Endometrial Cancer caused by Genes Mutation

Posted By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The incidence of endometrial cancer among white women are higher in comparison to black. According to the statistic, the risk of endometrial cancer among women is 1 in 7000. Every year, about 40,000 women in US are diagnosed with the disease. Women who carry certain mutation genes, such as  BRCA1 or the BRCA2 are associated to increased risk of endometrial cancer.

Endometrium is the inner lining of the mammalian uterus and very susceptible hormone change, particular to menstrual cycle. Endometrial cancer is a late adulthood cancer defined as a condition of which the cells of the endometrial lining of uterus have growth uncontrollable or become cancerous as a result of the alternation of cells DNA. It's the fourth most common cancer among women overall, after breast cancer, lung cancer, and bowel cancer.

The genes mutation
1. BRCA1 or the BRCA2 gene 
Women who carry the genes BRCA1 or the BRCA2, according to Familial Breast Cancer Research study are associated to risk of endometrial cancer, specialty for  the gene BRCA, but the excessive risk is largely attributable to a history of Tamoxifen use.(1) and in aged group between 45 to 70(2).

2. Mutations in DNA mismatch repair (MMR) genes
Mutations in DNA mismatch repair (MMR) genes affects the DNA repair prowess, elevating endometrial cancer risk, due to the loss of proofreading activity of Polε (3). The University of Oxford study, indicated that mutation of germline exonuclease domain ((EDMs) of POLE and POLD1 are associated to predispose to endometrial cancer (EC) risk(4), Other study showed that defection in either DNA proofreading or MMR may relate to genomic instability and tumourigenesis(5).

3. Phosphatase and tensin homolog (PTEN)
Mation of Mutations of this gene are associated to the development of many types of cancer, specially in altered gene in estrogen-dependent endometrioid endometrial carcinoma tumors(6)

4. K-ras mutations
K-ras gene, protein product plays an essential function in normal tissue signaling. Mutation of KRAS gene is associated to  the development of many cancers. According to the study by Haukel and University Hospital, KRAS mutations over amplification and expression were presented in 14.7% of primary lesions with no increase in metastatic lesions but in 18% of metastatic lesions, and high KRAS mRNA levels are associated with aggressive phenotype due to activation of ERK1/2 , (in regulating the malignant potential of cancer cells)(7). According to the study by Kanazawa University, 23% of patients with endometrial cancer carry  a mutation in exon 1 of KRAS(7) and 70% of Mutation in codon 12 of the K-ras gene in Serbian patients(8)

5.  β-catenin mutation
β-catenin plays an important role in dual function protein by regulating the coordination of cell–cell adhesion and gene transcription, Mutation and over expression are associated to increased risk of endometrial cancer(9). The Sapporo Medical University study insisted that alternation of the beta-catenin gene occurs in atypical hyperplasia or cancer, rather than in simple or complex hyperplasia without atypia(structural abnormality in a cell), during endometrial carcinogenesis(10).
In an immunohistochemically analyzed 80 endometrial samples (30 of normal endometrium, 20 of endometrial hyperplasia, and 30 of endometrial cancer), beta-catenin was observed in 30% of endometrial cancer samples(11).

6. Lynch syndrome
Lynch syndrome is an inherited condition with increased  risk of colon and other cancers, caused by a germ line mutation in a mismatch repair gene(12). The risk of Lynch syndrome among endometrial cancer patients is 4.6%(13). In a molecular screening for LS in patients with endometrial cancer  ≤ 70 years of age, the risk of  LS is 6% of cases(14), Inactivation of the mismatch repair genes MSH2 and MSH6 are associated to hereditary non-polyposis colorectal cancer (HNPCC; Lynch syndrome)(15).

Taking altogether, genetic mutation of certain genes is associated with increased risk of endometrial cancer. Fortunately, certain foods and herbs have found to be effective in suppressing the expression and blocking the preoperative mechanism and pathways. Please note that all articles written by Kyle J. Norton are for information & education only, please consult your Doctor & Related field specialist before applying.
 


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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References
(1) The incidence of endometrial cancer in women with BRCA1 and BRCA2 mutations: an international prospective cohort study by Segev Y, Iqbal J, Lubinski J, Gronwald J, Lynch HT, Moller P, Ghadirian P, Rosen B, Tung N, Kim-Sing C, Foulkes WD, Neuhausen SL, Senter L, Singer CF, Karlan B, Ping S, Narod SA; Hereditary Breast Cancer Study Group.(PubMed)
(2) The risk of endometrial cancer in women with BRCA1 and BRCA2 mutations. A prospective study by Beiner ME, Finch A, Rosen B, Lubinski J, Moller P, Ghadirian P, Lynch HT, Friedman E, Sun P, Narod SA; Hereditary Ovarian Cancer Clinical Study Group(PubMed)
(3) A common cancer-associated DNA polymerase {varepsilon} mutation causes an exceptionally strong mutator phenotype, indicating fidelity defects distinct from loss of proofreading by Kane DP, Shcherbakova PV(PubMed)
(4) [Identification and management of HNPCC syndrome (hereditary non polyposis colon cancer), hereditary predisposition to colorectal and endometrial adenocarcinomas].

[Article in French by Olschwang S, Bonaïti C, Feingold J, Frébourg T, Grandjouan S, Lasset C, Laurent-Puig P, Lecuru F, Millat B, Sobol H, Thomas G, Eisinger F.(PubMed)

(5) DNA polymerase ε and δ exonuclease domain mutations in endometrial cancer by Church DN, Briggs SE, Palles C, Domingo E, Kearsey SJ, Grimes JM, Gorman M, Martin L, Howarth KM, Hodgson SV; NSECG Collaborators, Kaur K, Taylor J, Tomlinson IP(PubMed)

