How to Prevent Onset of Pulmonary Fibrosis Naturally, MEDLINE Studies Show

Kyle J. Norton


Green tea may have a therapeutic and positive effect in reduced risk and progression and treatment of pulmonary fibrosis, some scientists suggested.

Pulmonary fibrosis (PF) is a chronic and progressive condition of lung disease characterized by reduced numbers and increased stiffness of air sac in the lungs (alveoli), affecting the lung breathing function to provide enough oxygen into the bloodstream

Green tea, is a precious drink processed numbers of health benefit known to almost everyone in Asia and Western world.

In the evaluation of green tea extract efficacy in pulmonary fibrosis caused by direct injury due to over expression of oxygen free radicals and inflammatory cells and fibroblasts in mice model with injection of Paraquat (0.3 mg/kg) into the right lungs of rats, after 2 weeks, then assigned the tested mice to group treated by green tea extract or non treatment groups and control group treated by saline, after assessment, researchers found that
* Non treatment group exerts a significant expression of pulmonary fibrosis, observed by contents of light microscopic morphometry and hydroxyproline and over capacity of ROS observed by the lipid perioxidation assay.

Light microscopic morphometry is valuable technique in the analysis of precancerous lesions at the light and electron microscopic level, in this case, it is pulmonary fibrosis.
Further examination also discovered that non treatment mice group displays a pronouncely increased
levels of malondialdehyde (MDA), an indication of over expression of free radicals in induction of oxidative stress caused by ROS chain reaction and endothelin (ET)-1, and prepro-ET-1 mRNA expression, a strong indication of the endothelium signals of vasoconstriction and local cellular growth and survival of air sac cells in the lungs (alveoli).

Malondialdehyde (MDA) is a marker of oxidative stress

Endothelin 1 (ET-1) is a potent vasoconstrictor

*In compared to non treatment and saline groups, green tea administered 1% GTE mixed with feed group shows significant decrease in pulmonary fibrosis, along with decreases in MDA, ET-1, and prepro-ET-1 mRNA expression



The result suggested that green tea inhibitorily oxidative activity in reduced expression of pulmonary fibrosis through promoted production of antioxidants and  antioxidants from the host to restore the ratio of antioxidant and free radicals and decreased the facilitation of proinflammatory cytokines in precipitated damage and apoptosis of lung cells and fibroblasts.


Dr. Kim HR, thelead author, after taking into account of other con founders said, "GTE inhibits paraquat-induced pulmonary fibrosis by suppression of oxidative stress and ET-1 expression".


Additional study of the neutrophils in the site of infection in initiated host defense and inflammation for pulmonary fibrosis development by the Medical School of Padova, revealed that application of green tea (-)epigallocatechin-3-gallate (EGCG) strongly inhibits neutrophil elastase by repressing the reactive oxygen species activity in induction of apoptosis of activated neutrophils.

In vitro, administration of EGCG dramatically inhibited chemokine expression, a secondary pro-inflammatory mediators induced by primary pro-inflammatory in activated neutrophil chemotaxis in migration of neutrophils of immune system to the site of infection.

Importantly, injection of green tea EGCG also demonstrated a significant effect by blocking neutrophil-mediated angiogenesis in vivo by initiated growth of new blood vessels to stimulate and fuel the ongoing lung cell damage and death of the cell in the alveoli.

These differentiation constituted a substantial and protective effect in enhanced resolution in a pulmonary inflammation model and significantly reduced consequent fibrosis.

Dr. Donà M, at the end of the analysis said, "These results provide molecular and cellular insights into the claimed beneficial properties of green tea and indicate that EGCG is a potent anti-inflammatory compound with therapeutic potential".


The above analysis of green tea effect in protect the lung against the development of pulmonary fibrosis caused by free radical chain reaction and over production of pro inflammatory factors were supported by the study of "the protective effect of green tea extract (GTE), curcumin, against N-acetyl cysteine (NAC) on experimentally induced pulmonary fibrosis" by Cairo University.

According to the study, application of curcumin (200 mg/kg b.w), GTE (150 mg/kg b.w), and NAC (490 mg/kg b.w) orally for 14 days with concomitant administration of cyclophosphamide (CP), revealed a strong activity in inhibited oxidative stress and lung myelo-peroxidase activity observed in animals of the CP group.

Cyclophosphamide is a chemodrug used to suppress the immune system.

Myelo-peroxidase (MPO) is a highly oxidative enzyme.

Treatment group also decreased the levels of N-acetyl-β-d-glucosaminidase, leukotriene C₄, and protein in bronchoalveolar lavage fluid (BALF) in demonstration of over reaction of immune response in induction of inflammation through inhibited production of proinflammatory cytokines (growth factor-β, interleukin -1β, and histamine) in initiated lung injure and induced apoptosis of lung cells.

