Herbal Turmeric Optimizes the Intestinal Mucosal Barrier Function Against Pathogens

By Kyle J. Norton


Intestinal mucosa processes a single cell layer of epithelial cells with a function to protect the intestine against invasive pathogens and ensure the function of intestinal in nutrients adsorption.

Biologically, the intestinal protection of the intestinal mucosal barrier function is associated with
*Bile and gastric acid produced the liver and stomach that only aid digestion but kills microorganism

* Defensins secretory epithelial cells with a function to protect the intestines against bacteria, fungi and many enveloped and nonenveloped viruses.

* Lysozyme is an enzyme that protects the intestine by causing the destruction of the cell walls of certain bacterias.

* Regenerating islet-derived protein 3 gammas (Reg3γ), an antibacterial lectin is a type of antimicrobial peptides found in the gut epithelial Paneth cells with a function to prevent microorganisms from coming into contact with the epithelial layer.

In other words, the intestinal mucosal barrier plays an essential role in the separation of the inside of the body from the outside environment, particularly in harmful microorganisms.

Dr. Oshima T the lead scientist in the examination of light junctions (TJs), the most important component for the construction of a constitutive barrier of epithelial cells that regulates the permeability of the barrier by tightly sealing the cell-cell junctions, wrote, "Gastrointestinal diseases including reflux esophagitis, inflammatory bowel disease, functional gastrointestinal disorders, and cancers may be regulated by these molecules, and disruption of their functions leads to chronic inflammatory conditions and chronic or progressive disease".

And, "regulation of the barrier function of epithelial cells by regulating the expression and localization of TJ proteins is a potential new target for the treatment of these diseases".

More precisely, by improving the intestinal mucosal barrier function, diseases associated with the gastrointestinal tract may be preventable.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

With an aim to find a potential ingredient for the protection of the intestinal mucosal barrier, researchers examined the effects of curcumin extensive pharmacological effects, on gastrointestinal diseases.

According to the analysis, curcumin exerted protective effects of the intestinal mucosal barrier through multiple pathways.

More precisely, curcumin protected the tissues of the intestinal mucosal barrier by

* By reducing the production of proinflammatory cytokines in orchestrating cell damage.

* By inhibiting the oxidative stress caused by overexpression of free radicals in facilitating the onset of chronic inflammation in the initiation of intestinal mucosal damage.

* By reducing levels of bacteria in the induction of infection that may weaken the function of the intestinal mucosal barrier.

Moreover, curcumin also protected the cells of intestinal mucosa against apoptosis.

Additional differentiation of the tested assays, researchers also found that curcumin also balances the ratio of gut microbiota associated with the regulation of intestinal microecology and intestinal immune response which plays a critical role in enhancing the intestinal mucosal barrier function.

Taken altogether, turmeric may be considered supplements for the improvement of intestinal mucosal barrier function, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) [Advances in the research of protective effect of curcumin on intestinal mucosalbarrier function].
[Article in Chinese; Abstract available in Chinese from the publisher] by He D1, Wang S2, Hu H2, Yin HY2. (PubMed)
(2) Gastrointestinal mucosal barrier function and diseases by Oshima T1, Miwa H. (PubMed)

Phytochemical Alliin Gobbles Up Plagues Against the Onset of Atherosclerosis

By Kyle J. Norton

Atherosclerosis is a medical condition induced arterial narrowing due to the accumulation of plague that weakens the arterial wall.

Atherosclerosis is the most common cause of heart disease and stroke in the Western world, depending on the location of oxygenated rich blood flow blockage.

Plague is made up of fat, cholesterol, calcium, and other substances in the blood.

According to the epidemiological studies, diseases associated with atherosclerosis include coronary heart disease (plaque in arteries in or leading to the heart), angina (chest pain from reduced blood flow to the heart muscle), carotid artery disease (plaque in neck arteries supplying blood to the brain),  and peripheral artery disease (plaque in arteries of the extremities, especially the legs).