(6) Genetics of Endometrial Cancers by Tsuyoshi Okuda,^1,* Akihiko Sekizawa,¹ Yuditiya Purwosunu,^{1, 2} Masaaki Nagatsuka,¹ Miki Morioka,¹ Masaki Hayashi,¹ and Takashi Okai(PubMed)
(7) KRAS gene amplification and overexpression but not mutation associates with aggressive and metastatic endometrial cancer by Birkeland E, Wik E, Mjøs S, Hoivik EA, Trovik J, Werner HM, Kusonmano K, Petersen K, Raeder MB, Holst F, Øyan AM, Kalland KH, Akslen LA, Simon R, Krakstad C, Salvesen HB.(PubMed)
(8) Genetic alterations in SMAD4 and K-ras in Serbian patients with endometrial carcinoma by Nikolic A, Ristanovic M, Perovic V, Trifunovic J, Perovic M, Radojkovic D.(PubMed)
(9) Frequent β-catenin gene mutations in atypical polypoid adenomyoma of the uterus by Takahashi H, Yoshida T, Matsumoto T, Kameda Y, Takano Y, Tazo Y, Inoue H, Saegusa M(PubMed)
(10) Mutation of beta-catenin gene in endometrial cancer but not in associated hyperplasia by Ashihara K, Saito T, Mizumoto H, Nishimura M, Tanaka R, Kudo R.(PubMed)
(11) Nuclear localization of beta-catenin in normal and carcinogenic endometrium by Nei H, Saito T, Yamasaki H, Mizumoto H, Ito E, Kudo R.(PubMed)
(12) Risks of colorectal and other cancers after endometrial cancer for women with Lynch syndrome by Win AK, Lindor NM, Winship I, Tucker KM, Buchanan DD, Young JP, Rosty C, Leggett B, Giles GG, Goldblatt J, Macrae FA, Parry S, Kalady MF, Baron JA, Ahnen DJ, Marchand LL, Gallinger S, Haile RW, Newcomb PA, Hopper JL, Jenkins MA(PubMed)
(13) Prevalence of Lynch syndrome among patients with newly diagnosed endometrial cancers by Egoavil C, Alenda C, Castillejo A, Paya A, Peiro G, Sánchez-Heras AB, Castillejo MI, Rojas E, Barberá VM, Cigüenza S, Lopez JA, Piñero O, Román MJ, Martínez-Escoriza JC, Guarinos C, Perez-Carbonell L, Aranda FI, Soto JL.(PubMed)
(14) Prospective evaluation of molecular screening for Lynch syndrome in patients with endometrial cancer ≤ 70 years by Leenen CH, van Lier MG, van Doorn HC, van Leerdam ME, Kooi SG, de Waard J, Hoedemaeker RF, van den Ouweland AM, Hulspas SM, Dubbink HJ, Kuipers EJ, Wagner A, Dinjens WN, Steyerberg EW.(PubMed)
(15) Structural, molecular and cellular functions of MSH2 and MSH6 during DNA mismatch repair, damage signaling and other noncanonical activities Michael A. Edelbrock^a,, Saravanan Kaliyaperumal^b, , Kandace J. Williams(Science direct)

The Popular Chinese recipe: Curried tomato and Shellfish broth

Posted By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Recipe contributed by 125 Chinese recipes with Bill Jones and Stephen Wong

6 scallops, thinly sliced
8 prawns, peeled and deveined
salt and freshly ground white pepper to taste
2 tsp. vegetable oil
1 small onion, sliced
1tbsp. curry powder, preferably madras
5 cups chicken stock
4 small tomatoes, seed and quartered
12 clams scrubbed
2 cups thinly sliced mustard green or sui choy (Napa cabbage)
salt and pepper to taste
season seafood with salt and pepper; set aside
In a large saucepan or soup pot, heat oil over medium heat for 30 seconds. Add onion and curry powder; sauté for 1 minute. Add chicken stock; bring to a boil. Add tomatoes and cook for 3 minutes. Add clam; cook until they open, about 2 - 5 minutes, depending on size. Skim off any impurities that rise to the top.
Add scallops, prawns and mustard green or cabbage; bring to a boil. Remove from heat. Season to taste with salt and pepper. Cover and allow to steep for 2 minutes. Serve immediately.


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The Holistic prevention, management and treatment of Polycystic Ovarian Syndrome: The fertility Herb Black Cohosh

By Kyle J. Norton Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


                    Polycystic Ovarian Syndrome

Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovasular disease(8)(13), acne(10)(14), endometrial cance(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to  continuously increase risk of type II diabetes, with no increasing altered glucose tolerance(20), CVD and hypertension(21).

The prevention and management  In Herbal Medicine

Polycystic ovary syndrome (PCOS) is unpreventable in Western medicine. Early diagnosis and treatment  may reduce risk of its complications, including infertility, metabolic syndrome, obesity, diabetes, cardiovascular diseases, stroke, etc.
                           
Reduce fat intake less than 30% of total calories with a low proportion of saturated fat and high in fiber from predominantly low-glycaemic-index-carbohydrate foods for patients with PCOs(827a). Calorie intake should be distributed between several meals per day with restricted intake of snacks and drinks(828).

                    The Fertility Herb: Black cohosh

Black cohosh is a glabrous herbaceous perennial plant, producing large, compound leaves from an underground rhizome and belongs to the family Ranunculaceae used in traditional medicine in treating symptoms of all kinds of gynaecological problems(905), including symptoms of premenstrual tension(907) and menopause(906)

1. Phytoestrogen
Phytoestrogen found it balck cohosh showed to occupy the estrogen receptor sites in women body(908), through it antiestrogenic and extrogenic effects(909), to induce hormone balancing may result in improving the chance of ovulation and fertility(910)(911).

2. Immunity
 Black cohosh processes anti inflammatory(913)(914) and anti oxidant(914) effect through enhancing immune system fighting against microbial(915)(916) invasion and irregular cell growth(917)(918) and other inflammatory diseases(913). According to School of Medicine, Wuhan University black cohosh may be beneficiary for patient with patients with coronary heart disease, atherosclerosis, pulmonary heart disease and thrombosis throught its anti inflammatory effects(912).

3. Metabolic Syndrome
In rat model study, black cohosh and its triterpene-saponins showed to reduce high load with fat tissue in the PFD and in the knee joints, body weight, serum leptin and cholesterol and glucose levels caused by metabolic syndrome, according to University Medical Center Göttingen(919). The consumption of black cohost also effectively decreases enhanced pituitary LH secretion, attenuates body weight gain, plasma lipids and intra-abdominal fat (IAF) accumulation, lowers FPI and has no effects on uterine mass(920).

4. Fertility
Use conjunction with clomiphene citrate, black cohosh induced endometrial thickness, serum progesterone and clinical pregnancy rate and cycle outcomes in some infertile couples(921). According to Assiut University, in the differentiation of  relatively low pregnancy rates in CC induction cycles of clomiphene citrate in infertile couple, follicular-phase supplements imicifuga racemosa or ethinyl oestradiol needed significantly fewer days for adequate follicular maturation, had a thicker endometrium and higher oestradiol concentration at the time of human chorionic gonadotrophin injection with better outcome of pregnancy rate(922)(923).

5. Condense Tannins
It also contains condense tannin, a type of proanthocyanidin which has been used as nutritional and therapeutic supplements in Europe in promoting the function of flavonoids as an antioxdant(924)(925)  to improve Immunity(926)(927) against auto immune response induced infertility(962)(933) and microbial invasion(928)(929), but also maintain DNA integrity about irregular cell growth(930)(931).

