#Herbal #Turmeric #Extract Inhibits Parameters Associated with the Acute and Chronic Vascular Inflammation, Researchers Reveal

Kyle J. Norton

Inflammation is a natural reaction of the immune system's self-protection to remove harmful stimuli, including damaged cells, irritants, pathogens... from our body.

Acute inflammatory inflammation is a result of the over-response of the immune system after sensing the injury or damage to the body by activating the protein associated with the production of pro-inflammatory cytokines.

The aim of the proinflammatory cytokines is to kill the invasive pathogens, which try to enter the body through the wound.

In the acute phase of infection, the immune system in the stimulating production of proinflammatory cytokines may induce overproduction of these cytokines can cause death or damage to the nearby cells, leading to scar formation and symptoms of localized swelling, redness, and fever.

Chronic inflammation is a serious condition caused by the immune system to adapt to the new change due to its inability to kill all the invasions within a set of times.

Vasoprotection is the process of improving the function of the blood vessels, including the use of herbal and natural remedies.

Blood vessels are the tubular structure including a vein, artery, or capillary which carries the blood through the tissues and organs pumped by the heart.

The 3 main types of blood vessels are arteries that deliver oxygen-rich blood from the heart to the tissues and organs of the body. Damage of arteries may induce coronary artery disease associated with the narrowing or blockage of the coronary arteries due to plaques accumulated in the arterial wall.

The veins that carry blood toward the heart. Chronic venous insufficiency (CVI) is a common condition associated with a disease of the veins that affects up to 20 percent of adults.

The capillaries or the smallest blood vessels that have been found to induce systemic capillary leak syndrome (SCLS) is a rare acquired disorder.

Vascular inflammation is a condition associated with the inflammation of the blood vessels caused by the overexpression of pro-inflammatory cytokines involved in vascular inflammation. Atherosclerosis is characterized by chronic inflammation of the vascular wall.

Chronic vascular inflammation has been found to cause historical changes in the blood vessel walls, leading to blood vessel wall thickening, weakening, narrowing or scarring on orchestrating blood flow restriction, resulting in organ and tissue damage.

The most common symptoms of vascular inflammation are associated with the reduced blood flow to supply nutrients and fluid to the body tissues, including fever, headache, fatigue, general aches, and pains, night sweats, rash, numbness, and weakness.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.

In findings, a potential compound for the treatment of acute vascular inflammation researchers evaluated the anti-inflammatory activity, and the cytotoxic effect of a novel chemically modified, non-carbonyl compound enriched Curcuma longa L. (C. longa) extract (CMCE).

According to the tested analysis, CMCE at the concentration of 1 or 10 μg/mL at 14 h, significantly decreased LPS (50-100 ng/mL) induced production of pro-inflammatory cytokines including TLR4 expression in THP-1 cells, human, and mouse whole blood.

In THP-1 cells, CMCE inhibited the expression of IRAK1, which plays a critical role in initiating an innate immune response against foreign pathogens, MAPK is involved in directing cellular responses to a diverse array of stimuli.

CMCE (30, 100, and 300 mg/kg; 10 days p.o.) pre-treated and LPS (10 mg/kg) in Swiss mice exhibited attenuated plasma TNF-α, IL-1β, nitrite, aortic iNOS expression, and vascular dysfunction associated with the production of pro-inflammatory cytokines.
In HL-60 cells., CMCE. exerted cytotoxic effects through cell cycle arrest on the Sub-G1 phase, increased apoptotic cells, loss of mitochondrial membrane in the cancer cells, and activation of cascade associated with pro-apoptosis.

Taken together, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of vascular inflammation, pending the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) A Standardized Chemically Modified Curcuma longa Extract Modulates IRAK-MAPK Signaling in Inflammation and Potentiates Cytotoxicity by Rana M1, Maurya P1, Reddy SS1, Singh V1, Ahmad H2, Dwivedi AK2, Dikshit M1, Barthwal MK. (PubMed)
(2) Curcumin: An Effective Inhibitor of Interleukin-6 by Ghandadi M1, Sahebkar A. (PubMed)

#Cranberry #Extract Disrupts Biofilm Structural Architecture That Causes Candida Albicans, Researchers Say

Kyle J. Norton


The fungus is a class of primitive organisms, including mushrooms, mold, and mildew, found in the air, in the soil, on plants, and in water.

Fungi reproduce through tiny spores in the air if you inhale the spores, it may spread to cause fungal infection, often starting in the lungs or on the skin.

Similar to other bacteria, there are millions of different fungal species on Earth, but only about 300 are known to infect people.

Conventionally, fungal infection is treated with antibiotics, including topical antifungal ointments or oral medications, depending on the severity of the disease.

Candida is a class of yeasts that cause fungal infections worldwide.

Candida albicans is a member of a large group of an organism whose cells contain complex structures enclosed within the membranes, including yeast and mold that live among the gut flora in the human mouth and gastrointestinal tract.

Under normal circumstances, Candida albicans do not cause harm to humans, but overgrowth results in candidiasis.

Oral candidiasis is an oral condition infected by the fungal C. Albicans found mostly in people with a weakened immune system including patients who are taking the immune-suppressive medicine.

Biofilms are microbial communities in which cells stick to each other and often also to a surface.

Symptoms of oral Candida overgrowth are worse on a damp day, including persistent drowsiness, lack of coordination, headaches, mood swings, loss of balance, rashes, bad breath, dry mouth, and postnasal drip.

There are many risk factors associated with Candida overgrowth including medical conditions that cause a weakened immune system, inhalant medicine, low levels of stomach acids, and pregnancy.

Some researchers suggested aging may be one of the major risk factors that cause Candida overgrowth

Dr. Aikaterini Flevari, the lead scientist said, "Candida species remain the most important cause of opportunistic infections worldwide, affecting predominantly patients over 65 years old, while they are considered to be the fourth most common cause of nosocomial bloodstream infections".

And, "The rapidly growing elderly population has specific physiological characteristics, which makes it susceptible to colonization and subsequent infection due to Candida species"

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belonging to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

On finding a potential compound for the treatment of Candida albicans, researchers examined the effects of polyphenol-rich cranberry extracts on dual-species Streptococcus mutans-Candida. albicans biofilms.

On S. mutans-C. albicans biofilms grown on saliva-coated hydroxyapatite discs (s-HA) mounted on the high-throughput Amsterdam Active Attachment model, cranberry extracts(ACE)/vehicle control was applied at the five minutes just before biofilm growth and subsequently, for similar exposure times, after 12 hours and 24 hours of biofilm growth.

Based on the analysis, treatment of ACE at doses of 500 to 1,000 μg/mL showed significant reductions in acidogenicity and metabolic activity, compared to the control.

Biovolumes of the EPS (P=0.003) and microbial biofilm components associated with the overgrowth of Candida albicans were significantly decreased by the application of ACE.

According to the qualitative assessment of confocal biofilm images, cranberry extract disrupted biofilm structural architecture that causes Candida albicans.

Moreover, ACE showed significantly fewer S. mutans (P=0.006) and C. Albicans (P=0.036) compared to the control.

Based on the findings, researchers aid, "Cranberry extracts inhibited cariogenic virulence properties of S. mutans-C. albicansdual-species biofilms in an in vitro model".