According to the statistics provided by the CDC, coronary heart disease (CHD)  caused by atherosclerosis is the most common type of heart disease, that kills over 370,000 people annually.

Every year about 735,000 Americans has a heart attack. Of these, 525,000 are a first heart attack and 210,000 happen in people who have already had a heart attack

Although there are many risk factors that increase the risk of plaque accumulation, some researchers suggested people who follow the high-fat diet without injection of an adequate amount of fruits and vegetables are at a higher risk of atherosclerosis.

Dr. Zhao Y, the lead scientist in the team of cardiovascular disease at the Chinese PLA General Hospital wrote, "Coronary artery disease has a significant genetic predisposition, which mainly results from atherosclerosis".

And, "(Pig fed with high-fat diet) At 6 months, plaque lesions appeared in the abdominal aorta and iliac artery, while at 8 months, they appeared in the coronary artery. At 12 months, atherosclerotic lesions could be found in all major arteries, while lipid core, cholesterol precipitation, and calcium deposition appeared in the most serious sites".

Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.

With an aim to find potential treatment for atherosclerosis, a leading cause of cardiovascular disease, researchers evaluated the capacity of Allium ursinum (wild garlic) leaf lyophilisate (WGLL; alliin content: 0.261%) to mitigate cardiovascular damage in hypercholesterolemic rabbits.

Selected tested New Zealand rabbits incldued in the study were divided into three groups: (i) cholesterol-free rabbit chow (control); (ii) rabbit chow containing 2% cholesterol (hypercholesterolemic, HC); (iii) rabbit chow containing 2% cholesterol + 2% WGLL (hypercholesterolemic treated, HCT); for eight weeks.

According to the differentiation at the zero- and eight-week time points, WGLL treatment protects the cardio functioning by mediating the increase in fractional shortening, right ventricular function; peak systolic velocity; tricuspid annular systolic velocity in live animals.

Furthermore, WGLL improved aortic and coronary flow.

In other words,  WGLL exerted cardiovascular protective activity by promoting the function of ventricles in blood circulation via regulating the blood pressure.

Moreover, according to the Western blot analysis, revealed WGLL-associated increases in HO-1 protein associated with reduced cardio oxidative stress and decreases in SOD-1 protein involved oxygen metabolism.

Interestingly, WGLL also expressed a significant decrease in aortic atherosclerotic plaque coverage, plasma ApoB, an important component of many lipoproteins involved in atherosclerosis and cardiovascular disease. and the activity of LDH and CK (creatine kinase) in plasma.

Particularly, the chemical compound also inhibited the plasma LDL.

Based on the findings, researchers wrote in the final report, "The results clearly demonstrate that WGLL has complex cardioprotective effects, suggesting future strategies for its use in prevention and therapy for atherosclerotic disorders".

Taken altogether, alliin may be considered supplements for the prevention and treatment of atherosclerosis, pending to the confirmation of the larger sample size and multicenter human study.

Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Anti-Atherogenic Properties of Allium ursinum Liophylisate: Impact on Lipoprotein Homeostasis and Cardiac Biomarkers in Hypercholesterolemic Rabbits by Bombicz M1,2, Priksz D3,4, Varga B5,6, Gesztelyi R7, Kertesz A8, Lengyel P9, Balogh P10, Csupor D11, Hohmann J12, Bhattoa HP13, Haines DD14, Juhasz B. (PubMed)
(2)  Atherosclerosis Induced by a High-Cholesterol and High-Fat Diet in the Inbred Strain of the Wuzhishan Miniature Pig by Zhao Y1, Xiang L1, Liu Y1, Niu M1, Yuan J1, Chen H. (PubMed)

Phytochemical Lycopene Inhibits Cancer Metastasis in Vitro and Vivo

By Kyle J. Norton

Cancer is a class of disease associated with irregular cell growth on the tissue of the specific organ.

Most cases of invasive cancer can spread to other organs in the body via lymph or blood.