6. Nervous Symptoms
Back cohost is said to contain chemical agent  to bind the activities to serotonin receptors(939) in decreasing the risk of depression(936), anxiety(934), sleep problem(935) and emotional and physical stress(937)induced risk of infertility(938).

side effects
1. Common side effects include
In high doses of black cohosh may cause abdominal pain, diarrhea, dizziness, headaches, joint pains, nausea, slow heart rate, tremors, visual dimness, vomiting, and weight gain, according to

University of Maryland Medical Center(941)(943)

2. Liver damage
Over dose of back cohosh may cause liver damage(940).
3. Digestive system
Over dose may cause occasional gastrointestinal discomfort, such as  diarrhea; nausea and vomiting. sweating; constipation(942).
4. Etc.

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months   

References
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O¹.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF¹, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndrome and healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R¹, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N¹, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB¹, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA¹, Arduc A², Tuna MM¹, Karakılıc E¹, Dagdelen I¹, Tutuncu Y¹, Berker D¹, Guler S¹.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO¹.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO¹, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J¹, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK¹, Katalenich B², Nagireddy P³, Chabbra P⁴, Kuhadiya N⁵, Fonseca V¹.(PubMed)
(14) Acne in hirsute women by Lumezi BG¹, Pupovci HL¹, Berisha VL¹, Goçi AU², Gerqari A³.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N¹, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H¹, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women With Polycystic Ovary Syndrome. by Whigham LD¹, Butz DE², Dashti H³, Tonelli M³, Johnson LK¹, Cook ME², Porter WP⁴, Eghbalnia HR⁵, Markley JL⁶, Lindheim SR⁷, Schoeller DA⁸, Abbott DH⁹, Assadi-Porter FM¹⁰.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA¹, Azizia MM¹, Hardiman PJ².(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M¹, Kjaer SK², Jensen A¹, Munk C¹, Mellemkjaer L³.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E¹.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E¹, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(827a) Diet and nutrition in polycystic ovary syndrome (PCOS): pointers for nutritional management by Farshchi H, Rane A, Love A, Kennedy RL(PubMed)
(828) The optimal diet for women with polycystic ovary syndrome? by Marsh K, Brand-Miller J.(PubMed)

(905) Predny ML, De Angelis P, Chamberlain JL (2006). Black cohosh (Actaea racemosa): An annotated Bibliography. General Technical Report SRS–97 (Department of Agriculture Forest Service, Southern Research Station). p. 99. Retrieved 2009-08-24.

(906) Black cohosh (Actaea/Cimicifuga racemosa): review of the clinical data for safety and efficacy in menopausal symptoms. by Mahady GB¹.(PubMed)

(907) Research highlights from the UIC/NIH Center for Botanical Dietary Supplements Research for Women’s Health: Black cohosh from the field to the clinic by Norman R Farnsworth¹ and Gail B. Mahady(PubMed)

(908) A phytoestrogen diarylheptanoid mediates estrogen receptor/Akt/glycogen synthase kinase 3β protein-dependent activation of the Wnt/β-catenin signaling pathway. by Bhukhai K¹, Suksen K, Bhummaphan N, Janjorn K, Thongon N, Tantikanlayaporn D, Piyachaturawat P, Suksamrarn A, Chairoungdua A.(PubMed)

(909) Isoflavones: chemistry, analysis, functions and effects on health and cancer by Ko KP¹.(PubMed)

(910) Adding the phytoestrogen Cimicifugae Racemosae to clomiphene induction cycles with timed intercourse in polycystic ovary syndrome improves cycle outcomes and pregnancy rates - a randomized trial by Shahin AY¹, Mohammed SA.(PubMed)

(911) Supplementation of clomiphene citrate cycles with Cimicifuga racemosa or ethinyl oestradiol--a randomized trial by Shahin AY¹, Ismail AM, Shaaban OM.(PubMed) 