N-acetyl-beta-D-glucosaminidase) in the analysis of kidney disease including nephrotoxicity.

Leukotriene C₄ is a leukotriene produced and secreted by eosinophils on activation.

Bronchoalveolar lavage fluid (BALF) is used to analyze interstitial lung diseases.

Protein abundance levels in BALF is a marker of lung diseases
 

Taken together, green tea and its bioactive polyphenols may be considered as a function food for prevention and treatment of pulmonary fibrosis through reducing oxidative stress and inflammatory effect in elevated risk and progression of the disease.

Reprint of this article is welcome with author name and link to the article sources intact https://kylejnorton.blogspot.ca/2018/03/the-magic-of-camellia-sinensis-leaves_4.html


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Neutrophil restraint by green tea: inhibition of inflammation, associated angiogenesis, and pulmonary fibrosis by Donà M1, Dell'Aica I, Calabrese F, Benelli R, Morini M, Albini A, Garbisa S.(PubMed)
(2) Green tea extract inhibits paraquat-induced pulmonary fibrosis by suppression of oxidative stress and endothelin-l expression by Kim HR1, Park BK, Oh YM, Lee YS, Lee DS, Kim HK, Kim JY, Shim TS, Lee SD(PubMed)
(3) Modulatory effects of curcumin and green tea extract against experimentally induced pulmonary fibrosis: a comparison with N-acetyl cysteine by Hamdy MA1, El-Maraghy SA, Kortam MA(PubMed)

How to Boost Your Immunity Naturally, US National Library of Medicine Studies Suggest

Kyle J. Norton

Carrots and tomatoes and theirs major bioactive carotenoids  may have a profound and positive effect in boosting immunity, some scientists suggested.

The results of the studies were carried out by numbers institutes in numbers of different differentiation, including Institute of Nutritional Physiology, Federal Research Centre for Nutrition.

You  can also view the abstract by clicking the links in the resources.

Immunity is a natural defense of organism with an aim to protect the host to resist a particular infection or toxin through expression of antibodies or sensitized white blood cells.

Carrot, a root vegetable with orange color is a sub spices of Daucus carota, belongings to the family Apiaceae, native to Asian and Europe.

Tomato is a red, edible fruit, genus Solanum, belongings to family Solanaceae, native to South America. 

Because of its health benefits, tomato is grown world wide for commercial purpose and often in green house.

In the investigation of the effect of beta-carotene has been shown to enhance immune functions in humans, the Institute of Nutritional Physiology, Federal Research Centre for Nutrition launched an study to examine whether vegetables rich in carotenoids, such as beta-carotene or lycopene, exert any modulation of immune function in healthy humans.

The blinded, randomized, cross-over study, included male subjects on a low-carotenoid diet consumed 330 ml/day of either tomato juice(37.0 mg/day lycopene) or carrot juice (27.1 mg/day beta-carotene and 13.1 mg/day alpha-carotene) for 2 weeks with a 2-week depletion period after juice intervention.

Epidemiological studies suggested that consuming carotenoids form food sources may provide a variety of health benefits including a reduced incidence of cancers, risk of cardiovascular disease, and improved eye health,.......

Reading of the immune status was assessed by measuring the related activity of natural killer (NK) cells, secretion of cytokines ( IL-2, IL-4, TNFalpha), and proliferation by activated peripheral blood mononuclear cells((T cells, B cells, NK cells).

Natural killer cells is a type of white blood cells formed a component of innate immune system with function in inhibited microorganisms infected cells.

Interleukin-2 (IL-2) is a type of inflammatory cytokine with function in signaling molecule in the immune system to protect the body against bacterial and viral in the acute phase of infection.

Interleukin-4 (IL-4) activated by lymphoid cells is the inflammatory cytokine critical for initiating humoral immunity against extracellular pathogens.

Both Interleukin-2 and 4 (IL-2and 4 ) play an important role in chronic inflammation and wound repair.

Tumor necrosis factor (TNF) including , tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a protein (cytokine) involved in systemic inflammation during acute phase of infection.

At the end of the experiment, researchers found that
* Both juices treated participants demonstrate relatively fast responses in plasma carotenoid concentrations (p < 0.0002) without inducing concomitant changes in immune functions.

* Intake of both tomato and carrot juice displays a significant activity of immunity in production of IL-2, NK cell cytotoxicity, and lymphocyte proliferation with maximum responses observed during depletion periods.

* In compared to the secretion of other inflammatory cytokines, TNF alpha exerts only at the end of the first intervention period.