Taken together, cranberry may be considered a remedy for the treatment of Candida albicans,, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Polyphenol-Rich Cranberry Extracts Modulate Virulence of Streptococcus mutans-Candida albicans Biofilms Implicated in the Pathogenesis of Early Childhood Caries by Philip N1, Leishman SJ2, Bandara H3, Walsh LJ. (PubMed)
(2) Cranberry-derived proanthocyanidins induce a differential transcriptomic response within Candida albicans urinary biofilms by Sundararajan A1, Rane HS2, Ramaraj T1, Sena J1, Howell AB3, Bernardo SM4, Schilkey FD1, Lee SA. (PubMed)
(3) Treatment of invasive candidiasis in the elderly: a review by Aikaterini Flevari,1 Maria Theodorakopoulou,1 Aristea Velegraki,2 Apostolos Armaganidis,1 and George Dimopoulos. (PMC)

#Turmeric's #Curcumin Protects the Heart Against Cardiac Dysfunction during Hypertrophy, According to Studies

Kyle J. Norton

Cardiomyocyte hypertrophy is a medical condition characterized by the thickening of the heart muscle, leading to reduced function of the heart in pumping blood throughout the body.
The heart formed part of the circulatory system is a muscular organ that pumps blood through the blood vessels of the body to provide oxygen and nutrients and remove metabolic wastes.
The heart muscles make up the bulk of the heart’s mass and control the heartbeat with high contractile strength and endurance.

Cardiac muscle also has a unique function to regulate heart performance by spreading electrochemical signals to all cells in the heart.

Damage to the heart muscle has been found to induce blood vessel diseases, such as coronary artery disease; and heart rhythm problems (arrhythmias).

In some cases, heart muscle disease also is found in patients with congenital heart defects.

The most common symptoms of cardiac hypertrophy are breathlessness with exertion or at rest, legs, ankles, and feet swelling. persistent fatigue, dizziness, lightheadedness, and fainting, particularly, in the symptoms of irregular heartbeats.

Conventionally, treatments of cardiac hypertrophy totally depend on the type of heart disease, including lowering blood pressure medication such as ACE inhibitors; lowering the heart rate, such as beta-blockers, normalizing heart beating, and balancing electrolytes in the body.

Making a healthy lifestyle change and moderate exercise may also be recommended by your doctor.

Cardiac hypertrophy has been found in patients with uncontrol high blood pressure accompanied by tobacco smoking. The condition is a common risk factor for heart attack and stroke.

Dr. Thomas Kahan, the lead scientist wrote, "Myocardial hypertrophy is also part of the remodeling process following an acute myocardial infarction, and is a common finding in patients with congestive heart failure caused by systolic and/or diastolic LV dysfunction".

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.

In finding a potential compound for the treatment of heart failure, researchers examined the efficacy of curcumin an anti-hypertrophic potential.

According to the tested analysis, curcumin encapsulated by carboxymethyl chitosan (CMC) nanoparticle conjugated to a myocyte-specific homing peptide was effective in the regression of cardiac hypertrophy in a rat (Rattus norvegicus) model.


Curcumin at a low dose of 5 mg/kg body weight compared to free Curcumin at 35 mg/kg body weight. showed a higher cardiac bioavailability, compared to other concentrations.

Furthermore, cardiac function during hypertrophy was significantly improved by the application of Curcumin/CMC-peptide by inhibiting the hypertrophy marker genes (ANF, β-MHC) and apoptotic mediators (Bax, Cytochrome-c) and activity of apoptotic markers (Caspase 3 and PARP) in the lower doses compared to higher doses.

Targeted Curcumin treatment significantly lowered p53 expression which is associated with pro-apoptotic function in cardiac hypertrophy.

Based on the findings, researchers wrote, "Curcumin and also attributes towards probable mechanistic insight into its therapeutic potential as a cardio-protective agent for regression of cardiac hypertrophy".


Taken together, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of cardiac hypertrophy, pending the confirmation of the larger sample size and multicenter human study.


Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Improved bioavailability of targeted Curcumin delivery efficiently regressed cardiac hypertrophy by modulating apoptotic load within cardiac micro environment by Ray A1, Rana S2, Banerjee D3, Mitra A4, Datta R5, Naskar S6, Sarkar S. (PubMed)
(2) Left ventricular hypertrophy in hypertension: its arrhythmogenic potential by Thomas Kahan1 and Lennart Bergfeldt. (PMC)

#Honey Shows A Strong Effect on Serum Levels of Cholesterol and Cognitive Function, Researchers Say

Kyle J. Norton


Scientists may have found a natural alternative for the treatment of depression according to studies.
Depression is a common and serious psychological illness, affecting the physical and mental functions of patients, including the ways patients feel, think, and act.

Some patients with depression may feel sadness and/or a loss of interest in activities once enjoyed.

There are many causes associated with the onset of depression, including genetics, changes in hormone levels, certain medical conditions, stress, grief, or difficult life circumstances that initiate the change of brain chemistry inducing depressive syndrome.

The most common symptoms of depression include sadness, hopelessness, guilt, change of mood, and loss of interest in friends, family, favorite activities, and sex.

Some patients with depression also experience cognitive symptoms of trouble concentrating, making decisions, remembering, and thoughts of harming themselves.

Readers may find other symptoms not be included in the article including behavior and physical symptoms.


According to the statistics provided by the Anxiety and Depression Association of America, major depressive disorder is the leading cause of disability in the U.S. for ages 15 to 44.3, affecting more than 16.1 million American adults, or about 6.7% of the U.S. population age 18 and older.

Some researchers suggested that the widespread depression in the Western world may be associated with life stress at work and home.

Dr. T. Plieger, the lead scientist in examining the effects of psychological stress on depression wrote, "A significantly closer relation between depression and life stress than between burnout and life stress was found in the healthy (z = 3.01, p = .003) as well as in the depressed sample".

"This finding was supported in both samples by means of a path analytic approach where the associations between life stress, burnout, and depression were controlled for the possible mediator and moderator effects, also considering the influence of age".

Honey is a miraculous product made by bees using nectar from flowers.

The rich golden liquid is considered one of the healthy sweet foods for replacing the use of white sugar and artificial sweeteners by many people.

Scientists searching for an alternative remedy for the treatment of depression with no side effects examined the effects of honey on several studies through searching the database of online medical literature.

8 studies that satisfied the standard criteria and guidelines were chosen, including 2 RCTs of human subjects and 6 animal studies.

The randomized studies suggested that depressed elderly treated with a mix of honey and barely exhibited a significant decrease in depression, stress, and mood disturbances scores compared to the control group.

In menopausal women, treatment with honey or a mix of honey and pollens exerted a significant activity in the improvement of the three subscales of the Menopause Rating Scale (MRS) by 68.3% and 70.9%, respectively.

The results also suggested that post-treatment demonstrates a better effect compared to pretreatment when the mixture of honey was applied.

Furthermore, the application showed similar effects on the serum levels of cholesterol, such as total, HDL, or LDL cholesterol), triglycerides, or oestradiol in both groups.

According to the survey returned participants reported that they observed improvements 3-4 days after the initiation of treatment. On a 10-point taste scale, (1 = very good and 10 = very bad) honey received an average score of 2.3, whereas a honey and pollen mix received an average score of 6.0.

Interestingly, the side effects of exhaustion and edema of the lower extremities were reported by some participants, and 2 participants were withdrawn from the study due to the taste of the mix of honey with bare powder.

In animal studies, all experiments displayed a positive effect of honey on depression. Some studies also found that honey improves depressive-like behaviors, cognitive function, and symptoms of anhedonia.

Furthermore, honey injection also showed a reduction of anxiety symptoms and an improvement in spatial memory.

Moreover, honey alone or a combination of honey and other bee products inhibited MAO enzyme activity in the liver of treated mice.

Where monoamine oxidase A (MAO-A), an enzyme that metabolizes monoamines was elevated in depressed patients.