(912) Pharmacological actions of sodium ferulate in cardiovascular system by Wang BH¹, Ou-Yang JP.(PubMed)
(913) Aqueous extracts of Cimicifuga racemosa and phenolcarboxylic constituents inhibit production of proinflammatory cytokines in LPS-stimulated human whole blood by Schmid D¹, Woehs F, Svoboda M, Thalhammer T, Chiba P, Moeslinger T.(PubMed)
(914) Inhibition of inducible nitric oxide synthesis by Cimicifuga racemosa (Actaea racemosa, black cohosh) extracts in LPS-stimulated RAW 264.7 macrophages by Schmid D¹, Gruber M, Woehs F, Prinz S, Etzlstorfer B, Prucker C, Fuzzati N, Kopp B, Moeslinger T.(PubMed)
(915) Triterpenoid glycoside from Cimicifuga racemosa by Lai GF¹, Wang YF, Fan LM, Cao JX, Luo SD.(PubMed)
(916) Extracts of Canadian first nations medicinal plants, used as natural products, inhibit neisseria gonorrhoeae isolates with different antibiotic resistance profiles by Cybulska P¹, Thakur SD, Foster BC, Scott IM, Leduc RI, Arnason JT, Dillon JA.(PubMed)
(917) Black cohosh (Cimicifuga racemosa [L.] Nutt.): safety and efficacy for cancer patients by Walji R¹, Boon H, Guns E, Oneschuk D, Younus J.(PubMed)
(918) Black cohosh, hot flushes, and breast cancer by Merchant S¹, Stebbing J².(PubMed)
(919) Cimicifuga racemosa and its triterpene-saponins prevent the Metabolic Syndrome and deterioration of cartilage in the knee joint of ovariectomized rats by similar mechanisms by Seidlova-Wuttke D¹, Eder N, Stahnke V, Kammann M, Stecher G, Haunschild J, Wessels JT, Wuttke W.(PubMed)
(920) Effects of black cohosh extract on body weight gain, intra-abdominal fat accumulation, plasma lipids and glucose tolerance in ovariectomized Sprague-Dawley rats by Rachoń D¹, Vortherms T, Seidlová-Wuttke D, Wuttke W.(PubMed)
(921) Adding phytoestrogens to clomiphene induction in unexplained infertility patients--a randomized trial by Shahin AY¹, Ismail AM, Zahran KM, Makhlouf AM.(PubMed)
(922) Supplementation of clomiphene citrate cycles with Cimicifuga racemosa or ethinyl oestradiol--a randomized trial by Shahin AY¹, Ismail AM, Shaaban OM.(PubMed)
(923) Adding the phytoestrogen Cimicifugae Racemosae to clomiphene induction cycles with timed intercourse in polycystic ovary syndrome improves cycle outcomes and pregnancy rates - a randomized trial by Shahin AY¹, Mohammed SA.(PubMed)
(924) Influence of grape seed proanthocyanidin extract in broiler chickens: effect on chicken coccidiosis and antioxidant status by Wang ML¹, Suo X, Gu JH, Zhang WW, Fang Q, Wang X.(PubMed)
(925) The fruit extract of Berberis crataegina DC: exerts potent antioxidant activity and protects DNA integrity by Charehsaz M¹, Sipahi H², Celep E³, Üstündağ A⁴, Cemiloğlu Ülker Ö⁵, Duydu Y⁶, Aydın A⁷, Yesilada E⁸.(PubMed)
(926) Grape consumption supports immunity in animals and humans by Percival SS¹.(PubMed)
(927) Effect of proanthocyanidin-rich extract from Pinus radiata bark on immune response of specific-pathogen-free White Leghorn chickens by Park IJ¹, Cha SY, Kang M, So YS, Go HG, Mun SP, Ryu KS, Jang HK.(PubMed)
(928) Synergistic effect of proanthocyanidin on the bactericidal action of the photolysis of H2O2 ,by Ikai H¹, Nakamura K, Kanno T, Shirato M, Meirelles L, Sasaki K, Niwano Y.(PubMed)
(929) Proanthocyanidin-rich extracts from cranberry fruit (Vaccinium macrocarpon Ait.) selectively inhibit the growth of human pathogenic fungi Candida spp. and Cryptococcus neoformans by Patel KD¹, Scarano FJ, Kondo M, Hurta RA, Neto CC.(PubMed)
(930) Oligomeric proanthocyanidin complexes (OPC) exert anti-proliferative and pro-apoptotic effects on prostate cancer cells by Neuwirt H¹, Arias MC, Puhr M, Hobisch A, Culig Z.(PubMed)
(931) The cytotoxic effects of a novel IH636 grape seed proanthocyanidin extract on cultured human cancer cells by Ye X¹, Krohn RL, Liu W, Joshi SS, Kuszynski CA, McGinn TR, Bagchi M, Preuss HG, Stohs SJ, Bagchi D.(PubMed)
(932) Antisperm immunity and infertility by Lu JC¹, Huang YF, Lu NQ.(PubMed)
(933) Immune infertility: towards a better understanding of sperm (auto)-immunity. The value of proteomic analysis by Bohring C¹, Krause W.(PubMed)
(934) Randomized, double-blind, placebo-controlled trial of Cimicifuga racemosa (black cohosh) in women with anxiety disorder due to menopause by Amsterdam JD¹, Yao Y, Mao JJ, Soeller I, Rockwell K, Shults J.(PubMed)
(935) Black cohosh (Cimicifuga racemosa) in tamoxifen-treated breast cancer patients with climacteric complaints - a prospective observational study by Rostock M¹, Fischer J, Mumm A, Stammwitz U, Saller R, Bartsch HH.(PubMed)
(936) Black cohosh and fluoxetine in the treatment of postmenopausal symptoms: a prospective, randomized trial by Oktem M¹, Eroglu D, Karahan HB, Taskintuna N, Kuscu E, Zeyneloglu HB.(PubMed)
(937) Black Cohosh and Chasteberry: Herbs Valued by Women for Centuries B Y J OSEPH L. M AYO , MD, FACOG
(938) Is infertility really associated with higher levels of mental distress in the female population? Results from the North-Trøndelag Health Study and the Medical Birth Registry of Norway by Biringer E¹, Howard LM, Kessler U, Stewart R, Mykletun A.(PubMed)
(939) Metabolism of Nω -methylserotonin, a serotonergic constituent of black cohosh (Cimicifuga racemosa, L. (Nutt.)), by human liver microsomes by Nikolić D¹, Li J, van Breemen RB.(PubMed)
(940) Mechanism of hepatotoxicity due to black cohosh (Cimicifuga racemosa): histological, immunohistochemical and electron microscopy analysis of two liver biopsies with clinical correlation by Enbom ET¹, Le MD², Oesterich L³, Rutgers J⁴, French SW².(PubMed)
(941)University of Maryland Medical Center((PubMed)
(942) [Efficacy and safety of Black cohosh (Actaea/Cimicifuga racemosa) in the treatment of vasomotor symptoms--review of clinical trials].[Article in Polish] by Kanadys WM¹, Leszczyńska-Gorzelak B, Oleszczuk J.(PubMed)
(943) Black cohosh: an alternative therapy for menopause? by Mahady GB¹, Fabricant D, Chadwick LR, Dietz B.(PubMed)

The Popular Chinese recipe: Asparagus ginger sesame cream soup

Posted By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Recipe contributed by 125 Chinese recipes with Bill Jones and Stephen Wong

1 tbsp. vegetable oil
1 large onion, coarsely chopped
1 tbsp. minced ginger root
8 0z. asparagus trimmed and chopped
4 cups of chicken stock
1 cup of light(10%) cream
1 tbsp. lemon juice
1 tsp. sesame oil
salt and pepper to taste
2 tbsp. cornstarch dissolved in 4 tbsp. (610ml) water
Minced fresh herbs(chives, basil thyme, rosemary) to taste
1tbsp toasted sesame seeds
In a large saucepan, heat oil over medium-high heat for 30 seconds. Add onion and ginger root; cook until onion softens and begin to change color. Add asparagus and chicken stock; bring mixture to a boil. Reduce heat and simmer for 15 minutes or until the asparagus is cooked.
Removed saucepan from heat and allow to cool. Transfer mixture in batches to a blender or load processor and process until smooth
Pour soup through a strainer; pushing as much puree through the mesh as possible (use the back od a wooden spoon to squeeze out liquid). Return liquid to the saucepan, add cream and warm to a simmer. Add lemon juice, sesame oil, season with salt and pepper. Add dissolved cornstarch; bring soup top a boil, stirring constantly until thickened. garnish with herbs, asparagus cream (direction at below), if desired and toast sesame seeds.

For special finish garnish with asparagus cream. To make asparagus cream. Puree4 spears of cooked asparagus in food processor, then push through a strainer.  Measure the puree and mix an equal amount of sour cream. Place a spoon of mixture in the center of each serving and sprinkle with toast sesame seeds.
Weight Loss the Easy Ways 
Andrea Albright Featured on Health and Fitness Jan. 2015
will Personally Coach You How to Get There The Easy Way

The Holistic prevention, management and treatment of Polycystic Ovarian Syndrome: The fertility Herb Angelica sinensis

By Kyle J. Norton Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


                    Polycystic Ovarian Syndrome

Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovasular disease(8)(13), acne(10)(14), endometrial cance(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to  continuously increase risk of type II diabetes, with no increasing altered glucose tolerance(20), CVD and hypertension(21).