* During the course of innervation, both juices show insignificant effects in modulated the secretion of IL-4.

These result suggested that lower plasma carotenoid concentrations in the blood stream may reduce the immune function in response to diseases caused by bacterial and viral infection, particularly in the acute phrase.

Occasional intake of tomato and carrot juice does not enhance body immunity, due to its function in time-delayed modulation of immune functions and its degradation caused by numbers of factors, including heat, light, oxygen, acid, transition metal, or interactions with radical species.

The conclusion truly addressed the important of carotenoids in modulated immune response in protection of body injure or damage during acute phrase of infection through inhibiting pro inflammatory over expression in induction of cytotoxity and damage to nearby healthy cells.

Further to reaffirm the effects of consumption of carotenoid-rich vegetables on the immune system, the Institute of Nutritional Physiology, Federal Research Centre for Nutrition conducted a study of 23 non-smokers, male subjects, who were not restricted in their daily diet, except that they had to abstain from fruit and vegetables high in carotenoids throughout the whole study period with blood collected weekly from subjects after a 12 h fast.

The study was also divided into four periods, each lasting 2 weeks: 

* Weeks 1-2: low-carotenoid period;

* Daily consumption of 330 ml tomato juice (40 mg lycopene/d, 1.5 mg beta-carotene/d) (weeks 3-4),
* 330 ml carrot juice (21.6 mg beta-carotene/d, 15.7 mg alpha-carotene/d, 0.5 mg lutein/d) (weeks 5-6)
* 10 g dried spinach powder (11.3 mg lutein/d, 3.1 mg beta-carotene/d) (weeks 7-8).

According to the assessment of T-lymphocyte and secretion of immunoreactive cytokines, lower concentration due to consumption of a low-carotenoid diet exerted a significantly reduced proliferation of function immune system observed in peripheral blood mononuclear cells (PBMC) cultured with concanavalin A.

At the end of first 2 weeks of tomato juice consumption and until the end of the intervention period, researchers found that intake of tomato juice with abundant carotenoids induced insignificant change of lymphocyte proliferation in compared to concentration at the end of the depletion period.

Similarly, the experiment also exerted a strong immune modulated effect in assessment of the secretion of cytokines binterleukin (IL)-2 and -4).

Dietary intervention improved the IL-2 and IL-4 secretion values. however the levels of IL-2 and IL-4 were significantly suppressed after the low-carotenoid diet.

The results at the end of the period also expressed the similarity of other studies " After carrot juice and spinach powder consumption the cytokine secretion capacity of PBMC was not significantly different from that at the end of the depletion period". 

Dr. Watzl B, the lead author after taking into account of other co and con founders said, " the results of the present study indicate that a low-carotenoid diet reduces T-lymphocyte functions and addition of tomato juice restores these functions". 

The unexplained changes in the plasma carotenoid concentrations, probably severed as an indication that other phytochemicals or other mechanisms in tomato and carrot juice may have a strong implication in modulated immune response other than cytokine secretion capacity of PBMC.

Taken together, tomato and carrot juice and theirs bioactive carotenoids may be considered as  functional foods in boosting immune function against foreign organsisms, particularly, in the acute phase of infection.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Supplementation of a low-carotenoid diet with tomato or carrot juice modulates immunefunctions in healthy men by Watzl B1, Bub A, Briviba K, Rechkemmer G(PubMed)
(2) Modulation of human T-lymphocyte functions by the consumption of carotenoid-rich vegetables by Watzl B1, Bub A, Brandstetter BR, Rechkemmer G.(PubMed)
(3) Factors influencing the chemical stability of carotenoids in foods by Boon CS1, McClements DJ, Weiss J, Decker EA(PubMed)

How to Accelerate Ecchymosis Healing, US National Library of Medicine Studies Find

Arnica may have a potential and therapeutic effect in reduced expression of Ecchymosis, some scientists suggested.

The results of these efficacy were confirmed by some studies conducted by numbers of respectable institutes, including University of Miami Miller School of Medicine and University of South Florida.

Ecchymosis is a condition of discoloration of the skin as a result of bleeding underneath. In most cases it is caused by bruising.


Arnica is a herbaceous species, genus perennial, belongings to the family Asteraceae, antive to Europe and Asia, used in herbal medicine for centuries to treat strains, sprains, and bruises.

Wound healing is process of repairing of damage of skin, tissues, organs, etc.

The ingredients
Helenalin, chamissonolid, Sesquiterpene lactone, lignans of the furofuran, dibenzylbutyrolactone, dibenzylbutyrolactol types, pinoresinol, epipinoresinol, phillygenin, matairesinol, nortrachelogenin, and nortracheloside, six dibenzylbutyrolactol derivative.