And, the anti-depressive effects were correlated to the volume of honey intake. In other words, greater improvements were associated with the increased administration of high doses of honey.

In order to reveal more information about honey depression activity, researchers examined
Tualang and Acacia honey in patients with stress-depression disorder.

Both Tualang and Acacia honey showed significant anti-depression activity by increasing the production of levels of antioxidants.

However, Tualang honey consumption was found to be more suitable in regulating weight-related effects of stress-depression disorder compared to that of Acacia honey which exerted more profound effects in alleviating depression effects and managing glucocorticoid imbalance effects of the stress-depression disorder.

Taken together, honey, particularly Tualang, and Acacia honey, used alone or combined with other bee products may be considered functional remedies for the prevention and treatment of depression, pending the confirmation of a large sample size and multicenter human study.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.

Sources
(1) Bee Honey as a Potentially Effective Treatment for Depression: A Review of Clinical and Preclinical Findings by Amira Mohammed Ali1* and Amin Omar Hendawy. (JOJ Nursing and Health Care)
(2) Potential used of Tualang and Acacia Honey in Ameliorating Stress-Depression Disorder: A Preliminary Study by Qamarul Hafiz Zainol Abidin, Nurul Hanani Mohd. Rujhan, Wan Iryani Wan Ismail. (Researcher Gate)
(3) Life stress as potential risk factor for depression and burnout by Author links open overlay panelT.PliegeraM.MelchersaC.MontagbR.MeermanncM.Reuterad. (Science Direct)

#Honey Inhibits the Expression of Oxidative Stress Against the Risk of Anxiety, Memory Impairment, and Lipid Peroxidation, Researchers Reveal

Kyle J. Norton

Scientists may have found a natural alternative for the treatment of diseases associated with oxidative stress, according to studies.

Oxidative stress is a medical condition associated with the overexpression of free radicals compared to low levels of antioxidant enzymes produced by the host.

In fact, free radicals are constantly produced in animal and human cells. The air we breathe, the things we eat, and the environment we contact are some factors that cause the production of reactive oxygen species (ROS).

Epidemiological studies suggested that oxidative stress can induce damage to the cell, lipid, proteins, and alternation of cell DNA, leading to chronic diseases, such as cardiovascular diseases, diabetes, and particularly, cancer.

How overexpression of free radicals causes damage to the cells. Researchers explained due to free radical unstable nature with unpair of electrons on the out ring of molecules, they constantly seek to donate or intercept the electron from other stable atoms, leading to a chain reaction that can not be stopped until all unpaired electrons are paired or inhibited by antioxidants.

These processes can lead to an imbalance of the ratio of free radicals and antioxidants produced by the host body resulting in oxidative stress, a major cause of cell, lipid, and protein damage.

In spite of free radical's harmful effects, one must understand that cellular oxygen species (ROS), are necessary with a moderate amount to protect our body in the mediation of antimicrobial infection, detoxification of potentially toxic compounds, and elimination of cancerous and other life-threatening cells through cytotoxicity.

On the other hand, antioxidants are stable molecules that inhibit oxidation. Antioxidants can reduce levels of free radicals and overexpression can limit the free radical function in carrying out their health benefits.

Therefore, in order to maintain good health, the levels of free radicals and antioxidants must be balanced.


Honey is a miraculous product made by bees using nectar from flowers.

The rich golden liquid is considered one of the healthy sweet foods for replacing the use of white sugar and artificial sweeteners many people.

Researchers on finding a natural compound for the inhibition of oxidative stress examined the honey activity on oxidative stress induced by lead acetate exposure in male Wistar rats.

The study included 24 male Wistar rats randomly divided into four groups: Control group received 1 ml/kg distilled orally for 28 days; while groups II-IV received 0.2% lead in drinking water and 1 ml/kg of distilled water, 1 ml/kg of honey, 1.5 ml/kg of honey respectively for 28 days.

Before pretreatment with honey, infected rats showed a decrease in locomotor and exploratory and decreased antioxidant activity increase in anxiety, memory impairment, and lipid peroxidation.

Co-administration of honey with lead inhibited neurotoxicity observed by the improvement in memory function decreased latency period and increased time spent in the target quadrant compared to the lead-exposed animals.


Injection of honey in the lead-fed group also increased locomotion, exploration, and decreased anxiety observed by the frequency of rearing, freezing duration, and the number of lines crossed by animals.

More importantly, the administration of honey improved the levels of antioxidant enzymes produced by the host observed by increased brain SOD, GST, and GSH activities compared to the lead-treated groups.


However, the honey pretreatment group showed no significant effect on MDA level, the oxidative stress marker.

These results suggested that honey exerted neuroprotective effects against lead-induced cognitive deficit probably by enhancing antioxidant activities without affecting the levels of MDA.

In order to reveal more information about honey antioxidative stress, researchers investigated the effects of Tualang honey (TH) protective activity against oxidative stress of exercise.

The study included 20 female athletes (aged 21.3 [2.1] years; body weight [BW] 54.1 [5.7] kg) who were randomly assigned into two groups and consumed either 1.5 g/kg BW TH (high honey; HH; n = 10) or 0.75 g/kg BW TH (low honey; LH; n = 10).

Injection of Tualang honey showed a reduction of MDA in the LH group compared to the HH group. In other words, less oxidative stress was found in the LH group.


The concentrations of total phenolic content (TPC) and antioxidant activity (ferric reducing antioxidant power [FRAP]) increased from baseline to 2 and 1 h after TH consumption, respectively, then the concentrations returned toward baseline at 3 h in both LH and HH groups.


MDA concentration significantly decreased (p < 0.05) from baseline to 2 h and significantly increased from 2 to 3 h in the HH group. Meanwhile, ROS levels increased significantly from 0.5 to 3 h in the HH group.

Compared to the HH group, the LH group showed similar trends but insignificant increased levels of MDA and ROS.

Taken together, honey particularly Tualang honey may be considered a functional remedy for the prevention and treatment of diseases related to the expression of oxidative stress with no side effects, pending the confirmation of a large sample size and multicenter human study



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before It's News, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.

Sources:
(1) Honey prevents neurobehavioural deficit and oxidative stress induced by lead acetate exposure in male Wistar rats- a preliminary study by Abdulmajeed WI1, Sulieman HB2, Zubayr MO2, Imam A3, Amin A2, Biliaminu SA4, Oyewole LA2, Owoyele BV. (PubMed)
(2) Dose-Response Effect of Tualang Honey on Postprandial Antioxidant Activity and Oxidative Stress in Female Athletes: A Pilot Study by Ahmad NS1, Abdul Aziz A2, Kong KW2, Hamid MSA3, Cheong JPG1, Hamzah SH1. (PubMed)
(3) The benefits and hazards of antioxidants: controlling apoptosis and other protective mechanisms in cancer patients and the human population by Salganik RI. (PubMed)

#GreenTea Protects the Brain Functioning and Improves Cognition Against the Onset of Psychopathological Symptoms, Researchers Say

Kyle J. Norton

Green tea may have a potential and positive effect in treating mood disorders, some scientists suggested.
Mood disorder is a psychological condition characterized by an elevated mood, including mania or hypomania. In other words, a syndrome is a group of mental illnesses that can affect how a person feels and thinks of him/herself and people in public life.

A mood disorder can be classified into depression, dysthymic disorder,... and bipolar disorder depending on the symptoms of expression.


The condition not only affects the personal life of the patient but also causes psychological and financial burdens to the immediate family members as the condition can only get worse over time.


According to the statistics in 2017, over 2.6 million Canadians aged 12 and over were diagnosed with mood disorders, affecting over 8% of the general population. Sadly, about one in seven Canadians will experience a mood disorder at some point in their life.