The prevention and management  In Herbal Medicine

Polycystic ovary syndrome (PCOS) is unpreventable in Western medicine. Early diagnosis and treatment  may reduce risk of its complications, including infertility, metabolic syndrome, obesity, diabetes, cardiovascular diseases, stroke, etc.
                           
Reduce fat intake less than 30% of total calories with a low proportion of saturated fat and high in fiber from predominantly low-glycaemic-index-carbohydrate foods for patients with PCOs(827a). Calorie intake should be distributed between several meals per day with restricted intake of snacks and drinks(828).

                    The Fertility Herb: Angelica sinensis

 Dang Qui (Angelica sinensis) is a herb of Genus Angelica from the family Apiaceae, indigenous to China, used as a Queen herb in traditional Chinese medicine as anti inflammatory(889), antispasmodic(890) and vasodilatory agent(891)(890), and to balance the hormones in women for a normal menstrual cycle and menstruation(890), reduce menopausal syndromes(888) and improve digestive system(890) and immunity(890).

1. Reproductive organs tonic
Traditional Chinese medicine views angelica roots as queen herb which has been used to enhance the productive system(892) for treatment of gynecological diseases(897) such as dysmenorrhea, amenorrhoea, menopause and promote menstrual health(892). It is said that angelica roots has the power to restore any deficiency caused by hormone imbalance(894)(895)(896).

2. Blood tonic
A reproductive blood tonic herb(894) not only help to increase blood production(895) to replace blood loss for women after menstruation(893), but also increases the blood flow to abdominal region(890)(891), for induction of healthy conception.

3. Digestive system
Dangqui consists a didestice system protective effects(898) against gastrointestinal damage, but also increases the digestive system function(890) in absorbing essential vitamins and minerals(890), thereby reducing the risks of infertility caused by nutrients deficiency(899).

4. Blood and qi deficiency
Blood(896) and qi(890)deficiency may lead to irregular menstrual cycle, absence of period or painful period(896). Angelica roots increase blood and qi flow(890), resulting in normalizing the function of reproductive organs(892)(897).

5. Kidney tonic
It is said that angelica root also helps to improve kidney function not only in regulating water and fluid through urinary extraction(900), but also improving kidney normal function in regulating the natural menstrual process(900) of the reproductive organs, induced fertility.

6. Immune system
 Angelica root containing variety chemicals strengthens the immune system(903) in fighting against infection and inflammation(894)(889), thereby decreasing the risk of yeast infection during menstruation(891) as well as forming of irregular cell growth in the reproductive organs(901)(902)(903).

Side effects
1. It may cause skin inflammation and rashes, if it is taken in high dose(904)
2. Since angelica root causes uterus constraction, the herb should be used on pregnant(904) unless with the approval of her herbalist(904).

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months   

References
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O¹.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF¹, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndrome and healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R¹, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N¹, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB¹, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA¹, Arduc A², Tuna MM¹, Karakılıc E¹, Dagdelen I¹, Tutuncu Y¹, Berker D¹, Guler S¹.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO¹.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO¹, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J¹, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK¹, Katalenich B², Nagireddy P³, Chabbra P⁴, Kuhadiya N⁵, Fonseca V¹.(PubMed)
(14) Acne in hirsute women by Lumezi BG¹, Pupovci HL¹, Berisha VL¹, Goçi AU², Gerqari A³.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N¹, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H¹, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women With Polycystic Ovary Syndrome. by Whigham LD¹, Butz DE², Dashti H³, Tonelli M³, Johnson LK¹, Cook ME², Porter WP⁴, Eghbalnia HR⁵, Markley JL⁶, Lindheim SR⁷, Schoeller DA⁸, Abbott DH⁹, Assadi-Porter FM¹⁰.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA¹, Azizia MM¹, Hardiman PJ².(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M¹, Kjaer SK², Jensen A¹, Munk C¹, Mellemkjaer L³.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E¹.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E¹, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(827a) Diet and nutrition in polycystic ovary syndrome (PCOS): pointers for nutritional management by Farshchi H, Rane A, Love A, Kennedy RL(PubMed)
(828) The optimal diet for women with polycystic ovary syndrome? by Marsh K, Brand-Miller J.(PubMed)

(889) Inhibitory effects of Angelica sinensis ethyl acetate extract and major compounds on NF-kappaB trans-activation activity and LPS-induced inflammation by Chao WW, Hong YH, Chen ML, Lin BF.(PubMed) 

(890) Dang Qui(Complementary and Alternative Healing University) 

(891) Angelica sinensis / Dong Quai(Golden Lotus Botanicals)

(892 Danggui to Angelica sinensis root: are potential benefits to European women lost in translation? A review by Hook IL¹.(PubMed)

(893) Metabolomics study of hematopoietic function of Angelica sinensis on blood deficiency mice model by Li PL¹, Sun HG¹, Hua YL¹, Ji P¹, Zhang L¹, Li JX¹, Wei Y²(PubMed)

(894) Molecular screening of Chinese medicinal plants for progestogenic and anti-progestogenic activity by Ahmed HM¹, Yeh JY, Tang YC, Cheng WT, Ou BR.(PubMed)

(895) Estrogenic activity of herbs commonly used as remedies for menopausal symptoms by Amato, Paula MD¹; Christophe, Sylvie PhD²; Mellon, Pamela L. PhD(Menopause) 

(896) Integrated standardization concept for Angelica botanicals using quantitative NM by Received 9 July 2011, Revised 17 August 2011, Accepted 20 August 2011, Available online 1 September 2011(Sience direct)
(894) [Experimental study on effects of 18 kinds of Chinese herbal medicine for synthesis of thromboxane A2 and PGI2].[Article in Chinese] by Wang SR¹, Guo ZQ, Liao JZ.(PubMed)
(895) Polysaccharide isolated from Angelica sinensis inhibits hepcidin expression in rats with iron deficiency anemia by Liu JY¹, Zhang Y, You RX, Zeng F, Guo D, Wang KP.(PubMed)
(896) [Hematopoietic effect of siwu decoction in the mice with blood deficiency induced by compound method of bleeding, starved feeding and exhausting].[Article in Chinese] by Tan W¹, Song CS, Tan HL, Liu LL, Ma ZC, Wang YG, Gao Y.(PubMed)
(897) Chemical fingerprinting and quantitative constituent analysis of Siwu decoction categorized formulae by UPLC-QTOF/MS/MS and HPLC-DAD by Shulan Su¹, Wenxia Cui¹², Wei Zhou¹, Jin-ao Duan^1*, Erxin Shang¹ and Yuping Tang(Chinese medicine)
 (898) Study of the gastrointestinal protective effects of polysaccharides from Angelica sinensis in rats.