In order to confirm the effect of herbal Arnice activity in treatment of ecchymosis in patients who under went rhinoplasty, the most common facial plastic surgical procedure, researchers at the joint study lead by the University of South Florida independently conducted a review of literature in databases (PubMed, SCOPUS, Embase, Web of Science, and the Cochrane database) from inception to September 2016, included studies that compared postoperative care methods (intervention groups) with no treatment (control group).

According to the final searching of 11 trials satisfied the criteria and guideline with a total of 627 patients, application of topical Arnica showed a significant effect in reduced eyelid ecchymosis during the first 7 days postoperative statistically in compared to the control group.

However, eyelid ecchymosis during the first 24 h postoperatively were statistically decreased in the cold compression group in compared to the control and treatment group.


Patients' questionnaires returned also expressed a strong satisfaction in the tapping application group than in the control group.


Also, the ratio of patient satisfaction was statistically higher in the tapping and Arnica application group than those of control.


Additionally, the analysis also found that surgeons had a significant tendency to decrease intranasal packing in remove pain from the surgery area as the placement was found to associate with more adverse effects in terms of postoperative ecchymosis in compared to non-packing.

Further differentiation to confirm the effectiveness of the combination of topical Arnica montana and Rhododendron tomentosum (Ledum palustre) in reducing postoperative ecchymosis in a select population of healthy volunteers after oculofacial surgery, researchers launched a review to examine the postoperative course, using topical Arnica and Ledum after undergoing common oculofacial procedures, including blepharoplasty, browpexy, and rhinoplasty, in the hands of 4 surgeons at tertiary referral centers from July 1, 2012 to December 31, 2012.

A total of 27 patients (16 females, 11 males) with age range of 18 to 70 years were included in the study.

Selected medical review showed that patients applied bilaterally topical hydrogel pads (OcuMend, Cearna Inc., Chicago, IL) containing Arnica 50 M (10) 50% and Ledum 50 M (10) after surgery through postoperative day(POD) 6 at each postoperative visit.


These results of everyday progression in patients were evaluated by their respective surgeons.

The physician-patient rating score were used to compare each patient's observed healing in each group.

Photographs in each examination also were recorded.

The median duration of follow-up was 7 days, range from 1 to 14 days.

According to the rating of final examination,
* The proportions of patients with markedly accelerated healing were 38.5% (5 of 13), 85.7% (6 of 7), 60.0% (12 of 20), and 51.9% (14 of 27) at POD 1 to 2, 3 to 5, 6 to 8, and overall, respectively.

* The proportions of patients with accelerated healing at the same time points were 15.4% (2 of 13), 14.3% (1 of 7), 30.0% (6 of 20), and 37.0% (10 of 27), respectively.


* The proportion of patients using Arnica/Ledum with markedly accelerated healing was significantly higher than the over all and time point proportion of the other groups at (post operative day) POD 3 to 5 (85.7%), POD 6 to 8 (60.0% ), and overall (51.9%) without inducing any adverse effects.

The findings suggested that combination of Arnica/Ledum were more effective in compared to other treatments.


Dr. Lee HS, the lead author said, "The preliminary results from this study demonstrate that the combination of topical Arnica montana and Rhododendron tomentosum (Ledum palustre) may be effective in reducing postoperative ecchymosis...., after oculofacial surgery".

Taken together, topical Arnica may be used alone or combined with other herbal medicine to accelerate the healing of ecchymosis



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Assessing the Effectiveness of Arnica montana and Rhododendron tomentosum (Ledum palustre) in the Reduction of Ecchymosis and Edema After Oculofacial Surgery: Preliminary Results by Kang JY1, Tran KD, Seiff SR, Mack WP, Lee WW.(PubMed)
(2) The effectiveness of postoperative intervention in patients after rhinoplasty: a meta-analysis by Lee HS1, Yoon HY1, Kim IH1, Hwang SH2.(PubMed)
(3) Is There a Role for Arnica and Bromelain in Prevention of Post-Procedure Ecchymosis or Edema? A Systematic Review of the Literature by Ho D1, Jagdeo J, Waldorf HA.(PubMed)

How to Prevent Onset of Inflammatory Related Diseases Naturally, Medline Model Studies Show

Kyle J. Norton

Carrots may have a profound and positive effect in reduced risk, progression and treatment of  inflammatory related diseases, some scientists suggested.

The results of the studies were conducted by numbers of best institutes including National Institute of Nutrition, Jamai Osmania and published on online medical literature.

Inflammation is a natural response of immune system to protect our body against foreign in induction of infection to the site of injure or damage.

However, over expression of proinflammatory cytokines is also associated to induce local cells death and formation of local scars.