According to the statistics provided by the Cancer Institue, between n 2011–2015, the number of new cases of cancer is 439.2 per 100,000 men and women per year (based on 2011–2015 cases). 

The number of cancer deaths (cancer mortality) is 163.5 per 100,000 men and women per year.

Under normal circumstance, cell growth is a natural process without even notice, every day millions of cell grow to replace millions of dead cells and to keep our body in balance and healthy.

Sometimes, acceleration of cells growth is necessary to prevent further damage to the body organ, such as cut, injure, etc., but after fulfilling their purposes, the growth of cells are back to a normal rate again due to our body growth inhibitors. Unfortunately, skin cells sometimes overgrow while healing, leading to scar to the skin.

In cancer cells, due to the alternation of DNA, can grow indefinitely. 

Cancer cell metastasis is the process that cancer cells break away from the primary site and travel through the blood or fluid circulation and form new tumors (metastatic tumors) in other parts of the body, similar to those of primary cancer.

Dr. RUI-AN WANG, the lead scientist in the explanation of the reasons for cancer metastasis, wrote, "Over several years, scientists investigating cancer have focused their efforts on elucidating the mechanisms underlying cancer metastasis, with the aim of finding a way to inhibit this process".

And, "Cancer metastasizes due to several factors, namely attack by the immune system, lack of oxygen and necessary nutrients, large amounts of lactic acid produced by glycolysis and increased cell death. Therefore, the majority of the presently available treatments for cancer also bear the potential to induce metastasis".

In other words, for the tumor to survive that must metastasize.

Lycopene is a phytochemical in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and perform various functions in photosynthesis.

In the urgency to find a natural ingredient for the inhibition of cancer cell metastasis, researchers examined the apo-10'-lycopenoic acid (ALA), a derivative of lycopene through cleavage by carotene-9',10'-oxygenase, on tumor progression and metastasis in both liver and lung cancer animal models.

According to the tested assays, ALA showed significant activity in a dose-dependent manner in inhibiting migration and invasion of liver and lung cancer cells (HuH7 and A549).

In other words, ALA constrained lung cancer cell from the induction of mechanisms associated with cancer cell spreading.

Furthermore, in HuH7 and immortalized lung BEAS-2B cells, ALA suppressing the function of remodeling actin in stimulating cancer cell mobility and membrane formation.

More importantly, ALA also inhibited both HuH7 and A549 cells. proliferation and migration by suppressing the genes associated with angiogenesis.

Moreover, according to the tested assays, ALA also decreased the expression of enzyme which plays a pivotal role in cell migration during physiological and pathological processes.

In human THE-2 liver cells, ALA in a dose-dependently increased the mRNA expression and protein levels of peroxisome proliferator‑activated receptor‑γ (PPARγ) involved in controlling angiogenesis, tumor progression and metastasis.

Based on the findings, Dr. Cheng J., the lead scientist wrote, "ALA inhibits cancer cell motility and angiogenesis and induces PPARγ expression, which could be one of the potential mechanisms for ALA protecting against tumor progression".

Taken altogether, phytochemical lycopene may be considered supplements for the prevention of cancer cell metastasis, pending on the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Peroxisome proliferator-activated receptor-γ inhibits pancreatic cancer cell invasion and metastasis via regulating MMP-2 expression through PTEN by Li Y1, Zhang DW1, Lin DQ1, Cao LQ1. (PubMed)
(1) Apo-10'-lycopenoic acid inhibits cancer cell migration and angiogenesis and induces peroxisome proliferator-activated receptor γ by Cheng J1, Miao B1, Hu KQ1, Fu X1, Wang XD. (PubMed)
(3) Reasons for cancer metastasis: A holistic perspective by RUI-AN WANG,1,2,3 YOU-YONG LU,4 and DAI-MING FAN (PubMed)

Ginger, the Natural Treatment for Endometriosis, with no Side Effects

By Kyle J. Norton

Endometriosis is a condition caused by endometrial tissues which grow somewhere in the body instead of in the endometrium. Most cases of endometriosis are in the organs in the pelvic area, including ovaries and fallopian tubes.