Cho CH¹, Mei QB, Shang P, Lee SS, So HL, Guo X, Li Y.(PubMed)

(899) Glyphosate, pathways to modern diseases II: Celiac sprue and gluten intolerance by Samsel A¹, Seneff S².(PubMed) 

(900) 36 Healing Herbs: The World's Best Medicinal Plants By Rebecca L. Johnson

(901) The antitumor effects of Angelica sinensis on malignant brain tumors in vitro and in vivo. by Tsai NM¹, Lin SZ, Lee CC, Chen SP, Su HC, Chang WL, Harn HJ.(PubMed)

(902) A novel polysaccharide, isolated from Angelica sinensis (Oliv.) Diels induces the apoptosis of cervical cancer HeLa cells through an intrinsic apoptotic pathway. by Cao W¹, Li XQ, Wang X, Fan HT, Zhang XN, Hou Y, Liu SB, Mei QB.(PubMed)

(903) Effects of a Chinese medical herbs complex on cellular immunity and toxicity-related conditions of breast cancer patients by Zhuang SR¹, Chiu HF, Chen SL, Tsai JH, Lee MY, Lee HS, Shen YC, Yan YY, Shane GT, Wang CK.(PubMed) 

(904) Dong Quai (the University of Marryland medical center)

Egg drop soup with Minced Beef and Cilantro

 Posted By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

6oz. lean ground beef
1/2 tsp. salt
2 tsp. soya sauce
1 tpsp. dry sherry or Chinese Shaoxing wine
2 tsp. minced ginger root
3tbsp. cornstarch divided
3 cups chicken stock
2 large eggs beaten
1 cup cilantro leaves, coarsely chopped
salt and fresh ground white pepper to taste
1. Ina small bowl, combine beef, salt, soya sauce, sherry, ginger root and 1tbsp of the cornstarch. Mix well and set aside to marinate for 20 minutes
In a large saucepan or soup pot, bring chicken stock to a boil. Add beef mixture, a little at a time, stirring to loosen the particles; cook for 2 minutes
Dissolve remaining cornstarch in 2tbsp. water; stir mixture into soup. Return to a boil; stirring until soup is slightly thicken. In a slow stream, pour egg into soup, stirring vigorously; cook until eggs are set, about 30 seconds. Stir in cilantro. Season to taste with salt and pepper. Serve immediately.

Weight Loss the Easy Ways 
Andrea Albright Featured on Health and Fitness Jan. 2015
will Personally Coach You How to Get There The Easy Way

The Holistic prevention, management and treatment of Polycystic Ovarian Syndrome: The fertility Herb Chaste tree berry

By Kyle J. Norton Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


                    Polycystic Ovarian Syndrome

Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovasular disease(8)(13), acne(10)(14), endometrial cance(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to  continuously increase risk of type II diabetes, with no increasing altered glucose tolerance(20), CVD and hypertension(21).

The prevention and management  In Herbal Medicine

Polycystic ovary syndrome (PCOS) is unpreventable in Western medicine. Early diagnosis and treatment  may reduce risk of its complications, including infertility, metabolic syndrome, obesity, diabetes, cardiovascular diseases, stroke, etc.
                           
Reduce fat intake less than 30% of total calories with a low proportion of saturated fat and high in fiber from predominantly low-glycaemic-index-carbohydrate foods for patients with PCOs(827a). Calorie intake should be distributed between several meals per day with restricted intake of snacks and drinks(827)(828).

                              The fertility herbs  
                                  Chaste tree berry

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region used in herbal medicine for thousands of year as anaphrodisiac herb and considered as Queen herb in tonifying female reproductive systems(869), including premenstrual problems(865) and menopause symtoms(866)(867)(868)(869). There was report that reports chaste tree berry stems and leaves used by women as bedding "to cool the heat of lust" during the time of the Thesmophoria(870),

1. Androstenedione
Chaste berry tree contains androstenedione which is the common precursor of female sex hormone by converting to testosterone and the estrogens. through the enzyme aromatase(871) by acting as a as a weak partial agonist(872) of the androgen receptor to reduce risk of hormone imbalance that causes infertility. Unfortunately, Epidemioligical evidences suugested that androstenedione may contribute to the worsening of PCOS features as women with PCOs are found to associate to high concentration of androstenedione(873)(874)(875).

2. Epitestosterone
Epitestosterone is an inactive epimer of the hormone testosterone which has been used to enhance athletic performance for some athelic during competition(876)(877). The phytochemical is also found to to improve sexual development(878), sexual desire and sexual arousal(879) induced fertility.

3. Hydroxyprogesterone and progesterone
Chaste tree contains plant hydroxyprogesterone which is a steroid hormone produced during the synthesis of glucocorticoids and sex steroids(880), including the corticosteroids and the androgens and the estrogens(881). The phytochemical also raises the levels of progesterone if it is loo low and reduces it when it is too high in the women body(882), induced fertility.

4. Iridoid
The herb also contaaining iridoid as a intermediator of the biosynthesis of alkaloids improves the immune system in fighting against inflammation(883) and lessens the risks of immune system abnormal function in production of antibody against sperm invasion(884).

5. Glycoside
Glycoside is a flavonoid acted as an antioxidant in increasing the immune system in fighting against forming of free radical as well as guarding our body against irregular cell browth infection and inflammation(885)(886), and reducing the risk of abnormal function of immune system in production of antibody against sperm invasion(884).

