA also found to induce increased expression of genes associated with cardiac cell apoptosis and inhibited genes expression of cardiac cell survival.

However, nanomicelle curcumin (50 mg/kg) administration significantly reduced the BPA toxic effects induced the aforementioned parameters in rat heart tissue.

Based on the findings, researchers said, "The results provide evidence that nanomicelle curcumin showed preventive effects on subchronic exposure to BPA induced toxicity in the heart tissue in rats".

Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of cardiotoxicity, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The protective activity of nanomicelle curcumin in bisphenol A-induced cardiotoxicity following subacute exposure in rats by Valokola MG1, Karimi G1,2, Razavi BM1,3, Kianfar M1, Jafarian AH4, Jaafari MR5, Imenshahidi M. (PubMed)
(2) Doxorubicin-Induced Cardiotoxicity: From Mechanisms to Development of Efficient Therapy By Danúbia Silva dos Santos and Regina Coeli dos Santos Goldenberg