Chemical Compounds Found in #Herbal #Coltsfoot Show Significantly Cytoprotective Activities Against ROS and Glucose Oxidase-Induced #OxidativeStress

Kyle J. Norton

Oxidative stress is a condition associated with the long-term imbalanced ratio of free radicals and antioxidants in the body, leading to protein, lipid, and cell damage that causes chronic illnesses such as heart disease, stroke, and diabetes.

In other words, the condition is caused either by overexpression of free radicals depletion of antioxidant enzymes produced by the host, or both.

Antioxidants are either produced by the body or injected into the body from outside sources such as the consumption of antioxidant-rich fruits and vegetables.

Free radicals are everywhere, including the air we breathe, the food we eat, and the body's daily functioning such as cell metabolism.

More precisely, any chemical compound that has an oxygen molecule can become a free radical after entering our body.

In healthy individuals, the antioxidant produced by the host is more than enough to counter the bombards of free radicals. However, people with a weakened immune system such as the elderly, and immature immune systems such as the baby may need the injection of antioxidants from outside sources.

Particularly, people with a suppressive immune system due to chemotherapy may be required to intake large amounts of antioxidant-rich food regularly.

However, free radicals in moderate amounts are needed for body functioning, including lower blood pressure, relax blood vessels to move blood, such as nitric oxide NO.


Coltsfoot(Tussilago farfara) is a perennial herbaceous plant, genus Tussilago, belonging to the family Asteraceae, native to Europe and Asia. The herb has been used for thousands of years to treat asthma, various coughs, bronchial congestion, respiratory disorders, headaches obstruction in the nasal passage, etc.

On finding a potential compound for the treatment of disease associated with oxidative stress, researchers examined the cytoprotective compound, 1-[(4S)-3,4-dihydro-4-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl]-methanone (1) isolated from the flower buds of Tussilago farfara L.

According to the tested analysis on (1) and other isolated compounds such as 3,4-dicaffeoyl isoquinic acid (2), trans-cinnamic acid (3), 4-hydroxyacetophenone (4), 4,5-dicaffeoylquinic acid methyl ester (5), 3,5-dicaffeoylquinic acid methyl ester (6), 4-hydroxybenzoic acid (7), isoquercetrin (8), and ligucyperonol (9), compounds 1 and 3 showed significant cytoprotective activities against glucose oxidase-induced oxidative stress in mouse fibroblast NIH3T3 cells and human keratinocyte HaCaT cells comapred others.

Furthermore, the MTT assay and lactate dehydrogenase leakage differentiation also supported the possibility of compounds 1 and 3 as potent cytoprotective agents against overexpression of ROS.

Taken altogether, coltsfoot may be considered a remedy for the treatment of disease associated with oxidative stress-induced cytotoxicity, pending the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Identification of cytoprotective constituents of the flower buds of Tussilago against glucose oxidase-induced oxidative stress in mouse fibroblast NIH3T3 cells and human keratinocyte HaCaT cells by Kang U1, Park J1, Han AR1, Woo MH2, Lee JH3, Lee SK4, Chang TS1, Woo HA5, Seo EK. (PubMed)