Monday 25 June 2018

Weight Loss And Weight Maintenance Problems? Try This Legume, Scientists Say

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.


Whole food ingredients in herbal plant have been found to process some significant effects in reduced risk and treatment of many diseases, but single ingredient isolated from such plants may induce opposite outcomes.

According to the University of Calgary study, dried peas fiber may have a profound and positive effect in induced and sustained weight loss in over weight and obese subjects.

Obesity is a medical condition characterized by excess body fat accumulated overtime.

Overweight is a condition of excess body weight relatively to the height. 

According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity.  

Statistic shows,  68% of American population are either overweight or obese.

The article written by LOUISE LUCAS AND ALAN RAPPEPORT and posted on Financial Times, suggested, " Diet aids are often more successful at shedding dollars than pounds – for manufacturers as well as consumers and "The weight-management industry, worth $11-billion in retail sales according to data company Euromonitor, should by rights be a major beneficiary of the times".

However, how many people have followed through all those programs? How may people have maintained the weight reduction? The answers are debatable, depending to who you talk to.

One thing for sure, most weight programs are not working to their promises, for whatever reasons, otherwise the statistic should show a rate reduction of obesity in US, over the years.

The health line in its website indicates, there are as much as 20 reasons, "Why You're Not Losing Weight" in the article with the same tittle,
1. Maybe You Are Losing Without Realizing it
2. You're Not Keeping Track of What You're Eating
3. You're Not Eating Enough Protein
4. You're Eating Too Many Calories
5. You're Not Eating Whole Foods
6. You're Not Lifting Weights
7. You're Binge Eating (Even on Healthy Food)
8. You're Not Doing Cardio
9. You're Still Drinking Sugar
10. You're Not Sleeping Well
11. You're Not Cutting Back on Carbohydrates
12. You're Eating Too Often
13. You're Not Drinking Water
14. You're Drinking Too Much Alcohol
15. You're Not Eating Mindfully
16. You Have a Medical Condition That is Making Things Harder
17. You're Addicted to Junk Food
18. You've Been Starving Yourself For Too Long
19. Your Expectations Are Unrealistic
20. You're Too Focused on "Dieting"

If you want to know more of the above differentiation, I courage you to click the cited link at  Why You're Not Losing Weight"

Dried pea is a small but nutritionally mighty member of the legume family, genus Pisum belongings to the family Fabaceae with healthy source of proteins, fibers, vitamins and minerals.

In a double blind, placebo controlled, parallel group study, with overweight and obese (BMI = 25-38) adults randomized to either a 15 g/d yellow pea fibre supplemented group or isocaloric placebo group for 12 weeks (n = 30/group), researchers found that peas fiber displays a significant effect in weight reduction through various mechanisms, including improvement of metabolic syndrome and gut microbiota expression.

Metabolic syndrome is associated to weight gain due to its effects in increased odds of low HDL and high triglycerides relative in compared to participants with continuously stable weights(4).

According to the Université de la Méditerranée, gut microbiota expression is correlated to host weight. And microbial changes in the human gut were proposed to be one of the possible causes of obesity(5).

Dr. Jennifer E Lambert, the lead author said, " feeding the prebiotic fibre oligofructose for 12 weeks reduced levels of the orexigenic hormone ghrelin and increased levels of the anorexigenic hormone PYY in overweight adults which corresponded with lower self-reported energy intake [13]. In the long-term, these changes in postprandial peptide secretion may promote weight loss through reductions in ad libitum food intake", and "Both bacterial abundance and composition can be altered with lifestyle changes. Indeed, part of the role of intestinal bacteria in weight control has been elucidated through study of patients receiving bariatric surgery".

Additionally, in the examined the nutritional effects and acceptability of two high-fiber hypocaloric diets differing in sources of fiber: (a) beans or (b) fruits, vegetables, and whole grains of 2 men, 18 women, mean age = 46.9, and mean BMI = 30.6.with participants completed 3-day food diaries in each of the two baseline weeks, researchers indicated that
*. There are no difference in outcome of fiber intake of all groups. Both diets increased fiber intake from 16.6 in compared to baseline.

*. Fiber intake showed a consistent effect in reduced weight status over treatment in both groups with mean weight loss was 1.4 kg.

*. Returned questionnaire also addressed  the hunger decreased and fullness increased during the testing period in both groups.

*. Both diets were rated as potentially acceptable as long as six months.

The findings evidences suggested that bean and fruits, vegetables, and whole grains fiber demonstrated a similar efficacy in increased satiation, and reduced hunger in induced weight loss.
.

Interestingly, in a total of 173 women and men, with a mean body mass index of approximately 36 kg m(-2) (one-fifth with diabetes type 2) randomised to a high-fibre bean-rich diet with fibre intakes of 35.5 (18.6) g day(-1) for women and 42.5 (30.3) g day(-1) for men, or a low-carbohydrate diet, researchers found that in 123 (71.1%) completers at 16 weeks
*. The mean (SD) weight loss of both groups was 4.1 (4.0) kg.

*, Fiber dietary group expresses a higher weight loss of 5.2 in compared to 4.5 kg in low-carbohydrate group.

3. High-fibre diet shows a better decreased low-density lipoprotein (LDL)-cholesterol and total cholesterol levels in compared to low-carbohydrate diet.

Dr. Tonstad S, the led author said."After 52 weeks, the low-carbohydrate (n = 24) group tended to retain weight loss better than the high-fibre group (P = 0.06), although total cholesterol remained lower with the bean-rich diet (P = 0.049)."

Taking altogether, there is no doubt that fibers of bean or other sources as functional foods, may have strong implication  in induced weight loos and weight management for over weight and obese subjects.

