Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Sunday 28 July 2019

Phytochemical Betanin, the Best Free Radical Scavenger

By Kyle J. Norton

Antioxidants are stable atoms which inhibit oxidation caused by free radical.

Free radical scavengers are types of antioxidant that inhibit free radicals before they can orchestrate a chain reaction that can not be stopped until all electrons in the outermost ring are paired or inhibited by antioxidants.

Oxidative stress is associated with chronic disease due to the imbalanced ratio of free radicals and antioxidants produced by the host includes heart disease, stroke, and diabetes.

Antioxidants besides produced by the body, they can also come into the body dietary sources.

In a healthy individual, an antioxidant produced by the body is good enough to counter the expression of free radicals induced by cell metabolism and free radicals induced by the environment such as the air we breathe and the food we eat.

However, people with a weakened immune system, intake of antioxidant from outside sources such as fruits and vegetables can be helpful.

Believe it or not. moderate free radicals in the body are necessary for the body functioning, including the promotion of heart function in blood circulation.

Most common types of free radical scavengers include
* Catalases, the very important enzyme is produced by the host that protect the cell from oxidative damage by free radicals.

*Glutathione peroxidase, is a cytosolic enzyme produced by the host that dissolves hydrogen peroxide to water and oxygen and peroxide radicals to alcohols and oxygen.

*Superoxide dismutase (SOD), is also produced by the host that dissolves superoxide radical into either ordinary molecular oxygen or hydrogen peroxide.

*Vitamin E, Vitamin C, and vitamin D.

Betanin is phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.

In the urgency to find a natural compound for the treatment of diseases associated with overexpression of free radicals, researchers examined the betanin free radical scavenging activity.

According to the Trolox equivalent antioxidant capacity (TEAC) assay, at a pH > 4, betanin is about 1.5-2.0-fold more active to scavenge free radical compared to those of anthocyanins.

More precisely, the exceptionally high antioxidant activity of betanin was associated with an increase of its H-donation and electron-donation ability, totally depending on the expression of cationic state to mono-, di- and tri-deprotonated states present at basic solutions.

In other words, the efficacy of betanin high free radical scavenging activity was dependent on the levels of pH.

Taken altogether, betanin may be considered supplements for the prevention and treatment of diseases associated with oxidative stress, pending to the confirmation of larger sample size and multicenter human study.

Intake of betanin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Betanin, the main pigment of red beet: molecular origin of its exceptionally high free radical-scavenging activity by Gliszczyńska-Swigło A1, Szymusiak H, Malinowska P. (PubMed)
(2) Betacyanins as phenol antioxidants. Chemistry and mechanistic aspects of the lipoperoxyl radical-scavenging activity in solution and liposomes by Tesoriere L1, Allegra M, Gentile C, Livrea MA. (PubMed)

Whole Food Tomato, the Anti-Insulin Resistance Natural Remedy

By Kyle J. Norton

Insulin resistance is a condition in which cells that convert glucose to energy in the muscles, body fat, intestine, and liver ignore the signal o the hormone insulin signaling.

In other words, patients with insulin resistance are hyperglycemic. The syndrome is a hallmark of type 2 diabetes.

According to statistics, over 100 million Americans are living with insulin resistance. Approximately 1 in 3, including half of those age 60 and older have a silent blood sugar problem known as insulin resistance.

There are no single causes of insulin resistance, Epidemiologically, aging, ethnicity, overweight or obese, too much belly fat, physical inactivity, smoking and certain medical conditions such as Cushing’s disease or polycystic ovary disease are some of the prevalent factors that induce the risk of the condition.

However, most people with some of the aforementioned risk factors have never developed insulin resistance.

Most common symptoms of patients with insulin resistance are tiredness, hunger and difficulty concentrating.

If you have experienced the above symptoms persistently, you may have insulin resistance, please make sure that you check with your doctor to rule out the possibility.

Out of many factors that increase the risk of insulin resistance, some researchers suggested the promotion of a high-fat diet over the past few decades may have a strong and negative impact on the rise of insulin resistance in the US.