Endometriosis also reacts to hormone signals of the monthly menstrual cycle, by building and breaking up tissues and eliminating them through the menstrual period.

According to the statistics provided by the Clinical Center of Niš,

* About 20% of reproductive age women with endometriosis are assymptomatic

* About 55% of women have developed the new onset of severe menstrual cramps

* About 25% of women with sub-fertility (less fertile than a normal couple), depending on the stages of endometriosis.

Endometriosis can be classified into 4 stages
* Minimal stage
The top surface, few in number. Commonly they are found in the inside wall of uterus, ligaments, and ovary, causing a significant reduction in both progesterone and its ratio with 17 beta-oestradiol, luteal dysfunction and abnormal secretory patterns(3). Minimal stage endometriosis may lead to unexplained causes of infertility(2).

* Mild stage
Deeper implants, greater numbers are presented. Commonly found in the same area as a minimal stage, causing worsening of oocyte quality. Mild stage of endometriosis may lead to infertility(4).

* Moderate stage:
Many implants, endometrial cysts are presented, affecting ovary function, and causing scar tissues and adhesion.

* Severe stage:
Intensive peritoneal implants, large endometriomas are presented with dense adhesion.

Conventionally, most cases of endometriosis are treated by pain medicines such as NSAIDs (non-steroidal anti-inflammatory drugs) and hormone therapy such as birth control pills with an aim to reduce pain and improve quality of life, including daily activity.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Researchers in the urgency to find natural compounds for the treatment of endometriosis with no side effects evaluated the efficacy and safety of acupuncture-moxibustion combined with modified Mojie tablet containing ginger in the prevention of the recurrence of endometriosis (EMS) after laparoscopic surgery.

The study included 120 cases of EMS after laparoscopic surgery, randomly assigned into an acupuncture-moxibustion group, a western medication group, a Chinese medication group and a combined therapy of acupuncture-moxibustion and Chinese medication group (combined therapy group).

Each group containing 30 participants was separated, before treatment, after treatment, in 3 months after treatment and in 6 months after treatment.

In the acupuncture-moxibustion group, acupuncture was applied at Xuehai (SP 10), Sanyinjiao (SP 6) and Guanyuan (CV 4); the isolated moxibustion with ginger was used at Guanyuan (CV 4), once a day, twice a week.

In the western medication group, gestrinone was prescribed for oral administration, 2.5 mg, once a day, twice a week.

In the Chinese medication group, the self-prepared Mojie tablet was prescribed for oral administration.

And, in the combined therapy group, acupuncture, moxibustion and modified Mojie tablet for oral administration were used in combination.

In 3 and 6 months after treatment, the positive rates of EHP-5 score were 0% (0/30) in the combined therapy group and 0% (0/30) in the acupuncture-moxibustion group, compared to the lower significantly than 13.3% (4/30) in the western medication group.

In follow-up stage of 6 months after treatment, according to the abdominal ultrasound examination, there was no recurrence case in the combined therapy group, compared to the lower than 13.3% (4/30) in the western medication group.

According to assays, the serum CA125 detection in the combined therapy group did not find any abnormal case, compared to the lower than 16.7% (5/30) in the western medication group (P < 0.05).

Based on the results, researchers wrote in the final report, "Acupuncture and moxibustion combined with modified Mojie tablet effectively prevent the recurrence of EMS after laparoscopic surgery and improve the life quality of the patients".