The amounts of fiber intake should be consulted with your doctors to prevent overdoses constipation.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Kyle J. Norton(Scholar, Master of Nutrition), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Evaluation of yellow pea fibre supplementation on weight loss and the gut microbiota: a randomizedcontrolled trialby Jennifer E Lambert,1 Jill A Parnell,2 Jay Han,3 Troy Sturzenegger,3 Heather A Paul,4 Hans J Vogel,4,5 and Raylene A Reimer1,4(PMC)
(2) Dietary adherence and satisfaction with a bean-based high-fiber weight loss diet: a pilot study by Turner TF1, Nance LM1, Strickland WD1, Malcolm RJ1, Pechon S1, O'Neil PM1.(PubMed)
(3) A high-fibre bean-rich diet versus a low-carbohydrate diet for obesity by Tonstad S1, Malik N, Haddad E.(PubMed)
(4) Metabolic Syndrome and Weight Gain in Adulthood by Dawn E. Alley1 and Virginia W. Chang(PMC)
(5) The relationship between gut microbiota and weight gain in humans by Angelakis E1, Armougom F, Million M, Raoult D.(PubMed)

*Infectious Diseases: The Anti Over Growth of Candida Diet That Works, Cited by MEDLINE

By Kyle J. Norton, Scholar, Master of Nutrition

Candida albicans are members of a large group of micro organism whose cells contain complex structures enclosed within the membranes, including yeast(2)(3), fungi(4)(5)(6), and mold(6) that live among the gut flora in the human mouth and gastrointestinal tract.

Non-albicans Candida (NAC) species cause 35-65% of all candidaemias in the general patient population(1).

According to joint study, in many cases, biofilm(microorganisms with cells stick to each other on a surface) formation(7) gene mutations(8) and overexpression of genes(9)(10) are often associated with increased candida resistance toward antifungal drugs.

Over growth of candida is associated to some life threatening and chronic implications, including toxic shock syndrome(TSS), scalded skin syndrome (SSS), irritable bowel syndrome ,..... and
Fibromyalgia(a)


The Anti Over Growth of Candida Diet 

1. Apple Cider Vinegar
Apple Cider Vinegar is a type of vinegar made from cider or apple must and has a pale to medium amber color.

Beside it is known for treating obesity(208)(209), the liquid is rich in natural enzymes which aid in digestion,

Apple cider vinegar also balances your body's pH level,

Its high amount of antioxidants also restore the natural balance of healthy bacteria in the gut by creating a perfect environment for those healthy bacteria to grow,  while keeping candida in check(207) by enhancing the immune function(210) in regulating the microorganism in the body.


2. Coconut oil
Coconut oil is extracted from the kernel or meat of matured coconut harvested from the coconut palm tree, native to the tropical world.

Coconut oil, is one of most effective antibacterial(including Candida)(211)(213), antioxidant(214), antiviral(215) agents, used in traditional medicinal remedies for treatment of benign prostatic hyperplasia(216) and inflammation(217). Caprylic acid, a minor constituent of coconut oil has been demonstrated to inhibit fungal growth(212)(218), both topically and internally.

3. Garlic
Garlic is species of Allium sativum, belongings to the family Alliaceae, used as both food and medicine in many cultures for thousands of years.

Garlic cloves are used as a remedy for infections(219)(220), digestive disorders(221), and fungal infections, including candida(222), due to large number of anti-fungal properties of sulphur, allicin, alliin, alliinase and S-allylcysteine.

4. Ginger
Ginger is a species of Zingiber officinale, belongings to the family Zingiberaceae, used as a delicacy, medicine, or spice in many cultures.

The gingerrols in ginger increase the motility of the gastrointestinal tract(223) and as analgesic(224)(226), sedative(225), antipyretic(226), antibacterial(227) and anti- inflammatory(228) properties.

Researcher (Am. J. Applied Sci., 6 (6): 1067-1069, 2009) found that ginger extract with plentiful of gingerol inhibits the growth of many bacteria and fungi, including candida ablicans(229)