Dr. Chad R. Hancock, the lead scientist wrote, "feeding rats high-fat diets that cause muscle insulin resistance results in a concomitant gradual increase in muscle mitochondria"

And, "a high-fat diet that raises FFA results in a gradual increase in mitochondria in rat skeletal muscle, with an increase in the capacity for fat oxidation, concomitant with the development of muscle insulin resistance".

Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

On findings a healthy food for the controlling high blood glucose, researchers examined the effect of dry tomato peel (DTP) on insulin resistance, and atherogenic dyslipidemia induced by a high-saturated-fat (HSF) diet on an animal model for 12 weeks.

The study included 40 selected BALB/c male mice (n=40) (8 weeks old, weighing 22.2±1.0 g) divided into four treatment groups (10 mice/group): (a) high-fat control diet (HF Ctrl), which contains sunflower oil as a sole source of fat; (b) HSF/high-cholesterol (HC) diet; (c) HSF/HC diet supplemented with 9% DTP and (d) HSF/HC diet supplemented with 17% DTP.

According to the results from the tested assays, supplementation with DTP not only increased the plasma lycopene concentration and reduced the development of indicators of metabolic syndrome, particularly in insulin resistance.

However, hepatic steatosis and inflammation caused by the injection of high-fat diet mice were not reversed with DTP supplementation.

In other words, DTP improved the plasma concentration of lycopene by normalizing the levels of blood glucose in tested mice through its anti-insulin resistance activity.

Dr. Zidani S, the lead scientist said, "Among mice fed the HSF/HC diet, DTP supplementation appears to have a beneficial effect on insulin resistance, which confirms the antiatherogenic effect of DTP".

In vivo, also in high-fat diet (HF)-induced obese mice, tomato vinegar beverage (TVB) at 14 mL kg(-1) body weight for 6 weeks not only inhibited the symptoms associated with fat accumulated in the liver but also promoted glucose tolerance, hyperinsulinemia, and HOMA-IR levels.

Levels of antioxidants in the tested also significantly improved by TVB. TVB inhibited oxidative stress by significantly increased glucokinase activity and decreased glucose-6-phosphatase activity in the liver,

More precisely, TVB enhanced glucose metabolism in obese mice.against the onset of insulin resistance.

Based on the findings, researchers wrote, "These results suggest that TVB prevents visceral obesity and insulin resistance via AMPK/PPARα-mediated fatty acid and glucose oxidation (Antioxidant property(TVB)".

Taken altogether, tomato may be considered a dietary supplements for the prevention and treatment of insulin resistance, pending to large sample size and multicenter human study.

Sources
(1) Effect of dry tomato peel supplementation on glucose tolerance, insulin resistance, and hepatic markers in mice fed high-saturated-fat/high-cholesterol diets by Zidani S1, Benakmoum A2, Ammouche A3, Benali Y4, Bouhadef A4, Abbeddou S. (PubMed)
(2) Anti-obesity and anti-insulin resistance effects of tomato vinegar beverage in diet-induced obese mice by Seo KI1, Lee J, Choi RY, Lee HI, Lee JH, Jeong YK, Kim MJ, Lee MK. (PubMed)
(3) High-fat diets cause insulin resistance despite an increase in muscle mitochondria by Chad R. Hancock, Dong-Ho Han, May Chen, Shin Terada, Toshihiro Yasuda, David C. Wright,and John O. Holloszy. (PubMed)

Saturday 27 July 2019

Cabbage and Baby Spinach in the Promotion of Digestive Health

By Kyle J. Norton

Gastrointestinal diseases are the conditions of the digestive system associated with the disorders involving the gastrointestinal tract, including esophagus, stomach, small intestine, large intestine, and rectum.

The digestive system includes gastrointestinal tract (GI), liver, pancreas, and gallbladder with a healthy function of breaking down food into nutrients and fluids for the body need.

There are many different types of gastrointestinal diseases, including irritable bowel syndrome (IBS), Crohn's disease, celiac disease, and lactose intolerance.