The exact causes of mood disorders are unknown, however, there are some underlying factors that can elevate the risk of the condition, including family history, previous mood disorder, depression, certain medical conditions, and long-term use of some medication.

Symptoms of mood disorders are totally depending on the type of the syndrome. If you are experiencing symptoms of feelings of hopelessness, long-term trouble sleeping or daytime sleepiness, poor concentration, and trouble concentrating or making decisions accompanied by physical symptoms of fatigue or low energy, you may have mood disorders. Please check with your doctor to rule out the possibility.
Green tea, a precious drink processes a number of health benefits known to almost everyone in Asia and the Western world.

In the concerns of the widespread mental disorders, researchers at Elsevier Launched an investigation to examine the effects of green tea or green tea extracts, l-theanine and epigallocatechin gallate both components of green tea on general neuropsychology, on the sub-category cognition and on brain functions in humans.


By searching the database of medical literature in PubMed for qualified studies that satisfy the guidelines and criteria set by the PRISMA statement.

Out of 21 selected studies, 4 were randomized controlled trials, 12 were cross-over studies (both assessed with an adapted version of the DELPHI list), 4 were cross-sectional studies and one was a cohort study (both assessed with an adapted version of the Newcastle-Ottawa assessment scale).

After assessing the results of all studies, researchers found that injection of green tea exerts a significant effect on psychopathological symptoms (e.g. reduction of anxiety), cognition (e.g. benefits in memory and attention), and brain function (e.g. activation of working memory seen in functional MRI).

Further analysis also suggested that the effects of green tea may be attributed to the combined influence of both caffeine and l-theanine, as separate administration of either substance is found to have a lesser impact.

Moreover, in the systematic review and meta-analysis conducted on 11 randomized placebo-controlled human studies of acute effects of tea constituents L-theanine and epigallocatechin gallate, administered alone or in combination with caffeine, on cognitive function and mood, researchers discovered that* Combined caffeine and L-theanine demonstrated some moderate effects in the first 2 hours postdose, on ladder alertness, attentional switching accuracy, and, to a lesser extent, some unisensory and multisensory attentional outcomes.

* Caffeine and L-theanine doses revealed trends toward greater change in effect size for caffeine dose than for L-theanine dose, particularly during the first hour postdose.

Additionally, in the study to evaluate whether the tea has any effect on mood and performance benefits, such as relaxation and concentration, researchers at Unilever Research and Development also conducted an extensive search of studies with consistent evidence for improved attention.

In the final report, researchers concluded after taking into account co and confounders
* Tea consumption also consistently improved self-reported alertness and arousal, whereas effects on pleasure or relaxation were less consistent.

* Intake of tea regularly has a strong impact on psychological functions such as work performance and creativity.


The findings suggested that moderate green tea consumption regularly and daily has significant acute benefits in both mood and performance in real-life situations.

Taken all together, there is no doubt that green tea containing a number of highly bioactive compounds such as caffeine, l-theanine, and epigallocatechin gallate may be considered a functional food to protect the brain functioning against the onset of mood disorders.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green tea effects on cognition, mood, and human brain function: A systematic review by Mancini E1, Beglinger C2, Drewe J2, Zanchi D1, Lang UE1, Borgwardt S3(PubMed)
(2) Acute effects of tea constituents L-theanine, caffeine, and epigallocatechin gallate on cognitive function and mood: a systematic review and meta-analysis by Camfield DA1, Stough C, Farrimond J, Scholey AB(PubMed)
(3) Acute effects of tea consumption on attention and mood by Einöther SJ1, Martens VE. (PubMed)

#Herbal #ChasteTreeBerry #Seeds Relieve the Symptoms of Arthritis by Blocking the Sensory Neuron Mediation, Researchers Find

Kyle J. Norton

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of years as an aphrodisiac herb and considered a Queen herb in treating menstrual problems and discomforts.

Arthritis, a common condition of pain and inflammation in the joints, the tissues, affects 54 million people in the US annually alone, according to the 2013-15 statistics.

In Freund's complete adjuvant (CFA) induced arthritis (AA) in a rat model. oral administration of treatment of Chaste Tree Berry seed expressed a strongly inhibited paw edema, reversed weight loss, and decreased arthritis score.


According to the Second Military Medical University, the efficacy of herbal medicine for the treatment of arthritis is the result in inhibition of pro-inflammatory cytokines and in the regulation of enzymes responsible for inflammation and pain. expression.

In support of the above, researchers in the examined histopathological studies found that Chaste Tree Berry showed a remarkable inhibition effect in decreased synovial inflammatory infiltration and synovial lining hyperplasia in the joints in animal models.

Some also researchers suggested that Chaste tree berry reduced symptoms of the pain of arthritis patients probably is associated with the blocking the stimulus by sensory neurons ability through mediating anti-inflammatory activity and interacted with the opioid system.

Taking together, Chaste Tree Berry (seed) processed analgesic properties may be used as therapeutic potential in ameliorated symptoms and treatment of inflammatory arthritis. A large amount intake can only be prescribed by herbalists.

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Therapeutic effects of standardized Vitex negundo seeds extract on complete Freund's adjuvant-induced arthritis in rats by Zheng CJ1, Zhao XX1, Ai HW1, Lin B1, Han T1, Jiang YP1, Xing X2, Qin LP3. (PubMed)
(2) Antinociceptive activities of the liposoluble fraction from Vitex negundo seeds by Zheng CJ1, Huang BK, Han T, Zhang QY, Zhang H, Rahman K, Qin LP.(PubMed)

The Effects of #Antioxidant Omega 3 Fatty Acids in the Suppression of #CancerCachexia in Patients with #PancreaticCancer, According to Studies

Kyle J. Norton

The pancreas is an oblong flattened gland in the digestive and endocrine system located in the abdomen. By secreting pancreatic juice into the small intestine, the pancreas helps to break down carbohydrates, proteins, and lipids.

Traditional Chinese medicine views the pancreas, as a vital organ that is responsible for the absorption of foods' qi and nutrients before passing them to other organs to nourish our body.

More precisely, the functions of the pancreas including
* Production of enzymes digest fat, protein, and
carbohydrates.

* The production of juices combined with juices from the intestines helps to do the job of breaking down protein, carbohydrates, and fat, therefore, it plays an important role in maintaining good health.

* Production of insulin, which is important in regulating the amount of sugar or glucose in the blood.

Pancreatic cancer is a chronic condition characterized by cell growth irregularly in the tissues of the pancreas.

According to statistics, every year, approximately, 55,000 adults in the United States are diagnosed with pancreatic cancer, accounting for 3% of all cancers and 7% of all cancer deaths.

The survival rate of pancreatic cancer even if diagnosed early is very low compared to other types of cancer. The 5-year survival rate for stage IA pancreatic cancer is only14%.

Researchers do not know what causes pancreatic cancer. They don't even know why people with the same health conditions in the same family, are susceptible to pancreatic cancer, while others do not.

The most common risk factors of pancreatic cancer are similar to those of common cancers, including age, family history, gender, ethnicity, smoking, being overweight or obese, and certain medical conditions such as diabetes.

Cancer cachexia is a condition a multifactorial syndrome associated with an ongoing loss of skeletal muscle mass.

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

In finding a potential phytochemical for the treatment of cancer, researchers examined the effects of omega-3 fatty acids in patients with pancreatic and bile duct cancer.

According to the administration of Racol®, an enteral nutrient formulated with omega-3 fatty acids to patients with unresectable pancreatic and bile duct cancer at 4 and 8 weeks after, pre-administration and administration showed a strong activity that increases skeletal muscle mass at both 4 and 8 weeks.