 Side effects
According to Drug.com the most common side effects of taking chaste berry tree include
Acne; cramping; diarrhea; hair loss; headache; increased menstrual flow; stomach pain; tiredness, etc....(887)

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months   

References
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O¹.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF¹, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndrome and healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R¹, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N¹, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB¹, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA¹, Arduc A², Tuna MM¹, Karakılıc E¹, Dagdelen I¹, Tutuncu Y¹, Berker D¹, Guler S¹.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO¹.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO¹, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J¹, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK¹, Katalenich B², Nagireddy P³, Chabbra P⁴, Kuhadiya N⁵, Fonseca V¹.(PubMed)
(14) Acne in hirsute women by Lumezi BG¹, Pupovci HL¹, Berisha VL¹, Goçi AU², Gerqari A³.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N¹, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H¹, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women With Polycystic Ovary Syndrome. by Whigham LD¹, Butz DE², Dashti H³, Tonelli M³, Johnson LK¹, Cook ME², Porter WP⁴, Eghbalnia HR⁵, Markley JL⁶, Lindheim SR⁷, Schoeller DA⁸, Abbott DH⁹, Assadi-Porter FM¹⁰.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA¹, Azizia MM¹, Hardiman PJ².(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M¹, Kjaer SK², Jensen A¹, Munk C¹, Mellemkjaer L³.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E¹.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E¹, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(827a) Diet and nutrition in polycystic ovary syndrome (PCOS): pointers for nutritional management by Farshchi H, Rane A, Love A, Kennedy RL(PubMed)
(828) The optimal diet for women with polycystic ovary syndrome? by Marsh K, Brand-Miller J.(PubMed)
(829) A clinical study on the short-term effect of berberine in comparison to metformin on the metabolic characteristics of women with polycystic ovary syndrome by Wei W, Zhao H, Wang A, Sui M, Liang K, Deng H, Ma Y, Zhang Y, Zhang H, Guan Y.(PubMed).
(830) Effect of Korean red ginseng extract in a steroid-induced polycystic ovary murine model by Pak SC, Kim SE, Oh DM, Shim KM, Jeong MJ, Lim SC, Nah SY, Park SH, Kang SS, Moon CJ, Kim JC, Kim SH, Bae CS.(PubMed)
(831) [Effects of ginseng total saponins on nerve growth factor expression in rat with estradiol valerate-induced polycystic ovaries].[Article in Chinese] by Kuang HY, Shao H, Hou LH, Wu XK.(PubMed)
(832) Cryptotanshinone reverses reproductive and metabolic disturbances in prenatally androgenized rats via regulation of ovarian signaling mechanisms and androgen synthesis by Xinming Yang , Yuehui Zhang , Xiaoke Wu , Chun Sik Bae , Lihui Hou , Haixue Kuang , Yongyan Wang , Elisabet Stener-Victorin(American society physiology)
(833) Aloe barbadensis Mill. formulation restores lipid profile to normal in a letrozole-induced polycystic ovarian syndrome rat model by Desai BN, Maharjan RH, Nampoothiri LP.(PubMed)
(834) Effect of Aloe barbadensis Mill. formulation on Letrozole induced polycystic ovarian syndrome rat model by Maharjan R, Nagar PS, Nampoothiri L.(PubMed)
(835) Effect of aloe vera gel to healing of burn wound a clinical and histologic study by Visuthikosol V¹, Chowchuen B, Sukwanarat Y, Sriurairatana S, Boonpucknavig V.(PubMed)
(836) Therapeutic effects of Aloe vera on cutaneous microcirculation and wound healing in second degree burn model in rats by Somboonwong J¹, Thanamittramanee S, Jariyapongskul A, Patumraj S.(PubMed)
(837) A comparative study of three Aloe species used to treat skin diseases in South African rural communities by Coopoosamy RM¹, Naidoo KK.(PubMed)
(838) How to Treat an Infected Sebaceous Cyst(WikiHow)
(839) Oral aloe vera for treatment of diabetes mellitus and dyslipidemia by Ngo MQ¹, Nguyen NN, Shah SA.(PubMed)
(840) Antioxidant effect of Aloe vera gel extract in streptozotocin-induced diabetes in rats by Rajasekaran S¹, Sivagnanam K, Subramanian S.(PubMed)
(841) Antihyperlipidemic Activity of Aloe succotrina in Rats: Possibly Mediated by Inhibition of HMG-CoA Reductase by Dhingra D¹, Lamba D¹, Kumar R², Nath P², Gauttam S³.(PubMed)
(842) Topical Aloe Vera (Aloe barbadensis Miller) Extract Does Not Accelerate the Oral Wound Healing in Rats by Coelho FH¹, Salvadori G, Rados PV, Magnusson A, Danilevicz CK, Meurer L, Martins MD.(PubMed)
(843) Traditional beliefs and practices among Mexican American immigrants with type II diabetes: A case study by Lemley M¹, Spies LA.(PubMed)
(844) Antidiarrhoeal, antisecretory and antispasmodic activities of Matricaria chamomilla are mediated predominantly through K+-channels activation by Mehmood MH¹, Munir S², Khalid UA³, Asrar M⁴, Gilani AH⁵.(PubMed)
(845) Chamomile: an anti-inflammatory agent inhibits inducible nitric oxide synthase expression by blocking RelA/p65 activity by Bhaskaran N¹, Shukla S, Srivastava JK, Gupta S.(PubMed)
(846) Effects of chamomile extract on biochemical and clinical parameters in a rat model of polycystic ovary syndrome by Farideh ZZ¹, Bagher M, Ashraf A, Akram A, Kazem M.(PubMed)
(847) Efficacy and safety of herbal stimulants and sedatives in sleep disorders by Gyllenhaal C¹, Merritt SL, Peterson SD, Block KI, Gochenour T.(PubMed)
(849)Effects of chamomile extract on biochemical and clinical parameters in a rat model of polycystic ovary syndrome by Farideh ZZ, Bagher M, Ashraf A, Akram A, Kazem M.(PubMed)
(850) High-rosmarinic acid spearmint tea in the management of knee osteoarthritis symptoms by Connelly AE¹, Tucker AJ, Tulk H, Catapang M, Chapman L, Sheikh N, Yurchenko S, Fletcher R, Kott LS, Duncan AM, Wright AJ.(PubMed)
(851) Investigation of biochemical and histopathological effects of Mentha piperita L. and Mentha spicata L. on kidney tissue in rats by Akdogan M¹, Kilinç I, Oncu M, Karaoz E, Delibas N.(PubMed)
(852) An update on plant derived anti-androgens. by Grant P, Ramasamy S.(PubMed)
(853) Spearmint herbal tea has significant anti-androgen effects in polycystic ovarian syndrome. A randomized controlled trial by Grant P.(PubMed)
(854) Effect of spearmint (Mentha spicata Labiatae) teas on androgen levels in women with hirsutism. by Akdoğan M, Tamer MN, Cüre E, Cüre MC, Köroğlu BK, Delibaş N.(PubMed)
(855) Anti-inflammatory effects of the chinese herbal formula sini tang in myocardial infarction rats by Liu J¹, Peter K², Shi D¹, Zhang L¹, Dong G¹, Zhang D¹, Breiteneder H², Bauer R³, Jakowitsch J⁴, Ma Y².(PubMed)
(856) Interaction of gypsum and the rhizome of Anemarrhena asphodeloides plays an important role in anti-allergic effects of byakkokakeishito in mice by Makino T¹, Shiraki Y, Mizukami H.(PubMed)
(857) Anti-ulcer and antioxidant activity of GutGard by Mukherjee M¹, Bhaskaran N, Srinath R, Shivaprasad HN, Allan JJ, Shekhar D, Agarwal A.(PubMed)
(858) Anti-convulsant action and amelioration of oxidative stress by Glycyrrhiza glabra root extract in pentylenetetrazole- induced seizure in albino rats by Chowdhury B¹, Bhattamisra SK, Das MC.(PubMed)
(859) Gan Cao(Complementary and Alternative Healing University)
(860) Treatment of polycystic ovary syndrome with spironolactone plus licorice by Armanini D, Castello R, Scaroni C, Bonanni G, Faccini G, Pellati D, Bertoldo A, Fiore C, Moghetti P(PubMed)
(861) [Effects of compound ganshao paste on the levels of sex hormones and hepatic transaminases in polycystic ovarian syndrome rat model].[Article in Chinese] by Wang YH, Wang HL, Zhang YL.(PubMed)
(862) Phytoestrogens and the metabolic syndrome by Jungbauer A¹, Medjakovic S.(PubMed)
(863) Immunomodulatory and Antidiabetic Effects of a New Herbal Preparation (HemoHIM) on Streptozotocin-Induced Diabetic Mice by Kim JJ¹, Choi J¹, Lee MK², Kang KY³, Paik MJ³, Jo SK⁴, Jung U⁴, Park HR⁴, Yee ST⁵.(PubMed)
(864) Preventative effect of an herbal preparation (HemoHIM) on development of airway inflammation in mice via modulation of Th1/2 cells differentiation by Kim JJ¹, Cho HW, Park HR, Jung U, Jo SK, Yee ST.(PubMed)
(865) [Effects of compound ganshao paste on the levels of sex hormones and hepatic transaminases in polycystic ovarian syndrome rat model].[Article in Chinese] by Wang YH, Wang HL, Zhang YL.(PubMed)
(864) HemoHIM improves ovarian morphology and decreases expression of nerve growth factor in rats with steroid-induced polycystic ovaries by Kim SH, Lee HJ, Kim JS, Moon C, Kim JC, Bae CS, Park HR, Jung U, Jo SK.(PubMed)
(865) Evaluating therapeutic effect in symptoms of moderate-to-severe premenstrual syndrome with Vitex agnus castus (BNO 1095) in Chinese women" by Ma L, Lin S, Chen R, Zhang Y, Chen F, Wang X.(PubMed)
(866) "Effects of a combination of Hypericum perforatum and Vitex agnus-castus on PMS-like symptoms in late-perimenopausal women: findings from a subpopulation analysis" by van Die MD, Bone KM, Burger HG, Reece JE, Teede HJ.(PubMed)
(867) Vitex agnus-castus (Chaste-Tree/Berry) in the treatment of menopause-related complaints" by van Die MD, Burger HG, Teede HJ, Bone KM.(PubMed)
(868) "[Herbal medicine in womens' life cycle].[Article in Hebrew]" by Ben-Arye E, Oren A, Ben-Arie A.(PubMed)
(869) Herbs of special interest to women by Hardy ML¹.(PubMed)
(870)  Chaste tree(Happyherbcompany)
(871) Devlin, edited by Thomas M. (2010). Textbook of biochemistry : with clinical correlations (7th ed. ed.). Hoboken, NJ: John Wiley & Sons. p. 432. ISBN 0470281731.