Most common causes of gastrointestinal diseases are a bacterial or viral infection, inflammation, poor circulation of the intestines, muscle dysfunction, gallstones, stress, particularly long-term use of anti-inflammatory drugs. However, gut microbiota, a community of microorganisms living in the gastrointestinal tract has been found to induce a significant effect on digestive health if imbalanced, including
* Reducing the function of gut microbiota to absorb the dietary nutrients of the digestive system, in nutrient metabolism,

* Reducing the function of gut microbiota in the inhibition of xenobiotics and drug toxicity through facilitating the excretion, in xenobiotic, and drug metabolism,

* Reducing the structural integrity of the gut mucosal barrier, leading to the weakened the epithelial cells function to protect the intestine against invasive pathogens.

* Reducing the gut microbiota interaction with the immune system against inflammatory immune disorders and inhibition of the risk of gastrointestinal diseases and non-gastrointestinal diseases caused by overexpression of bad bacteria, in immunomodulation.

Conventional medicine used for the treatment of gastrointestinal disorders is depending on the disease that triggers the disorder.such as antibiotics for bacterial infection, painkillers for stomach pain.

Cabbage is a species of Brassica oleracea belongings to the family Brassicaceae (or Cruciferae), native to the Mediterranean region along the seacoast. The veggie has a short stem of which is crowded a mass of leaves, usually green but in some varieties, it may be red or purplish.

On finding a natural compound for the improvement of digestive function in the absorption of nutrients, researchers examined the effects of co-digestion of a carotenoid-rich vegetable such as carrot, cherry tomato or baby spinach with an anthocyanin-rich vegetable such as red cabbage
intestinal cellular bioaccessibility (cBAC).

According to the analysis of the chemical constituents, the tested vegetables processed the concentration of % cBAC of lutein was 0.23-1.42%, lycopene 0.07-0.39%, α-carotene 0.01-0.12% and β-carotene 0.03-0.61% respectively.

Furthermore, the co-digestion of the vegetables/salads resulted in synergy in cellular antioxidant activity compared to those without salad.

Moreover, cellular anti-inflammatory activity was also a significant increase in vegetable co-digestion compared to single vegetable alone.

Additionally, among the tested vegetables, baby spinach co-digested with red cabbage showed synergistic bioactivities in all tested assays.

In other words, co-administration of vegetables work synergistically to provide higher improvement of digestive function compared to single vegetable through their antioxidant and anti-inflammatory activity.

Taken altogether, red cabbage may be considered a functional food for the promotion of digestive health, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effects on intestinal cellular bioaccessibility of carotenoids and cellular biological activity as a consequence of co-ingestion of anthocyanin- and carotenoid-rich vegetables by Phan MAT1, Bucknall MP2, Arcot J. (PubMed)

Turmeric and ω-3 Fatty Acids, the Natural Prevention and Treatment of Migraine Headache

By Kyle J. Norton

A headache is a condition characterized by pain in the region around the head or neck. Normally, it is a symptom of a number of different effects of certain diseases or the head and neck themselves.

Migraine headache is one most common headaches associated with a chronic neurological disorder of moderate to severe headaches, and nausea that usually develops gradually over 5–20 minutes and lasts for less than 60 minutes.

According to the statistics, approximately 15% of American have a migraine headache, as a result of the change in the brain and its surrounding blood vessels.

The exact causes of migraine headache are not identified. However, smoking, use of hormonal contraceptives, depolarization inside the neurons, long-term stress, abnormal calcium channels, and reduced magnesium levels, are some of the prevalent factors found in patients with the condition.

Most common symptoms of migraine headache are

* The prodrome symptoms happen in 40–60% of migraines is an occurrence of early symptoms that indicate the start of a migraine headache attacks, including altered mood, irritability, depression or euphoria, fatigue, yawning, excessive sleepiness, craving for a certain food, etc.

* The aura found in approximately 20 -40% migraine sufferers are symptoms of comprised focal neurological phenomena that appear gradually over five to 20 minutes and last fewer than 60 minutes.