In other words, Omega-3 fatty acid supplementation protects the skeletal muscle mass associated with cancer cachexia in patients with unresectable pancreatic cancer and may improve cancer.

Taken together, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered a functional food for the reduction of cancer cachexia in patients with pancreatic cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Omega-3 Fatty Acids Prevent Early Pancreatic Carcinogenesis via Repression of the AKT Pathway by Ding Y1, Mullapudi B2, Torres C3, Mascariñas E4,5, Mancinelli G6, Diaz AM7, McKinney R8, Barron M9, Schultz M10,11, Heiferman M12, Wojtanek M13, Adrian K14, DeCant B15,16, Rao S17, Ouellette M18, Tsao MS19, Bentrem DJ20, Grippo PJ. (PubMed)
(2) Effects of ω-3 Fatty Acid Supplementation in Patients with Bile Duct or Pancreatic Cancer Undergoing Chemotherapy by Abe K1, Uwagawa T2, Haruki K2, Takano Y2, Onda S2, Sakamoto T2, Gocho T2, Yanaga K. (PubMed)

#Tomatoes Modulate Proteins Assciated with the Immune Function Against the Onset of Low Grade Inflammatory Diseases, Studies Find

Kyle J. Norton

The immune system plays a critical role in the body's defense against infectious organisms and other pathogens.
The immune function can be classified into subsystems, including the innate and adaptive responses.

* The innate responses are the general response of the immune system that can act quickly to destroy invaders, regardless of the type of organism.


* The adaptive responses develop slowly on first exposure to a new pathogen. In some cases, it may take a week or so before the responses are effective.


However, due to the quick division of bacteria, (a single bacterium with a doubling time of one hour can produce almost 20 million progeny), therefore, our body is totally dependent on the innate immune system to destroy the invader in the first critical hours and days of exposure.

Believe it or not, if the innate immune subsystem cannot destroy the foreign invader in a set period of time from 3 -8 weeks, it will compromise, leading to low-grade inflammation in facilitating the onset of various diseases, including cardiovascular disease, diabetes, and arthritis.

Immune modulation is the process of increasing and decreasing immune functioning depending on the needs of the body. In people with a weakened immune system, modulation of the immune system is found to enhance immune functioning against infectious agents.

However, in people with overactive immunity, modulation of the immune function will reduce the risk of the immune system attacking the body tissues.


Tomato is a red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

With an aim to find a potential compound with immune-modulatory activity, researchers examined the influence of tomato aqueous extract (TAE) on the in vitro inflammatory response.


According to the results observed by the Murine macrophages (RAW264.7 cells), PBLs, and HUVECs incubated with TAE, TAE exerted a significant effect in the inhibition of pro-inflammatory cytokines such as L-1β, IL-6, IL-10, IL-12 and chemokines such as CCL2/MCP-1, CCL3/MIP-1α.

In the endothelial cell, TAE reduced ED-associated expression of adhesion molecules (ICAM-1, VCAM-1) associated with the production of inflammation.

In macrophages, the production of pro-inflammatory proteins associated with low-grade inflammation also inhibited the injection of TAE.

Based on the findings, researchers said, "During acute inflammation, TAE enhances cellular alertness and therefore the sensing of disturbed immune homeostasis in the vascular-endothelial compartment. Conversely, it blunts inflammatory mediators in macrophages during chronic inflammation".


In other words, TAE protects the integrity and viability of immune cells by modulating the immune activity depending on the needs of the body.


Furthermore, in a blinded, randomized, cross-over study, male subjects on a low-carotenoid diet consumed 330 ml/day of either tomato juice (37.0 mg/day lycopene) or carrot juice (27.1 mg/day beta-carotene and 13.1 mg/day alpha-carotene) for 2 weeks with a 2-week depletion period after juice intervention, researchers compared the effects of a low-carotenoid diet supplemented with either tomato (providing high amounts of lycopene) or carrot juice (providing high amounts of alpha- and beta-carotene) on immune functions in healthy man.


According to the results from the tested assays, juice consumption showed relatively fast responses in plasma carotenoid concentrations (p < 0.0002) without being accompanied by concomitant changes in immune functions.


However, increased plasma carotenoid concentrations after vegetable juice consumption were accompanied by a time-delayed modulation of immune functions in healthy men consuming a low-carotenoid diet.

Precisely, tomato juice modulated the immune function in a delay and concentration-dependent manner.

Taken together, tomatoes may be considered supplements for the modulation of immune function based on the body's needs, pending the confirmation of the larger sample size and multicenter human study.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Tomato Aqueous Extract Modulates the Inflammatory Profile of Immune Cells and Endothelial Cells by Schwager J1, Richard N2, Mussler B3, Raederstorff D. (PubMed)
(2) Supplementation of a low-carotenoid diet with tomato or carrot juice modulates immune functions in healthy men by Watzl B1, Bub A, Briviba K, Rechkemmer G. (PubMed)

#Herbal #Angelica Shows a Strong Effect on Proteins Associated with Bone Formation, Researchers Say

Kyle J. Norton

Osteoporosis is a condition of thinning of bone and bone tissues as a result of the loss of bone density over a long period of time.
The condition is a widespread degenerative disease of skeletal joints and often associated with senescence invertebrates due to excessive or abnormal mechanical loading of weight-bearing joints, arising from heavy long-term use or specific injuries and considered as a major health problem in both elderly men and women.


Scientists as of today do not know the exact causes of osteoporosis. However, they do know that certain factors are associated with the onset and progression of the disease.

Osteoporosis is a common disease among the elderly, probably due to the aging effect that induces nutrition deficiency such as
* Vitamin D insufficiency and reduced calcium absorption,

* Reduced hormone production, the drop of estrogen levels after menopause, can speed up bone loss.

* Reduced production of bone mass and increased bone reabsorption due to the balance shifts in favor of osteoclasts compared to those of osteoblasts.


Osteoclastogenesis is a procedure that includes many stages, that interfere with the specific stage of the process, diseases associated with imbalanced osteoclasts, and osteoblasts that may be preventable in the future.

The osteoclast is a type of cell differentiated from another type of cell called a macrophage that breaks down the bone and leads to bone resorption.

In other words, in osteoporotic patients, bone resorption is far more exceedingly to bone formation.

Furthermore, the imbalance of osteoclasts and osteoblasts also is found in patients with Paget's disease, rheumatoid arthritis, osteopetrosis, periodontal disease, and bone cancer metastases.

Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China. The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

On finding a potential compound for the improvement of bone mineral density, researchers examined the phytochemical Ligustilide (LIG), the main component of A. sinensis anti-osteoporotic effects.


According to the tested analysis, LIG significantly ameliorated the inhibition of bone formation in zebrafish caused by prednisolone.


Furthermore, the application also showed a strongly promoted osteoblast differentiation, including that of the pre-osteoblastic cell line MC3T3-E1 and bone marrow mesenchymal stem cells by reducing the oxidative stress to induce cell apoptosis by free radical H2O2 and enhancing the protein (Bcl-2) associated with anti-apoptotic functioning


The promotion of bone density of LIG was also found to induce the metabolic reaction of EGFR and ERK1/2 associated with instructions for making a receptor protein involved in bone formation by blocking the GPR30 signaling to induce bone mass increase.

Collectively, researchers said, "The results reveal that GPR30 is a positive switch for LIG to increase bone formation via regulation of EGFR, and these results provide evidence for the potential of LIG to treat osteoporosis".