Take all together, ginger may be used combined with other traditional medicine and therapies for the prevention and treatment of endometriosis and recurrent endometriosis, pending to the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) [Efficacy observation on the combination of acupuncture and Chinese medication in prevention of the recurrence of endometriosis after laparoscopic surgery] [Article in Chinese] by Zhang XY, Zhang CY. (PubMed)
(2) Mid to late luteal phase steroids in minimal stage endometriosis and unexplained infertility.
Barry-Kinsella C1, Sharma SC, Cottell E, Harrison RF(PubMed)
(3) Cyclical gonadotrophin and progesterone secretion in women with minimal endometriosis by Williams CA, Oak MK, Elstein M.(PubMed)
(4) Follicular fluid from infertile women with mild endometriosis may compromise the meiotic spindles of bovine metaphase II oocytes by Da Broi MG1, Malvezzi H, Paz CC, Ferriani RA, Navarro PA(PubMed)

Herbal Turmeric Inhibits the Onset and Progression of Chronic Prostatitis

By Kyle J. Norton

Prostatitis is a condition associated with the inflammation of the prostate and the areas around the prostate.

According to the statistics provided by the American Family Physician, approximately 8.2 percent of men in the US are living with prostatitis. The conditions account for 8 percent of visits to urologists, and up to 1 percent of visits to primary care physicians.

Believe it or not, in 2000, prostatitis has cost over $84 million, including the charge of diagnosis and treatment.

Most common symptoms of prostatitis are painful, difficult and/or frequent urinating, groin pain, rectal pain, abdominal pain and/or low back pain, fever, chills, and body aches.

In severe cases, patients may also experience symptoms of urethral discharge, painful ejaculation or sexual dysfunction and blood in the urine.

The exact causes of prostatitis are not identified, some researchers suggested that nerve damage in the lower urinary tract caused by surgery or trauma to the area has been found to induce prostatitis in patients.

Conventionally, most cases of prostatitis are treated by antibiotics in cases of infection, alpha blockers to relax the bladder neck and the muscle fibers and anti-inflammatory medicine to ease pain and discomforts.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

With an aim to find a potential and natural ingredient for the treatment of inflammatory diseases such as chronic prostatitis/ chronic pelvic pain syndrome type III (CP/CPPS), researchers examined the effect of turmeric on chronic bacterial prostatitis.

The phase II, the randomized, single-blinded, placebo-controlled clinical trial included 60 patients who were examined by University of Catania from June 2015 to January 2016 we enrolled 60 consecutive due to CP/CPPS III.

At the end of the experiment, the treatment group showed a significant improvement of National Institutes of Health Chronic Prostatitis Symptom Index, IIEF-5 (+ 3.5; p &lt; 0.01), particularly other symptomatic parameters compared to placebo.

Participants were then allocated to receive treatment (Group A) or placebo(Group B). Treatment consisted of rectal suppositories of Curcumin extract 350 mg (95%) and Calendula extracts 80 mg (1 suppository/die for 1 month). Patients of Group B received 1 suppository/die for 1 month of placebo. 

The efficacy of the treatment with Curcumin and Calendula was associated with the reduction of inflammatory cytokines and of inflammatory cells.

Based on the findings, Dr. Morgia G, the lead researcher said, "In this phase II clinical trial, we showed the clinical efficacy of the treatment with Curcumin and Calendula in patients with CP/CPPS III".

Taken altogether, turmeric used alone or combined with Calendula may be considered supplements for the prevention and treatment of chronic bacterial prostatitis and chronic pelvic pain syndrome, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) A phase II, randomized, single-blinded, placebo-controlled clinical trial on the efficacy of Curcumina and Calendula suppositories for the treatment of patients with chronic prostatitis/chronic pelvic pain syndrome type III by Morgia G1, Russo GI, Urzì D, Privitera S, Castelli T, Favilla V, Cimino S. (PubMed)
(2) Therapeutic roles of curcumin: lessons learned from clinical trials by Gupta SC1, Patchva S, Aggarwal BB. (PubMed)

Whole Food Tomato Normalizes Hepatic Markers Against Liver Damage and Injury

By Kyle J. Norton

Hepatic marker is a blood test that measures the function of the liver. In other words, according to the blood test results, your doctor may know the severity of the liver damage.

The liver is the largest internal organ in the body which plays a critical role to filter out blood from the digestive system before passing them to other parts of the body.