* The pain phase is a headache phase of the migraine attack usually begins within 60 minutes of the end of the aura phase.

* After the pain phase, 68% of the sufferers may experience the postdrome that may be lasted for average of 24 hours, including tiredness (71.8%), head pain (33.1%), cognitive difficulties (11.7%), ‘hangover’ (10.7%), gastrointestinal symptoms (8.4%), mood change (6.8%), and weakness (6.2%) with commonest symptoms being tiredness and low-grade headache.

Conventionally, treatments of a migraine headache include pain-relieving medications and prevention medication.

Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a potential compound for the treatment of headache, researchers examined the immunomodulatory effects of ω-3 fatty acids, nano-curcumin, and a combination of the two, on neuroinflammation and clinical symptoms in migraine patients.

The study included 74 episodic migraine patients received ω-3 fatty acids, nano-curcumin, a combination of them, or a placebo for a 2-month period.

According to the measurement of the expression of COX-2/iNOS (in peripheral mononuclear blood cells isolated from patients) and COX-2/iNOS serum levels, before and after the experiment researchers found

* Application of ω-3 fatty acids and nano-curcumin worked synergistically in the inhibition of the COX-2/iNOS mRNA and serum levels that have been found to induce inflammation in the brain.

* Furthermore, the combination also protected the neuron integrity in controlling the facial sensations that significantly reduce the frequency, severity, and duration of headaches.

After taking other factors into account, researchers wrote, "combination therapy of ω-3 fatty acids and nano-curcumin can be considered as a promising new approach in migraine prevention".

Taken altogether, turmeric used alone or combined with ω-3 fatty acids may be considered supplements for the prevention and treatment of migraine headache pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The Neuromodulatory Effects of ω-3 Fatty Acids and Nano-Curcumin on the COX-2/ iNOS Network in Migraines: A Clinical Trial Study from Gene Expression to Clinical Symptoms by Abdolahi M1, Jafarieh A2, Sarraf P3, Sedighiyan M4, Yousefi A2, Tafakhori A3, Abdollahi H1, Salehinia F1, Djalali M. (PubMed)

Mustard Promotes Depressant-Like Activity

By Kyle J. Norton

Depression is a normal response as part of our daily lives such as the loss of s job, the death of a loved one, and illness or a mental health disorder that can affect the way you eat, sleep, and the way you feel about yourself.

According to statistics provided by the WHO, depression is the leading cause of disability worldwide. Almost 75% of people with mental disorders remain untreated in developing countries with almost 1 million people taking their lives each year. In the US, approximately, 17.3 million adults had at least one major depressive episode.

The exact causes of depression are not identified. However, researchers suggested genetic preposition, brain chemistry, and change of hormone in the body are some of the common factors associated with the onset of the condition.

Most common symptoms of depression are psychological and physical related problems, including feelings of sadness, tearfulness, emptiness or hopelessness, irritability or frustration, loss of interest in most or all normal activities, such as sex, hobbies or sports, sleep disturbances, and reduced appetite and weight loss or increased cravings for food and weight gain.

Conventionally, depressant is a type of medicine used as a first-line treatment of depression. Some researchers suggested that making lifestyle changes such as regular moderate exercise, enough sleep, social support, healthy diet, and stress reduction can also contribute to successful depressive management.

Dr. Jerome Sarris and colleagues wrote, "There is now compelling evidence that a range of lifestyle factors are involved in the pathogenesis of depression. Many of these factors can potentially be modified, yet they receive little consideration in the contemporary treatment of depression, where medication and psychological intervention remain the first-line treatments".

And, "“Lifestyle Medicine” provides a nexus between public health promotion and clinical treatments, involving the application of environmental, behavioral, and psychological principles to enhance physical and mental wellbeing".

The mustard plant is a plant species in the genera Brassica and Sinapis belongings to the family Brassicaceae.
On finding a potent compound with depressant activity, researchers evaluated the depressant-like activity of a methanolic extract of B. juncea (Mustard) leaves.