Taken together, Herbal Angelica consists of LIG. maybe considered a functional herbal medicine for reducing the risk of osteoporosis, pending a larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Ligustilide, a major bioactive component of Angelica sinensis, promotes bone formation via the GPR30/EGFR pathway by Yang F1,2, Lin ZW1,2, Huang TY1,2, Chen TT1,2, Cui J1,2, Li MY1,2, Hua YQ. (PubMed)

#Healthyfood #Honey Shows a Symptomatic Relief for Children's Nocturnal Cough and Sleep Difficulty, According to Studies

Kyle J. Norton

Scientists may have found a natural alternative for the treatment of chronic cough, according to studies. Cough is a natural human reflex that clears the throat of mucus or foreign irritants.

Although it is not common, coughing also is used to clear foreign substances and irritants infrequently associated with a certain lung infection.

Unlike an acute cough, chronic cough is a cough that lasts more than eight weeks. The most common causes of a chronic cough are a postnasal drip, asthma, and acid reflux.


Believe it or not, postnasal drip, asthma, and acid reflux are found in 90% of patients with a chronic cough.

According to the statistics, approximately, 2.% of US adults suffer from a chronic cough, and the risk of chronic cough of current smokers is substantially higher compared to non-smokers.

Besides smoking, people with chronic lung diseases such as asthma, bronchiectasis, COPD, and previous lung infections with scars are also at increased risk of developing a chronic cough.


Some researchers suggested that obese children may also be at risk of chronic conditions.


Dr. S Deane, the lead scientist in the assessment of the obese risk of chronic cough in children said, "Obese children have more respiratory symptoms than their normal-weight peers and respiratory-related pathology increases with increasing weight"


And, "Some will need specialist assessment (box 1). Obesity produces mechanical effects on respiratory system performance. Breathlessness, wheezing, and cough are not related to increased airway responsiveness and may respond more to weight loss than bronchodilator therapy. A significant number of obese children have signs and symptoms of obstructive sleep apnoea largely related to the effect of obesity on upper airway dimensions".


These results strongly suggested that the increased weight of obese children is the major risk factor for the development of chronic cough.


Honey is a miraculous product made by bees using nectar from flowers.

The rich golden liquid is considered one of the healthy sweet foods for replacing the use of white sugar and artificial sweeteners by many people.

Scientists searching for a natural remedy for the treatment of a chronic cough without inducing adverse effects compared the effects of a single nocturnal dose of 3 honey products (eucalyptus honey, citrus honey, or Labiatae honey) to placebo (silan date extract) on nocturnal cough associated with childhood upper respiratory tract infections (URIs).

The study included 300 children aged 1 to 5 years with URIs, nocturnal cough, and illness duration of ≤ 7 days from 6 general pediatric community clinics. Eligible children received a single dose of 10 g of eucalyptus honey, citrus honey, Labiatae honey, or placebo administered 30 minutes before bedtime.

According to the results from 2 consecutive days, there was a significant improvement from the night before treatment to the night of treatment in the treatment group compared to the placebo.


Furthermore, according to the parents' review, the honey exhibited a higher than the silan date extract for symptomatic relief for their children's nocturnal cough and sleep difficulty.


In order to reveal more information about honey against a chronic cough in children, researchers examined the honey effect in the persistent post-infectious cough (PPC) that lasts more than three weeks or perhaps for many months.


The double-blind randomized controlled trial was conducted from 2008 to 2011 at the Baqiyatallah University Hospital, Tehran, Iran. included 97 adults who experienced PPC for more than three weeks randomly distributed into three groups.

Participants were given either a jam-like paste included honey plus coffee for the first group ('HC'), orprednisolone for the second group (steroid, 'S'), or guaifenesin for the third group (control, 'C').


All participants were told to dissolve a specified amount of their product in warm water and drink the solution every eight hours for one week.

The mean (+/- SD) cough scores pre- and post-treatment were: HC group 2.9 (0.3) pre-treatment and 0.2 (0.5) post-treatment (p < 0.001), and steroid ('S') group 3.0 (0.0) pre-treatment and 2.4 (0.6) post-treatment (p < 0.05)


The control ('C') group exerted mean (+/- SD) cough scores of 2.8 (0.4) pre-treatment and 2.7 (0.5) post-treatment (p > 0.05).


By Analysing the variance, researchers found that there is a significant difference between the mean cough frequency before and after treatment in the HC group, compared in the S group


Honey plus coffee was found to be the most effective modality for PPC, compared to other groups.


Taken together, honey may be considered an alternative remedy for the prevention and treatment of chronic coughs in children and adults, pending the confirmation of a large sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.

Sources
(1) Effect of honey on nocturnal cough and sleep quality: a double-blind, randomized, placebo-controlled study by Cohen HA1, Rozen J, Kristal H, Laks Y, Berkovitch M, Uziel Y, Kozer E, Pomeranz A, Efrat H. (PubMed)
(2) Honey plus coffee versus systemic steroid in the treatment of persistent post-infectious cough: a randomised controlled trial by Raeessi MA1, Aslani J, Raeessi N, Gharaie H, Karimi Zarchi AA, Raeessi F. (PubMed)
(3) Obesity and the pulmonologist by S Deane and A Thomson. (PMC)

#Herbal #Angelica Extract Protects Bone Density Against the Risk of Osteoporosis, Researchers Show

Kyle J. Norton

Osteoporosis is a condition of thinning of bone and bone tissues as a result of the loss of bone density over a long period of time.

The condition is a widespread degenerative disease of skeletal joints and is often associated with senescence invertebrates due to excessive or abnormal mechanical loading of weight-bearing joints, arising from heavy long-term use or specific injuries, and is considered a major health problem in both elderly men and women.

Scientists as of today do not know the exact causes of osteoporosis. However, they do know that certain factors are associated with the onset and progression of the disease.

Osteoporosis is a common disease among the elderly, probably due to the aging effect that induces nutrition deficiency, vitamin D, reduced hormone production and production of bone mass, and increased bone reabsorption.

Osteoclastogenesis is a procedure processed in many stages. Interferes with the specific stage of the process, can induce the imbalanced osteoclasts and osteoblast.

The osteoclast is a type of cell differentiated from another type of cell called a macrophage that breaks down the bone and leads to bone resorption.

In patients with osteoporosis, this balance shifts in favor of osteoclasts compared to those of osteoblasts.

In other words, in osteoporotic patients, bone resorption is far more exceedingly to bone formation.

Furthermore, the imbalance of osteoclasts and osteoblasts also is found in patients with Paget's disease, rheumatoid arthritis, osteopetrosis, periodontal disease, and bone cancer metastases.

Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China. The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen the heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

On finding a potential compound for the protection of bone density, researchers examined the effect of Angelica Sinensis (AS) extract on RANKL-induced osteoclast differentiation.

The study is to examine the osteoclast precursor cell line bone marrow macrophages (BMMs) cultured and stimulated with RANKL followed by treatment with AS at several doses by regulating the complex networks involved in osteoclastogenesis and bone resorption.

According to the results of the experiment, AS extract protected bone density by inhibiting RANKL-mediated osteoclast differentiation in bone marrow macrophages (BMMs) in a dose-dependent manner without any evidence of cytotoxicity.

AS extract also inhibited the mRNA expression of transcription factors that are activated in immune cells and other cell types following stimulation by a variety of factors in RANKL-treated BMMs.

In other words, AS protected bone density integrity against osteoclastogenesis and inhibited bone resorption, the expression of cytokines, growth factors, and hormones induced by the treatment of RANKL.