Furthermore, the liver also produces bile which has a strong impact on the building of cell membranes, production of steroid hormones and vitamin D and aiding the digestive system in the absorption of nutrients.

Liver transaminases aspartate transaminase (AST) and alanine transaminase (ALT) are some of the liver markers used by researchers to measure liver injury in a patient with some degree of intact liver function.

Aspartate transaminase (AST)  is an enzyme found primarily in the liver and kidney. High levels of ALT is associated with liver damage. ALT screening is used often in patients with
liver disease.

Alanine aminotransferase (ALT) is a liver enzyme. increased levels of ALT has been found in patients with liver damage.

Other liver enzymes such as Alkaline phosphatase (ALP) and Gamma-glutamyl transpeptidase (GGT) also have a similar effect as seen in ALT and AST.

More precisely, elevated liver enzymes is an indication of liver inflammation or cell damage.

Dr. Edoardo G. Giannin, the lead scientist in the explanation of liver enzymes alternation, wrote, "Abnormal liver enzyme levels may signal liver damage or alteration in bile flow. Liver enzyme alteration may be either the accompanying biochemical picture in a patient with symptoms or signs suggestive of liver disease or an isolated, unexpected finding in a patient who has undergone a wide range of laboratory tests for a nonhepatic disease or for minor, vague complaints".

And, "The pattern of enzyme abnormality, interpreted in the context of the patient's characteristics, can aid in directing the subsequent diagnostic work-up. Awareness of the prevalence of the determined liver disease in specific populations and of possible hepatic involvement during systemic illnesses or drug therapies may help the clinician identify the cause of alterations efficiently".

The results strongly suggested that testing hepatic markers of patients with liver disease may be helpful to identify the causes.

Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

In the urgency to discover healthy foods which process liver protective effects, researchers examined the effect of dry tomato peel (DTP) on hepatic markers on a high-saturated-fat (HSF) diet animal model for 12 weeks.

The study included 40 8 weeks old, weighing 22.2±1.0 g) BALB/c male mice (n=40) divided into four treatment groups (10 mice/group): (a) high-fat control diet (HF Ctrl), which contains sunflower oil as a sole source of fat; (b) HSF/high-cholesterol (HC) diet; (c) HSF/HC diet supplemented with 9% DTP and (d) HSF/HC diet supplemented with 17% DTP.

According to the tested assays, without supplement with DTP, HSF/HC diet treated mice showed significantly increased body weight gain, adipose tissue weight, insulin resistance and lipid peroxidation in the liver as well as the onset of liver steatosis and inflammation.

Upon the injection of DTP,  HSF/HC diet mice demonstrated a significant increase in plasma lycopene concentration and reduced markers associated with metabolic syndrome developing.

In other words, DTP inhibited the liver damage and injury marker through its anti-inflammatory and antioxidant activity and lipid metabolism

Taken altogether, tomato processed a high amount of lycopene may be considered a dietary supplements for liver protection, pending to large sample size and multicenter human study.

Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effect of dry tomato peel supplementation on glucose tolerance, insulin resistance, and hepatic markers in mice fed high-saturated-fat/high-cholesterol diets by Zidani S1, Benakmoum A2, Ammouche A3, Benali Y4, Bouhadef A4, Abbeddou S. (PubMed)
(2) Feeding tomato and broccoli powders enriched with bioactives improves bioactivity markers in rats by Liu AG1, Volker SE, Jeffery EH, Erdman JW Jr. (PubMed)
(3) Liver enzyme alteration: a guide for clinicians by Edoardo G. Giannini, Roberto Testa, and Vincenzo Savarino. (PMC)

Bromelain Suppresses Rheumatoid Arthritis in Vivo

By Kyle J. Norton

Rheumatoid Arthritis (RA) a chronic disorder as a result of inflammation, affecting mostly the flexible (synovial) joints and tissues and organs in the body.

The disease affects more women than men and generally occurs after the ages of 40, causing the diminished quality of life of many elders(1). 