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

(a) Infectious Disease: Beware Of Some Life Threatening And Chronic Complications Associated To Over Growth of Candida by Kyle J. Norton
(1) Non-albicans Candida spp. causing fungaemia: pathogenicity and antifungal resistance by Krcmery V1, Barnes AJ.(PubMed)
(2) Pathogenicity and drug resistance in Candida albicans and other yeastspecies. A review by Mishra NN1, Prasad T, Sharma N, Payasi A, Prasad R, Gupta DK, Singh R.(PubMed)
(3) Multidrug resistance in yeast Candida by Prasad R1, Kapoor K.(PubMerd)
(4) New evidence that Candida albicans possesses additional ATP-binding cassette MDR-like genes: implications for antifungal azole resistance. by Walsh TJ1, Kasai M, Francesconi A, Landsman D, Chanock SJ.(PubMed)
(5) Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters.by Sanglard D1, Kuchler K, Ischer F, Pagani JL, Monod M, Bille J.(PubMed)
(6) Structural analysis of phospho-D-mannan-protein complexes isolated from yeast and mold form cells of Candida albicans NIH A-207 serotype A strain by Shibata N1, Fukasawa S, Kobayashi H, Tojo M, Yonezu T, Ambo A, Ohkubo Y, Suzuki S.(PubMed)
(7) The effect of antifungal combination on transcripts of a subset of drug-resistance genes in clinical isolates of Candida species induced biofilms by Ibrahim NH1, Melake NA2, Somily AM3, Zakaria AS4, Baddour MM5, Mahmoud AZ6(PubMed)
(8) Antifungal drug resistance in pathogenic fungi. by Vanden Bossche H1, Dromer F, Improvisi I, Lozano-Chiu M, Rex JH, Sanglard D.(PubMed)
(9) The genetic basis of fluconazole resistance development in Candida albicans by Morschhäuser J1.(PubMed)
(10) A proteomic approach to understanding the development of multidrug-resistant Candida albicans strains by Kusch H1, Biswas K, Schwanfelder S, Engelmann S, Rogers PD, Hecker M, Morschhäuser J.(PubMed)
(Care 2)(209) Changes in anthropometric measurements, body composition, blood pressure, lipid profile, and testosterone in patients participating in a low-energy dietary intervention by Balliett M1, Burke JR.(PubMed)
(210) Apple Cider Vinegar Recipes(Immunology)
(211) Antimicrobial effects of virgin coconut oil and its medium-chain fatty acids on Clostridium difficile by Shilling M1, Matt L, Rubin E, Visitacion MP, Haller NA, Grey SF, Woolverton CJ.(PubMed)
(212) Short- and medium-chain fatty acids exhibit antimicrobial activity for oral microorganisms by Huang CB1, Alimova Y, Myers TM, Ebersole JL.(PubMed)
(213) Activity of virgin coconut oil, lauric acid or monolaurin in combination with lactic acid against Staphylococcus aureus by Tangwatcharin P1, Khopaibool P.(PubMed)
(214) Antioxidant capacity and phenolic acids of virgin coconut oil by Marina AM1, Man YB, Nazimah SA, Amin I.(PubMed)
(215) Coconut (Cocos nucifera L.: Arecaceae): in health promotion and disease prevention by DebMandal M1, Mandal S.(PubMed)
(216) Effects of coconut oil on testosterone-induced prostatic hyperplasiain Sprague-Dawley rats by de Lourdes Arruzazabala M1, Molina V, Más R, Carbajal D, Marrero D, González V, Rodríguez E.(PubMed)
(217) Anti-inflammatory, analgesic, and antipyretic activities of virgin coconut oil by Intahphuak S1, Khonsung P, Panthong A.(PubMed)
(218) Caprylic Acid and glyceryl trinitrate combination for eradication of biofilm by Rosenblatt J1, Reitzel RA2, Raad I2.(PubMed)
(219) Garlic blocks quorum sensing and promotes rapid clearing of pulmonary Pseudomonas aeruginosa infectionsby Bjarnsholt T1, Jensen PØ, Rasmussen TB, Christophersen L, Calum H, Hentzer M, Hougen HP, Rygaard J, Moser C, Eberl L, Høiby N, Givskov M.(PubMed)
(220) An in vitro assessment of the antibacterial effect of garlic (Allium sativum) on bacterial isolates from wound infectionsby Tessema B1, Mulu A, Kassu A, Yismaw G.(PubMed)
(221) Antileishmanial activity of a mixture of Tridax procumbens and Allium sativum in mice by Gamboa-Leon R1, Vera-Ku M1, Peraza-Sanchez SR2, Ku-Chulim C1, Horta-Baas A1, Rosado-Vallado M1.(PubMed)
(222) The effects of oral garlic on vaginal candida colony counts: a randomised placebo controlled double-blind trialby Watson CJ1, Grando D, Fairley CK, Chondros P, Garland SM, Myers SP, Pirotta M.(PubMed)
(223) Effects of ginger constituents on the gastrointestinal tract: role of cholinergic M3 and serotonergic 5-HT3 and 5-HT4 receptorsby Pertz HH1, Lehmann J, Roth-Ehrang R, Elz S.(PubMed)
(224) Ginger (Zingiber officinale Roscoe) prevents the development of morphine analgesic tolerance and physical dependence in ratsby Darvishzadeh-Mahani F1, Esmaeili-Mahani S, Komeili G, Sheibani V, Zare L.(PubMed)
(225) Stimulative and sedative effects of essential oils upon inhalation in mice.by Lim WC1, Seo JM, Lee CI, Pyo HB, Lee BC.(PubMed)
(226) Zingiber officinale Roscoe (ginger) as an adjuvant in cancer treatment: a reviewby Pereira MM1, Haniadka R, Chacko PP, Palatty PL, Baliga MS.(PubMed)
(227) Antibacterial activity of [10]-gingerol and [12]-gingerol isolated from ginger rhizome against periodontal bacteriaby Park M1, Bae J, Lee DS.(PubMed)
(228) Zerumbone enhances the Th1 response and ameliorates ovalbumin-induced Th2 responses and airway inflammation in miceby Shieh YH1, Huang HM2, Wang CC3, Lee CC4, Fan CK5, Lee YL6.(PubMed)

Sunday 24 June 2018

*Detoxification - How to Detox and Nourish Your Lung for Optimal Health


By Kyle J. Norton, Scholar, Master of Nutrition

Liver, kidney and skin.are 3 major and vital organs with function in protected our body against toxins accumulation.

Everyday toxins are removed by these organs to maintain the organs and tissue integrity and viability. So the body can perform its function in an optimized form.

If one of these organs starts to malfunction, others must take the toxins and remove them.

In cases of our body cannot completely remove all the toxins, toxins will be accumulated in the organs and tissue, leading to weakening of organs and tissue function in induction of chronic ailments.

Herbal medicine have been used to tonify and eliminate toxins from our body over thousand of years, according to Dr. Edward Group, one of the best natural detox methods is a six or seven day cleanse using distilled water, organic, raw apple cider vinegar, aloe vera, Oxy-Powder, and a probiotic supplement.

In fact, selection are so complex and professional, depending to the experience and preference of practitioners. Completely different methods used in compared to conventional medicine, treatment of one drug for all. In herbal medicine, same disease of 2 persons  may be treated with different formula and different diseases may be treated with the same formula

Herbal medicine in detoxed your lung

1. Lotus Root Tea
Made from the root of the esteemed Asian water lily, lotus root dissolves and eliminates mucus and lung congestion over time.

Lotus root traditionally has been used to neutralize toxins accumulated in the lung as well as in treating other respiratory diseases such as asthma, tuberculosis, and coughing.

Lotus root with tons of bioactive compounds such as total phenols, gallic acid and polyphenols and high levels of antioxidant activity protects the lung against onset of diseases(1).

According to the School of Health & Life Sciences, King's College, "the human lung, from infancy through to old age, can be subjected to deleterious oxidative events as a consequence of inhaling environmental pollutants or irritants, succumbing to several pulmonary diseases (including infant and adult respiratory distress syndromes, asthma, chronic obstructive pulmonary disease, cystic fibrosis and cancer) and receiving treatment for these diseases"(2).


2. Platycodon Root
Platycodon has been used in Chinese medicine for over a century in treating abscesses, respiratory disorders, and intestinal disorders.

Study shows that platycodon roots not only help to treat coughs due to purulent sputum and inflammation in the chest area but also demonstrate a lung protective activity(4).

According to Chungnam National University, in vitro, Platycodon grandiflorum root-derived saponins exerted inhibition of (Changkil saponins: CKS) ovalbumin-induced airway inflammation in mice(3).