Taken together, herbal Angelica may be considered an anti anti-steoclastogenesis and bone resorption remedy to protect the bone mineral density against the onset of osteoporosis, pending to larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Angelica sinensis extract inhibits RANKL-mediated osteoclastogenesis by down-regulated the expression of NFATc1 in mouse bone marrow cells by Kong L, Zhao Q, Wang X, Zhu J, Hao D1, Yang C. (PubMed)

#Healthyfood #Honey Shows a Statistically Significant Reduction of Pain, According to Studies

Kyle J. Norton

Scientists may have found a natural alternative pain relief remedy for alleviating pain, according to studies. found.

Pain relief is an action to remove pain, distress, and oppression by blocking the pain-transmitting information from nerve cells to the brain neurons.

Acute pain is any pain that lasts less than 6 months. Most cases of acute pain are due to physical damage such as soft tissue damage of a sprained ankle or a paper cut. Acute pain is relatively sharper and severe.

On the other hand, there are many risk factors associated with chronic pain. Some chronic pains can be caused by single factors such as diseases involving nerve damage to injuries that fail to heal properly. Others may result from several factors including diseases associated with normal aging.


Over-the-counter medications used for the treatment of pain include acetaminophen (Tylenol) and nonsteroidal anti-inflammatory drugs (NSAIDs).

Besides the gastrointestinal discomforts, long-term use of Tylenol may be additive. Overdoses or consumption together with alcohol, Tylenol can cause liver damage in severe cases.


If you are taking some over-the-counter medicine for pain-relieving, please make sure you know all the side effects of the preventive measure.

Honey is a miraculous product made by bees using nectar from flowers.

The rich golden liquid is considered one of the healthy sweet foods for replacing the use of white sugar and artificial sweeteners by many people.

Researchers on finding a natural ingredient for pain relief examined the honey effect as adjunct pain therapy.

The pain relief of honey was the result of the contribution of the numerous phytochemicals and components, including the interaction of protein, amino acid, flavonoids, phenolics, organic acid, pigment, water, and (high) sugar content in honey.


These components work together to relieve pain by exerting antibacterial, antiinflammation, and immunomodulation properties.


According to additional differentiation, honey reduced pain through the expression of the level of the central and peripheral nervous system or at the autonomic receptor sites involved in pain transmission via the cyclooxygenase pathway in nociception and pain.

Furthermore, in the examined the honey pain relief in post-tonsillectomy treatment with or without adenoidectomy, researchers launched a randomized, double-blind, placebo-controlled study that included 140 patients, who were older than eight.

Patients were divided into two equal groups, honey, and placebo.

Compared the acetaminophen plus honey for the honey group, and acetaminophen plus placebo for the placebo group, researchers found that
* According to the visual analog scale (VAS) and the number of painkillers taken within the first three postoperative days, acetaminophen and acetaminophen plus honey groups showed a statistically significant reduction of pain.

*The reduced use of painkillers differed significantly in every five postoperative days.

* Pain awoke at night is also reduced with no difference between groups.

* Honey injection exerted negligible side effects

These results strongly showed that postoperative honey administration reduces postoperative pain and analgesic requirements in patients after tonsillectomy.


Taken together, there is no doubt that honey may be considered a functional remedy for pain relief with few side effects, pending the confirmation of a large sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norriton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.

Sources
(1) Chapter 10 - Honey—A Natural Remedy for Pain Relief by Author links open overlay panelN.M.LazimA.Baharudin. (PubMed)
(2) Post Tonsillectomy Pain: Can Honey Reduce the Analgesic Requirements? by Peyman Boroumand,1 Mohammad Mahdi Zamani,2 Masoumeh Saeedi,1Omid Rouhbakhshfar,1 Seyed Reza Hosseini Motlagh,1 and Fatemeh Aarabi Moghaddam. (PubMed)

#Phytochemical 3,3'-Diindolylmethane In the Promotion of Enzymes and Antioxidant Activity Associated with Anti- Hematopoietic Injury, Researchers Find

Kyle J. Norton

Scientists may have found a bioactive ingredient for the protection of hematopoiesis with no side effects, according to studies.
Hematopoiesis is the process by which blood cells are formed, including the formation of all of the cellular components of blood and blood plasma.

1. Red blood cells with a function to transport oxygen and hemoglobin to the body.

2. White blood cells that form parts of the immune system, including
* T cells and B cells, that fight viruses, and tumors.

* Neutrophils that fight bacteria and fungi.

* Eosinophils that fight some parasites and initiate an inflammatory response.


* Basophils that release the histamines necessary for the inflammatory response.

* Macrophages, the first line of the immune response in the acute phase of infection.

3. Platelets (thrombocytes) for coagulation.

Diseases of the bone marrow, spleen, lymph nodes, and thymus may affect the process of hematopoiesis, leading to various diseases of the hematopoietic system.

3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, kale, etc.

On finding a natural compound for the treatment of hematopoietic injury, researchers examined the 3,3'-Diindolylmethane (DIM) effect on the hematopoietic system injury induced by total body irradiation (TBI) that leads to the generation of intracellular reactive oxygen species (ROS) and DNA damage.

In TBI-induced lethality mice, DIM ameliorated TBI-induced hematopoietic injury by inhibiting the production of ROS production in hematopoietic stem cells (HSCs).

Furthermore, DIM improved the bone marrow (BM) HSC frequency, hematopoietic progenitor cell (HPC) clonogenic function, and multilineage engraftment after transplantation in tested mice.

In an additional analysis of DIM anti-hematopoietic injury, researchers found that DIM promotes the genes associated with the increased production of antioxidant enzymes (nuclear factor erythroid 2-related factor 2 (Nrf2)) in the hematopoietic stem cells (HSCs) and decreased the production of free radicals (NADPH oxidase 4 (NOX4)).

DIM also protected the cells against apoptosis by increasing the expression of the anti-apoptotic protein (Bcl-2) and decreasing the expression of the pro-apoptotic protein (Bax).

The results strongly suggested that DIM attenuates TBI-induced hematopoietic injury through the inhibition of both oxidative stress in HSCs and hematopoietic cell apoptosis.

Dr. Lu L and colleagues wrote in the final report, "DIM protected BM hematopoietic cells against ionizing radiation and led to increased clonogenicity in vitro. Therefore, DIM has the potential to be used as an effective radioprotectant to ameliorate TBI-induced hematopoietic injury".

Taken together, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the protection and treatment of hematopoietic injury, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) 3,3'-diindolylmethane mitigates total body irradiation-induced hematopoietic injury in mice by Lu L1, Dong J2, Li D2, Zhang J2, Fan S. (PubMed)

Encapsulation of Asafoetida (ASF) and a CUR Found in #Herbal #Turmeric Provide Protection of the Onset of #Colitis, Scientists Say

Kyle J. Norton

Colitis is a condition associated with inflammation of the inner lining of the colon.
There is no exact cause of colitis. Certain risk factors such as colon infection, inflammatory bowel disease (Crohn's disease, ulcerative colitis), ischemic colitis, allergic reactions, and microscopic colitis have been found to increase the risk of the onset of the condition.

The most common symptoms of colitis are totally depending on the type, including abdominal pain, cramping, diarrhea, with or without blood in the stool.

Types of colitis according to the Catholic University of the Sacred Heart, include
microscopic colitis, ischemic colitis, segmental colitis associated with diverticula, radiation colitis, diversion colitis, eosinophilic colitis, and Behcet's colitis.

Epidemiologically, people with untreated colitis may experience complications of

* Congenital abnormalities
Women who are pregnant with Ulcerative colitis are associated with a significantly increased risk of some selected congenital abnormalities (limb deficiencies, obstructive urinary, and multiple congenital abnormalities) according to the birth outcomes in women with ulcerative colitis examined in nationwide.