According to CDC, Musculoskeletal disorders (MSDs) affects over 52 millions of adults in the US alone, including 294,000 children under age 18 with some form of arthritis or rheumatic conditions(2). 

Rheumatoid Arthritis can induce bone loss through elevating bone resorption without increasing bone formation(4). A cross-sectional population-based study of 1042 patients with rheumatoid arthritis showed that RA patients had an increased risk of death from various causes(4a).

Most common symptoms of RA are
* The feet and joints
Patient with rheumatoid arthritis (RA) often associates with valgus deformities of the feet and gait due to body function in an effort to support the collapsing longitudinal arch of the foot.

* The gait
Rheumatoid arthritis (RA) causes a significant reduction in joint motions, joint moments, such as decreased hip flexion-extension range, hip abduction, knee flexion-extension range.

* The hands
The effects of deformation of RA's hands can be described through the defects of bone ankylosis as a result of bone damage to the prolonged onset of the disease(12).

* The Muscle strength
The effects of muscle strength in a patient with RA may contribute to the prevalence of functional limitations physically of that can affect daily living and quality of life.

* Rheumatoid Nodules
Rheumatoid nodules, lump on the skin, closed to the joint have been found to affect the joints of patients with rheumatoid nodules.

* Conjunctival nodule
Although is rare in patients with rheumatoid arthritis, the appearance of the nodules may exhibit the

the severity of the underlying disease.

* Morning stiffness
Morning stiffness, as a marker of inflammatory activity that reflects the functional disability and pain is a very common symptom of patients in early rheumatoid arthritis.

Conventionally, there is no cure for RA. Medication is to relieve symptoms such as pain, slow the progression and improve quality of life, including disease-modifying antirheumatic drugs (DMARDs) and nonsteroidal anti-inflammatory drugs (NSAIDs) and corticosteroids.

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

With an aim to find a natural agent for the treatment of adjuvant rheumatic diseases, researchers examined the anti-inflammatory property of both enzyme therapy and combined therapy with cyclosporin in an animal model.

The study included rats with adjuvant-induced arthritis administered either cyclosporin A (2.5 or 5.0 mg/kg/day per os), a mixture of enzymes (Phlogenzym (PHL); 45 mg/kg twice daily intrarectally), or a combination of 2.5 mg cyclosporin A and 90 mg PHL for a period of 40 days.

According to the tested assays, the combination therapy with cyclosporin A plus PHLshowed a significantly inhibited both the inflammation and destructive arthritis-associated changes, such as serum albumin, changes in hind paw swelling and bone erosions.

Compared to the higher dose, 2.5 mg of cyclosporin A and PHL alone inhibited the disease markers to a lesser extent and a later stage of arthritis development.

In other words, the combination inhibited all parameters associated with the onset of adjuvant rheumatic diseases in a dose-dependent manner.

Based on the findings, researchers wrote, "The results show the inhibitory effect of enzyme therapy on rat adjuvant arthritis, as well as the efficacy of a low dose of cyclosporin A given in combination with enzyme therapy, which may be useful in the treatment of rheumatoid arthritis".

Taken altogether, bromelain used alone or combined with conventional medicine may be considered a remedy for the prevention and treatment of adjuvant rheumatic diseases, pending to the confirmation of the larger sample size and multicenter human study.

Intake of bromelain in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) [Proteolytic enzymes as an alternative in comparison with nonsteroidal anti-inflammatory drugs (NSAID) in the treatment of degenerative and inflammatory rheumatic disease: systematic review].
[Article in German] by Heyll U1, Münnich U, Senger V. (PubMed)
(2) Enzyme and combination therapy with cyclosporin A in the rat developing adjuvant arthritis by Rovenská E1, Svík K, Stancíková M, Rovenský J. (PubMed)
(3) Most Common Disease of elder: The Clinical Trials and Studies of musculoskeletal disorders(MSDs) - Rheumatoid Arthritis: The Signs and Symptoms by Kyle J. Norton