The study included alloxan monohydrate (120 mg/kg, ip) induced diabetic and nondiabetic rodents, pretreatment with methanolic extract of B. juncea leaves (BJ 100, 200, and 400 mg/kg/day, po).

According to all behavioral tests in diabetic rats and mice, pretreatment of all concentration of the methanolic extract of B. juncea leaves and Imipramine exhibited depressant and anti-motor function depressive effects.

Furthermore, repeated daily BJ treatments in a dose-dependent manner also increased the decreased contents of dopamine, norepinephrine, and serotonin associated with stress in the brain of diabetic rats induced alloxan monohydrate.

Moreover, brain dopamine level associated with increased activity in the reward and pleasure areas of the brain of BJ treated normal rats was much higher than that in control nondiabetics.

Based on the findings, researchers said, " BJ could be a nutritional alternative for combating exaggerated depression commonly associated with diabetes".

Taken altogether, mustard may be considered a functional food for the treatment of depression, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Antidepressant-like effects of Brassica juncea L. leaves in diabetic rodents by Thakur AK, Chatterjee SS, Kumar V. (PubMed)
(2) Lifestyle medicine for depression by Jerome Sarris,

1,2 Adrienne O’Neil,3,4 Carolyn E Coulson,3 Isaac Schweitzer,1 andMichael Berk. (PMC)

Friday 26 July 2019

Lycopene Processes A Strong Cardio Protective Activity

By Kyle J. Norton

Cardiovascular disease is a class of condition associated with the heart and blood vessels. In other words, CVD can be a result of anything that impedes the function of heart and blood vessels.

Cardio-protection is a process to preserve the function and integrity of the cardiac muscle cell.
In other words, cardio-protection is an action that protects heart muscle against damage, including the use of herbal medicine.

Cardiotoxicity induced by toxins reduced the heart pumping blood capability, leading to a decrease in oxygen-rich blood to nourish the body tissues and organs. Most common causes of cardiotoxicity are associated with patients who received chemotherapy and certain medications.

The heart formed part of the circulatory system is a muscular organ that pumps blood through the blood vessels to nourish the body cells, tissues and organs with oxygen and nutrients, and remove metabolic wastes.

Plaques building up inside the arteries as a result of high blood cholesterol and other substances such as calcium over time can harden and narrow the arteries, leading to a blood clot. A blood clot that causes damage to the heart muscles has been found to induce heart disease.

CVD is also found in many patients with high blood pressure which contributes to the hardening of the arteries.

Moreover, in the case of a blood clot that reduced blood flow to the brain, it causes a stroke.

Stroke is the leading cause of long-term disability in the United States. Each year, approximately 795,000 people suffer a stroke, including 600,000 first attacks, and 185,000 recurrent attacks.

According to the CVD statistics, heart disease kills more than 2,000 Americans every day.
Approximately 60 million Americans are living with heart disease.

Most common risk factors associated with the onset of cardiovascular disease are the increase of age. an unhealthy diet, lack of exercise, being overweight and smoking.

Lycopene is a phytochemical found in red fruits and vegetables in the class of carotenoid, a natural pigment with no vitamin A activity such as tomatoes, red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and perform various functions in photosynthesis.

On finding a potent ingredient for the protection of cardio damage, researchers examined the lycopene's cardioprotective effects against DFS and tulathromycin.

The study included Swiss albino mice that were divided into seven groups (eight per group) received saline (control), tulathromycin (a single subcutaneous dose of 28 mg/kg/bw on day 14), DFS (a single oral dose of 100 mg/kg/bw on day 14), tulathromycin plus DFS, or lycopene (oral, 10 mg/kg/bw daily for 15 d) combined with tulathromycin, DFS, or both.

According to the tested analysis, tulathromycin or DFS treated groups (individually or in combination) displayed a significantly elevated (p < 0.05) serum levels of Creatine kinase-myocardial B fraction (CK-MB), lactate dehydrogenase, and cardiac-specific troponin-T, the cardio-markers associated with significant heart tissue damage.