Carrot, a root vegetable with orange color is a sub spices of Daucus carota, belongings to the family Apiaceae, native to Asian and Europe.

Nutrients
1. Carbohydrates
2. Sugars
3. Fibre
4. Fat
5. Protein
6. Vitamin A
7. Thiamine (VittaminB1)
8. Riboflavin (Vittamin B2)
9. Niacin (Vittamin B3)
10. Vitamin B6
11. Folate (Vittamin B9)
12. Vitamin C

13. Vitamin K
14. Calcium
15. Iron
16. Magnesium
17. Molybdenum
18. Phosphorus
19. Potassium
20. Sodium

In the investigation the function of adipose tissue in induction of various metabolic diseases including insulin resistance, type 2 diabetes and non-alcoholic fatty liver disease (NAFLD) involved initiation of inflammatory development, researchers at the National Institute of Nutrition, Jamai Osmania launched an study to examine the effect of carrot intake and inflammatory status in male weanling Wistar rats.

The tested group of rats were divided into four groups and fed either control or high fructose diet of AIN-93G composition with or without carrot juice ingestion for an 8 week period.

AIN-93G was the  formulation published by the American Institute of Nutrition (AIN) committee in 1993 improving the laboratory standard, with an aim to accommodate the increased nutritional demands of rat or mouse growth.

At the end of the experiment, researcher indicated that 

* Carrot juice displays insignificant effect in adiposity and cell size of visceral fat depot as well as the retroperitoneal white adipose tissue (RPWAT).

The role of white adipose tissue (WAT) is to store excess fat for future use as sources of energy.

* In high fructose diet, application carrot juice exerts a strong activity in inhibited elevation of plasma free fatty acid (FFA), macrophage chemoattractant protein 1 (MCP1) (P ≤ 0.01) and high sensitive C-reactive protein (hsCRP) (P ≤ 0.05) levels.

Macrophages chemoattractant protein-1 (MCP-1/CCL2) is a chemokine with function in regulated migration and infiltration of macrophages, the mobile white blood cells. 

Levels of high sensitive C-reactive protein (hsCRP) is associated to the inflammation of blood-vessel walls.

Further analysis suggested that carrot juice decreased over expression of free cholesterol and  immune response through its antioxidant in inhibited the elevation of ROS in production of pro inflammatory cytokines.

In other words, carrot juice activated production of anti inflammatory factors in reduced over expression of inflammatory cytokines in facilitated onset and progression of inflammatory related diseases, including insulin resistance, type 2 diabetes and non-alcoholic fatty liver disease (NAFLD).

More over, in the additional differentiation of the effect of root vegetables in Immune-inflammatory signaling and metabolic effects, researchers at the joint study lead by the Agriculture and Agri-Food Canada, conducted a study to assess the bioaccessibility and bioavailability of purple carrot and potato derived anthocyanins and the molecular mechanisms to ameliorate cellular inflammation in a mono- and co-culture cell models.

In vitro gastrointestinal model, application of bioaccessibility of 44.62 and 71.8% for anthocyanins of purple carrot and potato demonstrated a strong activity in inhibition of cellular inflammation in Caco-2 cells.

According to the assay, the effectiveness of anthocyanins injection was found to transport across a transmembrane cell model.

The inhibition of anthocyanins during the transportation also reduced expression of pro inflammatory factors of IL-8 and TNF-α secretion,and expression of pro-inflammatory cytokines by blocking NF-κB, and MAPK, the pro inflammatory proteins in mediated inflammatory cellular signaling cascades.

Interleukin 8 is a chemokine produced by macrophages and other cell types in initiated production of inflammatory expression.

Tumor necrosis factor is a cell signaling protein (cytokine) involved systemic inflammation in acute phase infection of tissue injure and damage.

Dr. Zhang H, the lead scientist after taking into account of other co and con founders said, "Anthocyanins from purple carrots and potatoes possess a promising anti-inflammatory effect in model gut system" and "They (Anthocyanins) can be absorbed and act differently but are in general beneficial for inflammation-mediated diseases".