3. Wild Cherry Bark 
Wild cherry bark traditionally has been used to treat irritable and persistent cough of bronchitis, and pertussis due to increased irritability of respiratory mucosa.

The herb also exerts lung protective effects due to due to its astringent, sedative, antispasmodic, and bronchodilator actions in inhibited dries mucus, expectoration, coughing, particularly, in open of the airways(5).

4. Mullein 
Mullein contains coumarin and rotenone.

It has a long history of being used as a medicine for treatment for asthma and respiratory disorders.

The herb also sooths the mucous membranes, reduces inflammation and encourages healthy fluid production in the lungs.

According to the Xi'an Jiaotong University, Isofraxidin (IF), a coumarin compound isolated from the natural medicinal plants, including mullein displayed a significant anti-bacterial, anti-oxidant, and anti-inflammatory activities in protected the against injure in animal model(6).

Moreover, the phytochemical also show a marked protective effect against bronchial asthma induced by inhalation of histamine in conscious guinea pig(7).

5. Ephedra 
Epphedra has been used in Chinese medicine traditionally for 5,000 years in treating asthma, hay fever and the common cold.

It also helps to support healthy sinus nasal lung and respiratory function by removing toxins in the lung. 

“Ephedra, when taken as directed – no more than 90mg/day and not to be taken by those with pre-existing heart conditions – is safe and effective for those looking to lose weight,” said David Fabrican’t, the FDA’s appointed person on dietary supplement regulations,.after FDA lifting the 10-year ban on weight-loss blockbuster botanical ephedra.

Application of the herbal medicine were effective in protected bronchial epithelium(8), inhibited influenza viral pneumonia(9) and chronic obstructive pulmonary diseases (COPD)(10).

6. Elecampane 
Elecampane is also called horse-heal with function for treatment of shortness of breath and promotion of a strong lung.

Elecampane is a wonderful lung tonic.medicine for treating asthma, and soothing the lining of the lungs.

Accoridng to the study by the Daegu Gyeongbuk Institute for Oriental Medicine Industry, intake of
Elecampane exerted strong anti-asthmatic(11) and anti lung cancer(12) and inhibition of mucus hypersecretion effects in vitro(11).

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Bioactive compounds and antioxidant and antiproliferative activities of Korean white lotus cultivars by Park YS1, Towantakavanit K, Kowalska T, Jung ST, Ham KS, Heo BG, Cho JY, Yun JG, Kim HJ, Gorinstein S(PubMed)
(2) Vitamins and respiratory disease: antioxidant micronutrients in pulmonary health and disease by Kelly FJ(PubMed)
(3) Saponins, especially platyconic acid A, from Platycodon grandiflorum reduce airway inflammation in ovalbumin-induced mice and PMA-exposed A549 cells by Choi JH1, Jin SW, Kim HG, Choi CY, Lee HS, Ryu SY, Chung YC, Hwang YJ, Um YJ, Jeong TC, Jeong HG(PubMed)
(4) Platycodin D attenuates acute lung injury by suppressing apoptosis and inflammation in vivo and in vitro by Tao W1, Su Q2, Wang H3, Guo S4, Chen Y4, Duan J5, Wang S(PubMed)
(5) ALL ABOUT WILD CHERRY BARK (PRINTABLE MONOGRAPH) by Herbal Academy
(6) Protective effects of Isofraxidin against lipopolysaccharide-induced acute lunginjury in mice by Niu X1, Wang Y2, Li W3, Mu Q2, Li H2, Yao H2, Zhang H(PubMed)
(7) [Mechanism of the antiasthmatic effect of total coumarins in the fruit of Cnidium monnieri (L.)Cuss].[Article in Chinese] by Chen Z1, Duan X.(PubMed)
(8) Effect of San-ao Decoction, a traditional Chinese prescription, on IL-4 treated normal human bronchial epithelium by Li Y1, Wang MY, Fan XS, Qi X, Chen Y, Zhang H, Zhao QC(PubMed)
(9) Protective effects of Yinhuapinggan granule on mice with influenza viral pneumonia by Peng XQ1, Zhou HF1, Lu YY2, Chen JK1, Wan HT3, Zhang YY(PubMed)
(10) Polysaccharide from Ephedra sinica Stapf inhibits inflammation expression by regulating Factor-β1/Smad2 signaling by Liang S1, Meng X2, Wang Z3, Liu J4, Kuang H5, Wang Q(PubMed)
(11) Alleviaon of OVA-induced airway inflammation by flowers of Inula japonica in a murine model of asthma by Park YN1, Lee YJ, Choi JH, Jin M, Yang JH, Li Y, Lee J, Li X, Kim KJ, Son JK, Chang HW, Kim JY, Lee E(PubMed)
(12)1-o-acetylbritannilactone (ABL) inhibits angiogenesis and lung cancer cell growth through regulating VEGF-Src-FAK signaling by Zhengfu H1, Hu Z1, Huiwen M1, Zhijun L1, Jiaojie Z2, Xiaoyi Y3, Xiujun C(PubMed)





*Degenerative Disease: Beware of Dementia Caused By Acquired Or Hereditary Mutation of Genes, MEDLINE Studies Show

By Kyle J. Norton, Scholar and Master of Nutrition


According to US statistic, the rate has been falling sharply by 24 % from 2000 t0 2012 in age group of 65 and older. And the average age of people diagnosed with dementia in 2000, are 80.7 in compared to 82,4% in 2012(1).

One in 10 people will be diagnosed of dementia as some point in their lifetime. And 5.7 million Americans of all ages are living with Alzheimer's dementia in 2018. 

Sadly, Alzheimer's disease is the sixth-leading cause of death in the United States, and the fifth-leading cause of death among those age 65 and older(2).

The diseases also is a leading cause of in reduced quality of life due to disability and poor health.

Unfortunately, the prevalent risk of dementia have escalated substantially in the East due to economic prosperity over last 30 years in increased living standard of population over a billion.

As a large percentage of these population are followers of Western diet as they have made a lots of money in compared to others and the past.

Dementia is the loss of mental ability that is severe enough to interfere with people's every day quality of life.