* Nutritional deficiency
Malnutrition, particularly protein-energy malnutrition and vitamin and micronutrient deficiencies, as well as dysregulation of the intestinal microbiota, are common features of IBD.

Conventionally, besides treating colitis with antibiotics, certain medications also are prescribed to improve the symptoms and quality of life of the patients, including anti-diarrheal medications.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.

In finding a natural compound for the treatment of colitis, researchers examined the effects of a novel gut health product (GHP), an encapsulation of asafoetida (ASF) and a CUR complex used as a carrier agent to encapsulate bioactive components for the treatment of colitis.

According to the rat model of 5%, dextran sulfate sodium (DSS) induced UC, treatment of GHP significantly attenuated the disease activity index, colitis score, histopathological changes, and myeloperoxidase activity.

Furthermore, GHP also demonstrated significant protective effects against DSS-induced colitis.

Additionally, in an animal model of dextran sodium sulfate (DSS)-induced colitis, a specific, curcumin preparation containing essential turmeric oils (ETO-curcumin) compared to standard curcumin at three specific doses (0, 5, 25, or 50 mg/kg), both ETO and standard curcumin treatments provided protection against DSS-induced inflammation.

However, according to the tested assays, ETO-curcumin improved disease activity index (DAI) dose-dependently, compared to the anti-inflammatory efficacy of standard curcumin remained constant.
In other words, ETO-curcumin was superior in the expression of anti-inflammatory efficacy compared to standard curcumin.

Moreover, ETO-curcumin displayed anti-colitis activity in the colon by exerting anti-inflammatory cytokines including IL-10 and IL-11 as well as FOXP3.

Collectively, Dr. Toden S., the lead scientist, wrote in the final report, " The combined treatment of curcumin and essential turmeric oils provides superior protection from DSS-induced colitis than curcumin alone, highlighting the anti-inflammatory potential of turmeric".

Taken altogether, turmeric plus essential turmeric oils may be considered supplements for the prevention of colitis, pending the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Preparation, characterization, and anti-colitis activity of curcumin-asafoetida complex encapsulated in turmeric nanofiber by Gopi S1, Amalraj A2, Jude S2, Varma K2, Sreeraj TR2, Haponiuk JT3, Thomas S. (PubMed)
(2) Essential turmeric oils enhance the anti-inflammatory efficacy of curcumin in dextran sulfate sodium-induced colitis by Toden S1, Theiss AL2, Wang X3, Goel A. (PubMed)
(3) Colitis - The Complications by Kyle J. Norton

#Organosulfides, the Bioactive compoundsisolated from Garlic Process Strong Anti #SkinCancer Activity, Researchers Suggest

Kyle J. Norton

Polysulfides isolated from the organosulfides may have a profound effect in reducing the risk and treatment of skin cancer, according to studies.
Skin, a large organ that forms the out layers of our body has a serval layer of ectodermal tissue and protects the underlying muscles, bones, ligaments and internal organs against foreign pathogenic invasion.

Skin cancer is a medical condition characterized by disordered and irregular cell growth in the skin.

Most cases of primary skin cancer start in the cell on the surface of the inner lining of the skin. At the advanced stage, the cancerous cells can travel a distance away from the skin to infect other healthy tissues and organs through blood and fluid circulation.


There are 3 main types of cells in the top layer of the skin (called the epidermis):
Squamous cells, Basal cells, and Melanocytes.

Long-term cumulative sun exposure is one of the major causes of basal cell and squamous cell skin cancer. Exposure to ultraviolet (UV) radiation is the leading cause of melanoma.

Certain risk factors that make some people more susceptible to the development of skin cancer than others include the increase in age, weakened immune system, gender, skin tone, genetic preposition, and family history.

Some researchers also suggested that the general knowledge about the protection of skin against the onset of skin cancer is lacking, therefore, more education in this field may be necessary before the prevalence of skin cancer can be reduced.


Dr. Lee Wheless, the lead scientist in the concern of the association between skin characteristics and skin cancer prevention behaviors said, "Behaviors such as sunscreen use and wearing sun-protective clothing are thought to prevent certain types of skin cancer and precancerous lesions".

However, "The overall prevalence of prevention behaviors was low. Those with phenotypic risk factors for skin cancer were most likely to use sunscreen and sun-protective clothing. Those with high-risk skin cancer phenotypes may also be those who are most receptive to skin cancer prevention educational interventions".

Polysulfides are phytochemicals in a class of chemical compounds containing chains of sulfur atoms, belonging to the group of Organosulfides found abundantly in the oxidized product, including beer, wine, whiskey, garlic oil, etc.

In the concern of incidence of skin cancer which increases at an alarming rate, researchers at the National Taiwan University evaluated the anti-skin cancer activity of sulfur metabolites in garlic oil.
Diallyl trisulfide (DATS), a member of polysulfides was found to be more potent than mono- and disulfides against skin cancer.

Injection of DATS inhibited cell growth of human melanoma A375 and basal cell carcinoma (BCC) cells by increasing the cytotoxicity of the reactive oxygen species (ROS).

Furthermore, DATS also induced apoptosis of skin cancer cells through inducing the DNA damage and through cell cycle arrest at the G2/M phase, endoplasmic reticulum (ER) stress associated with the cancer cell proliferation and survival, and mitochondria-mediated apoptosis.

These results indicated the importance of DATS in the prevention and treatment of skin cancer by focusing on molecular mechanisms.

Furthermore, in the in-depth analysis of the effects of Diallyl sulfide (DAS), diallyl disulfide (DADS), and diallyl trisulfide (DATS), extracts from crushed garlic by steam-distillation against human melanoma A375 cells and basal cell carcinoma cells, researchers showed that DATS reveals better growth inhibition of A375 and BCC cells than DADS and DAS do.

Similar to the previous study, DATS increased intracellular reactive oxygen species (ROS) generation in the induction of cytotoxicity to the tested cancer cell lines.
The cell viability analysis reconfirmed the previous finding that DATS kills tested cancer cells in G(2)/M arrest.

Interestingly, DATS activated the p53 pathway in response to the oxidative DNA damage.
Where p53 is a protein associated with the regulation of the cell cycle and functions as a tumor suppression.

Dr. Wang HC, the lead scientist wrote in the final report of the experiment, "DATS also displayed a selective target of growth inhibition between skin cancer cells and normal keratinocyte HaCaT cells".

Taken altogether, Diallyl trisulfide (DATS) a bioactive compound from garlic may be used for the prevention and treatment of skin cancer, pending to reconfirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Molecular mechanisms of garlic-derived allyl sulfides in the inhibition of skin cancer progression by Wang HC1, Pao J, Lin SY, Sheen LY. (PubMed)
(2) Allyl sulfides inhibit cell growth of skin cancer cells through induction of DNA damage mediated G2/M arrest and apoptosis By Wang HC1, Yang JH, Hsieh SC, Sheen LY. (PubMed)
(3) Diallyl sulfide protects against ultraviolet B-induced skin cancers in SKH-1 hairless mouse: analysis of early molecular events in carcinogenesis by Cherng JM1, Tsai KD, Perng DS, Wang JS, Wei CC, Lin JC. (PubMed)
(4) The association between skin characteristics and skin cancer prevention behaviors by Lee Wheless,1 Ingo Ruczinski,3 Rhoda M. Alani,6,7 Sandra Clipp,4,10Judith Hoffman-Bolton,4,10 Timothy J. Jorgensen,4,11 Nanette J. Liégeois,6,8,9Paul T. Strickland,5 and Anthony J. Alberg. (PMC)