Taken together, carrot juice containing high amount of anthocyanins may be considered as functional food in prevented onset of inflammatory related diseases.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Bioaccessibility, bioavailability, and anti-inflammatory effects of anthocyanins from purple root vegetables using mono- and co-culture cell models by Zhang H1, Hassan YI1, Renaud J2, Liu R1, Yang C1, Sun Y1, Tsao R(PubMed)
(2) Carrot juice ingestion attenuates high fructose-induced circulatory pro-inflammatory mediators in weanling Wistar rats by Mahesh M1, Bharathi M1, Raja Gopal Reddy M1, Pappu P1, Putcha UK2, Vajreswari A1, Jeyakumar SM(PubMed)
(3) The effect of lutein- and zeaxanthin-rich foods v. supplements on macular pigment level and serological markers of endothelial activation, inflammation and oxidation: pilot studies in healthy volunteers by Graydon R1, Hogg RE, Chakravarthy U, Young IS, Woodside J(PubMed)

How to Alleviate Pain Caused by Muscles and Blood Vessels Constriction Naturally, Medline Model Studies Reveal

Kyle J. Norton


Anise may have potential and substantial relaxant effects in reduced over expression of vessel and muscle constrictions in precipitation of pain, some scientists suggested.

Anise is a flowering plant of the species of Pimpinella anisum, genus Pimpinella, belongings to the family Apiaceae native to to Egypt and the Mediterranean region, used in traditional herbal medicine as fragrance in soaps, oils, and mouth fresheners and stomachic, anti-septic, anti-spasmodic, ....


Chemical comstituents
Anethole, D-pinene, I-phellandrene, Alpha-terpineol, Safrol, Methyl chavicol, Resin, Shikimic acid, etc.

According to the evaluation of Anise 3 hidroalcoholic extracts claimed to have a substantial effect in tracheal and ileal smooth muscles in 3 different concentration of doses at 40% (HA(40%)), 60% (HA(60%)) or 80% (HA(80%)) researchers found that

* Application of all extracts at half maximum effect,50 microg/mL EC(50) inhibited acetylcholine-induced contraction. 

* However, the extract HA(60%) at 5-50 microg/mL(EC(5-50)) concentration dependently relaxed acetylcholine-pre-contracted tissues and HA(40%) and HA(80%) did not exert relaxant action in any volume out of indicated range.

These results suggested that the substantial effect in tracheal and ileal smooth muscles of Anise was associated to dose dependent manner. 

In other words, only certain concentrations of Anise hidroalcoholic extract are effective in reduced muscles and vessels constriction in induction of pain.

Injection of muscle constriction substances such as N(G)-nitro-L-arginine methyl ester (L-NAME, 100 microM), 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ, 3 microM) and oxyhemoglobin (10 microM) were also inhibited by HA(60%) in doses concentration dependent manner through the influence of muscle relaxation.

These inhibition suggested that Anise not only aemeliorates the tracheal and ileal smooth muscles pain caused by natural spasmodic activities but also pain caused by injection of muscle and vessel contraction substances.

Moreover, in additional treatment of nitric oxide synthase(L-NAME) in induced production of vascular smooth muscle cells and enhanced the maximal contraction induced by acetylcholine, administration of HA(60%) expressed a strong activity in modulated NO contractile response, stimulated by primary transmitter released by inhibitory nerves through cyclic GMP-dependent which is found to have a implication in the regulation of smooth muscle relaxation and other independent mechanisms

Further observation also indicated that injection of HA 60% showed an insignificant effect in calcium chloride(CaCl(2))-induced muscle contraction.

Dr. Tirapelli CR, the lead author at the Escola de Enfermagem de Ribeirão Preto. said, "The relaxant action displayed by Pimpinella anisum justifies its use in the folk medicine as an antispasmodic agent".

In isolated tracheal chains of the guinea pig induced by 10 microM methacholine in non-incubated tissues (group 1) and incubated tissues with 1 microM propranolol and 1 microM chlorpheniramine (group 2), to investigate the relaxant effect of Pimpinella anisum aqueous and ethanol extracts and essential oil, researchers showed that injections Anise aqueous and ethanol extracts, essential oil and theophylline, a conventional medicine used to relaxing bronchial smooth muscle in COPD and asthma patients display a substantial activity in exhibited relaxant effects in compared to those of controls.

There were no significant difference of both Pimpinella anisum aqueous and ethanol extracts in promoted muscle relaxation but both exerted lower efficacy in compared to those of theophylline.

Interestingly, the applications of essential oil and 10 nM atropine, a muscle relaxant medicine, used as nerve anticholinergic agent, blocked the neurotransmitter acetylcholine in the central and the peripheral nervous system in responsible for the involuntary movement of smooth muscles and reduced the muscle contraction caused by methacholine, a substance used to tighten the lung muscle and air way for test of asthma. 

These results indicated a potential activity of bronchodilatory and anticholinergic effects of essential oil, aqueous, and ethanol extracts from Anise.

However, researchers also found that application of all doses expressed insignificant effects in inhibited histamine (H(1)), smooth muscles, vascular endothelial cells, the heart, and the central nervous system or stimulated beta(2)-adrenergic receptor in binding to epinephrine.