And, Alzheimer's disease is the most common type of dementia in aging people.

Genetic mutation is a condition of changes of DNA structure and alteration in the inherited nucleic acid sequence of the genotype(169). There are always a concern of some dementia patients with inherited trails for passing them to their children.

According to medical literature, genes mutation, specific genes that cause autosomal dominant dementia in the family may increase substantial risk of early onset dementia.

However, one must also include disease-causing genes mutation as it is the most common age-related dementia.

Certain genes, according to Medline studies are associated to early onset of dementia, including

1. Linkage of Dementia with Lewy bodies (DLB) to 2q35-q26
Genetic mutation of chromosome 2q35-q36 Lewy bodies (DLB) are multiplex, due to its complex mechanism than generally monogenic disorders. Identifying the first familial DLB gene may contribute to an entry point of DLB pathology, according to Belgian family,researchers(170)

2. VCP gene R155H mutation
Some patients in the same family with frontotemporal dementia (FTD) have been diagnosed with high risk of cognitive decline due to the recurrent R155Hmutation, according to University of Genova(171).


3. Genetic mutation and Alzheimer's disease
4 genes have been identified to affect development of AD. with the amyloid precursor protein (APP ) gene, presenillin gene (PSEN-1), and presenillin gene (PSEN-1)) affect younger people, and apolipoprotein E (APOE ) iaffects older people(172).

4. Chromosome 3 (FTD-3) caused by a truncating mutation in CHMP2B
Presymptomatic CHMP2B mutation was found to associate to significantly decreased cerebral blood flow (CBF) affecting brain capillaries(173) and contributing to the early on set of dementia.

5. Mutations in the NOTCH3
Mutations in the NOTCH3 gene are responsible for hereditary stroke disorder, contributed to an adult onset of hereditary ischemic stroke, vascular dementia and psychiatric disorders(174).

References
(1) U.S. Dementia Rates Are Dropping Even as Population Ages, by NewYork Time
(2) 2018 ALZHEIMER'S DISEASE FACTS AND FIGURES by Alzheimer's Association
(169) Smoking: effects on multiple sclerosis susceptibility and disease progression by Dean M. Wingerchuk(PMC)
(170) Comprehensive genetic and mutation analysis of familial dementia with Lewy bodies linked to 2q35-q36 by Meeus B1, Nuytemans K, Crosiers D, Engelborghs S, Peeters K, Mattheijssens M, Elinck E, Corsmit E, De Deyn PP, Van Broeckhoven C, Theuns J.(PubMed)
(171) Inclusion body myopathy, Paget's disease of the bone and frontotemporal dementia: recurrence of the VCP R155H mutation in an Italian family and implications for genetic counselling by Viassolo V1, Previtali SC, Schiatti E, Magnani G, Minetti C, Zara F, Grasso M, Dagna-Bricarelli F, Di Maria E.(PubMed)
(172) About Dementia Types of Dementia Genetic Mutations(Dementia guide)
(173) Presymptomatic cerebral blood flow changes in CHMP2B mutation carriers of familial frontotemporal dementia (FTD-3), measured with MRI. by Lunau L1, Mouridsen K, Rodell A, Ostergaard L, Nielsen JE, Isaacs A, Johannsen P; FReJA Consortium.(PubMed)
(174) Novel mutation of the notch3 gene in arabic family with CADASIL. by Bohlega S1.(PubMed)

Saturday 23 June 2018

Anti Aging: The Natural Remedy Used Popularly In Skin Care Products Against All Aspects of Aging, Medline Studies Reveal

Kyle J. Norton


 Skin aging is a natural process with skin expression of thinner, paler and pigmented spots, including age spots, liver spots.

Herbal plants have formed a fundamental source for conventional medicine in discovery of single ingredient medication, including aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)..., particularly, in aging cosmetic products.

Numbers of herbal whole foods and theirs phytochemicals have been found in many anti aging products and they are sold to general public with or without clinical and non clinical trials.

How many of these types of products are actually working, the numbers are vague, depending to who do you talk to.

According to the statistic, 10 of most common herbal plants may be consumed or only be used as topical application, include aloe vera, the first in the list, avocado, almond, henna, sandalwood, saffron, elder tree, neem, lavender and amla. The list may be altered, depending to specialist preferences.

Some researchers suggested that honey best known for its properties of dressing for wounds and burns, may be also used as cosmetic anti aging substance as it exerts emollient, humectant, soothing, and hair conditioning effects, keeps the skin juvenile and retards wrinkle formation, regulates pH and prevents pathogen infections, through its antioxidant activities(1).

Cosmetic products are very profitable business. Global anti-aging market is growing rapidly, the total sale may reach over $331.41 billion by 2021, according to Orbis Research

The causes of skin aging can be both intrinsic and extrinsic factors, Dr. Poljšak B and colleagues in the study of skin aging said, " It is well accepted that oxidative stress contributes significantly to extrinsic skin aging, although findings point towards reactive oxygen species (ROS) as one of the major causes of and single most important contributor; not only does ROS production increase with age, but human skin cells' ability to repair DNA damage steadily decreases over the years"(3).

Oxidative stress over expression in the outer skin layer due to environment stress and lifestyle and diet preferences may interfere the normal growth of healthy skin, leading to onset of skin aging.

These results are actually caused by incapability of the body enzymes with function in stimulated production of antioxidants to counter the levels of free radicals and their domino effects, causing alternation of the ratio of antioxidants and reactive oxygen species in the host body in induction of skin aging..

Truly, intrinsic and extrinsic aging causes significant alter the skin structure and components, that subsequently can impair molecular characteristics and biochemical processes, suggested by Dr. Fang JY, the lead author at joint study lead by the Chang Gung University(2).

The list of preventable risk factors and common causes of skin aging can be interestingly, including
* UV exposure
* Makeup wipes
* Dirty makeup brushes
*Poor diet
* Stress,
* Smoking
* Excessive alcohol intake
* Repetitive facial expressions
* Physical inactivity,......

Aloe Vera or Aloe Vera supplement may be used to delay skin aging degeneration, particularly, in  expression of wrinkle.