Furthermore, cardio oxidative stress markers were also elevated in the tulathromycin or DFS treated groups tissue, including levels of nitric oxide and malondialdehyde.

The levels of antioxidant enzymes in the host treated by tulathromycin or DFS were significantly decreased observed in the cardio tissues, observed by the glutathione content and glutathione peroxidase, superoxide dismutase, and catalase antioxidant.

Moreover, compared to the control group, the mean pathology scores and the percentages of proteins involved in the production of pro-inflammatory cytokines were also increased substantially in the tulathromycin- and/or DFS-treated groups.

Believed it or not, co-administration of lycopene in the tulathromycin- and/or DFS-treated groups showed a significant amelioration of all parameter changes that caused cardio tissue damage.

Based on the findings, researchers said, "DFS could potentiate the cardiotoxic effects of tulathromycin, whereas lycopene can serve as a cardioprotective agent against DFS and tulathromycin."

Taken altogether, lycopene found in tomato may be considered supplements for the prevention and treatment of cardio damage, pending on the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources

(1) Aflatoxin B1 induced renal and cardiac damage in rats: Protective effect of lycopene by Yilmaz S1, Kaya E2, Karaca A2, Karatas O. (PubMed)

(2) Lycopene Attenuates Tulathromycin and Diclofenac Sodium-Induced Cardiotoxicity in Mice by Abdel-Daim MM1, Eltaysh R2, Hassan A3, Mousa SA. (PubMed)

Bromelain Induces Immunogenicity for the Needs of the Body

By Kyle J. Norton

Immunogenicity is a condition in which immune responses are regulated. In other words, immunogenicity is the ability to modulate the immune response to the body needs.

The immune system is the set of cells and their activity against antigens or infectious agents that comprises of the body's defense system against diseases.

The immune system plays a critical role in keeping us healthy and preventing infections.

The immune response is an action of the immune system activated by antigens, including immune response to pathogenic microorganisms and its products, allergies, graft rejections, as well as autoimmunity to self-antigens.

The immune response after pathogen recognition by the immune system, the macrophage cells stimulates the production of the release of pro-inflammatory cytokines with an aim to destroy the pathogens which try to enter the body.

With the antigen presentation takes place, the immune system also activates specific T helper cells

CD4 helper T cells that coordinate a targeted antigen-specific immune response.

However, if the immune system fails to kills all pathogens in the acute phase of infection in a set period of time between 3-8 weeks, it will compromise, leading a low-grade inflammation, a condition that facilitates many chronic diseases.

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

On finding a potential compound for the treatment of chronic inflammatory, malignant and autoimmune diseases, researchers examined the effects of bromelain immunological effect.

According to the tested assays,

* Bromelain induces pro-inflammatory cytokine production in peripheral blood mononuclear cells in vitro.

* Compared to no effect of IFN-alpha and IFN-gamma applied alone, bromelain synergistically increased TNF production.

* Injection of bromelain has a higher (10- to 40-fold) inducing capacity for TNF production compared to the untreated enzyme.

* Furthermore, PBMNC of healthy donors acquire the ability to produce TNF-alpha, IL-1 beta and IL-6 when incubated ex vivo with IFN-gamma compared to peripheral blood mononuclear cells in vitro.

Where IFN-alpha and IFN-gamma are cytokines that is critical for innate and adaptive immunity against viral, some bacterial and protozoal infections.

In other words, the oral administration of bromelain is related to their ability to induce cytokine production by modulating the immune activity.

Based on the findings, researchers said, "the biological effects observed after oral administration of polyenzyme preparations are related to their ability to induce cytokine production. This may explain the antitumor effects of such enzymes".

More precisely, "polyenzyme preparations may have a stronger immunomodulatory effect when used in combination with IFN-gamma".

Taken altogether, bromelain used alone or combined with conventional medicine may be considered a remedy for immunological effect, pending to the confirmation of the larger sample size and multicenter human study.