Dr. Boskabady MH, after taking into account of other co founders, said, "....showed that the relaxant effect of this plant is not due to an inhibitory effect of histamine (H(1)) or stimulatory effect of beta(2)-adrenergic receptors, but due to inhibitory effects on muscarinic receptors".

Collectively, the efficacy of Anise in elevated muscle and blood vessel pain was associated to  numbers of mechanism, not invoked the constriction caused by allergens or stimulants.

Taken together, Anise aqueous and ethanol extracts and essential oil may be used as adjunct herbal medicine in reduced risk of diseases associated to spasmodic muscle contraction in induction of muscle cramp accompanied by a sudden burst of pain caused by abnormal nerve stimulation or by abnormal activity of the muscles and vessels.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Antispasmodic and relaxant effects of the hidroalcoholic extract of Pimpinellaanisum (Apiaceae) on rat anococcygeus smooth muscle by Tirapelli CR1, de Andrade CR, Cassano AO, De Souza FA, Ambrosio SR, da Costa FB, de Oliveira AM.(PubMed)
(2) Relaxant effect of Pimpinella anisum on isolated guinea pig tracheal chains and its possible mechanism(s) by Boskabady MH1, Ramazani-Assari M.(PubMed)

How to Prevent Over Expression of Melanin in Induction of Age Spots Naturally, US National Library of Medicine Studies Reveal

Kyle J. Norton 

Green tea may have a therapeutic and positive effect in reduced age spot caused by over expression of melanin, some scientists suggested.

People with light complexion and lots of sun exposure over the years are found to associate with higher prevalent risk.

The results of these investigation were carried out by some world wide institutes, including the Chongqing Institute of Forensic Science.

You can view the publication through some online medical literature, if you want to know more of these subjects.

Age spot is the over expression of skin pigment in the surface of the skin, probably caused by Skin aging, sun exposure, or other forms of ultraviolet (UV) light exposure,....

Age spot may also be caused by hormone imbalance in induction of increased production of melanin, which is responsible for darkening the skin.

Green tea, is a precious drink processed numbers of health benefit and known to almost everyone in Asia and Western world.

In the investigation of Epigallocatechin gallate (EGCG), used as a constituent of cosmetic products, researchers found that applicationg EGCG exerts a significant effect as an antioxidant in exhibited anti-pigmentation properties.

Through measuring hyaluronic acid synthase (HAS) and hyaluronidase (HYAL) gene expression, EGCG also promoted skin hydration, through increased the expression of natural moisturizing factor-related gene, including Hyaluronan synthase (HAS)-1, and (HAS)-2.

HA synthase enzymes (HAS) amolescule with function of synthesized hyaluronan (HA) plays an essential role in protected skin fibroblasts against apoptosis, due to environment stress exposure.

Hyaluronidase ((HYAL) is an enzyme that cleaves HA.

In UVB irradiation conditions, application of EGCG protected the expression of decreased level of HYAL found in all tissues with 50% present in skin, thus reducing HaCaT cells in formation of free radicals and decreased in cell viability.

Melanin produced in melanocytes, under exposure UVB irradiation  with an aim to protect skin cells aganist UVB radiation damage.

Years of frequent and prolonged sun exposure and over expression of melanin may inducent aging spot

In other words, EGCG not only exhibited a strong effect in reduced over secretion of melanin but also enhanced cells integrity against forming of aging spot due to exposure UVB irradiation

HaCaT widely used in scientific research of epidermis, is a spontaneously immortalized human keratinocyte cell line isolated from adult human skin.

Dr. Kim E, the lead authors said, "EGCG might be used as a cosmetic ingredient with positive effects on skin hydration, moisture retention, and wrinkle formation, in addition to radical scavenging activity and reduction of melanin generation".

Furthermore, in confirmation of green tea efficacy in reduced over expression of skin pigment by evaluating the fatty acids contents in the green tea oil,  researchers indicated that all 3 major fatty acids isolated from oil were oleic acid (87.93±0.19%), stearic (5.14±0.06%) and palmitic (5.08±0.12%) acids.

Single application of each fatty acid demonstrated a strong protection of the cell viabilities through their antioxidant activity.

Moreover, the antioxidant activity of 3% tea seed oil exerted a greater cellular protection with cell viability of 90.38±7.77% in compared to other concentrations.

Some researchers suggested that green tea polyphenols and theophylline as polyphenol nanoparticles (PNs) may reduce skin aging through nanoparticle formation process involved copolymerization of monomers through exhibiting its free radicals scavenging activities.

Taking altogether, green tea and its bioactive compound such as EGCG may be used as natural and functional food for reduced over expression of melanin and skin pigment in induction of age spots.