Aloe Vera is species of succulent plant in the genus Aloe, belongings to the Family Xanthorrhoeaceae, native to Sudan.

It is very popular and cultivated commercially, due to its health benefits.

The herbal medicine has been used for treatment of many kinds of ailments, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated of cholesterol, etc.

Wrinkle is a skin degenerative condition caused by the loss of dermis and subcutaneous fat layer underneath the skin, leading to a slight line or fold on the skin, particular in the face.

According to the Food Ingredients & Technology Institute, daily oral intake of plant sterols of Aloe vera gel (Aloe sterol) significantly increases the skin barrier function, moisture, and elasticity in photoprotected skin, thus reducing risk of  skin wrinkle.

In a 12-week, randomized, double-blind, placebo-controlled study of 48 apparently healthy men (age range: 30-59 years; average: 45 years), given oral Aloe sterol supplementation for 12 weeks, at the end of week 12  researchers found that the application shows a significant improvement of the skin elasticity index in comparison to the baseline value.

Dr. Tanaka M, the lead author said, "Aloe sterol ingestion increased skin elasticity in the photodamaged skin of men aged <46 years, and "No Aloe sterol intake-dependent harmful phenomenon was observed during the intake period".

Furthermore, in vitro, Aloe sterols increased production of collagen and hyaluronic acid, natural substance in skin response to connective, epithelial, and neural tissues. approximately two-fold and 1.5-fold, and promoted gene expression levels in human dermal fibroblasts.

In fact, daily application of Aloe sterol-containing Aloe vera gel powder (AVGP) significantly reduced facial wrinkles in women aged ≥40 years as well as stimulating collagen and hyaluronic acid production by human dermal fibroblasts.

Injection of Aloe Vera gel enhanced healthy skin through promoting elasticity (R2), net elasticity (R5), and biological elasticity (R7) scores and skin fatigue area F3, according to the Food Ingredients and Technology Institute 12 weeks study suggested.

Taking altogether, there is no doubt that oral and topical administration of aloe vera or aloe vera supplements may improve skin condition caused by skin degeneration in all aspects, but quality of amount intake should only be prescribed by related field specialist.

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Kyle J. Norton, Scholar and Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Honey in dermatology and skin care: a review by Burlando B1, Cornara L(PubMed)
(2) Skin aging caused by intrinsic or extrinsic processes characterized with functional proteomics by Fang JY1,2, Wang PW3, Huang CH4, Chen MH5,6, Wu YR7, Pan TL(PubMed)
(3) Intrinsic skin aging: the role of oxidative stress by Poljšak B1, Dahmane RG, Godić A(PubMed)
(4) Effects of plant sterols derived from Aloe vera gel on human dermal fibroblasts in vitro and on skin condition in Japanese women by Tanaka M1, Misawa E1, Yamauchi K1, Abe F1, Ishizaki C2.(PubMed)
(5) Effects of Aloe Sterol Supplementation on Skin Elasticity, Hydration, and Collagen Score: A 12-Week Double-Blind, Randomized, Controlled Trial by Tanaka M1, Yamamoto Y, Misawa E, Nabeshima K, Saito M, Yamauchi K, Abe F, Furukawa F.(PubMed)
(6) Aloe sterol supplementation improves skin elasticity in Japanese men with sunlight-exposed skin: a 12-week double-blind, randomized controlled trial by Tanaka M1, Yamamoto Y2, Misawa E1, Nabeshima K1, Saito M1, Yamauchi K1, Abe F1, Furukawa F2.(PubMed)

Friday 22 June 2018

A Food That Protects Cell Integrity And DNA Transcription Against Most Types Of Cancer Onset, Medline Studies Revealed

Kyle J. Norton, Scholar, Master of Nutrition

Adding a portion of dried beans into your diet, may have a potential effect in reduced risk of cancers onset, according to the Division of Cancer Prevention, National Cancer Institute.

Dried beans are nutritionally mighty member of the legume family, belongings to the family Fabaceae.

The  healthy sources of dried legume, including protein, fibers, vitamins and minerals such as dietary fiber, fat, protein, vitamin A ( beta carotene, lutein and zeaxanthin), B vitamins, vitamin C, calcium, iron, magnesium, phosphorus, potassium, ...  and zinc can be included in anyone diet,

Certain genetic mutations may have significant influences in risk of cancers, such as BRCA1 and BRCA2 genes which can elevate risk of breast and ovarian cancers. 

According to statistic, women who carry mutated gene BRCA1 and 2 have a 50 to 85 percent increased risk of developing the disease by age of 70.

Other causes of cancer are unknown, however, researchers suggested that smoking and use of tobacco, unhealthy diet, family history, inactive physical activity, long term exposure to sun and other types of radiation, infected viruses,        and infectious diseases are some of potential risk factors that may have a strong impact on the development of cancers.

Cancer is a class of diseases characterized by cell growth  uncontrollably and disorderly, affecting all the organs and tissue.

Depending to its invasive nature, some cancers can travel a distance away from the original site to infect other parts of the body.

In the study to investigate 490,802 United States participants of the NIH-AARP Diet and Health cohort using Cox proportional hazard models adjusted for potential confounders and during 2,193,751 person years of follow-up from 1995/1996-2000, researchers found that
*. Intake of vegetables shows a significant effect in reduced risk of certain types of cancer.

* The relative hazard ratio risk of cancers was reduced to .95 in compared to control

*. Risk of cancers is reduced substantially as shown in highest tertile of leguminosae group (dried beans, string beans and peas, 0.80, 0.67-0.96) in compared to other groups.

Dried bean and string bean with abundant fiber scored the lower and lowerest relative risk ratio in compared to peas and other kinds of vegetables.

Further analysis of diets of African-American men and women, undergoing colonoscopies in order to examine the relationship between selected dietary factors and the risk for colon polyps, according to the multiple logistic regression model used to adjust for potential confounding variables and to determine which factors influence colorectal adenoma risk, researchers said, " consumption of legumes such as dried beans, split peas, or lentils was negatively associated with risk (of cancers)" and "Legumes are a good source of dietary fiber and of phytochemical compounds that may play a role in reducing adenoma formation or growth".