(872) "Partial agonist/antagonist properties of androstenedione and 4-androsten-3β,17β-diol" published on The Journal of Steroid Biochemistry and Molecular Biology. Volume 91, Issues 4–5, August 2004, Pages 247–257

(873) Effects of androstenedione, insulin and luteinizing hormone on steroidogenesis in human granulosa luteal cells by S. Greisen, T. Ledet3 and P. Ovesen(Oxford Journal)

(874) Elevated serum androstenedione is associated with a more severe phenotype in women with polycystic ovary syndrome (PCOS) by Georgopoulos NA¹, Papadakis E², Armeni AK¹, Katsikis I², Roupas ND¹, Panidis D².(PubMed)

(875) The influence of obesity on androstenedione to testosterone ratio in women with polycystic ovary syndrome (PCOS) and hyperandrogenemia by Misichronis G¹, Georgopoulos NA, Marioli DJ, Armeni AK, Katsikis I, Piouka AD, Saltamavros AD, Roupas ND, Panidis D.(PubMed)

(876) Evaluation of testosterone/epitestosterone ratio influential factors as determined in doping analysis by van de Kerkhof DH¹, de Boer D, Thijssen JH, Maes RA.(PubMed)

(877) Increased urinary testosterone/epitestosterone ratios found in Swedish athletes in connection with a national control program. Evaluation of 28 cases by Garle M¹, Ocka R, Palonek E, Björkhem I.(PubMed)

(878) Sex, drugs and sports: prostaglandins, epitestosterone and sexual development by Sanders BK¹.(PubMed)

(879) The Relation of Plasma Androgen Levels to Sexual Behaviors and Attitudes of Women1. by Persky, Harold PhD; Dreisbach, Lorraine MS; Miller, William R. PhD; O'Brien, Charles P. MD, PhD; Khan, Miftah A. MSc; Lief, Harold I. MD; Charney, Natalie; Strauss, Dorothy PhD(The Journal of biobehavior medicine)

(880) Human  17 - Hydroxyprogesterone, 17 - OHP ELISA kit Catalog No. E0454h

(881) 17 - Hydroxyprogesterone(Wikepieda)

(882) Agonistic and antagonistic properties of progesterone metabolites at the human mineralocorticoid receptor by Quinkler M¹, Meyer B, Bumke-Vogt C, Grossmann C, Gruber U, Oelkers W, Diederich S, Bahr V.(PubMed)

(883) In vitro and in vivo immunomodulatory activities of iridoids fraction from Barleria prionitis Linn by Ghule BV¹, Yeole PG.(PubMed)

(884) [Specific mucosal immunity in the female reproductive tract: protection against infectious diseases and regulation of fertility (part 2)].[Article in Czech] by Zivný J¹, Sterzl I.(PubMed)

(885) New chalcanonol glycoside from the seeds of saw palmetto: antiproliferative and antioxidant effects by Abdel Bar FM¹.(PubMed)

(886) Antioxidant properties, radical scavenging activity and biomolecule protection capacity of flavonoid naringenin and its glycoside naringin: a comparative study by Cavia-Saiz M¹, Busto MD, Pilar-Izquierdo MC, Ortega N, Perez-Mateos M, Muñiz P.(PubMed)

(887) chaste tree(Drug.com, know more, be sure)