Reprint of this article is welcome with author name and link to the article sources intact https://kylejnorton.blogspot.ca/

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Skin Protective Effect of Epigallocatechin Gallate by Kim E1, Hwang K2, Lee J3, Han SY4, Kim EM5, Park J6, Cho JY7.(PubMed)
(2) Green Tea Makes Polyphenol Nanoparticles with Radical-Scavenging Activities by Xiang S1, Yang P1, Guo H2, Zhang S1, Zhang X1, Zhu F1, Li Y1.(PubMed)
(3) Melanogenesis Inhibitory and Antioxidant Effects of Camellia oleifera Seed Oil by Chaikul P1,2, Sripisut T1,2, Chanpirom S1,2, Sathirachawan K1, Ditthawuthikul N1,2.(PubMed)

How To Prevent Platelet Aggregation and High Blood Pressure in Induction of Cardiovascular Disease Naturally, MEDLINE Studies Find

By Kyle J. Norton

In compared to herbal medicine; food therapy may even takes longer to ease symptoms, depending to stage of the treatment which directly address to the cause of the disease.

Adding a portion of beet in your daily diet may have a significant effect in improved blood circulation through anti platelet aggregation and anti hypertension activities, a recent and renowned study suggested.

Platelet aggregation is natural reaction of wound healing process of blood clotting in damage and injure of our body, to prevent infection and inflammation.

Beet, best known as the beetroot or garden beet and belongings to the amaranth family, is a perennial plant with leafy stems growing to 1–2 m tall.


According to the Barts & the London School of Medicine and Dentistry, dietary rich of nitrate vegetable or fruit, such as beet showed to exhibited vascular function in promotion of blood vessel and blood circulation function, thus reducing risk CVD.

In healthy volunteers, ingestion of a dietary nitrate load (beetroot juice 500 mL), approximately 3 hours after, correlated with peak increases in plasma nitrite concentration showed a significant effect in attenuated platelet aggregation in response to collagen and adenosine diphosphate (ADP), in cell energy metabolism. And decreased plasma nitrite, may block the decrease in blood pressure and abolished the inhibitory effects on platelet aggregation.


This findings suggested that regular drinking of dietary nitrate from food sources is necessary for maintenance of a healthy heart through decreased platelet aggregation and reduced blood pressure.


In 2 randomised crossover studies each in 24 (12 of each sex) healthy subjects with oral administrated dietary nitrate (250 ml beetroot juice) or potassium nitrate capsules (KNO3, 8 mmol) vs placebo control on platelet reactivity, researchers found that group treated with nitrate component shows a strong inhibition of platelet aggregation.


The study also demonstrated that inorganic nitrate ingestion, whether via the diet or through supplementation, may have a gender preference in decreased platelet reactivity in healthy males but not females counterpart.

Dr. Velmurugan S, the lead author said, " dietary nitrate (may be benefit) as an adjunct to current antiplatelet therapies to prevent atherothrombotic complications".


Furthermore, according to the review of the National Heart and Lung Institute, in vitro and in vivo, dietary nitrite exhibited cGMP in mediated the levels of platelet aggregation through expression of nitric oxide actions, 

And, in a model of thromboembolic radiolabeled platelet aggregation, injection of dietary nitrate or supplement showed a significantly inhibited platelet function in eNOS(-/-) mice.

Cyclic guanosine monophosphate (cGMP), a cyclic nucleotide plays both a stimulatory and an inhibitory role in platelet activation depending on concentration and timing.

NO also are best known for its function in regulating blood pressure and that impaired NO bioactivity is an important component of hypertension

Collectively, beet with high amount of dietary nitrate may be used as functional food combined conventional treatment in reduced risk of platelet aggregation and htpertension in induction of CVD.

People who are taking anti platelet aggregation medicine should consult with their doctors before applying large amount beet juice or juice with high concentration of nitrate.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite by Webb AJ1, Patel N, Loukogeorgakis S, Okorie M, Aboud Z, Misra S, Rashid R, Miall P, Deanfield J, Benjamin N, MacAllister R, Hobbs AJ, Ahluwalia A.(PubMed)
(2) Antiplatelet effects of dietary nitrate in healthy volunteers: involvement of cGMP and influence of sex by Velmurugan S1, Kapil V, Ghosh SM, Davies S, McKnight A, Aboud Z, Khambata RS, Webb AJ, Poole A, Ahluwalia A.(PubMed)
(3) Role of inorganic nitrate and nitrite in driving nitric oxide-cGMP-mediated inhibition of platelet aggregation in vitro and in vivo by Apostoli GL1, Solomon A, Smallwood MJ, Winyard PG, Emerson M.(PubMed)