Once again, dried beans exerted a highest effect in reduced risk of colorectal adenoma in compared to other types of legume.

Interestingly, in broaden scope of further exploration of the association between legume intake and cancer risk in a case-control study of 11 cancer sites in Uruguay between 1996 and 2004, including 3,539 cancer cases and 2,032 hospital controls, researchers suggested, intake of legume including dried peas demonstrate a substantially decreased risk of stomach and prostate cancer and other forms of cancer, including
*. Cavity and pharynx cancer had a relative odd risk ratio of OR=0.48

*. Esophagus cancer with OR = 0.54

*. Larynx cancer with OR = 0.55

*. Upper aerodigestive tract cancer with OR = 0.50

*. Stomach cancer with OR = 0.69

*. Colorectum cancer with OR = 0.43

*. Kidney cancer relative had odd risk ratio of .OR = 0.41

* With relative odd risk ratio of .68 on all sites combined



After adjusting to other risk factors researchers concluded, "Higher intake of legumes was associated with a decreased risk of several cancers including those of the upper aerodigestive tract, stomach, colorectum, and kidney, but not lung, breast, prostate or bladder".

These results suggested that the protective effect of dried beans in inhibited most types of cancer occurrence may be a result of improvement of  host cells integrity against alternation of  cells DNA transcription in induction of cancer.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca




Sources
(1) Legume intake and the risk of cancer: a multisite case-control study in Uruguay by Aune D1, De Stefani E, Ronco A, Boffetta P, Deneo-Pellegrini H, Acosta G, Mendilaharsu M.(PubMed)
(2) Legume intake and reduced colorectal adenoma risk in African-Americans by Agurs-Collins T1, Smoot D, Afful J, Makambi K, Adams-Campbell LL.(PubMed)
(3) Fruit and vegetable intake and head and neck cancer risk in a large United States prospective cohort study by Freedman ND1, Park Y, Subar AF, Hollenbeck AR, Leitzmann MF, Schatzkin A, Abnet CC.(PubMed)

Detoxification: Time To Detox, If You Experience Some Of These Symptoms

By Kyle J. Norton, Scholar, Master of Nutrition

Our body toxins are removed by some vital organs such as the liver, kidney and skin.

If one of these organs starts to malfunction, others must take the toxins and remove them.

In cases of our body cannot completely remove all the toxins, toxins will  be accumulated in the organs and tissue, leading to weakening of organs and tissue function in induction of chronic diseases.

1. The Liver
The liver plays a major role in metabolism.
It is among the few internal human organs capable of natural regeneration of lost tissue.
Liver has a vital function in removing toxins in our body, such as overdose of medication, vitamin A and other substances damages the normal function.
Symptoms of a weakened liver include:
a) Arthritis
b) Pale or Brittle nails
c) Unable to sleep
d) Bitter taste in the mouth
e) Limited muscle flexibility

Some of the herbal medicine may have a significant effect to promote liver function in eliminated toxins from our body including, milk thistle, a flower plant of the daisy family has been used in traditionally medicine for treatment of chronic liver disease.

The herbal medicine contains silymarin with impressive functions in protected liver function and expelled liver toxins.

In a study to compare Cirsium japonicum DC's flavonoids, liver protection against liver toxicity using carbon tetrachloride (CCl4) with silymarin as a positive control, researchers after taking into account of other co and founders found that silymarin exerts a clear hepatoprotective effect similar to those of Cirsium japonicum DC's flavonoids against toxins caused by injection of carbon tetrachloride (CCl4)(1)


2. The Kidneys
Works together with the Liver in removing toxins from our diet including overdose of medication through urinary extraction.

The kidneys also make hormones that control blood pressure, bone maintenance, and the production of red blood cells. Most cases of kidney disease are caused by high blood pressure, kidney inflammation and hardening of arterial walls.

Symptoms of a weakened kidney include:
a) Sexual dysfunction
b) Mental retardation
c) Low grade back pain
d) Weakness of knee and leg
e) Frequent urination


According to the University of Southern California, antioxidant phenolic compounds such as tannins, flavonoids, isoflavonoids, unsaturated organic acids and lignans; circulation enhancing compounds like saponins, and basic alkaloids with multiple targets (G-protein coupled receptors) nay have a profound and positive effect in improved kidney function(2).

The other compounds with properties in exertion of proinflammatory and antiinflammatory activities may also be included in these groups, such as fatty acids like linoleic (n-6) and α-linolenic (n-3) acids(2).

And these compounds can be found in many of Chinese herbal plants(2).

Dr. Lien EJ, the lead author said, "Attention is also drawn to the plants containing nephrotoxic aristolochic acid. Different directions of future research are also presented. We hope that this review may provide some leads for new drug (with kidney protective effect ) discovery and development, and more rational application of TCM"(2)..


3. The Skin
Skin is the largest organ of the integumentary system made up of multiple layers of epithelial tissues.

 It also is the third system with function to expel toxins from our body, if the liver and kidney cannot completely remove them.

Symptoms of toxic skin include:
a) Skin rashes caused by vitiligo and psoriasis
b) Red, itchy rash
c) Inflammation
d) Temporary disability

Duchesnea indica (Rosaceae family), used extensively in traditional Chinese medicine for treatment of varieties of disease and syndrome may have potential effect in protected skin against toxic substance accumulation.

According to the Kangwon National University, methanolic extract of D. indica (DIM) protected the skin toxicity through increasing the antioxidants levels of the host by utilized antioxidant in the extract and antioxidants produced enzymes in the body tissue.

Dr. Hu W, the lead scientist said, "Pretreatment of CCD-986Sk cells with methanolic extract of D. indica (DIM) improved the cell viability, enhanced activity of catalase, and decreased the leakage of lactate dehydrogenase (LDH) and the levels of malondialdehyde (MDA) and intracellular reactive oxygen species (ROS) in H(2)O(2) injured cells"(3).


4. The Intestine (except colon)
Intestine includes 2 parts 
 * The small intestine is further subdivided into the doudenum, jejunum and ileum. it helps to digest materials passing through and from where nutrients are absorbed.

* The large intestine is subdivided into the cecum and colon with unique function in absorbed water from digested material and any nutrients that may have escaped primary digestion in the ileum.
Symptoms of dysfunction of the intestine include:
a) Abdominal pain
b) Peripheral vision losses, night vision losses
c) Weight loss
d) Upset stomach, fever, earache, headache
e) Bowel obstruction
f) Muscle spasms and cramps

Sipjeondaebo-tang, a traditional herbal medicine formula, used to improve immune system against invasion of foreign pathogens., may be a potential herbal medicine in promoted gastrointestinal performance.

Application of Sipjeondaebo-tang water extract (SDTW; 200 mg/kg of body weight) to rats 2 h before the oral administration of absolute ethanol to induced dastric mucosal injury exerted a gastric protective effect by decreased the damage via conditioning the gastric mucosa, such as hemorrhage, hyperemia(4).

The results of these activities were observed by significantly reduced MDA concentration and  increased GSH contents and the activities of antioxidant enzymes(4).

Dr. Woo-Young Jeon, the lead scientists said, "In an acute toxicity study, no adverse effects of SDTW were observed at doses up to 5000 mg/kg/day"(4).

5. The Colon
The colon is the last portion of the digestive system.

It also has a function in extracted water and salt from solid waste before eliminating them from the anus.

Symptoms of a malfunctioning colon include:
a) Memory loss
b) Inability to concentrate and confusion
c) Joint pain
d) Weakening the colon's ability to properly eliminate all the waste materials
f) Autointoxication or self-poisoning.


Composition of extracts of 3 herbs medicine (Atractylodis Rhizoma Macrocephalae, Massa Medicata Fermentata, and Dolichoris Semen) has been known to exert GI protective activities
According to the study in evaluation of gut microbial niche by antibiotics like neomycin in produced gastrointestinal (GI) disorders conducted by the Dongguk University-Seoul, application of mixture augmented stool water content, decreased fecal population of Lactobacillus spp., changed the histology of intestine without inducing inflammation, reduced the colonic expression of zonula occludens-1 (ZO-1) and claudin-1, a marker of presence of bacteria, against neomycin-induced digestive dysfunction(5).

Dr. Bose S, the lead author said, "The combined treatment with any of the above agents ameliorated the histological changes of cecum and colon in neomycin-treated rats, and the magnitude of this effect was probiotic > HF-2 > HF-1"(5).

6. The Blood
If the liver, kidney and skin cannot completely remove toxins, they will be accumulated in the blood stream, causing inflammation of blood vessels and buildup of plaque.

Symptoms of poisoned blood include:
a) Illusion
b) Confusion
c) Black Stew
d) Black skin
e) Inflammation

According to the Dongguk University Seoul, Rhizoma Atractylodis Macrocephalae, Massa Medicata Fermentata, and Dolichoris Semen are Chinese herbal medicine used for treatment of symptoms induced by inflammation .

In LPS-mediated inflammatory insult, either individually in vitro using RAW264.7 cells or in combination in in vivo using rats, application of individual herb exerted a significantly anti-inflammatory activity through strongly attenuated the blood endotoxin and CRP levels, as well as the gut permeability, and significantly augmented the intestinal Lactobacillus spp. colonisation in LPS-treated rats(6).

 Lipopolysaccharide (LPS) is known to produce endotoxic shock by triggering systemic inflammatory responses.

7. Lung
The lung is the essential respiration organ with function in transported oxygen into the bloodstream, and released carbon dioxide from the bloodstream into the atmosphere.

Symptoms of a weakened lung include:
a) Build-up of mucus
b) Irritation of the eyes, nose, throat, lips and tongue
c) Blockage of air way
d) Sudden illness
e) Chronic cough
f) Tiredness or depression


In the study to analyze whether Esculentoside A (EsA), a saponin isolated from the Chinese herb Phytolacca esculenta with lung protective effect against lipopolysaccharide (LPS)-induced acute lung injury (ALI) researchers at the Jilin University found that injection of EsA shows marked effects by reducing inflammatory infiltration, thickening of the alveolar wall, and pulmonary congestion and decreases levels of tumor recrosis factor α and inflammatory factor interleukin 6 which are elevated by LPS(7).

After taking into account of other co and con con founders, Dr. Zhong WT, the lead researcher said, "EsA suppressed inflammatory responses in LPS-induced ALI through inhibition of the nuclear factor kappa B and mitogen activated protein kinase signaling pathways"(7).

Nuclear factor kappa B are signalling proteins with function in activated production of inflammatory cytokines.

Mitogen activated protein kinase signaling pathways are family of proteins with functions involved  numbers of fundamental cellular processes such as proliferation, differentiation, motility, stress response, apoptosis, and survival.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Hepatoprotective effect of flavonoids from Cirsium japonicum DC on hepatotoxicity in comparison with silymarin by Ma Q1, Wang LH, Jiang JG(PubMed)
(2) Phytochemical analysis of medicinal plants with kidney protective activities by Lien EJ1, Lien LL, Wang R, Wang J.(PubMed)
(3) Protective effect of the methanolic extract from Duchesnea indica against oxidative stress in vitro and in vivo by Hu W1, Han W, Huang C, Wang MH(PubMed)
(4) Gastroprotective effect of the traditional herbal medicine, Sipjeondaebo-tang water extract, against ethanol-induced gastric mucosal injury by Woo-Young Jeon, In-Sik Shin, Hyeun-Kyoo Shin, and Mee-Young Lee(PubMed)
(5) Intestinal Protective Effects of Herbal-Based Formulations in Rats against Neomycin Insult by Bose S1, Han KW, Lee MJ, Kim H(PubMed)
(6) In vitro and in vivo protective effects of fermented preparations of dietary herbsagainst lipopolysaccharide insult by Bose S1, Song MY, Nam JK, Lee MJ, Kim H(PubMed)
(7) Protective effect of esculentoside A on lipopolysaccharide-induced acute lunginjury in mice. by Zhong WT1, Jiang LX, Wei JY, Qiao AN, Wei MM, Soromou LW, Xie XX, Zhou X, Ci XX, Wang DC.(PubMed)